A hydrazide-anchored dendron scaffold for chemoselective ligation strategies

Liz O'Donovan, Paul De Bank

OAI: oai:purehost.bath.ac.uk:publications/42cca801-79fe-41ee-88ab-774b53e7fead • DOI: https://doi.org/10.1039/C4OB00870G

Chemoselective ligation, including “click” chemistry, has found wide utility in general synthetic strategies and the specific modification of polymers and biomolecules. This has resulted in a number of applications of such approaches, particularly in the biomedical area, including diagnostic imaging and drug delivery. However, tools to chemoselectively decorate target molecules with multiple copies of a particular drug, ligand or label are lacking. We describe the design and synthesis of a hydrazide-anchored dendron scaffold for chemoselective ligation to carbonyl moieties, and demonstrate its use in the modification of aldehyde-rich surfaces with the RGD integrin-binding ligand.