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Structure and Dynamics of GPCRs in Lipid Membranes
Over the past decade, the vast amount of information generated through structural and biophysical studies of GPCRs has provided unprecedented mechanistic insight into the complex signalling behaviour of these receptors. With...
Dr. Daniel F. Mahony Selected as President of Winthrop University
Winthrop University
Jan 01, 0001
Mahony will begin his duties on July 1, 2015. The President's House will be home to Mahony, his wife Laura and their two children, Gavin, 15, and Elena, 12. Dr. Daniel F. Mahony, dean of the College of Education, Health and...
Published by: Winthrop University
Characterisation of denatured states of sensory rhodopsin II by solution-state NMR.
Sensory rhodopsin II (pSRII), a retinal-binding photophobic receptor from Natronomonas pharaonis, is a novel model system for membrane protein folding studies. Recently, the SDS-denatured states and the kinetics for reversible...
NMR backbone resonance assignment and solution secondary structure determination of human NSD1 and NSD2.
Nader Amin, Daniel Nietlispach, Seema Qamar, Joe Coyle, Elisabetta Chiarparin, Glyn Williams
Feb 08, 2019
Proteins of the NSD family are histone-methyl transferases with critical functions in the regulation of chromatin structure and function. NSD1 and NSD2 are homologous proteins that function as epigenetic regulators of...
Histone-methyl transferase MMSET NMR resonance assignments NMR stability screen NSD family NSD1 NSD2 Nuclear receptor-binding SET domain WHSC1 Amino Acid Sequence Histone Methyltransferases Histone-Lysine N-Methyltransferase Humans Intracellular Signaling Peptides and Proteins Nuclear Magnetic Resonance Biomolecular Nuclear Proteins Protein Domains Protein Structure Secondary Repressor Proteins Solutions
McShane on the Transformation of Botany
Daniel Mayer
Mar 16, 2022
Daniel Mayer, leadership educator and researcher into the epistemology of biology, has long reflected on the nature of organization, both of organisms and of organizations. This is the topic of his recently completed PhD...
Published by: Memorial University of Newfoundland
Daring to Stretch toward the Ultimate Consummation
Daniel Helminiak
Mar 16, 2022
Daniel A. Helminiak is Emeritus Professor of Psychology, University of West Georgia. He holds PhDs in theology and psychology and has published widely in these fields and their applications to spirituality and sexuality. Among...
Published by: Memorial University of Newfoundland
A generalized approach for NMR studies of lipid-protein interactions based on sparse fluorination of acyl chains.
Alfredo De Biasio, Alain Ibáñez de Opakua, Mark J Bostock, Daniel Nietlispach, Tammo Diercks, Francisco J Blanco
Feb 08, 2019
Sparse lipid fluorination enhances the lipids' 1H signal dispersion, enables clean molecular distinction by 19F NMR, and evinces micelle insertion of proteins via fluorine-induced signal shifts. We present a minimal fluorination...
Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor.
Andras S Solt, Mark J Bostock, Binesh Shrestha, Prashant Kumar, Tony Warne, Christopher G Tate, Daniel Nietlispach
Jun 08, 2018
A complex conformational energy landscape determines G-protein-coupled receptor (GPCR) signalling via intracellular binding partners (IBPs), e.g., Gs and β-arrestin. Using 13C methyl methionine NMR for the β1-adrenergic...
Conformational plasticity of ligand-bound and ternary GPCR complexes studied by 19F NMR of the β1-adrenergic receptor.
J Niclas Frei, Richard W Broadhurst, Mark J Bostock, Andras Solt, Andrew J Y Jones, Florian Gabriel, Aditi Tandale, Binesh Shrestha, Daniel Nietlispach
Mar 06, 2020
G-protein-coupled receptors (GPCRs) are allosteric signaling proteins that transmit an extracellular stimulus across the cell membrane. Using 19F NMR and site-specific labelling, we investigate the response of the cytoplasmic...
Published by: Nature Communications
An Adaptable Phospholipid Membrane Mimetic System for Solution NMR Studies of Membrane Proteins.
Chih-Ta Henry Chien, Lukas R Helfinger, Mark J Bostock, Andras Solt, Yi Lei Tan, Daniel Nietlispach
May 31, 2018
Based on the saposin-A (SapA) scaffold protein, we demonstrate the suitability of a size-adaptable phospholipid membrane-mimetic system for solution NMR studies of membrane proteins (MPs) under close-to-native conditions. The...
Conformational plasticity of ligand-bound and ternary GPCR complexes studied by 19 F NMR of the β 1 -adrenergic receptor
J. Niclas Frei, Richard W. Broadhurst, Mark J. Bostock, Andras Solt, Andrew J. Y. Jones, Florian Gabriel, Aditi Tandale, Binesh Shrestha, Daniel Nietlispach
Feb 02, 2021
Abstract: G-protein-coupled receptors (GPCRs) are allosteric signaling proteins that transmit an extracellular stimulus across the cell membrane. Using 19F NMR and site-specific labelling, we investigate the response of the...
McShane on the Transformation of Botany
Daniel Mayer
Mar 16, 2022
Daniel Mayer, leadership educator and researcher into the epistemology of biology, has long reflected on the nature of organization, both of organisms and of organizations. This is the topic of his recently completed PhD...
Published by: Memorial University of Newfoundland
Daring to Stretch toward the Ultimate Consummation
Daniel Helminiak
Mar 16, 2022
Daniel A. Helminiak is Emeritus Professor of Psychology, University of West Georgia. He holds PhDs in theology and psychology and has published widely in these fields and their applications to spirituality and sexuality. Among...
Published by: Memorial University of Newfoundland
Being Native American in Business
Daniel Daniel Stewart, Amy K. Verbos, Carolyn Birmingham, Stephanie L. Black, Joseph Gladstone
Jan 01, 2017
Tribally-owned American Indian enterprises provide a unique cross-cultural setting for emerging Native American business leaders. This paper examines the manner in which American Indian leaders negotiate the boundaries between...
Native American leadership authentic leadership collective identity American Indian culture international business leadership Business Administration management and Operations Indigenous Studies
Published by: Digital Commons @ Texas A&M University-San Antonio
The Merry Wives of Windsor
Daniel Gordon
Jan 01, 0001
The Merry Wives of Windsor A story of LUST, GREED, and DIRTY LAUNDRYBy William Shakespeare, adapted by Daniel Gordon.
Shakespeare's The Merry Wives of Windsor uses more prose than any of his other plays, for indeed, these...
William Shakespeare Shakespeare Carolina Acting Dramatic Literature, Criticism and Theory Literature in English, British Isles Performance Studies
Published by: Winthrop University
Review of Daniel P. Scheid, The Cosmic Common Good. Oxford University Press, 2016. 248 pages
Jared Call
Jan 07, 2019
Earth was moderately cooler last year, but not by much. 2017, additionally, was a year of record-breaking disasters for the United States. These disasters included devastating California wildfires, a trio of hurricanes, hail...
Published by: Memorial University of Newfoundland
Joanna R Watson, Helen M Fox, Daniel Nietlispach, Jennifer L Gallop, Darerca Owen, Helen R Mott
May 05, 2016
BAR domain Cdc42 CIP4 FBP17 TOCA1 WASP actin Endocytosis Nuclear Magnetic Resonance (NMR) Protein-Protein Interaction Animals Carrier Proteins Fatty Acid-Binding Proteins Humans Monomeric GTP-Binding Proteins Protein Binding Protein Domains Protein Structure Quaternary Wiskott-Aldrich Syndrome Protein Neuronal Xenopus Proteins Xenopus laevis
Review of Daniel P. Scheid, The Cosmic Common Good. Oxford University Press, 2016. 248 pages
Jared Call
Jan 07, 2019
Earth was moderately cooler last year, but not by much. 2017, additionally, was a year of record-breaking disasters for the United States. These disasters included devastating California wildfires, a trio of hurricanes, hail...
Published by: Memorial University of Newfoundland
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