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Results: 335
Identifying binge drinkers based on parenting dimensions and alcohol-specific parenting practices
BACKGROUND: Most Dutch adolescents aged 16 to 18 engage in binge drinking. Previous studies have investigated how parenting dimensions and alcohol-specific parenting practices are related to adolescent alcohol consumption. Mixed...
Asymptotically cylindrical Calabi-Yau manifolds
Let M be a complete Ricci-flat Kähler manifold with one end and assume that this end converges at an exponential rate to [0, ∞) x X for some compact connected Ricci-flat manifold X. We begin by proving general structure...
Asymptotically cylindrical Calabi-Yau manifolds
Let M be a complete Ricci-flat Kähler manifold with one end and assume that this end converges at an exponential rate to [0, ∞) x X for some compact connected Ricci-flat manifold X. We begin by proving general structure...
Fractionation profiling
Georg HH Borner, Marco Y Hein, Jennifer Hirst, James R Edgar, Matthias Mann, Margaret S Robinson
Feb 13, 2019
We developed "fractionation profiling," a method for rapid proteomic analysis of membrane vesicles and protein particles. The approach combines quantitative proteomics with subcellular fractionation to generate signature protein...
NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients
Codon usage optimization in pluripotent embryonic stem cells
Abstract: Background: The uneven use of synonymous codons in the transcriptome regulates the efficiency and fidelity of protein translation rates. Yet, the importance of this codon bias in regulating cell state-specific...
A brain proteomic investigation of rapamycin effects in the <i>Tsc1</i><sup>+/-</sup> mouse model.
Hippocampus Frontal Lobe Animals Mice Mice Mutant Strains Tuberous sclerosis Disease Models Animal Sirolimus Tumor Suppressor Proteins Nerve Tissue Proteins Proteomics Tuberous Sclerosis Complex 1 Protein
Published by: Molecular autism
A brain proteomic investigation of rapamycin effects in the Tsc1+/- mouse model.
BACKGROUND: Tuberous sclerosis complex (TSC) is a rare monogenic disorder characterized by benign tumors in multiple organs as well as a high prevalence of epilepsy, intellectual disability and autism. TSC is caused by...
Functional patient-derived cellular models for neuropsychiatric drug discovery.
Mental health disorders are a leading cause of disability worldwide. Challenges such as disease heterogeneity, incomplete characterization of the targets of existing drugs and a limited understanding of functional interactions...
Risk Stratification and Treatment in Smoldering Multiple Myeloma.
Smoldering multiple myeloma is a heterogeneous asymptomatic precursor to multiple myeloma. Since its identification in 1980, risk stratification models have been developed using two main stratification methods: clinical...
Chronic Pain and Sleep Disorders in Primary Care.
BACKGROUND: Chronic pain (CP) and sleep disorders (SD) are highly prevalent in the general population. However, comprehensive data regarding the prevalence and characteristics of pain and SD in primary care are rare. METHODS...
Specification and epigenetic programming of the human germ line.
Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a unique gene regulatory network in germline-competent...
Proteomic Profiling as a Diagnostic Biomarker for Discriminating Between Bipolar and Unipolar Depression.
Sarah Kittel-Schneider, Tim Hahn, Frieder Haenisch, Rhiannon McNeill, Andreas Reif, Sabine Bahn
May 04, 2020
INTRODUCTION: Affective disorders are a major global burden, with approximately 15% of people worldwide suffering from some form of affective disorder. In patients experiencing their first depressive episode, in most cases it...
Thresholds for Arterial Wall Inflammation Quantified by 18F-FDG PET Imaging
Fleur M van der Valk, Simone L Verweij, Koos AH Zwinderman, Aart C Strang, Yannick Kaiser, Henk A Marquering, Aart J Nederveen, Erik SG Stroes, Hein J Verberne, James HF Rudd
May 05, 2016
Atherosclerosis Imaging Inflammation thresholds Aged Aorta Aortitis Arteritis Carotid Arteries Carotid Artery Diseases Case-Control Studies Female Fluorodeoxyglucose F18 Humans Male Middle Aged Observer Variation Plaque Atherosclerotic Positron-Emission Tomography Predictive Value of Tests Radiopharmaceuticals Reproducibility of Results
Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory.
Masaki Kinoshita, Meng Amy Li, Michael Barber, William Mansfield, Sabine Dietmann, Austin Smith
Sep 01, 2021
Genome remethylation is essential for mammalian development but specific reasons are unclear. Here we examined embryonic stem (ES) cell fate in the absence of de novo DNA methyltransferases. We observed that ES cells deficient...
Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15.
Jennifer Hirst, Georg HH Borner, James Edgar, Marco Y Hein, Matthias Mann, Frank Buchholz, Robin Antrobus, Margaret S Robinson
Feb 13, 2019
The AP-5 complex is a recently identified but evolutionarily ancient member of the family of heterotetrameric adaptor proteins (AP complexes). It is associated with two proteins that are mutated in patients with hereditary...
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