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Influence of alphaxalone on motor somatosensory evoked potentials in a female rhesus macaque (Macaca mulatta).
Henri Georges Michel Justin Bertrand, Joseph Adam Middleton, Stuart Nicolas Baker, Isabel Glover, Paul Andrew Flecknell
Aug 12, 2021
This communication reports the effect of alphaxalone on motor somatosensory evoked potential (SEPs) in a rhesus macaque. The animal was deeply anaesthetised with an infusion of ketamine, medetomidine, midazolam and alfentanil....
Mechanical Coupling Coordinates the Co-elongation of Axial and Paraxial Tissues in Avian Embryos.
Tissues undergoing morphogenesis impose mechanical effects on one another. How developmental programs adapt to or take advantage of these effects remains poorly explored. Here, using a combination of live imaging, modeling, and...
cell motility Cell Polarity Convergence Coupling elongation Feedback Mechanical forces neural tube (NT) notochord (NC) presomitic mesoderm (PSM) Animals Biomechanical Phenomena Body Patterning Cell Movement Cell Polarity Cell Tracking Chick Embryo Computer Simulation Embryo Nonmammalian Mesoderm Organogenesis Quail
Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site.
Akshay Sridhar, Sarah CR Lummis, Diletta Pasini, Aujan Mehregan, Marijke Brams, Kumiko Kambara, Daniel Bertrand, Erik Lindahl, Rebecca J Howard, Chris Ulens
Sep 14, 2021
Pentameric ligand-gated ion channels (pLGICs) are crucial mediators of electrochemical signal transduction in various organisms from bacteria to humans. Lipids play an important role in regulating pLGIC function, yet the...
Reductive Elimination at Carbon under Steric Control
Daniel Tolentino, Samuel Neale, Connie Isaac, Stuart MacGregor, Michael Whittlesey, Rodolphe Jazzar, Guy Bertrand
Jun 26, 2019
It has been previously demonstrated that stable singlet electrophilic carbenes can behave as metal surrogates in the activation of strong E-H bonds (E = H, B, N, Si, P), but it was believed that these activations only proceed...
Reductive Elimination at Carbon under Steric Control
Daniel Tolentino, Samuel Neale, Connie Isaac, Stuart MacGregor, Michael Whittlesey, Rodolphe Jazzar, Guy Bertrand
Jun 26, 2019
It has been previously demonstrated that stable singlet electrophilic carbenes can behave as metal surrogates in the activation of strong E-H bonds (E = H, B, N, Si, P), but it was believed that these activations only proceed...
SWATH-MS dataset of heat-shock treated Drosophila melanogaster embryos.
Bertrand Fabre, Dagmara Korona, Daniel JH Nightingale, Steven Russell, Kathryn S Lilley
Nov 20, 2017
Data independent acquisition (DIA) has emerged as a promising mass spectrometry based approach, combining the advantages of shotgun and targeted proteomics. Here we applied a DIA approach (termed SWATH) to monitor the dynamics...
Live-cell imaging reveals the spatiotemporal organization of endogenous RNA polymerase II phosphorylation at a single gene.
Linda S Forero-Quintero, William Raymond, Tetsuya Handa, Matthew N Saxton, Tatsuya Morisaki, Hiroshi Kimura, Edouard Bertrand, Brian Munsky, Timothy J Stasevich
Jun 27, 2021
The carboxyl-terminal domain of RNA polymerase II (RNAP2) is phosphorylated during transcription in eukaryotic cells. While residue-specific phosphorylation has been mapped with exquisite spatial resolution along the 1D genome...
Synthesis and evaluation of analogues of estrone-3-<em>O</em>-sulfamate as potent steroid sulfatase inhibitors
Estrone sulfamate (EMATE) is a potent irreversible inhibitor of steroid sulfatase (STS). In order to further expand SAR, the compound was substituted at the 2- and/or 4-positions and its 17-carbonyl group was also removed. The...
Live-cell imaging reveals the spatiotemporal organization of endogenous RNA polymerase II phosphorylation at a single gene
Linda S. Forero-Quintero, William Raymond, Tetsuya Handa, Matthew N. Saxton, Tatsuya Morisaki, Hiroshi Kimura, Edouard Bertrand, Brian Munsky, Timothy J. Stasevich
May 26, 2021
Abstract: The carboxyl-terminal domain of RNA polymerase II (RNAP2) is phosphorylated during transcription in eukaryotic cells. While residue-specific phosphorylation has been mapped with exquisite spatial resolution along the...
Cell-to-cell heterogeneity in Sox2 and Bra expression guides progenitor motility and destiny
Michèle Romanos, Guillaume Allio, Myriam Roussigné, Léa Combres, Nathalie Escalas, Cathy Soula, François Médevielle, Benjamin Steventon, Ariane Trescases, Bertrand Bénazéraf
Oct 05, 2021
Although cell-to-cell heterogeneity in gene and protein expression within cell populations has been widely documented, we know little about its biological functions. By studying progenitors of the posterior region of bird...
Characterisation of protein isoforms encoded by the Drosophila Glycogen Synthase Kinase 3 gene shaggy
Dagmara Korona, Daniel Nightingale, Bertrand Fabre, Michael Nelson, Bettina Fischer, Glynnis Johnson, Jonathan Lees, Simon Hubbard, Kathryn Lilley, Steven Russell
Aug 06, 2020
The Drosophila shaggy gene (sgg, GSK-3) encodes multiple protein isoforms with serine/threonine kinase activity and is a key player in diverse developmental signalling pathways. Currently it is unclear whether different Sgg...
Characterisation of protein isoforms encoded by the Drosophila Glycogen Synthase Kinase 3 gene shaggy.
Dagmara Korona, Daniel Nightingale, Bertrand Fabre, Michael Nelson, Bettina Fischer, Glynnis Johnson, Jonathan Lees, Simon Hubbard, Kathryn Lilley, Steven Russell
Jul 16, 2020
The Drosophila shaggy gene (sgg, GSK-3) encodes multiple protein isoforms with serine/threonine kinase activity and is a key player in diverse developmental signalling pathways. Currently it is unclear whether different Sgg...
Cell-to-cell heterogeneity in Sox2 and Bra expression guides progenitor motility and destiny.
Michèle Romanos, Guillaume Allio, Myriam Roussigné, Léa Combres, Nathalie Escalas, Cathy Soula, François Médevielle, Benjamin Steventon, Ariane Trescases, Bertrand Bénazéraf
Nov 05, 2021
Although cell-to-cell heterogeneity in gene and protein expression within cell populations has been widely documented, we know little about its biological functions. By studying progenitors of the posterior region of bird...
bird embryos cell motility developmental biology Heterogeneity mathematical modeling Morphogenesis neuromesodermal progenitors Animals Cell Differentiation Cell Lineage Embryo Nonmammalian Fetal Proteins Gene Expression Gene Expression Regulation Developmental Quail SOXB1 Transcription Factors T-Box Domain Proteins
Effect of User Involvement in Supply Chain Cloud Innovation
Cloud innovation has become increasingly important to supply chain innovation and performance. User involvement is a crucial part of cloud innovation. However, the effect of user involvement in supply chain cloud innovation has...
Published by: IGI Global Scientific Publishing
Reimagining the Mathematics Curriculum Through a Cross-Curricular and Maker Education Lens
Hiba Barek, Immaculate Namukasa, Rachelle Campigotto, Marja Bertrand, Derek Tangredi, Jade Roy, Kinful Aryee
Jan 01, 2023
Despite the positive impact of maker education on student learning, challenges towards its implementation in formal school settings still exist. There is limited research on maker education in teacher education programs and a...
Published by: IGI Global Scientific Publishing
Exploring electroencephalography with a model inspired by quantum mechanics.
Nicholas JM Popiel, Colin Metrow, Geoffrey Laforge, Adrian M Owen, Bobby Stojanoski, Andrea Soddu
Oct 05, 2021
An outstanding issue in cognitive neuroscience concerns how the brain is organized across different conditions. For instance, during the resting-state condition, the brain can be clustered into reliable and reproducible networks...
Synthesis and evaluation of analogues of estrone-3-<em>O</em>-sulfamate as potent steroid sulfatase inhibitors
Estrone sulfamate (EMATE) is a potent irreversible inhibitor of steroid sulfatase (STS). In order to further expand SAR, the compound was substituted at the 2- and/or 4-positions and its 17-carbonyl group was also removed. The...
Paintable Carbon Nanotube Coating-Based Textronics for Sustained Holter-Type Electrocardiography.
Sławomir Boncel, Rafał G Jędrysiak, Marek Czerw, Anna Kolanowska, Anna W Blacha, Maciej Imielski, Bertrand Jóźwiak, Marzena H Dzida, Heather F Greer, Aleksander Sobotnicki
Dec 08, 2022
A growing population suffering from or at high risk of developing cardiovascular diseases can benefit from rapid, precise, and readily available diagnostics. Textronics is an interdisciplinary approach for designing and...
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