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Lysosome positioning and mTOR activity in Lowe syndrome.
Lowe syndrome is a rare, developmental disorder caused by mutations in the phosphatase, OCRL. A study in this issue of EMBO Reports shows that OCRL is required for microtubule nucleation and that mutations in this protein lead...
Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL.
Maria Giovanna De Leo, Leopoldo Staiano, Mariella Vicinanza, Alessandro Luciani, Annamaria Carissimo, Margherita Mutarelli, Antonella Di Campli, Elena Polishchuk, Giuseppe Di Tullio, Valentina Morra, Elena Levtchenko, Francesca Oltrabella, Tobias Starborg, Michele Santoro, Diego di Bernardo, Olivier Devuyst, Martin Lowe, Diego L Medina, Andrea Ballabio, Maria Antonietta De Matteis
Sep 03, 2019
Phosphoinositides (PtdIns) control fundamental cell processes, and inherited defects of PtdIns kinases or phosphatases cause severe human diseases, including Lowe syndrome due to mutations in OCRL, which encodes a PtdIns(4,5)P2...
UK Labour and the EU Single Market
Josh Cole
May 28, 2020
This article looks at the UK Labour Party’s view of the EU single market over the last four decades, focussing on three case study periods when this issue was particularly salient: first, the time of the single market’s...
A support vector machine algorithm can successfully classify running ability when trained with wearable sensor data from anatomical locations typical of consumer technology
Greater understanding of differences in technique between runners may allow more beneficial feedback related to improving performance and decreasing injury risk. The purpose of this study was to develop and test a support vector...
The holographic dual of the entanglement wedge symplectic form
Josh Kirklin
Jun 06, 2020
Abstract: In this paper, we find the boundary dual of the symplectic form for the bulk fields in any entanglement wedge. The key ingredient is Uhlmann holonomy, which is a notion of parallel transport of purifications of density...
Deepwater Horizon
Josh Winsor
Apr 09, 2013
The Deepwater Horizon accident in 2010 was the largest oil spill in U.S history. The tragedy claimed the lives of 11 offshore workers and caused an estimated 4.9 million barrels of oil to leak into the ocean. To do this day the...
Published by: Memorial University of Newfoundland
Soft power from Ningxia to Cairo
Literary translation is a major part of China’s present soft power push. Substantial attention and resources are for the first time directed to the translation of Chinese literature into Arabic, in line with the geopolitical...
Reparations for Racism: Why the Persistence of Institutional Racism in America Demands More Than Equal Opportunity for Black Citizens
Alexander Lowe
Jan 01, 0001
Black Americans African Americans Distributive justice reparations John Rawls justice as fairness institutional racism reflective equilibrium difference principle equality of opportunity African American Studies Civil Rights and Discrimination Ethics and Political Philosophy Inequality and Stratification Race, Ethnicity and Post-Colonial Studies United States History
Published by: Ursinus College
Killing Kindly: Applying Jens Timmermann's Kantian Ethics of Animal Welfare to the Modern System of Livestock Farming
Alexander Lowe
Jan 01, 0001
This essay seeks to contribute to this conversation in an ethically applicable way, addressing specifically the Kantian vein of animal welfare discussed by Dr. Jens Timmermann in his essay When the Tail Wags the Dog: Animal...
Kantian ethics animal welfare Jens Timmermann Pain sentient animals food living conditions Diet slaughter Animal Husbandry animal rights Animal Studies Ethics and Political Philosophy
Published by: Ursinus College
The Grizzly, April 3, 2014
Dave Muoio, Caroline Sandberg, Briana Mullan, Evan Hill, Brian Thomas, Caitlin Tillson, Jonathan Vander Lugt, Jordan Breslow, Dana Feigenbaum, Giovanni Waters, Karch Connors
Jan 01, 0001
New USGA President Takes Role, States Goals Variety of Summer Jobs, Opportunities Offered on Campus Josh Emmons Discusses his Work, Answers Questions 83rd Student-Made "Lantern" to Come Out End of April Student-Directed Play...
Ursinus College Collegeville Pennsylvania newspaper student government Tony Sierzega Student employment Josh Emmons Lantern Health and Exercise Physiology Department theater Kevin Cox tuition Nile Thompson lacrosse Bob Scaramuzza wrestling baseball softball tennis cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The Tribal Blues
Josh Dunn
Jan 01, 0001
A poem
Magazine Literary Magazine Arts Magazine art poetry prose Creative Nonfiction Photography Creative Writing Creative Writing poetry
Published by: Winthrop University
Exponential asymptotics for steady parasitic capillary ripples on steep gravity waves
In this paper, we develop an asymptotic theory for steadily travelling gravity-capillary waves under the small-surface tension limit. In an accompanying work (Shelton et al., J. Fluid Mech., vol. 922, 2021) it was...
Reparations for Racism: Why the Persistence of Institutional Racism in America Demands More Than Equal Opportunity for Black Citizens
Alexander Lowe
Jan 01, 0001
This essay seeks to expose the causational effects of various forms of distributive justice on wealth inequality within the United States of America. Herein, several frameworks of distributive justice are assessed through John...
Racism Distributive justice reflective equilibrium reparations Rawls slavery egalitarianism desert-based Black Americans wealth inequality African American Studies Arts and Humanities Inequality and Stratification Philosophy race and ethnicity
Published by: Ursinus College
Echoes of Legend: Magic as the Bridge Between a Pagan Past and a Christian Future in Sir Thomas Malory's Le Morte Darthur
Josh Mangle
Jan 01, 0001
Sir Thomas Malory's Le Morte Darthur is a text that tells the story of King Arthur and his Knights of the Round Table. Malory wrote this tale by synthesizing various Arthurian sources, the most important of which being the...
King Arthur MAGIC Sir Thomas Malory Merlin Morgan le Fey Nynive Literature in English, British Isles
Published by: Winthrop University
Deepwater Horizon
Josh Winsor
Apr 09, 2013
The Deepwater Horizon accident in 2010 was the largest oil spill in U.S history. The tragedy claimed the lives of 11 offshore workers and caused an estimated 4.9 million barrels of oil to leak into the ocean. To do this day the...
Published by: Memorial University of Newfoundland
Inoculating Against Fake News About COVID-19
The outbreak of the SARS-CoV-2 novel coronavirus (COVID-19) has been accompanied by a large amount of misleading and false information about the virus, especially on social media. In this article, we explore the coronavirus...
Inoculating Against Fake News About COVID-19.
The outbreak of the SARS-CoV-2 novel coronavirus (COVID-19) has been accompanied by a large amount of misleading and false information about the virus, especially on social media. In this article, we explore the coronavirus...
GHG assessment of Bore Hill Farm Biodigester
This study takes the Bore Hill Farm Biodigester (BHFB) facility as a case study to explore the sources of Greenhouse Gas (GHG) emissions associated with commercial Anaerobic Digestion (AD), and some of the factors affecting...
Exponential asymptotics for steady parasitic capillary ripples on steep gravity waves
In this paper, we develop an asymptotic theory for steadily travelling gravity-capillary waves under the small-surface tension limit. In an accompanying work (Shelton et al., J. Fluid Mech., vol. 922, 2021) it was...
Does Exposure to Noise During Military Service Affect the Progression of Hearing Loss with Increasing Age?
It is traditionally believed that the effects of exposure to noise cease once the exposure itself has ceased. If this is the case, exposure to noise relatively early in life, for example during military service, should...
From evaporative to cooling crystallisation
Two new multi-component molecular complexes of cytosine and 5-fluorocytosine with 4-chloro-3,5-dinitrobenzoic acid are presented. Materials synthesis was achieved initially by evaporative crystallisation and the crystal...
Dynamic Characterization of an Adaptive Film-Riding Seal
Shaft seals control the leakage of fluid between areas of high pressure and low pressure around rotating components inside turbomachinery. Static seals are often subject to damaging rubs with the shaft, caused by assembly...
The relationship between pets owned and gender amongst college students
There is a gap between the number of men and women that own dogs. The Mintel Press Team states that "71% of men aged 18-44 own a dog compared to 60% of their female counterparts" (Mintel Press Team, 2016, para: 1). While this...
Published by: Harrisburg University of Science and Technology
Utilizing Commercially Fabricated Printed Circuit Boards as an Electrochemical Biosensing Platform
Printed circuit boards (PCBs) offer a promising platform for the development of electronics-assisted biomedical diagnostic sensors and microsystems. The long-standing industrial basis offers distinctive advantages for...
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