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Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
A Saini, AR Norman, D Cunningham, I Chau, M Hill, D Tait, T Hickish, T Iveson, F Lofts, D Jodrell, PJ Ross, J Oates
Sep 02, 2020
We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of 5-fluorouracil (5-FU) delivered by protracted intravenous infusion (PVI 5-FU) against the standard bolus regimen of 5-FU and folinic...
Secondary Metabolites of Osmanthus fragrans
Chen-Chen Fu, Fa-Ying Xu, Yu-Chen Qian, Hoi-Lun Koo, Yi-Fan Duan, Geng-Min Weng, Tai-Ping Fan, Mo-Xian Chen, Fu-Yuan Zhu
Aug 01, 2022
Osmanthus fragrans (scientific name: Osmanthus fragrans (Thunb.) Lour.) is a species of the Osmanthus genus in the family Oleaceae, and it has a long history of cultivation in China. O. fragrans is edible and is well known for...
Multifunctional peptide-assembled micelles for simultaneously reducing amyloid-β and reactive oxygen species.
The excessive production and deposition of amyloid-β (Aβ) is one of the most important etiologies of Alzheimer's disease (AD). The interaction between Aβ and metal ions produces aberrant reactive oxygen species (ROS), which...
Mechanistic insights into the novel glucose-sensitive behavior of P(NIPAM-co-2-AAPBA)
A glucose-sensitive polymer, poly(N-isopropylacrylamide-co-2-acrylamidophenylboronic acid) (P(NIPAM-co-2-AAPBA)), was synthesized by reversible addition fragmentation chain transfer (RAFT) copolymerization. Addition of glucose...
Mechanistic insights into the novel glucose-sensitive behavior of P(NIPAM-co-2-AAPBA)
A glucose-sensitive polymer, poly(N-isopropylacrylamide-co-2-acrylamidophenylboronic acid) (P(NIPAM-co-2-AAPBA)), was synthesized by reversible addition fragmentation chain transfer (RAFT) copolymerization. Addition of glucose...
Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts.
Huijun Ying, Hongmei Fu, Marlene L Rose, Ann M McCormack, Padmini Sarathchandra, Klaus Okkenhaug, Federica M Marelli-Berg
Jun 28, 2018
Chronic rejection is the major cause of long-term heart allograft failure, characterized by tissue infiltration by recipient T cells with indirect allospecificity. Phosphoinositol-3-kinase p110δ is a key mediator of T cell...
adenine Animals Cells Cultured Chronic Disease Class Ia Phosphatidylinositol 3-Kinase Female Flow Cytometry Graft Rejection H-Y Antigen Heart Transplantation Humans Immune Tolerance Male Mice Mice Inbred C57BL Mice Knockout Microscopy Fluorescence Phosphoinositide-3 Kinase Inhibitors Quinazolines Skin Transplantation T-Lymphocytes Transplantation Homologous
Modification of a Constitutive to Glucose-Responsive Liver-Specific Promoter Resulted in Increased Efficacy of Adeno-Associated Virus Serotype 8-Insulin Gene Therapy of Diabetic Mice.
We have previously used a hepatotropic adeno-associated viral (AAV) vector with a modified human insulin gene to treat diabetic mice. The HLP (hybrid liver-specific promoter) used was constitutively active and non-responsive to...
adeno-associated virus serotype 8 (AAV8) albumin enhancer (3′iALB) diabetes gene therapy glucose responsive element (GlRE) liver-specific glucose-responsive promoter long-term basal insulin expression Animals Dependovirus Diabetes mellitus Experimental Disease Models Animal Gene Expression Genetic Therapy Genetic Vectors Glucose Hepatocytes Humans Insulin Mice Promoter Regions Genetic Transgenes
On a new proposed mechanism of 5-fluorouracil-mediated cytotoxicity
Shobbir Hussain
May 01, 2020
The major molecular mode of action of the cytotoxic drug 5-fluorouracil (5-FU) is generally considered to result from thymidylate synthase inhibition. Recent findings relating to the function of the human uracil-5...
Application of Multimedia Data Feature Extraction Technology in Folk Art Creation
Ying-ying Gong
Jan 01, 2024
In the intelligent background, in order to carry out the folk art creation more conveniently, this article integrates the new technology of multimedia data features into the folk art creation to achieve the sustainable...
Published by: IGI Global Scientific Publishing
Intensive Imaging-based Follow-up of Surgically Treated Localised Renal Cell Carcinoma Does Not Improve Post-recurrence Survival
Saeed Dabestani, Christian Beisland, Grant D Stewart, Karim Bensalah, Eirikur Gudmundsson, Thomas B Lam, William Gietzmann, Paimaun Zakikhani, Lorenzo Marconi, Sergio Fernandéz-Pello, Serenella Monagas, Samuel Paul Williams, Christian Torbrand, Thomas Powles, Erik Van Werkhoven, Richard Meijer, Alessandro Volpe, Michael Staehler, Börje Ljungberg, Axel Bex
Dec 03, 2018
The optimal follow-up (FU) strategy for patients treated for localised renal cell carcinoma (RCC) remains unclear. Using the RECUR database, we studied imaging intensity utilised in contemporary FU to evaluate its association...
Topical treatment of actinic keratoses in organ transplant recipients
Zeeshaan-Ul Hasan, Ikhlaaq Ahmed, Rubeta N Matin, Victoria Homer, John T Lear, Ferina Ismail, Tristan Whitmarsh, Adele C Green, Jason Thomson, Alan Milligan, Sarah Hogan, Vanessa Van-de-Velde, Liza Mitchell-Worsford, Jonathan Kentley, Claire Gaunt, Yolande Jefferson-Hulme, Sarah J Bowden, Piers Gaunt, Keith Wheatley, Charlotte M Proby, Catherine A Harwood
Jun 14, 2022
BACKGROUND: The risk of cutaneous squamous cell carcinoma (cSCC) is significantly increased in organ transplant recipients (OTRs). Clearance of actinic keratoses (AKs) is generally regarded as a surrogate biomarker for cSCC...
On a new proposed mechanism of 5-fluorouracil-mediated cytotoxicity
Shobbir Hussain
May 01, 2020
The major molecular mode of action of the cytotoxic drug 5-fluorouracil (5-FU) is generally considered to result from thymidylate synthase inhibition. Recent findings relating to the function of the human uracil-5...
A Corpus-Based Study on the Translation Style of Five English Versions of Fu Sheng Liu Ji, Vol I
Bing Zhang
Oct 31, 2022
Using a corpus approach, this article investigates the translation styles of the first chapter of Fu Sheng Liu Ji at three levels: the statistical parameters, the translation of culture-specific lexis, and readability...
Published by: IGI Global Scientific Publishing
Ambient Air Pollution and Acute Ischemic Stroke-Effect Modification by Atrial Fibrillation.
Benjamin Yong-Qiang Tan, Jamie Sin Ying Ho, Andrew Fu-Wah Ho, Pin Pin Pek, Aloysius Sheng-Ting Leow, Yogeswari Raju, Ching-Hui Sia, Leonard Leong-Litt Yeo, Vijay Kumar Sharma, Marcus Eng-Hock Ong, Joel Aik, Huili Zheng
Oct 24, 2022
Acute ischemic strokes (AIS) are closely linked with air pollution, and there is some evidence that traditional cardiovascular risk factors may alter the relationship between air pollution and strokes. We investigated the effect...
SC3s
BACKGROUND: Today it is possible to profile the transcriptome of individual cells, and a key step in the analysis of these datasets is unsupervised clustering. For very large datasets, efficient algorithms are required to ensure...
SC3s
BACKGROUND: Today it is possible to profile the transcriptome of individual cells, and a key step in the analysis of these datasets is unsupervised clustering. For very large datasets, efficient algorithms are required to ensure...
Distributed interfacing by nanoscale photodiodes enables single-neuron light activation and sensory enhancement in 3D spinal explants.
Agnes Thalhammer, Mario Fontanini, Jiuyun Shi, Denis Scaini, Luca Recupero, Alexander Evtushenko, Ying Fu, Suraj Pavagada, Andrea Bistrovic-Popov, Ljiljana Fruk, Bozhi Tian, Laura Ballerini
Sep 12, 2022
Among emerging technologies developed to interface neuronal signaling, engineering electrodes at the nanoscale would yield more precise biodevices opening to progress in neural circuit investigations and to new therapeutic...
Bilateral Habenula deep brain stimulation for treatment-resistant depression
Chencheng Zhang, Yingying Zhang, Huichun Luo, Xinmeng Xu, Ti-Fei Yuan, Dianyou Li, Yi-Yun Cai, Hengfen Gong, Dai-Hui Peng, Yi-Ru Fang, Valerie Voon, Bomin Sun
Mar 07, 2022
Deep brain stimulation (DBS) of structures in the brain's reward system is a promising therapeutic option for patients with treatment-resistant depression (TRD). Recently, DBS of the habenula (HB) in the brain's anti-reward...
“Small, yet Beautiful”
We reconsider whether a grand multi-winner contest elicits more equilibrium effort than a collection of sub-contests. Fu and Lu (2009) employ a sequential winner-selection mechanism and find support for running a grand contest....
Personalized POI Recommendation Using CAGRU and Implicit Semantic Feature Extraction in LBSN
With the intention of addressing the concern that existing point of interest recommendation methods fail to fully utilize the auxiliary information of the point of interest, from which it is challenging to extricate a...
Published by: IGI Global Scientific Publishing
Using VR for Collaborative Learning
Although virtual reality (VR) has been technologically possible for decades, both logistical and pedagogical limitations have slowed progress relating to collaborating with others in virtual reality environments. This article...
Global Information Technology Computer Science and Information Technology Global Information Technology Physical Sciences and Engineering Business and Management
Published by: IGI Global Scientific Publishing
Anti-tumour efficacy of capecitabine in a genetically engineered mouse model of pancreatic cancer.
Aurélie Courtin, Frances M Richards, Tashinga E Bapiro, Jo L Bramhall, Albrecht Neesse, Natalie Cook, Ben-Fillippo Krippendorff, David A Tuveson, Duncan I Jodrell
Feb 12, 2020
Capecitabine (CAP) is a 5-FU pro-drug approved for the treatment of several cancers and it is used in combination with gemcitabine (GEM) in the treatment of patients with pancreatic adenocarcinoma (PDAC). However, limited...
Animals Antineoplastic Combined Chemotherapy Protocols Capecitabine Carcinoma Pancreatic Ductal Cell Line Tumor Cytidine Deaminase Deoxycytidine Disease Models Animal Drug Screening Assays Antitumor Fluorouracil Mice Mice Transgenic Neoplasm Transplantation Pancreatic Neoplasms prodrugs Tissue Distribution Gemcitabine
Long-run marginal cost pricing based on network spare capacity
Fu-Rong Li
Jan 01, 0001
This paper proposes a novel approach for providing long-run marginal cost (LRMC) pricing in network charges. The proposed approach makes use of the unused capacity of an exiting network to reflect the cost of advancing or...
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