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Results: 276
Increased GLP-1 response to oral glucose in pre-pubertal obese children.
Cosimo Giannini, Nicoletta Pietropaoli, Nella Polidori, Francesco Chiarelli, Maria Loredana Marcovecchio, Angelika Mohn
Aug 24, 2018
BACKGROUND: Gastrointestinal hormones, such as glucagon-like peptide (GLP-1), have been hypothesized to play a role in the pathogenesis of obesity-related complications. However, few data are available in youth. The objective of...
Pre-processing visualization of hyperspectral fluorescent data with Spectrally Encoded Enhanced Representations.
Wen Shi, Daniel E S Koo, Masahiro Kitano, Hsiao J Chiang, Le A Trinh, Gianluca Turcatel, Benjamin Steventon, Cosimo Arnesano, David Warburton, Scott E Fraser, Francesco Cutrale
Mar 10, 2020
Hyperspectral fluorescence imaging is gaining popularity for it enables multiplexing of spatio-temporal dynamics across scales for molecules, cells and tissues with multiple fluorescent labels. This is made possible by adding...
Published by: Nature Communications
The Disk Wind in GRS 1915+105 as Seen by Insight-Hard X-Ray Modulation Telescope
Abstract
We analyze three observations of GRS 1915+105 in 2017 by Insight–Hard X-ray Modulation Telescope when the source was in a spectrally soft state. We find strong absorption...
Honghui Liu, Yuhan Fu, Cosimo Bambi, Jiachen Jiang, Michael L Parker, Long Ji, Lingda Kong, Liang Zhang, Shu Zhang, Yuexin Zhang
Jul 08, 2022
Pre-processing visualization of hyperspectral fluorescent data with Spectrally Encoded Enhanced Representations.
Wen Shi, Daniel ES Koo, Masahiro Kitano, Hsiao J Chiang, Le A Trinh, Gianluca Turcatel, Benjamin Steventon, Cosimo Arnesano, David Warburton, Scott E Fraser, Francesco Cutrale
Feb 04, 2021
Hyperspectral fluorescence imaging is gaining popularity for it enables multiplexing of spatio-temporal dynamics across scales for molecules, cells and tissues with multiple fluorescent labels. This is made possible by adding...
CRISPRi screens reveal genes modulating yeast growth in lignocellulose hydrolysate.
Friederike Gutmann, Cosimo Jann, Filipa Pereira, Andreas Johansson, Lars M Steinmetz, Kiran R Patil
Mar 26, 2021
BACKGROUND: Baker's yeast is a widely used eukaryotic cell factory, producing a diverse range of compounds including biofuels and fine chemicals. The use of lignocellulose as feedstock offers the opportunity to run these...
Possessivi e partitivi nei dialetti italo-romanzi dell'Area Lausberg
Giuseppina Silvestri
Aug 19, 2019
L’ampia variazione morfologica e sintattica, che caratterizza i possessivi nelle varietà
italo-romanze non standard, non è stata oggetto finora di un’osservazione attenta
e continua. Vi sono tuttavia delle eccezioni : si pensi...
Published by: La lingua italiana. Storia, Struttura, Testi
STAT3 and TP53 mutations associate with poor prognosis in anaplastic large cell lymphoma.
Cosimo Lobello, Boris Tichy, Vojtech Bystry, Lenka Radova, Daniel Filip, Marek Mraz, Ivonne-Aidee Montes-Mojarro, Nina Prokoph, Hugo Larose, Huan-Chang Liang, Geeta G Sharma, Luca Mologni, David Belada, Katerina Kamaradova, Falko Fend, Carlo Gambacorti-Passerini, Olaf Merkel, Suzanne D Turner, Andrea Janikova, Sarka Pospisilova
Dec 02, 2020
Systemic Anaplastic Large Cell Lymphoma (sALCL) encompasses two distinct clinical entities of T-cell non-Hodgkin lymphoma: Anaplastic Lymphoma Kinase-positive (ALK+) ALCL and ALK-negative (ALK-) ALCL. These entities are...
Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis.
Suzanne E Eldridge, Aida Barawi, Hui Wang, Anke J Roelofs, Magdalena Kaneva, Zeyu Guan, Helen Lydon, Bethan L Thomas, Anne-Sophie Thorup, Beatriz F Fernandez, Sara Caxaria, Danielle Strachan, Ahmed Ali, Kanatheepan Shanmuganathan, Costantino Pitzalis, James R Whiteford, Frances Henson, Andrew W McCaskie, Cosimo De Bari, Francesco Dell'Accio
Oct 23, 2020
Cartilage loss leads to osteoarthritis, the most common cause of disability for which there is no cure. Cartilage regeneration, therefore, is a priority in medicine. We report that agrin is a potent chondrogenic factor and that...
STAT3 and TP53 mutations associate with poor prognosis in anaplastic large cell lymphoma
Cosimo Lobello, Boris Tichy, Vojtech Bystry, Lenka Radova, Daniel Filip, Marek Mraz, Ivonne-Aidee Montes-Mojarro, Nina Prokoph, Hugo Larose, Huan-Chang Liang, Geeta G. Sharma, Luca Mologni, David Belada, Katerina Kamaradova, Falko Fend, Carlo Gambacorti-Passerini, Olaf Merkel, Suzanne D. Turner, Andrea Janikova, Sarka Pospisilova
May 06, 2021
Reversible magnesium and aluminium ions insertion in cation-deficient anatase TiO<sub>2</sub>
Toshinari Koketsu, Jiwei Ma, Benjamin Morgan, Monique Body, Christophe Legein, Walid Dachraoui, Matthia Giannini, Arnaud Demortiere, Mathieu Salanne, François Dardoize, Henri Groult, Olaf Borkiewicz, Karena Chapman, Peter Strasser, Damien Dambournet
Nov 01, 2017
In contrast to monovalent lithium or sodium ions, the reversible insertion of multivalent ions such as Mg2+ and Al3+ into electrode materials remains an elusive goal. Here, we demonstrate a new strategy to...
Reversible magnesium and aluminium ions insertion in cation-deficient anatase TiO<sub>2</sub>
Toshinari Koketsu, Jiwei Ma, Benjamin Morgan, Monique Body, Christophe Legein, Walid Dachraoui, Matthia Giannini, Arnaud Demortiere, Mathieu Salanne, François Dardoize, Henri Groult, Olaf Borkiewicz, Karena Chapman, Peter Strasser, Damien Dambournet
Nov 01, 2017
In contrast to monovalent lithium or sodium ions, the reversible insertion of multivalent ions such as Mg2+ and Al3+ into electrode materials remains an elusive goal. Here, we demonstrate a new strategy to...
Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis.
Anke J Roelofs, Karolina Kania, Alexandra J Rafipay, Meike Sambale, Stephanie T Kuwahara, Fraser L Collins, Joanna Smeeton, Maxwell A Serowoky, Lynn Rowley, Hui Wang, René Gronewold, Chrysa Kapeni, Simón Méndez-Ferrer, Christopher B Little, John F Bateman, Thomas Pap, Francesca V Mariani, Joanna Sherwood, J Gage Crump, Cosimo De Bari
Oct 06, 2020
OBJECTIVES: Osteophytes are highly prevalent in osteoarthritis (OA) and are associated with pain and functional disability. These pathological outgrowths of cartilage and bone typically form at the junction of articular...
Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W. Zimmerman, Elisabeth Gurnhofer, Ivonne A. Montes-Mojarro, Brian J. Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K. Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D. Turner, A. Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Sep 22, 2021
Abstract: Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL....
Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis
Anke J Roelofs, Karolina Kania, Alexandra J Rafipay, Meike Sambale, Stephanie T Kuwahara, Fraser L Collins, Joanna Smeeton, Maxwell A Serowoky, Lynn Rowley, Hui Wang, René Gronewold, Chrysa Kapeni, Simón Méndez-Ferrer, Christopher B Little, John F Bateman, Thomas Pap, Francesca V Mariani, Joanna Sherwood, J Gage Crump, Cosimo De Bari
Sep 24, 2020
Understanding 6th-century barbarian social organization and migration through paleogenomics.
Carlos Eduardo G Amorim, Stefania Vai, Cosimo Posth, Alessandra Modi, István Koncz, Susanne Hakenbeck, Maria Cristina La Rocca, Balazs Mende, Dean Bobo, Walter Pohl, Luisella Pejrani Baricco, Elena Bedini, Paolo Francalacci, Caterina Giostra, Tivadar Vida, Daniel Winger, Uta von Freeden, Silvia Ghirotto, Martina Lari, Guido Barbujani, Johannes Krause, David Caramelli, Patrick J Geary, Krishna R Veeramah
Nov 21, 2018
A Paleogenomic Reconstruction of the Deep Population History of the Andes.
Nathan Nakatsuka, Iosif Lazaridis, Chiara Barbieri, Pontus Skoglund, Nadin Rohland, Swapan Mallick, Cosimo Posth, Kelly Harkins-Kinkaid, Matthew Ferry, Éadaoin Harney, Megan Michel, Kristin Stewardson, Jannine Novak-Forst, José M Capriles, Marta Alfonso Durruty, Karina Aranda Álvarez, David Beresford-Jones, Richard Burger, Lauren Cadwallader, Ricardo Fujita, Johny Isla, George Lau, Carlos Lémuz Aguirre, Steven LeBlanc, Sergio Calla Maldonado, Frank Meddens, Pablo G Messineo, Brendan J Culleton, Thomas K Harper, Jeffrey Quilter, Gustavo Politis, Kurt Rademaker, Markus Reindel, Mario Rivera, Lucy Salazar, José R Sandoval, Calogero M Santoro, Nahuel Scheifler, Vivien Standen, Maria Ines Barreto, Isabel Flores Espinoza, Elsa Tomasto-Cagigao, Guido Valverde, Douglas J Kennett, Alan Cooper, Johannes Krause, Wolfgang Haak, Bastien Llamas, David Reich, Lars Fehren-Schmitz
Mar 20, 2020
There are many unanswered questions about the population history of the Central and South Central Andes, particularly regarding the impact of large-scale societies, such as the Moche, Wari, Tiwanaku, and Inca. We assembled...
Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W Zimmerman, Elisabeth Gurnhofer, Ivonne A Montes-Mojarro, Brian J Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D Turner, A Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Jul 29, 2021
Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis...
Animals Basic-Leucine Zipper Transcription Factors Cell Line Tumor Cell Proliferation Cell Survival Gene Expression Regulation Neoplastic Humans Immunoconjugates Interleukin-15 Interleukin-2 Interleukin-2 Receptor alpha Subunit Ki-1 Antigen Lymphoma Large-Cell Anaplastic Mice Receptors Interleukin-2 Regulatory Sequences Nucleic Acid Repressor Proteins Signal Transduction Xenograft Model Antitumor Assays
Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W Zimmerman, Elisabeth Gurnhofer, Ivonne A Montes-Mojarro, Brian J Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D Turner, A Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Oct 24, 2021
Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis...
Published by: Nature Communications
Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target.
Hugo Larose, Nina Prokoph, Jamie D Matthews, Michaela Schlederer, Sandra Högler, Ali F Alsulami, Stephen P Ducray, Edem Nuglozeh, Feroze MS Fazaludeen, Ahmed Elmouna, Monica Ceccon, Luca Mologni, Carlo Gambacorti-Passerini, Gerald Hoefler, Cosimo Lobello, Sarka Pospisilova, Andrea Janikova, Wilhelm Woessmann, Christine Damm-Welk, Martin Zimmermann, Alina Federova, Andrea Malone, Owen Smith, Mariusz Wasik, Giorgio Inghirami, Laurence Lamant, Tom L Blundell, Wolfram Klapper, Olaf Merkel, Amos GA Burke, Shahid Mian, Ibraheem Ashankyty, Lukas Kenner, Suzanne D Turner
Apr 06, 2020
The evolution and changing ecology of the African hominid oral microbiome.
James A Fellows Yates, Irina M Velsko, Franziska Aron, Cosimo Posth, Courtney A Hofman, Rita M Austin, Cody E Parker, Allison E Mann, Kathrin Nägele, Kathryn Weedman Arthur, John W Arthur, Catherine C Bauer, Isabelle Crevecoeur, Christophe Cupillard, Matthew C Curtis, Love Dalén, Marta Díaz-Zorita Bonilla, J Carlos Díez Fernández-Lomana, Dorothée G Drucker, Elena Escribano Escrivá, Michael Francken, Victoria E Gibbon, Manuel R González Morales, Ana Grande Mateu, Katerina Harvati, Amanda G Henry, Louise Humphrey, Mario Menéndez, Dušan Mihailović, Marco Peresani, Sofía Rodríguez Moroder, Mirjana Roksandic, Hélène Rougier, Sandra Sázelová, Jay T Stock, Lawrence Guy Straus, Jiří Svoboda, Barbara Teßmann, Michael J Walker, Robert C Power, Cecil M Lewis, Krithivasan Sankaranarayanan, Katerina Guschanski, Richard W Wrangham, Floyd E Dewhirst, Domingo C Salazar-García, Johannes Krause, Alexander Herbig, Christina Warinner
Jun 11, 2021
The oral microbiome plays key roles in human biology, health, and disease, but little is known about the global diversity, variation, or evolution of this microbial community. To better understand the evolution and changing...
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP.
Francesca Bufalieri, Paola Infante, Flavia Bernardi, Miriam Caimano, Paolo Romania, Marta Moretti, Ludovica Lospinoso Severini, Julie Talbot, Ombretta Melaiu, Mirella Tanori, Laura Di Magno, Diana Bellavia, Carlo Capalbo, Stéphanie Puget, Enrico De Smaele, Gianluca Canettieri, Daniele Guardavaccaro, Luca Busino, Angelo Peschiaroli, Simonetta Pazzaglia, Giuseppe Giannini, Gerry Melino, Franco Locatelli, Alberto Gulino, Olivier Ayrault, Doriana Fruci, Lucia Di Marcotullio
Jul 23, 2020
The Hedgehog (Hh) pathway is essential for embryonic development and tissue homeostasis. Aberrant Hh signaling may occur in a wide range of human cancers, such as medulloblastoma, the most common brain malignancy in childhood....
IL10RA modulates crizotinib sensitivity in NPM1-ALK+ anaplastic large cell lymphoma.
Nina Prokoph, Nicola A Probst, Liam C Lee, Jack M Monahan, Jamie D Matthews, Huan-Chang Liang, Klaas Bahnsen, Ivonne A Montes-Mojarro, Elif Karaca-Atabay, Geeta G Sharma, Vikas Malik, Hugo Larose, Sorcha D Forde, Stephen P Ducray, Cosimo Lobello, Qi Wang, Shi-Lu Luan, Šárka Pospíšilová, Carlo Gambacorti-Passerini, GA Amos Burke, Shahid Pervez, Andishe Attarbaschi, Andrea Janíková, Hélène Pacquement, Judith Landman-Parker, Anne Lambilliotte, Gudrun Schleiermacher, Wolfram Klapper, Ralf Jauch, Wilhelm Woessmann, Gilles Vassal, Lukas Kenner, Olaf Merkel, Luca Mologni, Roberto Chiarle, Laurence Brugières, Birgit Geoerger, Isaia Barbieri, Suzanne D Turner
May 26, 2020
Anaplastic large cell lymphoma (ALCL) is a T-cell malignancy predominantly driven by a hyperactive anaplastic lymphoma kinase (ALK) fusion protein. ALK inhibitors, such as crizotinib, provide alternatives to standard...
Antineoplastic Agents CRISPR-Cas Systems Cell Line Crizotinib Dose-Response Relationship Drug Drug Resistance Neoplasm Gene Editing Gene Expression Humans Immunohistochemistry Interleukin-10 Receptor alpha Subunit Lymphoma Large-Cell Anaplastic Models Biological Nucleophosmin Protein Kinase Inhibitors Protein-Tyrosine Kinases STAT3 Transcription Factor Signal Transduction
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