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Results: 290
Reference thresholds for the TEN(HL) test for people with normal hearing.
OBJECTIVE: To estimate normative values and repeatability of thresholds for the TEN(HL) test for diagnosing dead regions in the cochlea, as a function of signal frequency, TEN(HL) level, age and gender. DESIGN: The TEN(HL) test...
Lysosome positioning and mTOR activity in Lowe syndrome.
Lowe syndrome is a rare, developmental disorder caused by mutations in the phosphatase, OCRL. A study in this issue of EMBO Reports shows that OCRL is required for microtubule nucleation and that mutations in this protein lead...
Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL.
Maria Giovanna De Leo, Leopoldo Staiano, Mariella Vicinanza, Alessandro Luciani, Annamaria Carissimo, Margherita Mutarelli, Antonella Di Campli, Elena Polishchuk, Giuseppe Di Tullio, Valentina Morra, Elena Levtchenko, Francesca Oltrabella, Tobias Starborg, Michele Santoro, Diego di Bernardo, Olivier Devuyst, Martin Lowe, Diego L Medina, Andrea Ballabio, Maria Antonietta De Matteis
Sep 03, 2019
Phosphoinositides (PtdIns) control fundamental cell processes, and inherited defects of PtdIns kinases or phosphatases cause severe human diseases, including Lowe syndrome due to mutations in OCRL, which encodes a PtdIns(4,5)P2...
Human leukemia cells (HL-60) proteomic and biological signatures underpinning cryo-damage are differentially modulated by novel cryo-additives.
Noha AS Al-Otaibi, Juliana S Cassoli, Daniel Martins-de-Souza, Nigel Kh Slater, Hassan Rahmoune
Feb 07, 2019
BACKGROUND: Cryopreservation is a routinely used methodology for prolonged storage of viable cells. The use of cryo-protective agents (CPAs) such as dimethylsulfoxide (DMSO), glycerol, or trehalose is paramount to reducing...
The Role of Music in Families of Children With Hearing Loss and Normal Hearing in Australia, Finland, and the UK.
The primary aim of this current study was to compare the role, importance and value placed on music by families with normally hearing (NH) children, to those who had a child with a hearing loss (HL) who wore either hearing aids...
Allergic disease, corticosteroid use, and risk of Hodgkin lymphoma
Meena Rafiq, Andrew Hayward, Charlotte Warren-Gash, Spiros Denaxas, Arturo Gonzalez-Izquierdo, Georgios Lyratzopoulos, Sara Thomas
Feb 07, 2020
BACKGROUND: Immunodeficiency syndromes (acquired/congenital/iatrogenic) are known to increase Hodgkin lymphoma (HL) risk, but the effects of allergic immune dysregulation and corticosteroids are poorly understood. OBJECTIVE: We...
allergic disease Hodgkin lymphoma allergic rhinitis Asthma Atopic dermatitis corticosteroids eczema risk Adolescent Adrenal Cortex Hormones Adult Case-Control Studies Child Child Preschool Female Hodgkin Disease Humans Hypersensitivity Immediate Immunocompromised Host Immunosuppressive Agents Male United Kingdom Young Adult
S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells.
K Vrzalikova, M Ibrahim, M Vockerodt, T Perry, S Margielewska, L Lupino, E Nagy, E Soilleux, D Liebelt, R Hollows, A Last, G Reynolds, M Abdullah, H Curley, M Care, D Krappmann, R Tooze, J Allegood, S Spiegel, W Wei, CBJ Woodman, PG Murray
Dec 18, 2018
The Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma (HL) are characterised by the aberrant activation of multiple signalling pathways. Here we show that a subset of HL displays altered expression of...
Disaccahrides-Based Cryo-Formulant Effect on Modulating Phospho/Mitochondrial Lipids and Biological Profiles of Human Leukaemia Cells.
Marc-Sebastian F Straka, Noha Abdullah Al-Otaibi, Philip D Whitfield, Mary K Doherty, Bruno FE Matarèse, Nigel Kh Slater, Hassan Rahmoune
May 05, 2021
BACKGROUND/AIMS: The use of novel cryo-additive agents to increase cell viability post-cryopreservation is paramount to improve future cell based-therapy treatments. We aimed to establish the Human Leukemia (HL-60) cells...
The Role of Music in Families of Children With Hearing Loss and Normal Hearing in Australia, Finland, and the UK.
The primary aim of this current study was to compare the role, importance and value placed on music by families with normally hearing (NH) children, to those who had a child with a hearing loss (HL) who wore either hearing aids...
The synthesis and characterisation of coordination and hydrogen-bonded networks based on 4-(3,5-dimethyl-1H-pyrazol-4-yl)benzoic acid
MacGuire R. Bryant, Andrew D. Burrows, Christopher M. Fitchett, Chris S. Hawes, Sally O. Hunter, Luke L. Keenan, David J. Kelly, Paul E. Kruger, Mary F. Mahon, Christopher Richardson
May 21, 2015
The synthesis, structural and thermal characterisation of a number of coordination complexes featuring the N,O-heteroditopic ligand 4-(3,5-dimethyl-1H-pyrazol-4-yl)benzoate, HL are reported. The reaction of H2L...
Genetic susceptibility to radiation-induced breast cancer after Hodgkin lymphoma.
Annemieke WJ Opstal-van Winden, Hugoline G de Haan, Michael Hauptmann, Marjanka K Schmidt, Annegien Broeks, Nicola S Russell, Cécile PM Janus, Augustinus DG Krol, Frederieke H van der Baan, Marie L De Bruin, Anna M van Eggermond, Joe Dennis, Hoda Anton-Culver, Christopher A Haiman, Elinor J Sawyer, Angela Cox, Peter Devilee, Maartje J Hooning, Julian Peto, Fergus J Couch, Paul Pharoah, Nick Orr, Douglas F Easton, Berthe MP Aleman, Louise C Strong, Smita Bhatia, Rosie Cooke, Leslie L Robison, Anthony J Swerdlow, Flora E van Leeuwen
Feb 20, 2019
Female Hodgkin lymphoma (HL) patients treated with chest radiotherapy (RT) have a very high risk of breast cancer. The contribution of genetic factors to this risk is unclear. We therefore examined 211 155 germline...
Adult Aged Aged 80 and over Breast Neoplasms Cancer Survivors Case-Control Studies Female Genetic Predisposition to Disease Genotype Hodgkin Disease Humans Middle Aged Neoplasms Radiation-Induced Neoplasms Second Primary Odds Ratio Polymorphism Single Nucleotide Quality Control Radiotherapy Dosage Regression Analysis risk Young Adult
Managing heritage language development
Drawing on theories of family language policy and literacy environment, this inquiry explores and describes how family language policy is managed through literacy resources and literacy related activities in transnational...
Hodgkin Lymphoma Presenting With Spinal Cord Compression
Nicola Bloxham, Justin Cross, Matthew Garnett, Jessica Bewick, Kate Armon, Catherine Elizabeth Hook, Matthew Murray
Jun 29, 2021
Hodgkin lymphoma (HL) can present with extra-nodal disease, but spinal cord compression is exceptionally rare. We describe a 15-year-old presenting with hip/back pain with normal initial examination. Persistent pain and raised...
Advanced Hodgkin lymphoma in the East of England
James Russell, Angela Collins, Alexis Fowler, Mamatha Karanth, Chandan Saha, Suzanne Docherty, Joseph Padayatty, Kyaw Maw, Isabel Lentell, Lisa Cooke, Andrew Hodson, Nimish Shah, Shalal Sadullah, Nicholas Grigoropoulos, Wendi Qian, Amy A Kirkwood, Benjamin J Uttenthal, Peter Johnson, George A Follows
Mar 15, 2021
Treatment with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) or escalated(e)-BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisolone) remains the international...
ABVD Advanced stage Escalated BEACOPP Hodgkin lymphoma Real-world data Response-adapted therapy Adolescent Adult Antineoplastic Combined Chemotherapy Protocols Bleomycin Clinical Trials as Topic Combined Modality Therapy cyclophosphamide Dacarbazine Doxorubicin England Etoposide Female Follow-Up Studies Hematopoietic Stem Cell Transplantation Hodgkin Disease Humans Kaplan-Meier Estimate Male Middle Aged Multicenter Studies as Topic prednisone Pregnancy Pregnancy Complications Neoplastic Procarbazine Progression-Free Survival Retrospective Studies Treatment Outcome Vinblastine Vincristine Young Adult
Reparations for Racism: Why the Persistence of Institutional Racism in America Demands More Than Equal Opportunity for Black Citizens
Alexander Lowe
Jan 01, 0001
Black Americans African Americans Distributive justice reparations John Rawls justice as fairness institutional racism reflective equilibrium difference principle equality of opportunity African American Studies Civil Rights and Discrimination Ethics and Political Philosophy Inequality and Stratification Race, Ethnicity and Post-Colonial Studies United States History
Published by: Ursinus College
Killing Kindly: Applying Jens Timmermann's Kantian Ethics of Animal Welfare to the Modern System of Livestock Farming
Alexander Lowe
Jan 01, 0001
This essay seeks to contribute to this conversation in an ethically applicable way, addressing specifically the Kantian vein of animal welfare discussed by Dr. Jens Timmermann in his essay When the Tail Wags the Dog: Animal...
Kantian ethics animal welfare Jens Timmermann Pain sentient animals food living conditions Diet slaughter Animal Husbandry animal rights Animal Studies Ethics and Political Philosophy
Published by: Ursinus College
Sensitivity of future hadron colliders to leptoquark pair production in the di-muon di-jets channel
Abstract: We estimate the future sensitivity of the high luminosity (HL-) and high energy (HE-) modes of the Large Hadron Collider (LHC) and of a 100 TeV future circular collider (FCC-hh) to leptoquark (LQ) pair production in...
Sensitivity of future hadron colliders to leptoquark pair production in the di-muon di-jets channel
Abstract: We estimate the future sensitivity of the high luminosity (HL-) and high energy (HE-) modes of the Large Hadron Collider (LHC) and of a 100 TeV future circular collider (FCC-hh) to leptoquark (LQ) pair production in...
Reparations for Racism: Why the Persistence of Institutional Racism in America Demands More Than Equal Opportunity for Black Citizens
Alexander Lowe
Jan 01, 0001
This essay seeks to expose the causational effects of various forms of distributive justice on wealth inequality within the United States of America. Herein, several frameworks of distributive justice are assessed through John...
Racism Distributive justice reflective equilibrium reparations Rawls slavery egalitarianism desert-based Black Americans wealth inequality African American Studies Arts and Humanities Inequality and Stratification Philosophy race and ethnicity
Published by: Ursinus College
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