CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS.
Litao Sun,
Na Wei,
Bernhard Kuhle,
David Blocquel,
Scott Novick,
Zaneta Matuszek,
Huihao Zhou,
Weiwei He,
Jingjing Zhang,
Thomas Weber,
Rita Horvath,
Philippe Latour,
Tao Pan,
Paul Schimmel,
Patrick R Griffin,
Xiang-Lei Yang
May 24, 2021
Through dominant mutations, aminoacyl-tRNA synthetases constitute the largest protein family linked to Charcot-Marie-Tooth disease (CMT). An example is CMT subtype 2N (CMT2N), caused by individual mutations spread out in AlaRS...