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Results: 14
MADGAN
Changhee Han, Leonardo Rundo, Kohei Murao, Tomoyuki Noguchi, Yuki Shimahara, Zoltán Ádám Milacski, Saori Koshino, Evis Sala, Hideki Nakayama, Shin'ichi Satoh
Jul 12, 2021
BACKGROUND: Unsupervised learning can discover various unseen abnormalities, relying on large-scale unannotated medical images of healthy subjects. Towards this, unsupervised methods reconstruct a 2D/3D single medical image to...
Normative design using inductive learning
In this paper we propose a use-case-driven iterative design methodology for normative frameworks, also called virtual institutions, which are used to govern open systems. Our computational model represents the normative...
Normative design using inductive learning
In this paper we propose a use-case-driven iterative design methodology for normative frameworks, also called virtual institutions, which are used to govern open systems. Our computational model represents the normative...
MADGAN
Changhee Han, Leonardo Rundo, Kohei Murao, Tomoyuki Noguchi, Yuki Shimahara, Zoltán Ádám Milacski, Saori Koshino, Evis Sala, Hideki Nakayama, Shin’ichi Satoh
Apr 26, 2021
Abstract: Background: Unsupervised learning can discover various unseen abnormalities, relying on large-scale unannotated medical images of healthy subjects. Towards this, unsupervised methods reconstruct a 2D/3D single medical...
Integrated omics unveil the secondary metabolic landscape of a basal dinoflagellate
Girish Beedessee, Takaaki Kubota, Asuka Arimoto, Koki Nishitsuji, Ross F. Waller, Kanako Hisata, Shinichi Yamasaki, Noriyuki Satoh, Jun’ichi Kobayashi, Eiichi Shoguchi
Oct 13, 2020
Abstract: Background: Some dinoflagellates cause harmful algal blooms, releasing toxic secondary metabolites, to the detriment of marine ecosystems and human health. Our understanding of dinoflagellate toxin biosynthesis has...
Integrated omics unveil the secondary metabolic landscape of a basal dinoflagellate
Girish Beedessee, Takaaki Kubota, Asuka Arimoto, Koki Nishitsuji, Ross F. Waller, Kanako Hisata, Shinichi Yamasaki, Noriyuki Satoh, Jun’ichi Kobayashi, Eiichi Shoguchi
Oct 13, 2021
Abstract: Background: Some dinoflagellates cause harmful algal blooms, releasing toxic secondary metabolites, to the detriment of marine ecosystems and human health. Our understanding of dinoflagellate toxin biosynthesis has...
Integrated omics unveil the secondary metabolic landscape of a basal dinoflagellate.
Girish Beedessee, Takaaki Kubota, Asuka Arimoto, Koki Nishitsuji, Ross F Waller, Kanako Hisata, Shinichi Yamasaki, Noriyuki Satoh, Jun'ichi Kobayashi, Eiichi Shoguchi
Dec 14, 2020
BACKGROUND: Some dinoflagellates cause harmful algal blooms, releasing toxic secondary metabolites, to the detriment of marine ecosystems and human health. Our understanding of dinoflagellate toxin biosynthesis has been hampered...
Differential interaction with TREM2 modulates microglial uptake of modified Aβ species.
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation.
Anna Vilalta, Ye Zhou, Jean Sevalle, Jennifer K Griffin, Kanayo Satoh, David H Allendorf, Suman De, Mar Puigdellívol, Arturas Bruzas, Miguel A Burguillos, Roger B Dodd, Fusheng Chen, Yalun Zhang, Patrick Flagmeier, Lisa-Maria Needham, Masahiro Enomoto, Seema Qamar, James Henderson, Jochen Walter, Paul E Fraser, David Klenerman, Steven F Lee, Peter St George-Hyslop, Guy C Brown
Apr 07, 2021
BMPR2 mutations and survival in pulmonary arterial hypertension
Jonathan DW Evans, Barbara Girerd, David Montani, Xiao-Jian Wang, Nazzareno Galiè, Eric D Austin, Greg Elliott, Koichiro Asano, Ekkehard Grünig, Yi Yan, Zhi-Cheng Jing, Alessandra Manes, Massimiliano Palazzini, Lisa A Wheeler, Ikue Nakayama, Toru Satoh, Christina Eichstaedt, Katrin Hinderhofer, Matthias Wolf, Erika B Rosenzweig, Wendy K Chung, Florent Soubrier, Gérald Simonneau, Olivier Sitbon, Stefan Gräf, Stephen Kaptoge, Emanuele Di Angelantonio, Marc Humbert, Nicholas W Morrell
Jan 13, 2016
Hemichordate genomes and deuterostome origins.
Oleg Simakov, Takeshi Kawashima, Ferdinand Marlétaz, Jerry Jenkins, Ryo Koyanagi, Therese Mitros, Kanako Hisata, Jessen Bredeson, Eiichi Shoguchi, Fuki Gyoja, Jia-Xing Yue, Yi-Chih Chen, Robert M Freeman, Akane Sasaki, Tomoe Hikosaka-Katayama, Atsuko Sato, Manabu Fujie, Kenneth W Baughman, Judith Levine, Paul Gonzalez, Christopher Cameron, Jens H Fritzenwanker, Ariel M Pani, Hiroki Goto, Miyuki Kanda, Nana Arakaki, Shinichi Yamasaki, Jiaxin Qu, Andrew Cree, Yan Ding, Huyen H Dinh, Shannon Dugan, Michael Holder, Shalini N Jhangiani, Christie L Kovar, Sandra L Lee, Lora R Lewis, Donna Morton, Lynne V Nazareth, Geoffrey Okwuonu, Jireh Santibanez, Rui Chen, Stephen Richards, Donna M Muzny, Andrew Gillis, Leonid Peshkin, Michael Wu, Tom Humphreys, Yi-Hsien Su, Nicholas H Putnam, Jeremy Schmutz, Asao Fujiyama, Jr-Kai Yu, Kunifumi Tagawa, Kim C Worley, Richard A Gibbs, Marc W Kirschner, Christopher J Lowe, Noriyuki Satoh, Daniel S Rokhsar, John Gerhart
Apr 23, 2020
Acorn worms, also known as enteropneust (literally, 'gut-breathing') hemichordates, are marine invertebrates that share features with echinoderms and chordates. Together, these three phyla comprise the deuterostomes. Here we...
State-of-the-art global models underestimate impacts from climate extremes.
Jacob Schewe, Simon N Gosling, Christopher Reyer, Fang Zhao, Philippe Ciais, Joshua Elliott, Louis Francois, Veronika Huber, Heike K Lotze, Sonia I Seneviratne, Michelle TH van Vliet, Robert Vautard, Yoshihide Wada, Lutz Breuer, Matthias Büchner, David A Carozza, Jinfeng Chang, Marta Coll, Delphine Deryng, Allard de Wit, Tyler D Eddy, Christian Folberth, Katja Frieler, Andrew D Friend, Dieter Gerten, Lukas Gudmundsson, Naota Hanasaki, Akihiko Ito, Nikolay Khabarov, Hyungjun Kim, Peter Lawrence, Catherine Morfopoulos, Christoph Müller, Hannes Müller Schmied, René Orth, Sebastian Ostberg, Yadu Pokhrel, Thomas AM Pugh, Gen Sakurai, Yusuke Satoh, Erwin Schmid, Tobias Stacke, Jeroen Steenbeek, Jörg Steinkamp, Qiuhong Tang, Hanqin Tian, Derek P Tittensor, Jan Volkholz, Xuhui Wang, Lila Warszawski
Mar 15, 2019
Global impact models represent process-level understanding of how natural and human systems may be affected by climate change. Their projections are used in integrated assessments of climate change. Here we test, for the first...
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.
G Schumann, C Liu, P O'Reilly, H Gao, P Song, B Xu, B Ruggeri, N Amin, T Jia, S Preis, M Segura Lepe, S Akira, C Barbieri, S Baumeister, S Cauchi, T-K Clarke, S Enroth, K Fischer, J Hällfors, SE Harris, S Hieber, E Hofer, J-J Hottenga, Å Johansson, PK Joshi, N Kaartinen, J Laitinen, R Lemaitre, A Loukola, J Luan, L-P Lyytikäinen, M Mangino, A Manichaikul, H Mbarek, Y Milaneschi, A Moayyeri, K Mukamal, C Nelson, J Nettleton, E Partinen, R Rawal, A Robino, L Rose, C Sala, T Satoh, R Schmidt, K Schraut, R Scott, AV Smith, JM Starr, A Teumer, S Trompet, AG Uitterlinden, C Venturini, A-C Vergnaud, N Verweij, V Vitart, D Vuckovic, J Wedenoja, L Yengo, B Yu, W Zhang, JH Zhao, DI Boomsma, J Chambers, DI Chasman, T Daniela, E de Geus, I Deary, JG Eriksson, T Esko, V Eulenburg, OH Franco, P Froguel, C Gieger, HJ Grabe, V Gudnason, U Gyllensten, TB Harris, A-L Hartikainen, AC Heath, L Hocking, A Hofman, C Huth, M-R Jarvelin, JW Jukema, J Kaprio, JS Kooner, Z Kutalik, J Lahti, C Langenberg, T Lehtimäki, Y Liu, PAF Madden, N Martin, A Morrison, B Penninx, N Pirastu, B Psaty, O Raitakari, P Ridker, R Rose, JI Rotter, NJ Samani, H Schmidt, TD Spector, D Stott, D Strachan, I Tzoulaki, P van der Harst, CM van Duijn, P Marques-Vidal, P Vollenweider, NJ Wareham, JB Whitfield, J Wilson, B Wolffenbuttel, G Bakalkin, E Evangelou, Y Liu, KM Rice, S Desrivières, SA Kliewer, DJ Mangelsdorf, CP Müller, D Levy, P Elliott
Feb 16, 2017
Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a...