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Diminished seroconversion following a single SARS-COV-2 vaccine in ocrelizumab-treated relapsing-remitting multiple sclerosis patients.
Zoya Georgieva, Rainer Dӧffinger, Dinakantha Kumararatne, Alasdair Coles, Claire McCarthy
Oct 08, 2021
BACKGROUND: Despite impressive efficacy in immunocompetent individuals, the immunogenicity of a single dose of COVID-19 vaccine in B-cell-deplete patients remains unknown. OBJECTIVES: We aimed to quantify real-world vaccine...
Diminished seroconversion following a single SARS-COV-2 vaccine in ocrelizumab-treated relapsing-remitting multiple sclerosis patients.
Zoya G Georgieva, Rainer Dӧffinger, Dinakantha Kumararatne, Alasdair J Coles, Claire McCarthy
May 25, 2022
BACKGROUND: Despite impressive efficacy in immunocompetent individuals, the immunogenicity of a single dose of COVID-19 vaccine in B-cell-deplete patients remains unknown. OBJECTIVES: We aimed to quantify real-world vaccine...
Implementation of an E-Learning System in Dental Education
The purpose of the study is to consider the features of the implementation of an e-learning system at the Institute of Dentistry named after E.V. Borovsky at First Moscow State Medical University (Sechenov University) was...
Published by: IGI Global Scientific Publishing
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
The MS Remyelinating Drug Bexarotene (an RXR Agonist) Promotes Induction of Human Tregs and Suppresses Th17 Differentiation In Vitro
Christopher M. Gaunt, Daniel B. Rainbow, Ruairi J. Mackenzie, Lorna B. Jarvis, Hani S. Mousa, Nicholas Cunniffe, Zoya Georgieva, J. William Brown, Alasdair J. Coles, Joanne L. Jones
Aug 26, 2021
The retinoid X receptor agonist bexarotene promotes remyelination in patients with multiple sclerosis. Murine studies have also demonstrated that RXR agonists have anti-inflammatory effects by enhancing the ability of...
The MS Remyelinating Drug Bexarotene (an RXR Agonist) Promotes Induction of Human Tregs and Suppresses Th17 Differentiation In Vitro.
Christopher M Gaunt, Daniel B Rainbow, Ruairi J Mackenzie, Lorna B Jarvis, Hani S Mousa, Nicholas Cunniffe, Zoya Georgieva, J William Brown, Alasdair J Coles, Joanne L Jones
Jul 19, 2021
T cells Th17 & Tregs cells Autoimmunity Multiple Sclerosis retinoid X receptor (RXR) retinoids Adult Alitretinoin Bexarotene CD4-Positive T-Lymphocytes Cells Cultured Clinical Trials as Topic Fatty Acids Unsaturated Female Forkhead Transcription Factors Humans Leukocytes Mononuclear lymphopoiesis Middle Aged remyelination Retinoid X Receptors T-Lymphocytes Regulatory Tetrahydronaphthalenes Th17 Cells
25 Years of Research in Human Lactation
Donna Tracy Geddes, Zoya Gridneva, Sharon Lisa Perrella, Leon Robert Mitoulas, Jacqueline Coral Kent, Lisa Faye Stinson, Ching Tat Lai, Vanessa Sakalidis, Alecia-Jane Twigger, Peter Edwin Hartmann
Oct 29, 2021
Researchers have recently called for human lactation research to be conceptualized as a biological framework where maternal and infant factors impacting human milk, in terms of composition, volume and energy content are studied...
25 Years of Research in Human Lactation
Donna Tracy Geddes, Zoya Gridneva, Sharon Lisa Perrella, Leon Robert Mitoulas, Jacqueline Coral Kent, Lisa Faye Stinson, Ching Tat Lai, Vanessa Sakalidis, Alecia-Jane Twigger, Peter Edwin Hartmann
Sep 02, 2021
Researchers have recently called for human lactation research to be conceptualized as a biological framework where maternal and infant factors impacting human milk, in terms of composition, volume and energy content are studied...
The MS Remyelinating Drug Bexarotene (an RXR Agonist) Promotes Induction of Human Tregs and Suppresses Th17 Differentiation <i>In Vitro</i>.
Christopher M Gaunt, Daniel B Rainbow, Ruairi J Mackenzie, Lorna B Jarvis, Hani S Mousa, Nicholas Cunniffe, Zoya Georgieva, J William Brown, Alasdair J Coles, Joanne L Jones
Sep 27, 2021
Published by: Frontiers in immunology
Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation.
Alexander Samoshkin, Alexei Arnaoutov, Lars ET Jansen, Ilia Ouspenski, Louis Dye, Tatiana Karpova, James McNally, Mary Dasso, Don W Cleveland, Alexander Strunnikov
Dec 18, 2020
Condensins I and II in vertebrates are essential ATP-dependent complexes necessary for chromosome condensation in mitosis. Condensins depletion is known to perturb structure and function of centromeres, however the mechanism of...
Adenosine Triphosphatases Amino Acid Sequence Aurora Kinase B Aurora Kinases Autoantigens Base Sequence Centromere Centromere Protein A Chromatin Chromosomal Proteins Non-Histone DNA Primers DNA-Binding Proteins HeLa Cells Histones Humans Microscopy Electron Transmission Microscopy Fluorescence Mitosis Multiprotein Complexes Protein Serine-Threonine Kinases
Remyelination varies between and within lesions in multiple sclerosis following bexarotene.
J William L Brown, Ferran Prados, Daniel R Altmann, Baris Kanber, Jonathan Stutters, Nick G Cunniffe, Joanne L Jones, Zoya G Georgieva, Edward J Needham, Cyrus Daruwalla, Claudia Gandini Wheeler-Kingshott, Peter Connick, Siddharthan Chandran, Robin Franklin, David MacManus, Rebecca Samson, Alasdair Coles, Declan Chard
Oct 24, 2022
Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer.
Muhammed Murtaza, Sarah-Jane Dawson, Katherine Pogrebniak, Oscar M Rueda, Elena Provenzano, John Grant, Suet-Feung Chin, Dana WY Tsui, Francesco Marass, Davina Gale, H Raza Ali, Pankti Shah, Tania Contente-Cuomo, Hossein Farahani, Karey Shumansky, Zoya Kingsbury, Sean Humphray, David Bentley, Sohrab P Shah, Matthew Wallis, Nitzan Rosenfeld, Carlos Caldas
Sep 18, 2015
Adult Antineoplastic Combined Chemotherapy Protocols Bayes Theorem Brain Neoplasms Breast Neoplasms Carcinoma Ductal breast Case-Control Studies Clonal Evolution DNA Neoplasm Deoxycytidine Female Humans Lapatinib Liver Neoplasms Lung Neoplasms Mutation Neoplasm Metastasis Quinazolines Receptor ErbB-2 Receptors Estrogen Sequence Analysis DNA Spinal Neoplasms Tamoxifen Trastuzumab Gemcitabine
Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma.
Caryn S Ross-Innes, Jennifer Becq, Andrew Warren, R Keira Cheetham, Helen Northen, Maria O'Donovan, Shalini Malhotra, Massimiliano di Pietro, Sergii Ivakhno, Miao He, Jamie MJ Weaver, Andy G Lynch, Zoya Kingsbury, Mark Ross, Sean Humphray, David Bentley, Rebecca C Fitzgerald
Feb 13, 2020
The molecular genetic relationship between esophageal adenocarcinoma (EAC) and its precursor lesion, Barrett's esophagus, is poorly understood. Using whole-genome sequencing on 23 paired Barrett's esophagus and EAC samples...
Remyelination varies between and within lesions in multiple sclerosis following bexarotene.
J William L Brown, Ferran Prados, Daniel R Altmann, Baris Kanber, Jonathan Stutters, Nick G Cunniffe, Joanne L Jones, Zoya G Georgieva, Edward J Needham, Cyrus Daruwalla, Claudia Gandini Wheeler-Kingshott, Peter Connick, Siddharthan Chandran, Robin Franklin, David MacManus, Rebecca Samson, Alasdair Coles, Declan Chard
Sep 18, 2022
Spinal muscular atrophy diagnosis and carrier screening from genome sequencing data.
Xiao Chen, Alba Sanchis-Juan, Courtney E French, Andrew J Connell, Isabelle Delon, Zoya Kingsbury, Aditi Chawla, Aaron L Halpern, Ryan J Taft, NIHR BioResource, David R Bentley, Matthew ER Butchbach, F Lucy Raymond, Michael A Eberle
Feb 17, 2021
PURPOSE: Spinal muscular atrophy (SMA), caused by loss of the SMN1 gene, is a leading cause of early childhood death. Due to the near identical sequences of SMN1 and SMN2, analysis of this region is challenging. Population-wide...
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.
Lorna B Jarvis, Daniel B Rainbow, Valerie Coppard, Sarah K Howlett, Zoya Georgieva, Jessica L Davies, Harpreet Kaur Mullay, Joanna Hester, Tom Ashmore, Aletta Van Den Bosch, James T Grist, Alasdair J Coles, Hani S Mousa, Stefano Pluchino, Krishnaa T Mahbubani, Julian L Griffin, Kourosh Saeb-Parsy, Fadi Issa, Luca Peruzzotti-Jametti, Linda S Wicker, Joanne L Jones
Nov 22, 2021
The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is...
Published by: Communications biology
Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus.
Gonca Bayraktar, PingAn Yuanxiang, Alessandro D Confettura, Guilherme M Gomes, Syed A Raza, Oliver Stork, Shoji Tajima, Isao Suetake, Anna Karpova, Ferah Yildirim, Michael R Kreutz
Jul 29, 2021
DNA methylation is a crucial epigenetic mark for activity-dependent gene expression in neurons. Very little is known about how synaptic signals impact promoter methylation in neuronal nuclei. In this study we show that protein...
Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus
Gonca Bayraktar, PingAn Yuanxiang, Alessandro D. Confettura, Guilherme M. Gomes, Syed A. Raza, Oliver Stork, Shoji Tajima, Isao Suetake, Anna Karpova, Ferah Yildirim, Michael R. Kreutz
Feb 09, 2021
Abstract: DNA methylation is a crucial epigenetic mark for activity-dependent gene expression in neurons. Very little is known about how synaptic signals impact promoter methylation in neuronal nuclei. In this study we show that...
Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus
Gonca Bayraktar, PingAn Yuanxiang, Alessandro D. Confettura, Guilherme M. Gomes, Syed A. Raza, Oliver Stork, Shoji Tajima, Isao Suetake, Anna Karpova, Ferah Yildirim, Michael R. Kreutz
Oct 09, 2020
Abstract: DNA methylation is a crucial epigenetic mark for activity-dependent gene expression in neurons. Very little is known about how synaptic signals impact promoter methylation in neuronal nuclei. In this study we show that...
Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One)
J William L Brown, Nick G Cunniffe, Ferran Prados, Baris Kanber, Joanne L Jones, Edward Needham, Zoya Georgieva, David Rog, Owen R Pearson, James Overell, David MacManus, Rebecca S Samson, Jonathan Stutters, Charles ffrench-Constant, Claudia AM Gandini Wheeler-Kingshott, Carla Moran, Paul D Flynn, Andrew W Michell, Robin Jm Franklin, Siddharthan Chandran, Daniel R Altmann, Declan T Chard, Peter Connick, Alasdair J Coles
May 31, 2021
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.
Lorna B Jarvis, Daniel B Rainbow, Valerie Coppard, Sarah K Howlett, Zoya Georgieva, Jessica L Davies, Harpreet Kaur Mullay, Joanna Hester, Tom Ashmore, Aletta Van Den Bosch, James T Grist, Alasdair J Coles, Hani S Mousa, Stefano Pluchino, Krishnaa T Mahbubani, Julian L Griffin, Kourosh Saeb-Parsy, Fadi Issa, Luca Peruzzotti-Jametti, Linda S Wicker, Joanne L Jones
Aug 04, 2021
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73
Lorna B. Jarvis, Daniel B. Rainbow, Valerie Coppard, Sarah K. Howlett, Zoya Georgieva, Jessica L. Davies, Harpreet Kaur Mullay, Joanna Hester, Tom Ashmore, Aletta Van Den Bosch, James T. Grist, Alasdair J. Coles, Hani S. Mousa, Stefano Pluchino, Krishnaa T. Mahbubani, Julian L. Griffin, Kourosh Saeb-Parsy, Fadi Issa, Luca Peruzzotti-Jametti, Linda S. Wicker, Joanne L. Jones
Oct 18, 2021
Abstract: The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro...
Imaging breast cancer using hyperpolarized carbon-13 MRI.
Ferdia A Gallagher, Ramona Woitek, Mary A McLean, Andrew B Gill, Raquel Manzano Garcia, Elena Provenzano, Frank Riemer, Joshua Kaggie, Anita Chhabra, Stephan Ursprung, James T Grist, Charlie J Daniels, Fulvio Zaccagna, Marie-Christine Laurent, Matthew Locke, Sarah Hilborne, Amy Frary, Turid Torheim, Chris Boursnell, Amy Schiller, Ilse Patterson, Rhys Slough, Bruno Carmo, Justine Kane, Heather Biggs, Emma Harrison, Surrin S Deen, Andrew Patterson, Titus Lanz, Zoya Kingsbury, Mark Ross, Bristi Basu, Richard Baird, David J Lomas, Evis Sala, James Wason, Oscar M Rueda, Suet-Feung Chin, Ian B Wilkinson, Martin J Graves, Jean E Abraham, Fiona J Gilbert, Carlos Caldas, Kevin M Brindle
Feb 06, 2020
Imaging breast cancer using hyperpolarized carbon-13 MRI.
Ferdia A Gallagher, Ramona Woitek, Mary A McLean, Andrew B Gill, Raquel Manzano Garcia, Elena Provenzano, Frank Riemer, Joshua Kaggie, Anita Chhabra, Stephan Ursprung, James T Grist, Charlie J Daniels, Fulvio Zaccagna, Marie-Christine Laurent, Matthew Locke, Sarah Hilborne, Amy Frary, Turid Torheim, Chris Boursnell, Amy Schiller, Ilse Patterson, Rhys Slough, Bruno Carmo, Justine Kane, Heather Biggs, Emma Harrison, Surrin S Deen, Andrew Patterson, Titus Lanz, Zoya Kingsbury, Mark Ross, Bristi Basu, Richard Baird, David J Lomas, Evis Sala, James Wason, Oscar M Rueda, Suet-Feung Chin, Ian B Wilkinson, Martin J Graves, Jean E Abraham, Fiona J Gilbert, Carlos Caldas, Kevin M Brindle
Feb 22, 2020
Our purpose is to investigate the feasibility of imaging tumor metabolism in breast cancer patients using 13C magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized 13C label exchange between injected [1-13C]pyruvate...
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