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Results: 77
Philip McShane
Conn O'Donovan
Jun 30, 2010
Conn O'Donovan looks back on McShane's early years and influences.
Published by: Memorial University of Newfoundland
Philip McShane
Conn O'Donovan
Jun 30, 2010
Conn O'Donovan looks back on McShane's early years and influences.
Published by: Memorial University of Newfoundland
crystal-torture
crystal-torture is a Python, Fortran, and OpenMP module for the analysis of diffusion networks in crystal structures. Ionic diffusion through crystalline solids depends not only on the dynamics of ions within the crystal, but...
RNA Dynamics in T Cell Activation
Emily Conn Gantman
Jan 01, 0001
Eukaryotic cells employ multiple posttranscriptional mechanisms to fine tune gene expression programs in response to external signals. Regulation of messenger RNA and microRNA by RNA-binding proteins is critical to the control...
Published by: Rockefeller University
crystal-torture
crystal-torture is a Python, Fortran, and OpenMP module for the analysis of diffusion networks in crystal structures. Ionic diffusion through crystalline solids depends not only on the dynamics of ions within the crystal, but...
Screening for Barrett's Esophagus
New improved methods are required for the early detection of esophageal adenocarcinoma in order to reduce mortality from this aggressive cancer. In this review we discuss different screening methods which are currently under...
A hydrazide-anchored dendron scaffold for chemoselective ligation strategies
Chemoselective ligation, including “click” chemistry, has found wide utility in general synthetic strategies and the specific modification of polymers and biomolecules. This has resulted in a number of applications of such...
A hydrazide-anchored dendron scaffold for chemoselective ligation strategies
Chemoselective ligation, including “click” chemistry, has found wide utility in general synthetic strategies and the specific modification of polymers and biomolecules. This has resulted in a number of applications of such...
A photocleavable linker for the chemoselective functionalization of biomaterials
The functionalization of matrices with ‘‘caged’’ functional groups and their subsequent selective uncaging is a promising approach for generating patterns of bioactive molecules to guide cell growth or recreate in vivo...
A photocleavable linker for the chemoselective functionalization of biomaterials
The functionalization of matrices with ‘‘caged’’ functional groups and their subsequent selective uncaging is a promising approach for generating patterns of bioactive molecules to guide cell growth or recreate in vivo...
Heterodimerization of Arabidopsis calcium/proton exchangers contributes to regulation of guard cell dynamics and plant defense responses.
Bradleigh Hocking, Simon J Conn, Murli Manohar, Bo Xu, Asmini Athman, Matthew A Stancombe, Alex R Webb, Kendal D Hirschi, Matthew Gilliham
Oct 07, 2021
Arabidopsis thaliana cation exchangers (CAX1 and CAX3) are closely related tonoplast-localized calcium/proton (Ca2+/H+) antiporters that contribute to cellular Ca2+ homeostasis. CAX1 and CAX3 were previously shown to interact in...
Role of TFF3 as an adjunct in the diagnosis of Barrett's esophagus using a minimally invasive esophageal sampling device-The CytospongeTM.
The incidence of esophageal carcinoma continues to increase whilst its prognosis remains poor. The most dramatic reduction in mortality is likely to follow early diagnosis of the preinvasive precursor lesion, Barrett's esophagus...
Pilot study to establish a prospective neonatal cohort
BACKGROUND: Genetic risk variants and preterm birth are early and potent risk factors for later neuropsychiatric disorders. To understand the interrelationships between these factors, a large-scale genetic study of very preterm...
Contribution of de novo and inherited rare CNVs to very preterm birth.
Hilary S Wong, Megan Wadon, Alexandra Evans, George Kirov, Neena Modi, Michael C O'Donovan, Anita Thapar
Feb 14, 2020
BACKGROUND: The genomic contribution to adverse health sequelae in babies born very preterm (<32 weeks' gestation) is unknown. We conducted an investigation of rare CNVs in infants born very preterm as part of a study to...
Detection of early neoplasia in Barrett's esophagus using lectin-based near-infrared imaging
André A Neves, Massimiliano di Pietro, Maria O'Donovan, Dale J Waterhouse, Sarah E Bohndiek, Kevin M Brindle, Rebecca C Fitzgerald
Feb 09, 2018
BACKGROUND AND STUDY AIMS: Endoscopic surveillance for Barrett's esophagus (BE) is limited by long procedure times and sampling error. Near-infrared (NIR) fluorescence imaging minimizes tissue autofluorescence and optical...
Use of Cytosponge as a triaging tool to upper gastrointestinal endoscopy during the COVID-19 pandemic.
Massimiliano di Pietro, Ines Modolell, Maria O'Donovan, Catherine Price, Nastazja D Pilonis, Irene Debiram-Beecham, Rebecca C Fitzgerald
Sep 10, 2020
During the COVID-19 pandemic, endoscopy services have been severely curtailed—eg, in England, UK, a 30% reduction of diagnostic endoscopies has been reported for the period between January and April, 2020, compared with the same...
Autofluorescence-Directed Confocal Endomicroscopy in Combination With a Three-Biomarker Panel Can Inform Management Decisions in Barrett's Esophagus.
Massimiliano di Pietro, Elizabeth L Bird-Lieberman, Xinxue Liu, Tara Nuckcheddy-Grant, Helga Bertani, Maria O'Donovan, Rebecca C Fitzgerald
Nov 16, 2015
Aged Algorithms Aneuploidy Barrett Esophagus Biomarkers Biopsy Cyclin A Disease Progression Esophagoscopy esophagus False Positive Reactions Female Humans Male Microscopy Confocal Middle Aged Narrow Band Imaging Optical Imaging Precancerous Conditions Sensitivity and Specificity Tumor Suppressor Protein p53 Watchful Waiting
Alterations in the Ca2+ toolkit in oesophageal adenocarcinoma.
Alana L Cutliffe, Sharon L McKenna, Darshan S Chandrashekar, Alvin Ng, Ginny Devonshire, Rebecca C Fitzgerald, Tracey R O'Donovan, John J Mackrill
Oct 01, 2022
AIM: To investigate alterations in transcription of genes, encoding Ca2+ toolkit proteins, in oesophageal adenocarcinoma (OAC) and to assess associations between gene expression, tumor grade, nodal-metastatic stage, and patient...
Gastro-esophageal reflux disease symptoms and demographic factors as a pre-screening tool for Barrett's esophagus.
Xinxue Liu, Angela Wong, Sudarshan R Kadri, Andrej Corovic, Maria O'Donovan, Pierre Lao-Sirieix, Laurence B Lovat, Rodney W Burnham, Rebecca C Fitzgerald
Feb 13, 2020
BACKGROUND: Barrett's esophagus (BE) occurs as consequence of reflux and is a risk factor for esophageal adenocarcinoma. The current "gold-standard" for diagnosing BE is endoscopy which remains prohibitively expensive and...
Phenotypic Manifestation of Genetic Risk for Schizophrenia During Adolescence in the General Population.
Comparative outcomes of radiofrequency ablation for Barrett's oesophagus with different baseline histology.
Wei Keith Tan, Arti Rattan, Maria O'Donovan, Tara Nuckcheddy, Bincy Alias, Vijay Sujendran, Massimiliano di Pietro
Aug 27, 2020
BACKGROUND: Radiofrequency ablation (RFA) is currently recommended for dysplastic Barrett's oesophagus (BO); however, there are limited data on treatment response when stratified by baseline histology. OBJECTIVE: The objective...
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