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Results: 284
Regulation of the Anaphase-Promoting Complex Examined at the Single Cell Level
Andrej Ondracka
Jan 01, 0001
Cell cycle transitions are driven by oscillations of cyclin-cyclin dependent kinase (CDK) activity and associated cyclin degradation, mediated by ubiquitylation by the anaphase-promoting complex (APC). In this work, I analyzed...
Published by: Rockefeller University
Predicting genes associated with RNA methylation pathways using machine learning.
Georgia Tsagkogeorga, Helena Santos-Rosa, Andrej Alendar, Dan Leggate, Oliver Rausch, Tony Kouzarides, Hendrik Weisser, Namshik Han
Sep 25, 2022
RNA methylation plays an important role in functional regulation of RNAs, and has thus attracted an increasing interest in biology and drug discovery. Here, we collected and collated transcriptomic, proteomic, structural and...
PET Imaging of Post-infarct Myocardial Inflammation.
PURPOSE OF REVIEW: To examine the use of positron emission tomography (PET) for imaging post-infarct myocardial inflammation and repair. RECENT FINDINGS: Dysregulated immune responses after myocardial infarction are associated...
Novel Positron Emission Tomography Tracers for Imaging Vascular Inflammation
Abstract: Purpose of Review: To provide a focused update on recent advances in positron emission tomography (PET) imaging in vascular inflammatory diseases and consider future directions in the field. Recent Findings: While PET...
PET Imaging of Post-infarct Myocardial Inflammation
Abstract: Purpose of Review: To examine the use of positron emission tomography (PET) for imaging post-infarct myocardial inflammation and repair. Recent Findings: Dysregulated immune responses after myocardial infarction are...
Predicting genes associated with RNA methylation pathways using machine learning.
Georgia Tsagkogeorga, Helena Santos-Rosa, Andrej Alendar, Dan Leggate, Oliver Rausch, Tony Kouzarides, Hendrik Weisser, Namshik Han
Aug 25, 2022
RNA methylation plays an important role in functional regulation of RNAs, and has thus attracted an increasing interest in biology and drug discovery. Here, we collected and collated transcriptomic, proteomic, structural and...
DDX3X RNA helicase affects breast cancer cell cycle progression by regulating expression of KLF4.
DDX3X is a multifunctional RNA helicase with documented roles in different cancer types. Here, we demonstrate that DDX3X plays an oncogenic role in breast cancer cells by modulating the cell cycle. Depletion of DDX3X in MCF7...
Gene expression regulation by the Chromodomain helicase DNA-binding protein 9 (CHD9) chromatin remodeler is dispensable for murine development.
Andrej Alendar, Jan-Paul Lambooij, Rajith Bhaskaran, Cesare Lancini, Ji-Ying Song, Huub van Vugt, Margriet Snoek, Anton Berns
May 26, 2020
Chromodomain helicase DNA-binding (CHD) chromatin remodelers regulate transcription and DNA repair. They govern cell-fate decisions during embryonic development and are often deregulated in human pathologies. Chd1-8 show upon...
Novel Positron Emission Tomography Tracers for Imaging Vascular Inflammation
Abstract: Purpose of Review: To provide a focused update on recent advances in positron emission tomography (PET) imaging in vascular inflammatory diseases and consider future directions in the field. Recent Findings: While PET...
Positron emission tomography imaging in cardiovascular disease.
Positron emission tomography (PET) imaging is useful in cardiovascular disease across several areas, from assessment of myocardial perfusion and viability, to highlighting atherosclerotic plaque activity and measuring the extent...
Novel Positron Emission Tomography Tracers for Imaging Vascular Inflammation
Abstract: Purpose of Review: To provide a focused update on recent advances in positron emission tomography (PET) imaging in vascular inflammatory diseases and consider future directions in the field. Recent Findings: While PET...
PET Imaging of Post-infarct Myocardial Inflammation
Abstract: Purpose of Review: To examine the use of positron emission tomography (PET) for imaging post-infarct myocardial inflammation and repair. Recent Findings: Dysregulated immune responses after myocardial infarction are...
METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation.
Luca Pandolfini, Isaia Barbieri, Andrew J Bannister, Alan Hendrick, Byron Andrews, Natalie Webster, Pierre Murat, Pia Mach, Rossella Brandi, Samuel C Robson, Valentina Migliori, Andrej Alendar, Mara d'Onofrio, Shankar Balasubramanian, Tony Kouzarides
Apr 05, 2019
7-methylguanosine (m7G) is present at mRNA caps and at defined internal positions within tRNAs and rRNAs. However, its detection within low-abundance mRNAs and microRNAs (miRNAs) has been hampered by a lack of sensitive...
7-methylguanosine G-Quadruplexes METTL1 RNA methylation SAM-dependent methyltransferase cell migration high-throughput sequencing let-7 miRNA biogenesis microRNA A549 Cells Base Sequence Biological Assay Caco-2 Cells Cell Movement Cell Proliferation Guanosine HEK293 Cells Humans Methylation Methyltransferases MicroRNAs Nucleic Acid Conformation RNA processing Post-Transcriptional
Cellulose Nanocrystal-Templated Tin Dioxide Thin Films for Gas Sensing.
Alesja Ivanova, Bruno Frka-Petesic, Andrej Paul, Thorsten Wagner, Askhat N Jumabekov, Yury Vilk, Johannes Weber, Jörn Schmedt Auf der Günne, Silvia Vignolini, Michael Tiemann, Dina Fattakhova-Rohlfing, Thomas Bein
Jan 15, 2020
Porous tin dioxide is an important low-cost semiconductor applied in electronics, gas sensors, and biosensors. Here, we present a versatile template-assisted synthesis of nanostructured tin dioxide thin films using cellulose...
Gastro-esophageal reflux disease symptoms and demographic factors as a pre-screening tool for Barrett's esophagus.
Xinxue Liu, Angela Wong, Sudarshan R Kadri, Andrej Corovic, Maria O'Donovan, Pierre Lao-Sirieix, Laurence B Lovat, Rodney W Burnham, Rebecca C Fitzgerald
Feb 13, 2020
BACKGROUND: Barrett's esophagus (BE) occurs as consequence of reflux and is a risk factor for esophageal adenocarcinoma. The current "gold-standard" for diagnosing BE is endoscopy which remains prohibitively expensive and...
Pattern of arterial inflammation and inflammatory markers in people living with HIV compared with uninfected people.
Nevio Taglieri, Rachele Bonfiglioli, Isabella Bon, Pietro Malosso, Andrej Corovic, Matteo Bruno, Elizabeth Le, Bianca Granozzi, Tullio Palmerini, Gabriele Ghetti, Martina Tamburello, Antonio Giulio Bruno, Francesco Saia, Jason Tarkin, James Rudd, Leonardo Calza, Stefano Fanti, Maria Carla Re, Nazzareno Galié
Jan 04, 2021
STUDY DESIGN: To compare arterial inflammation (AI) between people living with HIV (PLWH) and uninfected people as assessed by 18F-Fluorodeoxyglucose (18F-FDG)-positron emission tomography (PET). METHODS: We prospectively...
Novel Approach for Assessing Postinfarct Myocardial Injury and Inflammation Using Hybrid Somatostatin Receptor Positron Emission Tomography/Magnetic Resonance Imaging.
Andrej Ćorović, Deepa Gopalan, Christopher Wall, Marta Peverelli, Stephen P Hoole, Patrick A Calvert, Roido Manavaki, Tim D Fryer, Luigi Aloj, Martin J Graves, Martin R Bennett, James HF Rudd, Jason M Tarkin
Feb 17, 2023
Post-infarct inflammation and its resolution modulate ischemic injury after myocardial infarction (MI). While cardiac magnetic resonance imaging (MRI) is useful for assessing ventricular function, viability and structural...
Pattern of arterial inflammation and inflammatory markers in people living with HIV compared with uninfected people.
Nevio Taglieri, Rachele Bonfiglioli, Isabella Bon, Pietro Malosso, Andrej Corovic, Matteo Bruno, Elizabeth Le, Bianca Granozzi, Tullio Palmerini, Gabriele Ghetti, Martina Tamburello, Antonio Giulio Bruno, Francesco Saia, Jason M Tarkin, James HF Rudd, Leonardo Calza, Stefano Fanti, Maria Carla Re, Nazzareno Galié
Aug 03, 2022
18F-fluorodeoxyglucose-positron emission tomography Arterial inflammation HIV Arteritis Atherosclerosis Biomarkers Fluorodeoxyglucose F18 HIV Infections Humans Inflammation Positron Emission Tomography Computed Tomography Radiopharmaceuticals Tomography X-Ray Computed Vascular Cell Adhesion Molecule-1
Quality control requirements for the correct annotation of lipidomics data.
Harald C Köfeler, Thomas O Eichmann, Robert Ahrends, John A Bowden, Niklas Danne-Rasche, Edward A Dennis, Maria Fedorova, William J Griffiths, Xianlin Han, Jürgen Hartler, Michal Holčapek, Robert Jirásko, Jeremy P Koelmel, Christer S Ejsing, Gerhard Liebisch, Zhixu Ni, Valerie B O'Donnell, Oswald Quehenberger, Dominik Schwudke, Andrej Shevchenko, Michael JO Wakelam, Markus R Wenk, Denise Wolrab, Kim Ekroos
Oct 11, 2021
Ancient genomes reveal a high diversity of Mycobacterium leprae in medieval Europe.
Verena J Schuenemann, Charlotte Avanzi, Ben Krause-Kyora, Alexander Seitz, Alexander Herbig, Sarah Inskip, Marion Bonazzi, Ella Reiter, Christian Urban, Dorthe Dangvard Pedersen, G Michael Taylor, Pushpendra Singh, Graham R Stewart, Petr Velemínský, Jakub Likovsky, Antónia Marcsik, Erika Molnár, György Pálfi, Valentina Mariotti, Alessandro Riga, M Giovanna Belcastro, Jesper L Boldsen, Almut Nebel, Simon Mays, Helen D Donoghue, Sonia Zakrzewski, Andrej Benjak, Kay Nieselt, Stewart T Cole, Johannes Krause
Sep 08, 2018
Studying ancient DNA allows us to retrace the evolutionary history of human pathogens, such as Mycobacterium leprae, the main causative agent of leprosy. Leprosy is one of the oldest recorded and most stigmatizing diseases in...
Pericoronary and periaortic adipose tissue density are associated with inflammatory disease activity in Takayasu arteritis and atherosclerosis.
Christopher Wall, Yuan Huang, Elizabeth P V Le, Andrej Ćorović, Christopher P Uy, Deepa Gopalan, Chuoxin Ma, Roido Manavaki, Tim D Fryer, Luigi Aloj, Martin J Graves, Enrico Tombetti, Ben Ariff, Paul Bambrough, Stephen P Hoole, Rosemary A Rusk, David R Jayne, Marc R Dweck, David Newby, Zahi A Fayad, Martin R Bennett, James E Peters, Piotr Slomka, Damini Dey, Justin C Mason, James H F Rudd, Jason M Tarkin
Nov 22, 2021
Aims
To examine pericoronary adipose tissue (PCAT) and periaortic adipose tissue (PAAT) density on coronary computed tomography angiography for assessing arterial inflammation in Takayasu arteritis (TAK) and...
Published by: European heart journal open
Somatostatin Receptor PET/MR Imaging of Inflammation in Patients With Large Vessel Vasculitis and Atherosclerosis.
Andrej Ćorović, Christopher Wall, Meritxell Nus, Deepa Gopalan, Yuan Huang, Maria Imaz, Michal Zulcinski, Marta Peverelli, Anna Uryga, Jordi Lambert, Dario Bressan, Robert T Maughan, Charis Pericleous, Suraiya Dubash, Natasha Jordan, David R Jayne, Stephen P Hoole, Patrick A Calvert, Andrew F Dean, Doris Rassl, Tara Barwick, Mark Iles, Mattia Frontini, Greg Hannon, Roido Manavaki, Tim D Fryer, Luigi Aloj, Martin J Graves, Fiona J Gilbert, Marc R Dweck, David E Newby, Zahi A Fayad, Gary Reynolds, Ann W Morgan, Eric O Aboagye, Anthony P Davenport, Helle F Jørgensen, Ziad Mallat, Martin R Bennett, James E Peters, James HF Rudd, Justin C Mason, Jason M Tarkin
Feb 25, 2023
BACKGROUND: Assessing inflammatory disease activity in large vessel vasculitis (LVV) can be challenging by conventional measures. OBJECTIVES: We aimed to investigate somatostatin receptor 2 (SST2) as a novel...
Takayasu arteritis Atherosclerosis Giant Cell Arteritis Inflammation Molecular Imaging somatostatin receptor Humans Receptors Somatostatin Prospective Studies Fluorodeoxyglucose F18 Inflammation Positron-Emission Tomography Magnetic Resonance Imaging Takayasu arteritis Coronary Vessels Atherosclerosis Myocardial Infarction Giant Cell Arteritis Radiopharmaceuticals
Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer.
Adam Shlien, Keiran Raine, Fabio Fuligni, Roland Arnold, Serena Nik-Zainal, Serge Dronov, Lira Mamanova, Andrej Rosic, Young Seok Ju, Susanna L Cooke, Manasa Ramakrishna, Elli Papaemmanuil, Helen R Davies, Patrick S Tarpey, Peter Van Loo, David C Wedge, David R Jones, Sancha Martin, John Marshall, Elizabeth Anderson, Claire Hardy, Oslo Breast Cancer Research Consortium ICGC Breast Cancer Working Group, Violetta Barbashina, Samuel AJR Aparicio, Torill Sauer, Øystein Garred, Anne Vincent-Salomon, Odette Mariani, Sandrine Boyault, Aquila Fatima, Anita Langerød, Åke Borg, GIlles Thomas, Andrea L Richardson, Anne-Lise Børresen-Dale, Kornelia Polyak, Michael R Stratton, Peter J Campbell
Nov 01, 2018
Disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription, coordinated secondary pathway alterations, and increased transcriptional noise. To catalog the rules governing how somatic...
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