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Harmonization and Categorization of Metrics and Criteria for Evaluation of Recommender Systems in Healthcare From Dual Perspectives
Researchers' choice of metrics and criteria in evaluating recommender systems depends on what the researcher feels is popular among other researchers, or sometimes based on the objective of the research. There is no harmonized...
Published by: IGI Global Scientific Publishing
Plant vascular development
Vascular tissues in plants are crucial to provide physical support and to transport water, sugars and hormones and other small signalling molecules throughout the plant. Recent genetic and molecular studies have identified...
Biomarker Glycoprotein Acetyls Is Associated With the Risk of a Wide Spectrum of Incident Diseases and Stratifies Mortality Risk in Angiography Patients.
Johannes Kettunen, Scott C Ritchie, Olga Anufrieva, Leo-Pekka Lyytikäinen, Jussi Hernesniemi, Pekka J Karhunen, Pekka Kuukasjärvi, Jari Laurikka, Mika Kähönen, Terho Lehtimäki, Aki S Havulinna, Veikko Salomaa, Satu Männistö, Mika Ala-Korpela, Markus Perola, Michael Inouye, Peter Würtz
Apr 15, 2019
BACKGROUND: Integration of systems-level biomolecular information with electronic health records has led to recent interest in the glycoprotein acetyls (GlycA) biomarker-a serum- or plasma-derived nuclear magnetic resonance...
Cytokinin and Auxin Display Distinct but Interconnected Distribution and Signaling Profiles to Stimulate Cambial Activity.
The use of mechanistic evidence in drug approval.
Causality Epistemology evaluation Evidence-Based Medicine philosophy of medicine Drug Approval Drug Discovery Drug Dosage Calculations Drug-Related Side Effects and Adverse Reactions Evidence-Based Medicine Pharmacogenetics Philosophy Medical Prescription Drugs Randomized Controlled Trials as Topic Treatment Outcome
Residual porosity of 3D-LAM-printed stainless-steel electrodes allows galvanic exchange platinisation
James Weber, Andrew J. Wain, Heidi Piili, Ville Pekka Matilainen, Anne Vuorema, Gary A. Attard, Frank Marken
Apr 27, 2016
Stainless-steel rods were manufactured by laser additive manufacturing (LAM or "3D-printing") from a stainless-steel (316L) powder precursor, and then investigated and compared to conventional stainless steel in...
Dynamics and impact of homologous recombination on the evolution of Legionella pneumophila.
Sophia David, Leonor Sánchez-Busó, Simon R Harris, Pekka Marttinen, Christophe Rusniok, Carmen Buchrieser, Timothy G Harrison, Julian Parkhill
Oct 23, 2019
Legionella pneumophila is an environmental bacterium and the causative agent of Legionnaires' disease. Previous genomic studies have shown that recombination accounts for a high proportion (>96%) of diversity within several...
Residual porosity of 3D-LAM-printed stainless-steel electrodes allows galvanic exchange platinisation
James Weber, Andrew J. Wain, Heidi Piili, Ville Pekka Matilainen, Anne Vuorema, Gary A. Attard, Frank Marken
Apr 27, 2016
Stainless-steel rods were manufactured by laser additive manufacturing (LAM or "3D-printing") from a stainless-steel (316L) powder precursor, and then investigated and compared to conventional stainless steel in...
ELIMÄKI Locus Is Required for Vertical Proprioceptive Response in Birch Trees.
Juan Alonso-Serra, Xueping Shi, Alexis Peaucelle, Pasi Rastas, Matthieu Bourdon, Juha Immanen, Junko Takahashi, Hanna Koivula, Gugan Eswaran, Sampo Muranen, Hanna Help, Olli-Pekka Smolander, Chang Su, Omid Safronov, Lorenz Gerber, Jarkko Salojärvi, Risto Hagqvist, Ari Pekka Mähönen, Ykä Helariutta, Kaisa Nieminen
Dec 10, 2019
eIF6 rebinding dynamically couples ribosome maturation and translation.
Pekka Jaako, Alexandre Faille, Shengjiang Tan, Chi C Wong, Norberto Escudero-Urquijo, Pablo Castro-Hartmann, Penny Wright, Christine Hilcenko, David J Adams, Alan J Warren
Apr 24, 2022
Protein synthesis is a cyclical process consisting of translation initiation, elongation, termination and ribosome recycling. The release factors SBDS and EFL1-both mutated in the leukemia predisposition disorder...
The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA.
Anne K Hyvärinen, Jaakko LO Pohjoismäki, Aurelio Reyes, Sjoerd Wanrooij, Takehiro Yasukawa, Pekka J Karhunen, Johannes N Spelbrink, Ian J Holt, Howard T Jacobs
Nov 23, 2017
The mammalian mitochondrial transcription termination factor mTERF binds with high affinity to a site within the tRNA(Leu(UUR)) gene and regulates the amount of read through transcription from the ribosomal DNA into the...
Simultaneous investigation of the liquid transport and swelling performance during tablet disintegration.
Mohammed Al-Sharabi, Daniel Markl, Theona Mudley, Prince Bawuah, Anssi-Pekka Karttunen, Cathy Ridgway, Patrick Gane, Jarkko Ketolainen, Kai-Erik Peiponen, Thomas Rades, J Axel Zeitler
May 28, 2020
Fast disintegrating tablets have commonly been used for fast oral drug delivery to patients with swallowing difficulties. The different characteristics of the pore structure of such formulations influence the liquid transport...
Influence of Genetic Variation in PDE3A on Endothelial Function and Stroke.
Matthew Traylor, Ali Amin Al Olama, Leo-Pekka Lyytikäinen, Sandro Marini, Jaeyoon Chung, Rainer Malik, Martin Dichgans, Mika Kähönen, Terho Lehtimäki, Christopher D Anderson, Olli T Raitakari, Hugh S Markus
Dec 09, 2019
Cyclic Nucleotide Phosphodiesterases Type 3 Genetics Genome-Wide Association Study stroke vascular endothelium Adolescent Adult Brain Ischemia Child Cyclic Nucleotide Phosphodiesterases Type 3 Endothelium Vascular Female Follow-Up Studies Genetic Predisposition to Disease genetic variation Humans Hypertension Male Middle Aged Polymorphism Single Nucleotide Pregnancy Pregnancy Complications Cardiovascular Retrospective Studies Risk Factors Vasodilation Young Adult
Comprehensive identification of single nucleotide polymorphisms associated with beta-lactam resistance within pneumococcal mosaic genes.
Claire Chewapreecha, Pekka Marttinen, Nicholas J Croucher, Susannah J Salter, Simon R Harris, Alison E Mather, William P Hanage, David Goldblatt, Francois H Nosten, Claudia Turner, Paul Turner, Stephen D Bentley, Julian Parkhill
Jun 25, 2019
Traditional genetic association studies are very difficult in bacteria, as the generally limited recombination leads to large linked haplotype blocks, confounding the identification of causative variants. Beta-lactam antibiotic...
Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy.
Artika P Nath, Scott C Ritchie, Nastasiya F Grinberg, Howard Ho-Fung Tang, Qin Qin Huang, Shu Mei Teo, Ari V Ahola-Olli, Peter Würtz, Aki S Havulinna, Kristiina Santalahti, Niina Pitkänen, Terho Lehtimäki, Mika Kähönen, Leo-Pekka Lyytikäinen, Emma Raitoharju, Ilkka Seppälä, Antti-Pekka Sarin, Samuli Ripatti, Aarno Palotie, Markus Perola, Jorma S Viikari, Sirpa Jalkanen, Mikael Maksimow, Marko Salmi, Chris Wallace, Olli T Raitakari, Veikko Salomaa, Gad Abraham, Johannes Kettunen, Michael Inouye
Oct 04, 2019
GWAS blood cell traits cardiometabolic diseases colocalisation analysis Cytokines eQTLs metabolites Multivariate Analysis protein QTLs Adolescent Adult Aged Biomarkers Blood Proteins Cardiovascular Diseases Child Cytokines Female Follow-Up Studies Gene Regulatory Networks Genetic Pleiotropy Genetic Predisposition to Disease Genome Human Genome-Wide Association Study Humans Longitudinal Studies Male Middle Aged Polymorphism Single Nucleotide Prognosis Prospective Studies Quantitative Trait Loci Young Adult
Galvanic exchange platinization reveals laser-inscribed pattern in 3D-LAM-printed steel
Alex G.M. Litherland, Lee M. Spurway, Sergey N. Gordeev, Barak D.B. Aaronson, Andrew J. Wain, Michael A. O’Connell, Heidi Piili, Mikko Hovilehto, Ville Pekka Matilainen, Anne Vuorema, Frank Marken
Jun 01, 2018
Galvanic exchange involving dissolution of iron and the simultaneous growth of platinum onto 316 L stainless steel was investigated for specimens manufactured by 3D-printing, and the behavior was compared to conventional...
Galvanic exchange platinization reveals laser-inscribed pattern in 3D-LAM-printed steel
Alex G.M. Litherland, Lee M. Spurway, Sergey N. Gordeev, Barak D.B. Aaronson, Andrew J. Wain, Michael A. O’Connell, Heidi Piili, Mikko Hovilehto, Ville Pekka Matilainen, Anne Vuorema, Frank Marken
Jun 01, 2018
Galvanic exchange involving dissolution of iron and the simultaneous growth of platinum onto 316 L stainless steel was investigated for specimens manufactured by 3D-printing, and the behavior was compared to conventional...
Impact of gender on event rates at 1 year in patients with newly diagnosed non-valvular atrial fibrillation
A John Camm, Gabriele Accetta, Wael Al Mahmeed, Giuseppe Ambrosio, Samuel Z Goldhaber, Sylvia Haas, Petr Jansky, Gloria Kayani, Frank Misselwitz, Seil Oh, Ali Oto, Pekka Raatikainen, Jan Steffel, Martin van Eickels, Ajay K Kakkar, GARFIELD-AF Investigators
Mar 18, 2020
OBJECTIVES: Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) explored the impact of gender, risk factors and anticoagulant (AC) treatment on 1-year outcomes in patients with non-valvular atrial...
A plasma metabolite score of three eicosanoids predicts incident type 2 diabetes
Karolina Tuomisto, Joonatan Palmu, Tao Long, Jeramie D Watrous, Kysha Mercader, Kim A Lagerborg, Allen Andres, Marko Salmi, Sirpa Jalkanen, Ramachandran S Vasan, Michael Inouye, Aki S Havulinna, Jaakko Tuomilehto, Pekka Jousilahti, Teemu J Niiranen, Susan Cheng, Mohit Jain, Veikko Salomaa
Apr 05, 2022
INTRODUCTION: Peptide markers of inflammation have been associated with the development of type 2 diabetes. The role of upstream, lipid-derived mediators of inflammation such as eicosanoids, remains less clear. The aim of this...
AINTEGUMENTA and the D-type cyclin CYCD3;1 regulate root secondary growth and respond to cytokinins.
Ricardo S Randall, Shunsuke Miyashima, Tiina Blomster, Jing Zhang, Annakaisa Elo, Anna Karlberg, Juha Immanen, Kaisa Nieminen, Ji-Young Lee, Tatsuo Kakimoto, Karolina Blajecka, Charles W Melnyk, Annette Alcasabas, Celine Forzani, Miho Matsumoto-Kitano, Ari Pekka Mähönen, Rishikesh Bhalerao, Walter Dewitte, Ykä Helariutta, James AH Murray
Sep 29, 2018
Higher plant vasculature is characterized by two distinct developmental phases. Initially, a well-defined radial primary pattern is established. In eudicots, this is followed by secondary growth, which involves development of...
EFL1 mutations impair eIF6 release to cause Shwachman-Diamond syndrome.
Shengjiang Tan, Laëtitia Kermasson, Angela Hoslin, Pekka Jaako, Alexandre Faille, Abraham Acevedo-Arozena, Etienne Lengline, Dana Ranta, Maryline Poirée, Odile Fenneteau, Hubert Ducou le Pointe, Stefano Fumagalli, Blandine Beaupain, Patrick Nitschké, Christine Bôle-Feysot, Jean-Pierre de Villartay, Christine Bellanné-Chantelot, Jean Donadieu, Caroline Kannengiesser, Alan J Warren, Patrick Revy
May 15, 2019
Adolescent Animals Cells Cultured DNA Mutational Analysis Disease Models Animal Disease Susceptibility Female Genome-Wide Association Study Humans Infant Male Mice Mice Transgenic Models Molecular Mutation Pedigree Peptide Elongation Factors Peptide Initiation Factors Phenotype Protein Conformation Ribonucleoprotein U5 Small Nuclear Shwachman-Diamond Syndrome Structure-Activity Relationship whole genome sequencing
Towards a Secure DevOps Approach for Cyber-Physical Systems
Barbara Russo, Martin Jaatun, Pekka Abrahamsson, Goetz Botterweck, Hadi Ghanbari, Petri Kettunen, Tommi Mikkonen, Anila Mjeda, Jürgen Münch, Anh Duc, Xiaofeng Wang
Jul 01, 2020
With the expansion of cyber-physical systems (CPSs) across critical and regulated industries, systems must be continuously updated to remain resilient. At the same time, they should be extremely secure and safe to operate and...
Systems & Software Design Computer Science and Information Technology Systems and Software Engineering
Published by: IGI Global Scientific Publishing
A plasma metabolite score of three eicosanoids predicts incident type 2 diabetes
Karolina Tuomisto, Joonatan Palmu, Tao Long, Jeramie D Watrous, Kysha Mercader, Kim A Lagerborg, Allen Andres, Marko Salmi, Sirpa Jalkanen, Ramachandran S Vasan, Michael Inouye, Aki S Havulinna, Jaakko Tuomilehto, Pekka Jousilahti, Teemu J Niiranen, Susan Cheng, Mohit Jain, Veikko Salomaa
May 09, 2022
INTRODUCTION: Peptide markers of inflammation have been associated with the development of type 2 diabetes. The role of upstream, lipid-derived mediators of inflammation such as eicosanoids, remains less clear. The aim of this...
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