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Results: 299
Genomic plasticity associated with antimicrobial resistance in Vibrio cholerae.
Jyoti Verma, Satyabrata Bag, Bipasa Saha, Pawan Kumar, Tarini Shankar Ghosh, Mayanka Dayal, Tarosi Senapati, Seema Mehra, Prasanta Dey, Anbumani Desigamani, Dhirendra Kumar, Preety Rana, Bhoj Kumar, Tushar K Maiti, Naresh C Sharma, Rupak K Bhadra, Ankur Mutreja, G Balakrish Nair, Thandavarayan Ramamurthy, Bhabatosh Das
Jun 17, 2019
Antimicrobial resistance Cholera Genome mobile genetic elements Proteome Anti-Bacterial Agents Cholera Conjugation Genetic DNA Transposable Elements Diarrhea Drug Resistance Multiple Bacterial evolution Molecular Feces Gene Transfer Horizontal genetic variation Genome Bacterial Genomic Islands Humans Imipenem india Interspersed Repetitive Sequences Phenotype Plasmids Prophages Proteome Vibrio cholerae Vibrio cholerae O1 whole genome sequencing
NMR backbone resonance assignment and solution secondary structure determination of human NSD1 and NSD2.
Nader Amin, Daniel Nietlispach, Seema Qamar, Joe Coyle, Elisabetta Chiarparin, Glyn Williams
Feb 08, 2019
Proteins of the NSD family are histone-methyl transferases with critical functions in the regulation of chromatin structure and function. NSD1 and NSD2 are homologous proteins that function as epigenetic regulators of...
Histone-methyl transferase MMSET NMR resonance assignments NMR stability screen NSD family NSD1 NSD2 Nuclear receptor-binding SET domain WHSC1 Amino Acid Sequence Histone Methyltransferases Histone-Lysine N-Methyltransferase Humans Intracellular Signaling Peptides and Proteins Nuclear Magnetic Resonance Biomolecular Nuclear Proteins Protein Domains Protein Structure Secondary Repressor Proteins Solutions
Side-by-side comparison of Notch- and C83 binding to γ-secretase in a complete membrane model at physiological temperature.
γ-Secretase cleaves the C99 fragment of the amyloid precursor protein, leading to formation of aggregated β-amyloid peptide central to Alzheimer's disease, and Notch, essential for cell regulation. Recent cryogenic electron...
Gender inclusive sport
This commentary develops the concept of gender inclusive sport: sport that is inclusive and affirming of––and safe for––all women and sex and gender minoritized people, regardless of whether their bodies, gender expression...
Gender inclusive sport
This commentary develops the concept of gender inclusive sport: sport that is inclusive and affirming of––and safe for––all women and sex and gender minoritized people, regardless of whether their bodies, gender expression...
Predictive Modeling of Stress in the Healthcare Industry During COVID-19
There was a substantial medicine shortage and an increase in morbidity due to the second wave of the COVID-19 pandemic in India. This pandemic has also had a drastic impact on healthcare professionals' psychological health as...
Published by: IGI Global Scientific Publishing
Oligomer Diversity during the Aggregation of the Repeat Region of Tau.
Magnus Kjaergaard, Alexander J Dear, Franziska Kundel, Seema Qamar, Georg Meisl, Tuomas PJ Knowles, David Klenerman
Sep 20, 2018
aggregation mechanism amyloid oligomers Kinetic modeling single-molecule FRET Tau Amyloid beta-Peptides Codon Fluorescence Resonance Energy Transfer Genes Synthetic Humans Kinetics Models Molecular Neurofibrillary Tangles Polymers protein aggregation Pathological single molecule imaging tau Proteins
Advanced Object Detection in Bio-Medical X-Ray Images for Anomaly Detection and Recognition
The human vision system is mimicked in the format of videos and images in the area of computer vision. As humans can process their memories, likewise video and images can be processed and perceptive with the help of computer...
Published by: IGI Global Scientific Publishing
Inherited and Sporadic Amyotrophic Lateral Sclerosis and Fronto-Temporal Lobar Degenerations arising from Pathological Condensates of Phase Separating Proteins.
Michael Fernandopulle, GuoZhen Wang, Jonathon Nixon-Abell, Seema Qamar, Varun Balaji, Ryuta Morihara, Peter H St George-Hyslop
Jul 08, 2019
ANXA11 Amyotrophic Lateral Sclerosis FUS TDP-43 biological condensates fronto-temporal dementia gelation Hydrogels local RNA translation neuronal transport granules phase separation Stress granules Amyotrophic Lateral Sclerosis Annexins Biological Transport DNA-Binding Proteins Frontotemporal Lobar Degeneration Humans Intracellular Membranes Mutation Missense Neurodegenerative Diseases Neurons Protein Processing Post-Translational RNA-Binding Protein FUS Temporal Lobe
Experiences of a mobile phone delivered brief intervention for hazardous drinking
Danielle Fernandes, Ethel D'Souza, Seema Sambari, Grace Marimilha Pacheco, Joseline D’souza, Richard Velleman, Urvita Bhatia, Abhijit Nadkarni
Dec 31, 2023
Background
This study explores the experiences of participants receiving a mobile-based brief intervention (BI) for hazardous drinking in India, to determine characteristics that influenced engagement and examine perceived...
This study explores the experiences of participants receiving a mobile-based brief intervention (BI) for hazardous drinking in India, to determine characteristics that influenced engagement and examine perceived...
Experiences of a mobile phone delivered brief intervention for hazardous drinking
Danielle Fernandes, Ethel D'Souza, Seema Sambari, Grace Marimilha Pacheco, Joseline D’souza, Richard Velleman, Urvita Bhatia, Abhijit Nadkarni
Dec 31, 2023
Background
This study explores the experiences of participants receiving a mobile-based brief intervention (BI) for hazardous drinking in India, to determine characteristics that influenced engagement and examine perceived...
This study explores the experiences of participants receiving a mobile-based brief intervention (BI) for hazardous drinking in India, to determine characteristics that influenced engagement and examine perceived...
Advanced Object Detection in Bio-Medical X-Ray Images for Anomaly Detection and Recognition
The human vision system is mimicked in the format of videos and images in the area of computer vision. As humans can process their memories, likewise video and images can be processed and perceptive with the help of computer...
Medicine and Healthcare Medical Diagnosis and Practice Medical Imaging Computer Science and Information Technology Media and Communications
Published by: IGI Global Scientific Publishing
Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition.
Yi Shen, Francesco Simone Ruggeri, Daniele Vigolo, Ayaka Kamada, Seema Qamar, Aviad Levin, Christiane Iserman, Simon Alberti, Peter St George-Hyslop, Tuomas PJ Knowles
Feb 24, 2021
Membrane-less organelles resulting from liquid-liquid phase separation of biopolymers into intracellular condensates control essential biological functions, including messenger RNA processing, cell signalling and...
Study of Control of Primary PPH in Cases of Placenta Previa by Intrauterine Packing in GGS Medical College and Hospital Faridkot
Nishi Garg and Grover Seema
Apr 04, 2015
Placenta Previa is a major cause of haemmorrhage in Obstetrics. There can be severe haemorrhage from the placental site after its removal. Various methods have been used to control bleeding .Intrauterine packing is very...
Published by: IJHS Medical Association
The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration.
Peter St George-Hyslop, Julie Qiaojin Lin, Akinori Miyashita, Emma C Phillips, Seema Qamar, Suzanne J Randle, GuoZhen Wang
Sep 05, 2018
Amyotrophic Lateral Sclerosis arginine methylation Cation-pi interactions frontotemporal dementia phase separation RNA binding proteins Amyotrophic Lateral Sclerosis biophysics Cytoplasmic Granules DNA-Binding Proteins frontotemporal dementia Frontotemporal Lobar Degeneration Humans Mutation Neurodegenerative Diseases Protein Domains Protein Processing Post-Translational RNA-Binding Protein FUS RNA-Binding Proteins Temporal Lobe
A high-resolution structure of the EF-hand domain of human polycystin-2.
Autosomal dominant polycystic kidney disease (ADPKD) affects over 1:1000 of the worldwide population and is caused by mutations in two genes, PKD1 and PKD2. PKD2 encodes a 968-amino acid membrane spanning protein, Polycystin-2...
The systematic development of a mobile phone–delivered brief intervention for hazardous drinking in India
Abhijit Nadkarni, Sheina Costa, Devika Gupta, Danielle Fernandes, Alexander Catalano, Richard Velleman, Seema Sambari, Subhash Pednekar, Farah Hussain, Ethel D'Souza, Amruta Houde, Neal Chaudhuri, Anna Heath
Jul 01, 2021
Background: The treatment gap for alcohol use disorders (AUD) in India is the highest among all mental health and substance use disorders. Despite evidence of the cost effectiveness of brief interventions (BIs) for hazardous...
Study of Control of Primary PPH in Cases of Placenta Previa by Intrauterine Packing in GGS Medical College and Hospital Faridkot
Nishi Garg and Grover Seema
Apr 04, 2015
Placenta Previa is a major cause of haemmorrhage in Obstetrics. There can be severe haemorrhage from the placental site after its removal. Various methods have been used to control bleeding .Intrauterine packing is very...
Published by: IJHS Medical Association
Mitochondrial ROS control neuronal excitability and cell fate in frontotemporal dementia.
Noemí Esteras, Olga Kopach, Marta Maiolino, Vincenzo Lariccia, Salvatore Amoroso, Seema Qamar, Selina Wray, Dmitri A Rusakov, Morana Jaganjac, Andrey Y Abramov
May 31, 2021
INTRODUCTION: The second most common form of early-onset dementia-frontotemporal dementia (FTD)-is often characterized by the aggregation of the microtubule-associated protein tau. Here we studied the mechanism of tau-induced...
4R tau AMPA receptors MAPT 10+16 NMDA receptors Calcium Signaling frontotemporal dementia Glutamate Induced Pluripotent Stem Cells mitochondrial antioxidants mitochondrial reactive oxygen species Tau frontotemporal dementia Humans Induced Pluripotent Stem Cells Mitochondria Neurons Reactive Oxygen Species Receptors N-Methyl-D-Aspartate tau Proteins
Functional connexin35 increased in the myopic chicken retina.
Seema Banerjee, Qing Wang, George Tang, Chunghim So, Sze Wan Shan, King Kit Li, Chi-Wai Do, Feng Pan
Jun 14, 2021
Our previous research showed that increased phosphorylation of connexin (Cx)36 indicated extended coupling of AII amacrine cells (ACs) in the rod-dominant mouse myopic retina. This research will determine whether...
The systematic development of a mobile phone–delivered brief intervention for hazardous drinking in India
Abhijit Nadkarni, Sheina Costa, Devika Gupta, Danielle Fernandes, Alexander Catalano, Richard Velleman, Seema Sambari, Subhash Pednekar, Farah Hussain, Ethel D'Souza, Amruta Houde, Neal Chaudhuri, Anna Heath
Jul 01, 2021
Background: The treatment gap for alcohol use disorders (AUD) in India is the highest among all mental health and substance use disorders. Despite evidence of the cost effectiveness of brief interventions (BIs) for hazardous...
Spatially non-uniform condensates emerge from dynamically arrested phase separation.
Nadia A Erkamp, Tomas Sneideris, Hannes Ausserwöger, Daoyuan Qian, Seema Qamar, Jonathon Nixon-Abell, Peter St George-Hyslop, Jeremy D Schmit, David A Weitz, Tuomas P J Knowles
Mar 13, 2023
The formation of biomolecular condensates through phase separation from proteins and nucleic acids is emerging as a spatial organisational principle used broadly by living cells. Many such biomolecular condensates are not...
Published by: Nature Communications
Differential interaction with TREM2 modulates microglial uptake of modified Aβ species.
Increased Connexin36 Phosphorylation in AII Amacrine Cell Coupling of the Mouse Myopic Retina.
Seema Banerjee, Qin Wang, Fuxin Zhao, George Tang, Chunghim So, Dennis Tse, Chi-Ho To, Yun Feng, Xiangtian Zhou, Feng Pan
Jun 15, 2020
Myopia is a substantial public health problem worldwide. In the myopic retina, distant images are focused in front of the photoreceptors. The cells and mechanisms for retinal signaling that account either for emmetropization...
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