Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Stavroula Kanoni,
Sarah E Graham,
Yuxuan Wang,
Ida Surakka,
Shweta Ramdas,
Xiang Zhu,
Shoa L Clarke,
Konain Fatima Bhatti,
Sailaja Vedantam,
Thomas W Winkler,
Adam E Locke,
Eirini Marouli,
Greg JM Zajac,
Kuan-Han H Wu,
Ioanna Ntalla,
Qin Hui,
Derek Klarin,
Austin T Hilliard,
Zeyuan Wang,
Chao Xue,
Gudmar Thorleifsson,
Anna Helgadottir,
Daniel F Gudbjartsson,
Hilma Holm,
Isleifur Olafsson,
Mi Yeong Hwang,
Sohee Han,
Masato Akiyama,
Saori Sakaue,
Chikashi Terao,
Masahiro Kanai,
Wei Zhou,
Ben M Brumpton,
Humaira Rasheed,
Aki S Havulinna,
Yogasudha Veturi,
Jennifer Allen Pacheco,
Elisabeth A Rosenthal,
Todd Lingren,
Qiping Feng,
Iftikhar J Kullo,
Akira Narita,
Jun Takayama,
Hilary C Martin,
Karen A Hunt,
Bhavi Trivedi,
Jeffrey Haessler,
Franco Giulianini,
Yuki Bradford,
Jason E Miller,
Archie Campbell,
Kuang Lin,
Iona Y Millwood,
Asif Rasheed,
George Hindy,
Jessica D Faul,
Wei Zhao,
David R Weir,
Constance Turman,
Hongyan Huang,
Mariaelisa Graff,
Ananyo Choudhury,
Dhriti Sengupta,
Anubha Mahajan,
Michael R Brown,
Weihua Zhang,
Ketian Yu,
Ellen M Schmidt,
Anita Pandit,
Stefan Gustafsson,
Xianyong Yin,
Jian'an Luan,
Jing-Hua Zhao,
Fumihiko Matsuda,
Hye-Mi Jang,
Kyungheon Yoon,
Carolina Medina-Gomez,
Achilleas Pitsillides,
Jouke Jan Hottenga,
Andrew R Wood,
Yingji Ji,
Zishan Gao,
Simon Haworth,
Noha A Yousri,
Ruth E Mitchell,
Jin Fang Chai,
Mette Aadahl,
Anne A Bjerregaard,
Jie Yao,
Ani Manichaikul,
Chii-Min Hwu,
Yi-Jen Hung,
Helen R Warren,
Julia Ramirez,
Jette Bork-Jensen,
Line L Kårhus,
Anuj Goel,
Maria Sabater-Lleal,
Raymond Noordam,
Pala Mauro,
Floris Matteo,
Aaron F McDaid,
Pedro Marques-Vidal,
Matthias Wielscher,
Stella Trompet,
Naveed Sattar,
Line T Møllehave,
Matthias Munz,
Lingyao Zeng,
Jianfeng Huang,
Bin Yang,
Alaitz Poveda,
Azra Kurbasic,
Claudia Lamina,
Lukas Forer,
Markus Scholz,
Tessel E Galesloot,
Jonathan P Bradfield,
Sanni E Ruotsalainen,
EWarwick Daw,
Joseph M Zmuda,
Jonathan S Mitchell,
Christian Fuchsberger,
Henry Christensen,
Jennifer A Brody,
Miguel Vazquez-Moreno,
Mary F Feitosa,
Mary K Wojczynski,
Zhe Wang,
Michael H Preuss,
Massimo Mangino,
Paraskevi Christofidou,
Niek Verweij,
Jan W Benjamins,
Jorgen Engmann,
Noah L Tsao,
Anurag Verma,
Roderick C Slieker,
Ken Sin Lo,
Nuno R Zilhao,
Phuong Le,
Marcus E Kleber,
Graciela E Delgado,
Shaofeng Huo,
Daisuke D Ikeda,
Hiroyuki Iha,
Jian Yang,
Jun Liu,
Ayşe Demirkan,
Hampton L Leonard,
Jonathan Marten,
Mirjam Frank,
Börge Schmidt,
Laura J Smyth,
Marisa Cañadas-Garre,
Chaolong Wang,
Masahiro Nakatochi,
Andrew Wong,
Nina Hutri-Kähönen,
Xueling Sim,
Rui Xia,
Alicia Huerta-Chagoya,
Juan Carlos Fernandez-Lopez,
Valeriya Lyssenko,
Suraj S Nongmaithem,
Swati Bayyana,
Heather M Stringham,
Marguerite R Irvin,
Christopher Oldmeadow,
Han-Na Kim,
Seungho Ryu,
Paul RHJ Timmers,
Liubov Arbeeva,
Rajkumar Dorajoo,
Leslie A Lange,
Gauri Prasad,
Laura Lorés-Motta,
Marc Pauper,
Jirong Long,
Xiaohui Li,
Elizabeth Theusch,
Fumihiko Takeuchi,
Cassandra N Spracklen,
Anu Loukola,
Sailalitha Bollepalli,
Sophie C Warner,
Ya Xing Wang,
Wen B Wei,
Teresa Nutile,
Daniela Ruggiero,
Yun Ju Sung,
Shufeng Chen,
Fangchao Liu,
Jingyun Yang,
Katherine A Kentistou,
Bernhard Banas,
Giuseppe Giovanni Nardone,
Karina Meidtner,
Lawrence F Bielak,
Jennifer A Smith,
Prashantha Hebbar,
Aliki-Eleni Farmaki,
Edith Hofer,
Maoxuan Lin,
Maria Pina Concas,
Simona Vaccargiu,
Peter J van der Most,
Niina Pitkänen,
Brian E Cade,
Sander W van der Laan,
Kumaraswamy Naidu Chitrala,
Stefan Weiss,
Amy R Bentley,
Ayo P Doumatey,
Adebowale A Adeyemo,
Jong Young Lee,
Eva Rb Petersen,
Aneta A Nielsen,
Hyeok Sun Choi,
Maria Nethander,
Sandra Freitag-Wolf,
Lorraine Southam,
Nigel W Rayner,
Carol A Wang,
Shih-Yi Lin,
Jun-Sing Wang,
Christian Couture,
Leo-Pekka Lyytikäinen,
Kjell Nikus,
Gabriel Cuellar-Partida,
Henrik Vestergaard,
Bertha Hidalgo,
Olga Giannakopoulou,
Qiuyin Cai,
Morgan O Obura,
Jessica van Setten,
Xiaoyin Li,
Jingjing Liang,
Hua Tang,
Natalie Terzikhan,
Jae Hun Shin,
Rebecca D Jackson,
Alexander P Reiner,
Lisa Warsinger Martin,
Zhengming Chen,
Liming Li,
Takahisa Kawaguchi,
Joachim Thiery,
Joshua C Bis,
Lenore J Launer,
Huaixing Li,
Mike A Nalls,
Olli T Raitakari,
Sahoko Ichihara,
Sarah H Wild,
Christopher P Nelson,
Harry Campbell,
Susanne Jäger,
Toru Nabika,
Fahd Al-Mulla,
Harri Niinikoski,
Peter S Braund,
Ivana Kolcic,
Peter Kovacs,
Tota Giardoglou,
Tomohiro Katsuya,
Dominique de Kleijn,
Gert J de Borst,
Eung Kweon Kim,
Hieab HH Adams,
M Arfan Ikram,
Xiaofeng Zhu,
Folkert W Asselbergs,
Adriaan O Kraaijeveld,
Joline WJ Beulens,
Xiao-Ou Shu,
Loukianos S Rallidis,
Oluf Pedersen,
Torben Hansen,
Paul Mitchell,
Alex W Hewitt,
Mika Kähönen,
Louis Pérusse,
Claude Bouchard,
Anke Tönjes,
Yii-Der Ida Chen,
Craig E Pennell,
Trevor A Mori,
Wolfgang Lieb,
Andre Franke,
Claes Ohlsson,
Dan Mellström,
Yoon Shin Cho,
HyeJin Lee,
Jian-Min Yuan,
Woon-Puay Koh,
Sang Youl Rhee,
Jeong-Taek Woo,
Iris M Heid,
Klaus J Stark,
Martina E Zimmermann,
Henry Völzke,
Georg Homuth,
Michele K Evans,
Alan B Zonderman,
Ozren Polasek,
Gerard Pasterkamp,
Imo E Hoefer,
Susan Redline,
Katja Pahkala,
Albertine J Oldehinkel,
Harold Snieder,
Ginevra Biino,
Reinhold Schmidt,
Helena Schmidt,
Stefania Bandinelli,
George Dedoussis,
Thangavel Alphonse Thanaraj,
Sharon LR Kardia,
Patricia A Peyser,
Norihiro Kato,
Matthias B Schulze,
Giorgia Girotto,
Carsten A Böger,
Bettina Jung,
Peter K Joshi,
David A Bennett,
Philip L De Jager,
Xiangfeng Lu,
Vasiliki Mamakou,
Morris Brown,
Mark J Caulfield,
Patricia B Munroe,
Xiuqing Guo,
Marina Ciullo,
Jost B Jonas,
Nilesh J Samani,
Jaakko Kaprio,
Päivi Pajukanta,
Teresa Tusié-Luna,
Carlos A Aguilar-Salinas,
Linda S Adair,
Sonny Augustin Bechayda,
H Janaka de Silva,
Ananda R Wickremasinghe,
Ronald M Krauss,
Jer-Yuarn Wu,
Wei Zheng,
Anneke Iden Hollander,
Dwaipayan Bharadwaj,
Adolfo Correa,
James G Wilson,
Lars Lind,
Chew-Kiat Heng,
Amanda E Nelson,
Yvonne M Golightly,
James F Wilson,
Brenda Penninx,
Hyung-Lae Kim,
John Attia,
Rodney J Scott,
DC Rao,
Donna K Arnett,
Steven C Hunt,
Mark Walker,
Heikki A Koistinen,
Giriraj R Chandak,
Josep M Mercader,
Maria C Costanzo,
Dongkeun Jang,
Noël P Burtt,
Clicerio Gonzalez Villalpando,
Lorena Orozco,
Myriam Fornage,
EShyong Tai,
Rob M van Dam,
Terho Lehtimäki,
Nish Chaturvedi,
Mitsuhiro Yokota,
Jianjun Liu,
Dermot F Reilly,
Amy Jayne McKnight,
Frank Kee,
Karl-Heinz Jöckel,
Mark I McCarthy,
Colin NA Palmer,
Veronique Vitart,
Caroline Hayward,
Eleanor Simonsick,
Cornelia M van Duijn,
Zi-Bing Jin,
Jia Qu,
Haretsugu Hishigaki,
Xu Lin,
Winfried März,
Vilmundur Gudnason,
Jean-Claude Tardif,
Guillaume Lettre,
Leen M 't Hart,
Petra JM Elders,
Scott M Damrauer,
Meena Kumari,
Mika Kivimaki,
Pim van der Harst,
Tim D Spector,
Ruth JF Loos,
Michael A Province,
Esteban J Parra,
Miguel Cruz,
Bruce M Psaty,
Ivan Brandslund,
Peter P Pramstaller,
Charles N Rotimi,
Kaare Christensen,
Samuli Ripatti,
Elisabeth Widén,
Hakon Hakonarson,
Struan FA Grant,
Lambertus ALM Kiemeney,
Jacqueline de Graaf,
Markus Loeffler,
Florian Kronenberg,
Dongfeng Gu,
Jeanette Erdmann,
Heribert Schunkert,
Paul W Franks,
Allan Linneberg,
J Wouter Jukema,
Amit V Khera,
Minna Männikkö,
Marjo-Riitta Jarvelin,
Zoltan Kutalik,
Cucca Francesco,
Dennis O Mook-Kanamori,
Ko Willems van Dijk,
Hugh Watkins,
David P Strachan,
Niels Grarup,
Peter Sever,
Neil Poulter,
Lee-Ming Chuang,
Jerome I Rotter,
Thomas M Dantoft,
Fredrik Karpe,
Matt J Neville,
Nicholas J Timpson,
Ching-Yu Cheng,
Tien-Yin Wong,
Chiea Chuen Khor,
Hengtong Li,
Charumathi Sabanayagam,
Annette Peters,
Christian Gieger,
Andrew T Hattersley,
Nancy L Pedersen,
Patrik KE Magnusson,
Dorret I Boomsma,
Allegonda HM Willemsen,
LAdrienne Cupples,
Joyce BJ van Meurs,
Mohsen Ghanbari,
Penny Gordon-Larsen,
Wei Huang,
Young Jin Kim,
Yasuharu Tabara,
Nicholas J Wareham,
Claudia Langenberg,
Eleftheria Zeggini,
Johanna Kuusisto,
Markku Laakso,
Erik Ingelsson,
Goncalo Abecasis,
John C Chambers,
Jaspal S Kooner,
Paul S de Vries,
Alanna C Morrison,
Scott Hazelhurst,
Michèle Ramsay,
Kari E North,
Martha Daviglus,
Peter Kraft,
Nicholas G Martin,
John B Whitfield,
Shahid Abbas,
Danish Saleheen,
Robin G Walters,
Michael V Holmes,
Corri Black,
Blair H Smith,
Aris Baras,
Anne E Justice,
Julie E Buring,
Paul M Ridker,
Daniel I Chasman,
Charles Kooperberg,
Gen Tamiya,
Masayuki Yamamoto,
David A van Heel,
Richard C Trembath,
Wei-Qi Wei,
Gail P Jarvik,
Bahram Namjou,
M Geoffrey Hayes,
Marylyn D Ritchie,
Pekka Jousilahti,
Veikko Salomaa,
Kristian Hveem,
Bjørn Olav Åsvold,
Michiaki Kubo,
Yoichiro Kamatani,
Yukinori Okada,
Yoshinori Murakami,
Bong-Jo Kim,
Unnur Thorsteinsdottir,
Kari Stefansson,
Jifeng Zhang,
YEugene Chen,
Yuk-Lam Ho,
Julie A Lynch,
Daniel J Rader,
Philip S Tsao,
Kyong-Mi Chang,
Kelly Cho,
Christopher J O'Donnell,
John M Gaziano,
Peter WF Wilson,
Timothy M Frayling,
Joel N Hirschhorn,
Sekar Kathiresan,
Karen L Mohlke,
Yan V Sun,
Andrew P Morris,
Michael Boehnke,
Christopher D Brown,
Pradeep Natarajan,
Panos Deloukas,
Cristen J Willer,
Themistocles L Assimes,
Gina M Peloso
Jan 27, 2023
BACKGROUND: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of...