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Multidrug resistant enteric fever in South Asia
Christopher M Parry, Isabela Ribeiro, Kamini Walia, Priscilla Rupali, Stephen Baker, Buddha Basnyat
Apr 10, 2019
Investments in newer diagnostics and antimicrobial treatments are critical to improve management of enteric fever in South Asia, say Christopher Parry and colleagues
A method to infer positive selection from marker dynamics in an asexual population.
MOTIVATION: The observation of positive selection acting on a mutant indicates that the corresponding mutation has some form of functional relevance. Determining the fitness effects of mutations thus has relevance to many...
Fitness Inference from Short-Read Data
Christopher JR Illingworth
Jul 30, 2015
fitness landscape Influenza Linkage Disequilibrium selection within-host evolution Adaptation Physiological Alleles Animals Biological Evolution evolution Molecular Ferrets Genetic Fitness Hemagglutinin Glycoproteins Influenza Virus Humans Influenza A virus H5N1 Subtype Influenza Human Linkage Disequilibrium Models Genetic Orthomyxoviridae Infections Reassortant Viruses selection Genetic
A novel framework for inferring parameters of transmission from viral sequence data.
Transmission between hosts is a critical part of the viral lifecycle. Recent studies of viral transmission have used genome sequence data to evaluate the number of particles transmitted between hosts, and the role of selection...
A large effective population size for established within-host influenza virus infection.
effective population size evolutionary biology Genetic Drift infectious disease microbiology selection Virus within-host evolution Child Preschool Genetic Drift Genome Viral Humans Immunocompromised Host Infant Influenza B virus Influenza Human Population Density selection Genetic Stochastic Processes whole genome sequencing
Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers
covid-19 FFP3 PPE SARS-CoV-2 EPIDEMIOLOGY Global Health healthcare worker infectious disease mask microbiology viruses Adult Aerosols Aged covid-19 Health Personnel Humans Incidence infection control masks Middle Aged Models Theoretical Respiratory Protective Devices SARS-CoV-2 United Kingdom Young Adult
Mutational load causes stochastic evolutionary outcomes in acute RNA viral infection.
Mutational load is known to be of importance for the evolution of RNA viruses, the combination of a high mutation rate and large population size leading to an accumulation of deleterious mutations. However, while the effects of...
Evaluating genetic drift in time-series evolutionary analysis.
The Wright-Fisher model is the most popular population model for describing the behaviour of evolutionary systems with a finite population size. Approximations have commonly been used but the model itself has rarely been tested...
Inferring Fitness Effects from Time-Resolved Sequence Data with a Delay-Deterministic Model.
A common challenge arising from the observation of an evolutionary system over time is to infer the magnitude of selection acting upon a specific genetic variant, or variants, within the population. The inference of selection...
On the effective depth of viral sequence data.
Christopher JR Illingworth, Sunando Roy, Mathew A Beale, Helena Tutill, Rachel Williams, Judith Breuer
May 02, 2018
Genome sequence data are of great value in describing evolutionary processes in viral populations. However, in such studies, the extent to which data accurately describes the viral population is a matter of importance. Multiple...
Dazzling Organist to Play Byrnes Auditorium July 6
Winthrop University
Jan 01, 0001
The concert is at 5 p.m. July 6 in Byrnes Auditorium. It is a free cultural event. Christopher Houlihan recorded his first two CDs when he was in college.
Published by: Winthrop University
Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers.
Mark Ferris, Rebecca Ferris, Chris Workman, Eoin O'Connor, David A Enoch, Emma Goldesgeyme, Natalie Quinnell, Parth Patel, Jo Wright, Geraldine Martell, Christine Moody, Ashley Shaw, christopher Illingworth, Nicholas Matheson, Michael Weekes
Nov 10, 2021
Background: Respiratory protective equipment recommended in the UK for healthcare workers (HCWs) caring for patients with COVID-19 comprises a fluid-resistant surgical mask (FRSM), except in the context of aerosol generating...
The Ursinus Weekly, April 29, 1918
Musical treat by the Metropolitan Artists Varsity easily wallops Military College nine Chem-Bi banquet a delightful occasion Address of Dr. Christopher Noss Psychology of advertising Scholarship students' recital Ursinus...
Ursinus College Collegeville Pennsylvania newspaper baseball YMCA YWCA cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites.
Adam J Reid, Arthur M Talman, Hayley M Bennett, Ana R Gomes, Mandy J Sanders, Christopher JR Illingworth, Oliver Billker, Matthew Berriman, Mara Kn Lawniczak
Oct 10, 2018
Single-cell RNA-sequencing is revolutionising our understanding of seemingly homogeneous cell populations but has not yet been widely applied to single-celled organisms. Transcriptional variation in unicellular malaria parasites...
Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus.
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