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Anti-decubitus bed mattress may interfere with cerebrovascular pressure reactivity measures due to induced ICP and ABP cyclic peaks.
Tas Jeanette, Borg Melisa, Smielewski Peter, Czosnyka Marek, Beqiri Erta, Ercole Ari, Aries Marcel
Jan 29, 2020
Severe traumatic brain injury (TBI) patients are monitored with continuous arterial blood pressure (ABP) and intracranial pressure (ICP). The pressure reactivity index (PRx) is a frequently used correlation coefficient between...
Normalising renal tissue oxygen tension with higher inspired oxygen concentration may be falsely reassuring. Comment on Br J Anaesth 2020;125
Ari Ercole
Oct 20, 2020
A recent study by Iguchi et al (Anaesth 2020;125(2):192-200) showed that measured renal tissue oxygen tension falls under anaesthesia and may apparently be normalised by increasing arterial oxygen tension. In reality tissue...
Radiofrequency properties of two different Licox® parenchymal brain tissue oxygen probe designs.
Ari Ercole
May 29, 2018
Neuroimaging and continuous multimodality neuromonitoring are both central to the intensive care management of patients with severe traumatic brain injury. Guidelines recommend the use of multimodality monitors including brain...
Evaluation of the self-inflating bag-valve-mask and non-rebreather mask as preoxygenation devices in volunteers.
OBJECTIVE: To evaluate and compare the effectiveness and tolerability of preoxygenation with the self-inflating bag-valve-mask (BVM) and non-rebreather mask (NRM) as are used before emergency anaesthesia. DESIGN: Device...
Cerebrovascular Signal Complexity Six Hours after Intensive Care Unit Admission Correlates with Outcome after Severe Traumatic Brain Injury.
ICP approximate entropy autoregulation complexity Traumatic brain injury Adolescent Adult blood pressure Brain Injuries Traumatic Cerebrovascular Circulation Female Heart Rate Humans Intensive Care Units Male Middle Aged Patient Admission Retrospective Studies Severity of Illness Index Survival Rate Time Factors Treatment Outcome Young Adult
Can network science reveal structure in a complex healthcare system? A network analysis using data from emergency surgical services.
INTRODUCTION: Hospitals are complex systems and optimising their function is critical to the provision of high quality, cost effective healthcare. Metrics of performance have to date focused on the performance of individual...
In Silico Model of Critical Cerebral Oxygenation after Traumatic Brain Injury
Cerebral oxygen delivery is central to the modern intensive care of patients with severe traumatic brain injury. Low brain tissue oxygen tension (PbtO2) results from microvascular collapse and diffusion limitation and is...
HDF5-Based Data Format for Archiving Complex Neuro-monitoring Data in Traumatic Brain Injury Patients.
OBJECTIVES: Modern neuro-critical care units generate high volumes of data. These data originate from a multitude of devices in various formats and levels of granularity. We present a new data format intended to store these data...
Signal Information Prediction of Mortality Identifies Unique Patient Subsets after Severe Traumatic Brain Injury
Nonlinear physiological signal features that reveal information content and causal flow have recently been shown to be predictors of mortality after severe traumatic brain injury (TBI). The extent to which these features...
Ethnic and regional variations in hospital mortality from COVID-19 in Brazil
BACKGROUND: Brazil ranks second worldwide in total number of COVID-19 cases and deaths. Understanding the possible socioeconomic and ethnic health inequities is particularly important given the diverse population and fragile...
End-tidal and arterial carbon dioxide gradient in serious traumatic brain injury after prehospital emergency anaesthesia
James Price, Daniel D Sandbach, Ari Ercole, Alastair Wilson, Ed Benjamin Graham Barnard
Sep 16, 2020
Objectives: In the UK, 20% of patients with severe traumatic brain injury (TBI) receive prehospital emergency anaesthesia (PHEA). Current guidance recommends an end-tidal carbon dioxide (ETCO2) of 4.0–4.5 kPa (30.0–33.8 mm Hg)...
Sepsis-3 criteria in AmsterdamUMCdb
Sepsis is a major healthcare problem with substantial mortality and a common reason for admission to the intensive care
unit (ICU). For this reason, the management of sepsis is an important area of ICU research. A number of...
Prehospital determinants of successful resuscitation after traumatic and non-traumatic out-of-hospital cardiac arrest.
BACKGROUND: Out-of-hospital cardiac arrest (OHCA) is prevalent in the UK. Reported survival is lower than in countries with comparable healthcare systems; a better understanding of outcome determinants may identify areas for...
cardiac arrest doctors in PHC prehospital care prehospital care clinical management trauma major trauma management Aged Aged 80 and over Cohort Studies Emergency Medical Services Emergency Service hospital Female Humans Logistic Models Male Middle Aged Out-of-Hospital Cardiac Arrest Registries Resuscitation Retrospective Studies Survival Analysis
Glucose Dynamics of Cortical Spreading Depolarization in Acute Brain Injury
Andrew R Stevens, Isabel HX Ng, Adel Helmy, Peter JA Hutchinson, David K Menon, Ari Ercole
Feb 11, 2019
Cortical spreading depolarization (CSD) is an emerging mode of secondary neuronal damage in acute brain injury (ABI). Subsequent repolarisation is a metabolic process requiring glucose. Instances of CSD and glucose derangement...
Bayesian model selection for multilevel models using integrated likelihoods.
Multilevel linear models allow flexible statistical modelling of complex data with different levels of stratification. Identifying the most appropriate model from the large set of possible candidates is a challenging problem. In...
Machine learning in intensive care medicine
Lucas M Fleuren, Patrick Thoral, Duncan Shillan, Ari Ercole, Paul WG Elbers, Right Data Right Now Collaborators
Apr 09, 2020
In 1986 the world was shaken by the Challenger space shuttle disaster. In the years that followed, the American National Aeronautics and Space Administration (NASA) called for a strategy change in space technology development...
Between-centre differences for COVID-19 ICU mortality from early data in England.
Since the first cases in November 2019, the spread of SARS-CoV-2 infections has placed unprecedented strain on healthcare. The intensive care unit (ICU) is of particular concern as large numbers of patients with severe...
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