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Two-step Procedure Based on the Least Squares and Instrumental Variable Methods for Simultaneous Estimation of von Bertalanffy Growth Parameters
Advanced in the present article is a Two-step procedure designed on the methods of the least squares (LS) and instrumental variable (IV) techniques for simultaneous estimation of the three unknown parameters L∞, K and t0, which...
Published by: IGI Global Scientific Publishing
Variational Autoencoders for Cancer Data Integration
Nikola Simidjievski, Cristian Bodnar, Ifrah Tariq, Paul Scherer, Helena Andres Terre, Zohreh Shams, Mateja Jamnik, Pietro Liò
Jan 17, 2020
International initiatives such as the Molecular Taxonomy of Breast Cancer International Consortium are collecting multiple data sets at different genome-scales with the aim to identify novel cancer bio-markers and predict...
Launching of ships from horizontal berth by tipping tables – CFD simulation of wave generation
The paper considers the side launching of ships from a horizontal berth by tipping tables. The launching process is split into the six phases and a system of nonlinear di erential equations of motion is established. The system...
Variational Autoencoders for Cancer Data Integration
Nikola Simidjievski, Cristian Bodnar, Ifrah Tariq, Paul Scherer, Helena Andres Terre, Zohreh Shams, Mateja Jamnik, Pietro Liò
Feb 10, 2020
International initiatives such as the Molecular Taxonomy of Breast Cancer International Consortium are collecting multiple data sets at different genome-scales with the aim to identify novel cancer bio-markers and predict...
Artificial Intelligence Machine Learning Deep learning multi-omic analysis variational autoencoder bioinformactics cancer–breast cancer integrative data analyses
Published by: Frontiers in genetics
Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation.
Nikola S Dzhindzhev, George Tzolovsky, Zoltan Lipinszki, Mohammed Abdelaziz, Janus Debski, Michal Dadlez, David M Glover
Apr 20, 2018
The conserved process of centriole duplication requires Plk4 kinase to recruit and promote interactions between Sas6 and Sas5/Ana2/STIL (respective nomenclature of worms/flies/humans). Plk4-mediated phosphorylation of Ana2/STIL...
Variational Autoencoders for Cancer Data Integration
Nikola Simidjievski, Cristian Bodnar, Ifrah Tariq, Paul Scherer, Helena Andres Terre, Zohreh Shams, Mateja Jamnik, Pietro Liò
Dec 25, 2019
International initiatives such as the Molecular Taxonomy of Breast Cancer International Consortium are collecting multiple data sets at different genome-scales with the aim to identify novel cancer bio-markers and predict...
Vibration induced refrigeration using ferroelectric materials.
Anuruddh Kumar, Aditya Chauhan, Satyanarayan Patel, Nikola Novak, Rajeev Kumar, Rahul Vaish
May 09, 2019
This article aims to propose a cantilever based cooling device employing non-axis symmetric placement of bulk ferroelectric patches. Ambient mechanical vibrations produce large stresses in cantilevers resulting in elastocaloric...
Tissue specific requirement of Drosophila Rcd4 for centriole duplication and ciliogenesis.
Pallavi Panda, Levente Kovacs, Nikola Dzhindzhev, Agnieszka Fatalska, Veronica Persico, Marco Geymonat, Maria Giovanna Riparbelli, Giuliano Callaini, David M Glover
Nov 03, 2021
Rcd4 is a poorly characterized Drosophila centriole component whose mammalian counterpart, PPP1R35, is suggested to function in centriole elongation and conversion to centrosomes. Here, we show that rcd4 mutants exhibit fewer...
Control of translation elongation in health and disease.
John RP Knight, Gavin Garland, Tuija Pöyry, Emma Mead, Nikola Vlahov, Aristeidis Sfakianos, Stefano Grosso, Fabio De-Lima-Hedayioglu, Giovanna R Mallucci, Tobias von der Haar, C Mark Smales, Owen J Sansom, Anne E Willis
Apr 29, 2020
Regulation of protein synthesis makes a major contribution to post-transcriptional control pathways. During disease, or under stress, cells initiate processes to reprogramme protein synthesis and thus orchestrate the appropriate...
Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K.
Cryo-EM structural analysis of FADD
Joanna L Fox, Michelle A Hughes, Xin Meng, Nikola A Sarnowska, Ian R Powley, Rebekah Jukes-Jones, David Dinsdale, Timothy J Ragan, Louise Fairall, John WR Schwabe, Nobuhiro Morone, Kelvin Cain, Marion MacFarlane
Mar 05, 2021
Regulated cell death is essential in development and cellular homeostasis. Multi-protein platforms, including the Death-Inducing Signaling Complex (DISC), co-ordinate cell fate via a core FADD:Caspase-8 complex and its...
CASP8 and FADD-Like Apoptosis Regulating Protein Caspase 8 Catalytic Domain Cloning Molecular Cryoelectron Microscopy Death Domain Receptor Signaling Adaptor Proteins Escherichia coli Fas-Associated Death Domain Protein Gene Expression Genetic Vectors HEK293 Cells Humans Models Molecular Protein Binding Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Interaction Domains and Motifs Protein Isoforms Protein Multimerization Receptor-Interacting Protein Serine-Threonine Kinases Recombinant Proteins Regulated Cell Death Tumor Necrosis Factor-alpha
Machine-learning ready data on the thermal power consumption of the Mars Express Spacecraft.
Matej Petković, Luke Lucas, Jurica Levatić, Martin Breskvar, Tomaž Stepišnik, Ana Kostovska, Panče Panov, Aljaž Osojnik, Redouane Boumghar, José A Martínez-Heras, James Godfrey, Alessandro Donati, Sašo Džeroski, Nikola Simidjievski, Bernard Ženko, Dragi Kocev
May 24, 2022
We present six datasets containing telemetry data of the Mars Express Spacecraft (MEX), a spacecraft orbiting Mars operated by the European Space Agency. The data consisting of context data and thermal power consumption...
Machine-learning ready data on the thermal power consumption of the Mars Express Spacecraft.
Matej Petković, Luke Lucas, Jurica Levatić, Martin Breskvar, Tomaž Stepišnik, Ana Kostovska, Panče Panov, Aljaž Osojnik, Redouane Boumghar, José A Martínez-Heras, James Godfrey, Alessandro Donati, Sašo Džeroski, Nikola Simidjievski, Bernard Ženko, Dragi Kocev
Jun 29, 2022
We present six datasets containing telemetry data of the Mars Express Spacecraft (MEX), a spacecraft orbiting Mars operated by the European Space Agency. The data consisting of context data and thermal power consumption...
Intensive versus Guideline Blood Pressure and Lipid Lowering in Patients with Previous Stroke
Baseline characteristics, analysis plan and report on feasibility for the Prevention Of Decline in Cognition After Stroke Trial (PODCAST).
Polly Scutt, Dan Blackburn, Kailash Krishnan, Clive Ballard, Alistair Burns, Gary A Ford, Jonathan Mant, Peter Passmore, Stuart Pocock, John Reckless, Nikola Sprigg, Rob Stewart, Joanna M Wardlaw, Philip M Bath
May 02, 2018
BACKGROUND: A common complication after stroke is development of cognitive impairment and dementia. However, effective strategies for reducing the risk of developing these problems remain undefined. Potential strategies include...
Aged Aged 80 and over Antihypertensive Agents Biomarkers blood pressure Cholesterol LDL Clinical Protocols Cognition Cognition Disorders Dementia Feasibility Studies Female Humans Hypolipidemic Agents Male Neuropsychological Tests Patient Selection Pilot Projects Prospective Studies Sample Size stroke Stroke Rehabilitation Time Factors Treatment Outcome United Kingdom
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
Asis Palazon, Petros A Tyrakis, David Macias, Pedro Veliça, Helene Rundqvist, Susan Fitzpatrick, Nikola Vojnovic, Anthony T Phan, Niklas Loman, Ingrid Hedenfalk, Thomas Hatschek, John Lövrot, Theodoros Foukakis, Ananda W Goldrath, Jonas Bergh, Randall S Johnson
May 31, 2018
Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α, but not HIF-2α, was...
HIF transcription factors VEGF angiogenesis cytotoxic T cells Hypoxia Immunotherapy Animals Breast Neoplasms CD8-Positive T-Lymphocytes Cell Line Tumor Cells Cultured Disease Progression Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Hypoxia-Inducible Factor 1 alpha Subunit Mice Inbred C57BL Mice Knockout Neoplasms Experimental Neovascularization Pathologic T-Lymphocytes Cytotoxic Vascular Endothelial Growth Factor A
Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke
Joanna M Wardlaw, Fergus Doubal, Rosalind Brown, Ellen Backhouse, Lisa Woodhouse, Philip Bath, Terence J Quinn, Thompson Robinson, Hugh S Markus, Richard McManus, John T O’Brien, David J Werring, Nikola Sprigg, Adrian Parry-Jones, Rhian M Touyz, Steven Williams, Yee-Haur Mah, Hedley Emsley, the R4VaD Investigators
Apr 09, 2021
Background: Stroke commonly affects cognition and, by definition, much vascular dementia follows stroke. However, there are fundamental limitations in our understanding of vascular cognitive impairment, restricting understanding...
Cryo-EM structural analysis of FADD
Joanna L. Fox, Michelle A. Hughes, Xin Meng, Nikola A. Sarnowska, Ian R. Powley, Rebekah Jukes-Jones, David Dinsdale, Timothy J. Ragan, Louise Fairall, John W. R. Schwabe, Nobuhiro Morone, Kelvin Cain, Marion MacFarlane
Feb 05, 2021
Abstract: Regulated cell death is essential in development and cellular homeostasis. Multi-protein platforms, including the Death-Inducing Signaling Complex (DISC), co-ordinate cell fate via a core FADD:Caspase-8 complex and its...
Duration of untreated psychosis and clinical outcomes of first episode psychosis
Automated Detection of Candidate Subjects With Cerebral Microbleeds Using Machine Learning.
Vaanathi Sundaresan, Christoph Arthofer, Giovanna Zamboni, Robert A Dineen, Peter M Rothwell, Stamatios N Sotiropoulos, Dorothee P Auer, Daniel J Tozer, Hugh Markus, Karla L Miller, Iulius Dragonu, Nikola Sprigg, Fidel Alfaro-Almagro, Mark Jenkinson, Ludovica Griffanti
Feb 03, 2022
Cerebral microbleeds (CMBs) appear as small, circular, well defined hypointense lesions of a few mm in size on T2*-weighted gradient recalled echo (T2*-GRE) images and appear enhanced on susceptibility weighted images (SWI). Due...
Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets.
Nikola Dolezalova, Anja Gruszczyk, Kerry Barkan, John A Gamble, Sam Galvin, Till Moreth, Kevin O'Holleran, Krishnaa T Mahbubani, Jackie A Higgins, Fiona M Gribble, Frank Reimann, Jakub Surmacki, Simon Andrews, John J Casey, Francesco Pampaloni, Michael P Murphy, Graham Ladds, Nigel Kh Slater, Kourosh Saeb-Parsy
May 24, 2021
Cryopreservation offers the potential to increase the availability of pancreatic islets for treatment of diabetic patients. However, current protocols, which use dimethyl sulfoxide (DMSO), lead to poor cryosurvival of islets. We...
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