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The tragedy of the emeritus and the fates of anatomical collections
Nick Hopwood
Mar 11, 2019
Retirement can be a significant period in modern academic careers, and emeritus professors have shaped the fates of collections in departments and disciplines. This is evidenced by reconstructing the meanings of Alfred...
The tragedy of the emeritus and the fates of anatomical collections
Nick Hopwood
Mar 31, 2020
Retirement can be a significant period in modern academic careers, and emeritus professors have shaped the fates of collections in departments and disciplines. This is evidenced by reconstructing the meanings of Alfred...
Published by: BJHS themes
Using single-cell technologies to map the human immune system - implications for nephrology.
Advances in single-cell technologies are transforming our understanding of cellular identity. For instance, the application of single-cell RNA sequencing and mass cytometry technologies to the study of immune cell populations in...
Naive Pluripotent Stem Cells Derived Directly from Isolated Cells of the Human Inner Cell Mass.
Ge Guo, Ferdinand von Meyenn, Fatima Santos, Yaoyao Chen, Wolf Reik, Paul Bertone, Austin Smith, Jennifer Nichols
Feb 16, 2016
Animals Blastocyst Cell Differentiation Cell Line Cell Lineage Cell Proliferation Cells Cultured DNA Methylation Fluorescent Antibody Technique Gene Expression Profiling Germ Layers Human Embryonic Stem Cells Humans Mice Myocytes Cardiac Pluripotent Stem Cells Reverse Transcriptase Polymerase Chain Reaction Signal Transduction
Defined conditions for propagation and manipulation of mouse embryonic stem cells.
Carla Mulas, Tüzer Kalkan, Ferdinand von Meyenn, Harry G Leitch, Jennifer Nichols, Austin Smith
Feb 23, 2019
DIFFERENTIATION Embryonic Stem Cells Pluripotency self-renewal Animals CRISPR-Cas Systems Cell Culture Techniques Cell Cycle Cell Differentiation Coculture Techniques Culture Media Embryo Mammalian Embryonic Stem Cells Humans Karyotyping Mice Mice Inbred C57BL Mouse embryonic stem cells Neurons RNA Small Interfering Signal Transduction
Medical students consulting from home
INTRODUCTION: Lockdowns during the COVID-19 pandemic had a disruptive effect on medical education when they prevented medical students accessing real patients. To address this, we piloted 35 medical students at home consulting...
Multi-tissue DNA methylation age predictor in mouse.
Thomas M Stubbs, Marc Jan Bonder, Anne-Katrien Stark, Felix Krueger, BI Ageing Clock Team, Ferdinand von Meyenn, Oliver Stegle, Wolf Reik
Jun 28, 2019
BACKGROUND: DNA methylation changes at a discrete set of sites in the human genome are predictive of chronological and biological age. However, it is not known whether these changes are causative or a consequence of an...
Optoacoustic Imaging in Inflammation.
Adrian P Regensburger, Emma Brown, Gerhard Krönke, Maximilian J Waldner, Ferdinand Knieling
Apr 29, 2021
Optoacoustic or photoacoustic imaging (OAI/PAI) is a technology which enables non-invasive visualization of laser-illuminated tissue by the detection of acoustic signals. The combination of "light in" and "sound out" offers...
Transcriptional analysis identifies potential novel biomarkers associated with successful ex-vivo perfusion of human donor lungs.
Using Experiential Learning to Improve Student Attitude and Learning Quality in Software Engineering Education
Experiential learning (EL) has great potential to transform students’ learning experience. Few studies, however, have focused on the use of EL in computer science education. The purpose of this study was to examine students'...
Published by: IGI Global Scientific Publishing
Cytokine absorption during human kidney perfusion reduces delayed graft function-associated inflammatory gene signature.
John R Ferdinand, Sarah A Hosgood, Tom Moore, Ashley Ferro, Christopher J Ward, Tomas Castro-Dopico, Michael L Nicholson, Menna R Clatworthy
Nov 13, 2020
Transplantation is the optimal treatment for most patients with end-stage kidney disease but organ shortage is a major challenge. Normothermic machine perfusion (NMP) has been used to recondition marginal organs; however...
The Use of Machine Learning Algorithms in the Classification of Sound
This study is a systematic review of literature on the classification of sounds in three domains - Bioacoustics, Biomedical acoustics, and Ecoacoustics. Specifically, 68 conferences and journal articles published between 2010...
Published by: IGI Global Scientific Publishing
Structural insights into TRPV2 activation by small molecules
Goncalo Lopes Bernardes, ruth pumroy, Anna Protopopova, Tabea Fricke, Iris Lange, Ferdinand Haug, Phuong Nguyen, pamela gallo, Barbara sousa, vladimir yarov-yarovoy, andreas leffler, vera moiseenkova-bell
Jun 07, 2022
Transient receptor potential vanilloid 2 (TRPV2) is involved in many critical physiological and pathophysiological processes, making it a promising drug target. Here we present cryo-electron microscopy (cryo-EM) structures of...
Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution.
Tobias Messmer, Ferdinand von Meyenn, Aurora Savino, Fátima Santos, Hisham Mohammed, Aaron Tin Long Lun, John C Marioni, Wolf Reik
Mar 19, 2019
Conventional human embryonic stem cells are considered to be primed pluripotent but can be induced to enter a naive state. However, the transcriptional features associated with naive and primed pluripotency are still not fully...
Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions
Oliver Thompson, Ferdinand von Meyenn, Zoe Hewitt, John Alexander, Andrew Wood, Richard Weightman, Sian Gregory, Felix Krueger, Simon Andrews, Ivana Barbaric, Paul J. Gokhale, Harry D. Moore, Wolf Reik, Marta Milo, Serena Nik-Zainal, Kosuke Yusa, Peter W. Andrews
Mar 23, 2021
Abstract: The occurrence of repetitive genomic changes that provide a selective growth advantage in pluripotent stem cells is of concern for their clinical application. However, the effect of different culture conditions on the...
Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone.
Miriam R Berry, Rebeccah J Mathews, John R Ferdinand, Chenzhi Jing, Kevin W Loudon, Elizabeth Wlodek, Thomas W Dennison, Christoph Kuper, Wolfgang Neuhofer, Menna R Clatworthy
Jun 22, 2018
Lower urinary tract infections are among the most common human bacterial infections, but extension to the kidneys is rare. This has been attributed to mechanical forces, such as urine flow, that prevent the ascent of bladder...
CCL2 NAFT5 Diabetes Insipidus Kidney macrophage monocyte salt sodium Urinary tract infection uropathogenic E. coli Animals Cell Line Chemokine CCL2 Chemokines Diabetes Insipidus Humans Kidney Kidney Medulla Lipopolysaccharide Receptors Mice Mice Inbred C57BL Monocytes Phagocytes salinity sodium Transcription Factors Urinary Tract Infections Urine Uropathogenic Escherichia coli
Cytokine absorption during human kidney perfusion reduces delayed graft function–associated inflammatory gene signature
John R. Ferdinand, Sarah A. Hosgood, Tom Moore, Ashley Ferro, Christopher J. Ward, Tomas Castro‐Dopico, Michael L. Nicholson, Menna R. Clatworthy
Jun 04, 2021
Original Article Original Articles delayed graft function (DGF) donors and donation: deceased organ perfusion and preservation
Published by: American Journal of Transplantation
Bromodomain Inhibitors Modulate FcγR-Mediated Mononuclear Phagocyte Activation and Chemotaxis.
Gemma D Banham, Colin YC Lee, John R Ferdinand, Rebeccah J Matthews, Chenzhi Jing, Nicholas Smithers, Rab K Prinjha, Menna R Clatworthy
May 24, 2022
IgG antibodies form immune complexes (IC) that propagate inflammation and tissue damage in autoimmune diseases such as systemic lupus erythematosus. IgG IC engage Fcγ receptors (FcγR) on mononuclear phagocytes (MNP), leading to...
The Grizzly, December 7, 2006
Kerri Landis, Marlena M. McMahon-Purk, Akasya Benge, Corinne Liccketto, Sarah Keck, Simon Marcus, Tracey Ferdinand, Lane Taylor, Paul P. Doghramji, Caroline Meiers, Brandon Brown, Alex Ernst, Matt Flyntz, Matthew Pastor
Jan 01, 0001
Facing Facebook: Ursinus Administrators Show Students the Dangers of Internet Use New Berman Exhibit to be Longest Running Show Ursinus Administration Supports WeCAN's Backing of Workers' Rights Sounds of Gospel Music Bless...
Ursinus College Collegeville Pennsylvania newspaper Facebook Racism Berman Art Museum worker rights gospel choir Floy Lewis Bakes Center pledging Christmas Basketball cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Wnt Inhibition Facilitates RNA-Mediated Reprogramming of Human Somatic Cells to Naive Pluripotency.
Nicholas Bredenkamp, Jian Yang, James Clarke, Giuliano Giuseppe Stirparo, Ferdinand von Meyenn, Sabine Dietmann, Duncan Baker, Rosalind Drummond, Yongming Ren, Dongwei Li, Chuman Wu, Maria Rostovskaya, Sarah Eminli-Meissner, Austin Smith, Ge Guo
Oct 16, 2019
RNA-mediated reprogramming Wnt signaling Human pluripotent stem cells human pre-implantation epiblast Induced Pluripotent Stem Cells molecular reprogramming naive pluripotency Biomarkers Cellular Reprogramming FIBROBLASTS Gene Expression Profiling Humans Induced Pluripotent Stem Cells RNA RNA Messenger Reproducibility of Results Signal Transduction Wnt Proteins
The Grizzly, November 2, 2006
Kerri Landis, Marlena M. McMahon-Purk, Tracey Ferdinand, Erin Padovani, Salia Zouande, Lane Taylor, Akasya Benge, Matt Flyntz, Alex Ernst, Gabe Vanarman, Matthew Pastor, Tyler Johnson, Danielle Langdon
Jan 01, 0001
Escape Velocity Dancers Light Up the Stage in the Black Box Theater Letter to the Editor Drive to Support the Troops a Success Ursinus Homecoming 2006: "There's No Place Like Home" Blood Drive a Success on Campus Batteries...
Ursinus College Collegeville Pennsylvania newspaper dance Judiciary Board Homecoming Omega Chi Barbara R. von Schlegell ghost stories Football Soccer field hockey cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
High-resolution label-free mapping of murine kidney vasculature by raster-scanning optoacoustic mesoscopy
Colin A Goebel, Emma Brown, Fabian B Fahlbusch, Alexandra L Wagner, Adrian Buehler, Thomas Raupach, Martin Hohmann, Moritz Späth, Neal Burton, Joachim Woelfle, Michael Schmidt, Andrea Hartner, Adrian P Regensburger, Ferdinand Knieling
Aug 06, 2022
BACKGROUND: Chronic kidney disease (CKD) is a global burden affecting both children and adults. Novel imaging modalities hold great promise to visualize and quantify structural, functional, and molecular organ damage. The aim of...
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.
Tomas Castro-Dopico, Thomas W Dennison, John R Ferdinand, Rebeccah J Mathews, Aaron Fleming, Dean Clift, Benjamin J Stewart, Chenzhi Jing, Konstantina Strongili, Larisa I Labzin, Edward JM Monk, Kourosh Saeb-Parsy, Clare E Bryant, Simon Clare, Miles Parkes, Menna R Clatworthy
Feb 18, 2019
Inflammatory bowel disease is a chronic, relapsing condition with two subtypes, Crohn's disease (CD) and ulcerative colitis (UC). Genome-wide association studies (GWASs) in UC implicate a FCGR2A variant that alters the binding...
Fcγ receptors IL-1β IgG inflammatory bowel disease type 17 immunity Animals Antibodies Bacterial Colitis Colitis Ulcerative Dextran Sulfate Gastrointestinal Microbiome Gene Expression Regulation Genotype Humans Immunoglobulin G Inflammation Interleukin-1beta Interleukin-8 Intestinal Mucosa MACROPHAGES Mice Phagocytes RNA Messenger Reactive Oxygen Species Receptors IgG Th17 Cells
In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissue.
Zhi Li, Zewen K Tuong, Isaac Dean, Claire Willis, Fabrina Gaspal, Rémi Fiancette, Suaad Idris, Bethany Kennedy, John R Ferdinand, Ana Peñalver, Mia Cabantous, Syed Murtuza Baker, Jeremy W Fry, Gianluca Carlesso, Scott A Hammond, Simon J Dovedi, Matthew R Hepworth, Menna R Clatworthy, David R Withers
May 27, 2022
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