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Retinal regions shape human and murine Müller cell proteome profile and functionality.
Lew Kaplan, Corinne Drexler, Anna M Pfaller, Santra Brenna, Kirsten A Wunderlich, Andrea Dimitracopoulos, Juliane Merl-Pham, Maria-Theresa Perez, Ursula Schlötzer-Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M Hauck, Antje Grosche
Nov 05, 2022
The human macula is a highly specialized retinal region with pit-like morphology and rich in cones. How Müller cells, the principal glial cell type in the retina, are adapted to this environment is still poorly understood. We...
The Trope of Silence in the Work of Herta Müller
P Shopin
Aug 09, 2017
With reference to Herta Müller’s fiction and non-fiction, my essay explores how the trope of silence is engaged to make sense of more abstract concepts. Drawing on conceptual metaphor theory, I argue that Müller uses silence as...
Language as a force for good in the work of Herta Müller
P Shopin
Oct 02, 2017
Herta Müller creates sophisticated metaphors to convey her vision of language and its relationship to suffering and subjugation. With reference to both her fiction and non‐fiction, this essay explores how she uses the idea of...
Silicone vs. Polyurethane Stent
Ureteric stents are conventionally used in daily urological practice. There is ongoing debate on the superiority of different stent materials, particularly in terms of patient tolerance. We conducted a literature review to...
Cycles and circulation
Nick Hopwood, Staffan Müller-Wille, Janet Browne, Christiane Groeben, Shigehisa Kuriyama, Maaike van der Lugt, Guido Giglioni, Lynn K Nyhart, Hans-Jörg Rheinberger, Ariane Dröscher, Warwick Anderson, Peder Anker, Mathias Grote, Lucy van de Wiel
Aug 12, 2021
We invite systematic consideration of the metaphors of cycles and circulation as a long-term theme in the history of the life and environmental sciences and medicine. Ubiquitous in ancient religious and philosophical traditions...
recycling Diagrams Metaphors Life cycles Circles Canonical icons Biology History Ancient History Medieval History 15th Century History 16th Century History 17th Century History 18th century History 19th Century History 20th Century History 21st Century history of medicine Philosophy
Published by: History and philosophy of the life sciences
IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment.
Josy Augustine, Sofia Pavlou, Imran Ali, Kevin Harkin, Ema Ozaki, Matthew Campbell, Alan W Stitt, Heping Xu, Mei Chen
Jan 20, 2020
BACKGROUND: Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and resides in the nuclei of various cell types. In the neural retina, IL-33 is predominately expressed in Müller cells although its role in health and...
The convictions of a realist
Mathias Haeussler
Sep 20, 2018
This article reconstructs concepts of ‘European solidarity’ in Helmut Schmidt’s political thought. Tracing Schmidt’s beliefs from the late 1940s to the period of his chancellorship and beyond, it shows how his concepts of...
HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia.
Freya M Mowat, Ulrich FO Luhmann, Alexander J Smith, Clemens Lange, Yanai Duran, Sarah Harten, Deepa Shukla, Patrick H Maxwell, Robin R Ali, James WB Bainbridge
Mar 18, 2019
BACKGROUND: Hypoxia plays a key role in ischaemic and neovascular disorders of the retina. Cellular responses to oxygen are mediated by hypoxia-inducible transcription factors (HIFs) that are stabilised in hypoxia and induce the...
The relationship between usage and citations in an open access mega-journal
Abstract: How do the level of usage of an article, the timeframe of its usage and its subject area relate to the number of citations it accrues? This paper aims to answer this question through an observational study of usage and...
COVID 19
Purpose: The purpose of this essay is to enrich the discussion at the intersection of responsible management education (RME) and the pandemic with new views that explore together the inhibitors of and drivers for a strengthening...
Upper Palaeolithic genomes reveal deep roots of modern Eurasians.
Eppie R Jones, Gloria Gonzalez-Fortes, Sarah Connell, Veronika Siska, Anders Eriksson, Rui Martiniano, Russell L McLaughlin, Marcos Gallego Llorente, Lara M Cassidy, Cristina Gamba, Tengiz Meshveliani, Ofer Bar-Yosef, Werner Müller, Anna Belfer-Cohen, Zinovi Matskevich, Nino Jakeli, Thomas FG Higham, Mathias Currat, David Lordkipanidze, Michael Hofreiter, Andrea Manica, Ron Pinhasi, Daniel G Bradley
Dec 04, 2015
Transforming Unjust Structures
The "capability approach" of development economist Amartya Sen, who received the Nobel Prize for Economics in 1998, poses a major challenge to the dominant paradigm of neo-classical economics. According to Sen, human well-being...
Published by: Springer
Cycles and circulation
Nick Hopwood, Staffan Müller-Wille, Janet Browne, Christiane Groeben, Shigehisa Kuriyama, Maaike van der Lugt, Guido Giglioni, Lynn K Nyhart, Hans-Jörg Rheinberger, Ariane Dröscher, Warwick Anderson, Peder Anker, Mathias Grote, Lucy van de Wiel, Fifteenth Ischia Summer School on the History of the Life Sciences
May 03, 2021
Risks of AI-Assisted Learning on Student Critical Thinking
Artificial Intelligence (AI) has increasingly become a transformative force in the education sector, offering unprecedented opportunities to enhance learning experiences and outcomes. This study examines the potential adverse...
Published by: IGI Global Scientific Publishing
Transforming Unjust Structures
The "capability approach" of development economist Amartya Sen, who received the Nobel Prize for Economics in 1998, poses a major challenge to the dominant paradigm of neo-classical economics. According to Sen, human well-being...
Published by: Springer
Research information standards adoption
While Research Information continues to mature as an area of expertise, discussions regarding the implementation and adoption of standardisation initiatives, such as CASRAI and CERIF, have intensified. Possessing the capacity to...
Transcriptional and Translational Products of Avian Erythroblastosis and Avian Myeloblastosis Viruses
Steven Mathias Anderson
Jan 01, 0001
The transcription and translation products of two avian acute leukemia viruses, avian erythroblastosisvirus (AEV) and avian myeloblastosisvirus (AMV) , were examined. AEV is defective in virus replication and requires the...
Published by: Rockefeller University
The geometry of multi-marginal Skorokhod Embedding
The Skorokhod Embedding Problem is one of the classical problems in the theory of stochastic processes, with applications in many different fields [cf. the surveys (Hobson in: Paris-Princeton lectures on mathematical finance...
Heat treatment of thioredoxin fusions increases the purity of α-helical transmembrane protein constructs.
Membrane proteins play key roles in cellular signaling and transport, represent the majority of drug targets, and are implicated in many diseases. Their relevance renders them important subjects for structural, biophysical, and...
Heat treatment Membrane Proteins Protein purification thioredoxin ATP Synthetase Complexes Bacterial Proteins Cloning Molecular Cystic Fibrosis Transmembrane Conductance Regulator Escherichia coli Fusobacteria Gene Expression Genetic Vectors Hot Temperature Humans Models Molecular Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Interaction Domains and Motifs Protein Subunits Recombinant Fusion Proteins Solubility Thioredoxins
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