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Context is everything
Abstract: The TP53 genomic locus is a target of mutational events in at least half of cancers. Despite several decades of study, a full consensus on the relevance of the acquisition of p53 gain-of-function missense mutants has...
Context is everything
Abstract: The TP53 genomic locus is a target of mutational events in at least half of cancers. Despite several decades of study, a full consensus on the relevance of the acquisition of p53 gain-of-function missense mutants has...
Faculty Members Showcase Their New Works at Winthrop Galleries
Winthrop University
Jan 01, 0001
As part of the "New Works" exhibition, fine arts faculty members Paul Martyka and Marge Loudon Moody will exhibit new pieces in the Rutledge Gallery. Phil Moody of fine arts has collaborated with design faculty Gerry Derksen...
Published by: Winthrop University
Context is everything
The TP53 genomic locus is a target of mutational events in at least half of cancers. Despite several decades of study, a full consensus on the relevance of the acquisition of p53 gain-of-function missense mutants has not been...
Exploiting tumour addiction with a serine and glycine-free diet.
Understanding cancer metabolism is key to unveil the Achilles’ heel of cancer cells and provide novel therapeutic interventions for patients. While the rerouting of metabolic pathways during development1 or cancer transformation...
Do Mutations Turn p53 into an Oncogene?
The key role of p53 as a tumor suppressor became clear when it was realized that this gene is mutated in 50% of human sporadic cancers, and germline mutations expose carriers to cancer risk throughout their lifespan. Mutations...
Grade Level Placement for Refugee Students
Suzanne Fitzpatrick
Dec 20, 2018
As a university student and teacher in Toronto I studied, lived, worked with and taught refugees from almost all over the world. In the mid-1990s I had a pivotal conversation with a colleague who confided, “I lost my surname and...
Published by: The Morning Watch: Educational and Social Analysis
Bastard Child Born at the Seashore
Samantha Fitzpatrick
Oct 28, 2014
Published by: Memorial University
Experiences of dyadic sport friendships as a function of self and partner attachment characteristics.
Objectives: To examine the link between adolescent-parent attachment relationships and experiences of friendship quality in the context of the Actor-Partner Interdependence Model.
Design and method: One...
Design and method: One...
Bastard Child Born at the Seashore
Samantha Fitzpatrick
Oct 28, 2014
Published by: Memorial University
Experiences of dyadic sport friendships as a function of self and partner attachment characteristics.
Objectives: To examine the link between adolescent-parent attachment relationships and experiences of friendship quality in the context of the Actor-Partner Interdependence Model.
Design and method: One...
Design and method: One...
Commensal microbes and p53 in cancer progression.
Aetiogenesis of cancer has not been fully determined. Recent advances have clearly defined a role for microenvironmental factors in cancer progression and initiation; in this context, microbiome has recently emerged with a...
Smyd2 conformational changes in response to p53 binding
Smyd2 lysine methyltransferase regulates monomethylation of histone and nonhistone lysine residues using S-adenosylmethionine cofactor as the methyl donor. The nonhistone interactors include several tumorigenic targets...
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