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![Cover Image for [18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases.](https://coverimages.igi-global.com/images/search-article.png)
[18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases.
Elijah Mak, Antonina Kouli, Negin Holland, Nicolas Nicastro, George Savulich, Ajenthan Surendranathan, Maura Malpetti, Roido Manavaki, Young T Hong, Tim D Fryer, Franklin Aigbirhio, James B Rowe, John T O'Brien, Caroline H Williams-Gray
Sep 05, 2021
While [18F]-AV-1451 was developed as a PET radiotracer with high affinity for hyperphosphorylated tau, it has been proposed that loss of 'off-target' [18F]-AV-1451 binding to neuromelanin in the substantia nigra could be a...
[18F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion.
Richard W Bevan-Jones, Thomas E Cope, Simon P Jones, Luca Passamonti, Young T Hong, Tim Fryer, Robert Arnold, Jonathan P Coles, Franklin A Aigbirhio, Karalyn Patterson, John T O'Brien, James B Rowe
Nov 29, 2018
The PET ligand [18F]AV-1451 was developed to bind tau pathology in Alzheimer's disease, but increased binding has been shown in both genetic tauopathies and in semantic dementia, a disease strongly associated with TDP-43...
Monolayer Kagome metals AV<sub>3</sub>Sb<sub>5</sub>.
Recently, layered kagome metals AV3Sb5 (A = K, Rb, and Cs) have emerged as a fertile platform for exploring frustrated geometry, correlations, and topology. Here, using first-principles and mean-field...
Published by: Nature Communications
Systematic biases in determining dust attenuation curves through galaxy SED fitting
Jianbo Qin, Xian Zhong Zheng, Min Fang, Zhizheng Pan, Stijn Wuyts, Yong Shi, Yingjie Peng, Valentino Gonzalez, Fuyan Bian, Jia-Sheng Huang, Qiu-sheng Gu, Wenhao Liu, Qinghua Tan, Dong Dong Shi, Jian Ren, Yuheng Zhang, Man Qiao, Run Wen, Shuang Liu
Mar 31, 2022
While the slope of the dust attenuation curve (δ) is found to correlate with effective dust attenuation (AV) as obtained through spectral energy distribution (SED) fitting, it remains unknown how the fitting degeneracies shape...
Systematic biases in determining dust attenuation curves through galaxy SED fitting
Jianbo Qin, Xian Zhong Zheng, Min Fang, Zhizheng Pan, Stijn Wuyts, Yong Shi, Yingjie Peng, Valentino Gonzalez, Fuyan Bian, Jia-Sheng Huang, Qiu-sheng Gu, Wenhao Liu, Qinghua Tan, Dong Dong Shi, Jian Ren, Yuheng Zhang, Man Qiao, Run Wen, Shuang Liu
Mar 31, 2022
While the slope of the dust attenuation curve (δ) is found to correlate with effective dust attenuation (AV) as obtained through spectral energy distribution (SED) fitting, it remains unknown how the fitting degeneracies shape...
Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.
W Richard Bevan-Jones, Thomas E Cope, P Simon Jones, Sanne S Kaalund, Luca Passamonti, Kieren Allinson, Oliver Green, Young T Hong, Tim D Fryer, Robert Arnold, Jonathan P Coles, Franklin I Aigbirhio, Andrew J Larner, Karalyn Patterson, John T O'Brien, James B Rowe
Apr 17, 2020
The clinical syndromes of frontotemporal dementia are clinically and neuropathologically heterogeneous, but processes such as neuroinflammation may be common across the disease spectrum. We investigated how neuroinflammation...
Published by: Brain : a journal of neurology
Large Reductions in Match Play Physical Performance Variables Across a Professional Football Season with Control for Situational and Contextual Variables
This investigation examined match play physical performance across a professional football season using a multicamera computerized tracking system. A linear mixed-effects model, controlling for situational and contextual...
Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia.
Edward A Hayter, Sophie MT Wehrens, Hans PA Van Dongen, Alessandra Stangherlin, Shobhan Gaddameedhi, Elena Crooks, Nichola J Barron, Luigi A Venetucci, John S O'Neill, Timothy M Brown, Debra J Skene, Andrew W Trafford, David A Bechtold
Jun 18, 2021
Electrical activity in the heart exhibits 24-hour rhythmicity, and potentially fatal arrhythmias are more likely to occur at specific times of day. Here, we demonstrate that circadian clocks within the brain and heart set daily...
Codon optimality in cancer.
A key characteristic of cancer cells is their increased proliferative capacity, which requires elevated levels of protein synthesis. The process of protein synthesis involves the translation of codons within the mRNA coding...
Routine Outcome Monitoring in CAMHS
Background: Many CAMHS teams across the United Kingdom are now required to use Routine Outcome Monitoring (ROM). However, some clinicians hold negative attitudes towards ROM and various practical implementation issues have...
How unusual is the United Kingdom Coalition (and what are the chances of it happening again)?
Charles Lees
Jan 01, 0001
This article draws upon insights from theoretical and empirical studies of coalition behaviour in multiparty politics to examine the formation of the United Kingdom coalition following the general election of 6 May 2010. It...
The ‘long-term’ effects of universal school-based anxiety prevention trials
Objective: Previous reviews demonstrate that universal school-based anxiety prevention programs are generally effective in the short-term, but have not yet provided a clear evaluation of the longer-term effects. This review...
Summated Training and Match Load Predictors of Salivary Immunoglobulin-A, Alpha-Amylase, Testosterone, Cortisol and T:C Profile Changes in Elite-Level Professional Football Players
We examined how summated training and match load measures relate to salivary immunological and hormonal profile changes in professional football players. Data were collected from 18 elite-level professional male football players...
Routine Outcome Monitoring in CAMHS
Background: Many CAMHS teams across the United Kingdom are now required to use Routine Outcome Monitoring (ROM). However, some clinicians hold negative attitudes towards ROM and various practical implementation issues have...
The influence of goal-state access cost on planning during problem solving
Two problem-solving experiments investigated the relationship between planning and the cost of accessing goal-state information using the theoretical framework of the soft constraints hypothesis (Gray Fu, 2004; Gray, Simms, Fu...
Large Reductions in Match Play Physical Performance Variables Across a Professional Football Season with Control for Situational and Contextual Variables
This investigation examined match play physical performance across a professional football season using a multicamera computerized tracking system. A linear mixed-effects model, controlling for situational and contextual...
Designing information fusion for the encoding of visual–spatial information
In a simulated aircraft navigation task, a fusion technique known as triangulation was used to improve the accuracy and onscreen availability of location information from two separate radars. Three experiments investigated...
The ‘long-term’ effects of universal school-based anxiety prevention trials
Objective: Previous reviews demonstrate that universal school-based anxiety prevention programs are generally effective in the short-term, but have not yet provided a clear evaluation of the longer-term effects. This review...
The influence of goal-state access cost on planning during problem solving
Two problem-solving experiments investigated the relationship between planning and the cost of accessing goal-state information using the theoretical framework of the soft constraints hypothesis (Gray Fu, 2004; Gray, Simms, Fu...
The grammaticalization of epistemicity in Ibero-Romance
AV Corr
Aug 16, 2017
Typologically-unexpected overt expletives can be found in a restricted number of non-standard Ibero-Romance null-subject varieties. Historical data suggest that these overt expletives, which in today’s varieties show both...
Theory of radiation trapping by the accelerating solitons in optical fibers
We present a theory describing trapping of the normally dispersive radiation by the Raman solitons in optical fibers. Frequency of the radiation component is continuously blueshifting, while the soliton is redshifting....
Theory of radiation trapping by the accelerating solitons in optical fibers
We present a theory describing trapping of the normally dispersive radiation by the Raman solitons in optical fibers. Frequency of the radiation component is continuously blueshifting, while the soliton is redshifting....
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