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Results: 473
BRG1 and NPM-ALK Are Co-Regulated in Anaplastic Large-Cell Lymphoma; BRG1 Is a Potential Therapeutic Target in ALCL.
Gavin D Garland, Stephen P Ducray, Leila Jahangiri, Perla Pucci, GA Amos Burke, Jack Monahan, Raymond Lai, Olaf Merkel, Ana-Iris Schiefer, Lukas Kenner, Andrew J Bannister, Suzanne D Turner
Jan 07, 2022
Anaplastic large-cell lymphoma (ALCL) is a T-cell malignancy driven in many cases by the product of a chromosomal translocation, nucleophosmin-anaplastic lymphoma kinase (NPM-ALK). NPM-ALK activates a plethora of pathways that...
Children's Transport Built Environments
Melody Smith, Rebecca Amann, Alana Cavadino, Deborah Raphael, Robin Kearns, Roger Mackett, Lisa Mackay, Penelope Carroll, Euan Forsyth, Suzanne Mavoa, Jinfeng Zhao, Erika Ikeda, Karen Witten
Jan 06, 2020
Children's independent mobility is declining internationally. Parents are the gatekeepers of children's independent mobility. This mixed methods study investigates whether parent perceptions of the neighbourhood environment...
Signalling involving MET and FAK supports cell division independent of the activity of the cell cycle-regulating CDK4/6 kinases.
Factorial Structure and Validity of Depression (PHQ-9) and Anxiety (GAD-7) Scales after Traumatic Brain Injury.
Ali Teymoori, Anastasia Gorbunova, Fardzadeh E Haghish, Ruben Real, Marina Zeldovich, Yi-Jhen Wu, Suzanne Polinder, Thomas Asendorf, David Menon, CENTER-TBI Investigators and Participants, Nicole V Steinbüchel
Apr 30, 2020
BACKGROUND:The dimensionality of depression and anxiety instruments have recently been a source of controversy. OBJECTIVES AND DESIGN:In a European-wide sample of patients after Traumatic Brain Injury (TBI), we aim to examine...
Published by: Journal of clinical medicine
Point OutWords
Ailbhe McKinney, Kathryn L. Hotson, Alicia Rybicki, Emma J. L. Weisblatt, Claudia Días, Juliet Foster, Sofía S. Villar, Suzanne Murphy, Matthew K. Belmonte
Jan 22, 2021
Abstract: Background: Point OutWords is a caregiver-delivered, iPad-assisted intervention for non-verbal or minimally verbal children with autism. It aims to develop prerequisite skills for communication such as manual and oral...
Missed opportunities for diagnosing brain tumours in primary care
Fiona M Walter, Clarissa Penfold, Alexis Joannides, Smiji Saji, Margaret Johnson, Colin Watts, Andrew Brodbelt, Michael D Jenkinson, Stephen J Price, Willie Hamilton, Suzanne E Scott
Mar 19, 2019
BACKGROUND: Brain tumours are uncommon, and have extremely poor outcomes. Patients and GPs may find it difficult to recognise early symptoms because they are often non-specific and more likely due to other conditions. AIM: To...
Central Nervous System Neoplasms Diagnosis primary brain neoplasms PRIMARY CARE Symptoms Adult Brain Neoplasms Critical Pathways England Female general practitioners Health Knowledge Attitudes practice Help-Seeking Behavior Humans Male Middle Aged Physician-Patient Relations Primary Health Care qualitative research Quality Improvement Symptom Assessment
Anti-ALK Antibodies in Patients with ALK-Positive Malignancies Not Expressing NPM-ALK.
Overcoming hurdles to intervention studies with autistic children with profound communication difficulties and their families.
Ailbhe McKinney, Emma JL Weisblatt, Kathryn L Hotson, Zahra Bilal Ahmed, Claudia Dias, Dorit BenShalom, Juliet Foster, Suzanne Murphy, Sofía S Villar, Matthew K Belmonte
Jul 30, 2021
Autistic children who speak few or no words or who have an intellectual disability are the most in need of new understandings and treatments, but the most often left out of the research that can bring these benefits. Researchers...
The Grizzly, February 8, 1994
Erika Compton, Hope Rinehimer, Michael Woodruff, Mark Leiser, Fred Woll, Craig Faucher, Victor Gil, Jayson Blocksidge, Richard P. Richter, Tom Epler, Sue Boyer, Ed Markowski, Kristen Cornell, Suzanne Ledonne, Harley David Rubin, Jen Diamond
Jan 01, 0001
Ursinus Celebrates 125 Years of Academics An Evaluation of the 128 Credit System In Celebration of Black History Month: Al Eaton Brings on His One-Man Show Ursinus Crimes Reported Who Freed South Africa? Guys Pledging...
Ursinus College Collegeville Pennsylvania newspaper Basketball Paul Coppola wrestling gymnastics Office of Continuing Education Wismer dining hall jazz ensemble Robert Burns Woodward Berman Art Museum Airband Reimert Hall campus security Craig Faucher Al Eaton Martin Luther King Jr. Nicholas Berry Nelson Mandela Founders Day credit policy cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury
Maryse C Cnossen, Jilske A Huijben, Mathieu van der Jagt, Victor Volovici, Thomas van Essen, Suzanne Polinder, David Nelson, Ari Ercole, Nino Stocchetti, Giuseppe Citerio, Wilco C Peul, Andrew I R Maas, David Menon, Ewout W Steyerberg, Hester F Lingsma
Sep 06, 2017
Abstract
Background
No definitive evidence exists on how intracranial hypertension should be treated in patients with traumatic brain injury (TBI). It is therefore likely that...
Connecting gene expression data from connectivity map and in silico target predictions for small molecule mechanism-of-action analysis.
Extending in silico mechanism-of-action analysis by annotating targets with pathways
The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay.
Erik Hjerde, Marit Sjo Lorentzen, Matthew TG Holden, Kathy Seeger, Steinar Paulsen, Nathalie Bason, Carol Churcher, David Harris, Halina Norbertczak, Michael A Quail, Suzanne Sanders, Scott Thurston, Julian Parkhill, Nils Peder Willassen, Nicholas R Thomson
Sep 06, 2019
BACKGROUND: The fish pathogen Aliivibrio salmonicida is the causative agent of cold-water vibriosis in marine aquaculture. The Gram-negative bacterium causes tissue degradation, hemolysis and sepsis in vivo. RESULTS: In total, 4...
Neighbourhoods for Active Kids
Melody Oliver, Julia McPhee, Penelope Carroll, Erika Ikeda, Suzanne Mavoa, Lisa Mackay, Robin A Kearns, Marketta Kyttä, Lanuola Asiasiga, Nicholas Garrett, Judy Lin, Roger Mackett, Caryn Zinn, Helen Moewaka Barnes, Victoria Egli, Kate Prendergast, Karen Witten
Dec 18, 2019
INTRODUCTION: New Zealand children's physical activity, including independent mobility and active travel, has declined markedly over recent decades. The Neighbourhoods for Active Kids (NfAK) study examines how neighbourhood...
Accelerometry Built environment Child-centred methods obesity Participatory GIS Accelerometry Body Height Body Size Body Weight Child Cities Cross-Sectional Studies Diet Exercise Family Female Geographic Information Systems Health Behavior Humans Male Multilevel Analysis New Zealand Residence Characteristics Schools Social Environment Socioeconomic Factors Travel Waist Circumference Walking
Psychometric Characteristics of the Patient-Reported Outcome Measures Applied in the CENTER-TBI Study.
Nicole von Steinbuechel, Katrin Rauen, Fabian Bockhop, Amra Covic, Ugne Krenz, Anne Marie Plass, Katrin Cunitz, Suzanne Polinder, Lindsay Wilson, Ewout W Steyerberg, Andrew IR Maas, David Menon, Yi-Jhen Wu, Marina Zeldovich, The Center-Tbi Participants And Investigators
Aug 19, 2021
Traumatic brain injury (TBI) may lead to impairments in various outcome domains. Since most instruments assessing these are only available in a limited number of languages, psychometrically validated translations are important...
Primary post-transplant lymphoproliferative disorder of the central nervous system
Mary M Taj, Britta Maecker-Kolhoff, Rebecca Ling, Simon Bomken, Birgit Burkhardt, Alan KS Chiang, Monika Csoka, Anna Füreder, Stéphanie Haouy, Jelena Lazic, Natalia Miakova, Veronique Minard-Colin, Suzanne D Turner, Anne Uyttebroeck, Andishe Attarbaschi, the international Berlin-Frankfurt-Münster (i-BFM) Study Group European Intergroup for Childhood Non-Hodgkin’s Lymphoma (EICNHL)
Feb 17, 2021
Primary central nervous system (CNS) post-transplant lymphoproliferative disorder (PTLD) in childhood is rare. Twenty-five patients were retrieved from nine European Intergroup for Childhood Non-Hodgkin's Lymphoma and/or...
Central Nervous System outcome post-transplant lymphoproliferative disorder transplant Treatment Adolescent Adult Allografts Brain Neoplasms Child Child Preschool Disease-Free Survival Female Hematopoietic Stem Cell Transplantation Humans Infant Injections Spinal Lymphoproliferative Disorders Male Organ Transplantation Rituximab Survival Rate
Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities
Takuhiro Sonoyama, Lukas K. J. Stadler, Mingyan Zhu, Julia M. Keogh, Elana Henning, Fuki Hisama, Peter Kirwan, Magdalena Jura, Beata K. Blaszczyk, David C. DeWitt, Bas Brouwers, Marko Hyvönen, Inês Barroso, Florian T. Merkle, Suzanne M. Appleyard, Gary A. Wayman, I. Sadaf Farooqi
Jun 04, 2021
Abstract: Brain-derived neurotrophic factor (BDNF) signals through its high affinity receptor Tropomyosin receptor kinase-B (TrkB) to regulate neuronal development, synapse formation and plasticity. In rodents, genetic...
Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy.
Adjusting for confounding by indication in observational studies
Maryse C Cnossen, Thomas A van Essen, Iris E Ceyisakar, Suzanne Polinder, Teuntje M Andriessen, Joukje van der Naalt, Iain Haitsma, Janneke Horn, Gaby Franschman, Pieter E Vos, Wilco C Peul, David K Menon, Andrew IR Maas, Ewout W Steyerberg, Hester F Lingsma
Sep 20, 2018
INTRODUCTION: Observational studies of interventions are at risk for confounding by indication. The objective of the current study was to define the circumstances for the validity of methods to adjust for confounding by...
Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers
Variation in general supportive and preventive intensive care management of traumatic brain injury
Jilske A Huijben, Victor Volovici, Maryse C Cnossen, Iain K Haitsma, Nino Stocchetti, Andrew IR Maas, David K Menon, Ari Ercole, Giuseppe Citerio, David Nelson, Suzanne Polinder, Ewout W Steyerberg, Hester F Lingsma, Mathieu van der Jagt, CENTER-TBI Investigators and Participants
May 02, 2018
BACKGROUND: General supportive and preventive measures in the intensive care management of traumatic brain injury (TBI) aim to prevent or limit secondary brain injury and optimize recovery. The aim of this survey was to assess...
blood pressure Europe Fever Glucose intensive care unit Nutrition Seizure Survey Traumatic brain injury ventilation Adult Brain Injuries Traumatic Comparative Effectiveness Research Europe Female Humans Intensive Care Units Male Program Evaluation Quality of Health Care Surveys and Questionnaires Trauma Centers
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.
Victoria S Burchell, David E Nelson, Alvaro Sanchez-Martinez, Marta Delgado-Camprubi, Rachael M Ivatt, Joe H Pogson, Suzanne J Randle, Selina Wray, Patrick A Lewis, Henry Houlden, Andrey Y Abramov, John Hardy, Nicholas W Wood, Alexander J Whitworth, Heike Laman, Helene Plun-Favreau
Aug 08, 2017
Compelling evidence indicates that two autosomal recessive Parkinson's disease genes, PINK1 (PARK6) and Parkin (PARK2), cooperate to mediate the autophagic clearance of damaged mitochondria (mitophagy). Mutations in the F-box...
Animals Animals Genetically Modified Carbonyl Cyanide m-Chlorophenyl Hydrazone Cell Line Tumor Cells Cultured Drosophila F-Box Proteins Female Fertility FIBROBLASTS Humans Male Microtubule-Associated Proteins Mitochondria Mitochondrial Degradation Mutation Parkinson Disease Protein Transport Proton Ionophores RNA Small Interfering Time Factors Ubiquitin-Protein Ligases Ubiquitination
Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency.
Monica Ceccon, Maria Elena Boggio Merlo, Luca Mologni, Teresa Poggio, Lydia M Varesio, Matteo Menotti, Silvia Bombelli, Roberta Rigolio, Andrea D Manazza, Filomena Di Giacomo, Chiara Ambrogio, Giovanni Giudici, Cesare Casati, Cristina Mastini, Mara Compagno, Suzanne D Turner, Carlo Gambacorti-Passerini, Roberto Chiarle, Claudia Voena
Jan 08, 2016
Animals Apoptosis Blotting Western Cell Line Tumor Cell Survival Cells Cultured Crizotinib Dose-Response Relationship Drug Drug Synergism Extracellular Signal-Regulated MAP Kinases Histones Humans Hydrazines Lymphoma Large-Cell Anaplastic Mice Inbred NOD Mice Knockout Mice SCID Microscopy Confocal Nucleophosmin Oncogene Proteins Fusion Protein Kinase Inhibitors Protein-Tyrosine Kinases Pyrazoles Pyridines RNA Interference Signal Transduction Transplantation Heterologous Triazoles
Encephalopathy induced by Alzheimer brain inoculation in a non-human primate.
Charlotte Gary, Suzanne Lam, Anne-Sophie Hérard, James E Koch, Fanny Petit, Pauline Gipchtein, Stephen J Sawiak, Raphaëlle Caillierez, Sabiha Eddarkaoui, Morvane Colin, Fabienne Aujard, Jean-Philippe Deslys, French Neuropathology Network, Emmanuel Brouillet, Luc Buée, Emmanuel E Comoy, Fabien Pifferi, Jean-Luc Picq, Marc Dhenain
Sep 03, 2020
Alzheimer's disease is characterized by cognitive alterations, cerebral atrophy and neuropathological lesions including neuronal loss, accumulation of misfolded and aggregated β-amyloid peptides (Aβ) and tau proteins. Iatrogenic...
Alzheimer’s disease Cerebral atrophy COGNITIVE IMPAIRMENT Microcebus murinus MOUSE Neurodegenerative disease Neuronal function Prion tau pathology β-Amyloid pathology Alzheimer Disease Animals Brain Brain Diseases Cheirogaleidae Electroencephalography Female Humans Magnetic Resonance Imaging Male Mice Mice Transgenic Primates Species Specificity
Examining pathways between genetic liability for schizophrenia and patterns of tobacco and cannabis use in adolescence.
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