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Results: 93
A 15.5 GHz detection of the galaxy cluster minihalo in RXJ1720.1+2638
YC Perrott, P Carvalho, PJ Elwood, KJB Grainge, DA Green, K Javid, TZ Jin, C Rumsey, RDE Saunders
Sep 22, 2021
RXJ1720.1+2638 is a cool-core, 'relaxed-appearing' cluster with a minihalo
previously detected up to 8.4 GHz, confined by X-ray-detected cold fronts. We
present observations of the minihalo at 13 - 18 GHz with the...
The early course and treatment of posttraumatic stress disorder in very young children
Caitlin Hitchcock, Benjamin Goodall, Isobel M Wright, Adrian Boyle, David Johnston, Darren Dunning, Julia Gillard, Kirsty Griffiths, Ayla Humphrey, Anna McKinnon, Inderpal K Panesar, Aliza Werner-Seidler, Peter Watson, Patrick Smith, Richard Meiser-Stedman, Tim Dalgleish
Jun 15, 2021
BACKGROUND: The introduction of developmentally adapted criteria for posttraumatic stress disorder (PTSD) has improved the identification of ≤6-year-old children with clinical needs. Across two studies, we assess predictors of...
Self-reported physical functional health predicts future bone mineral density in EPIC-Norfolk cohort.
Sarah Perrott, Kathryn Martin, Victoria L Keevil, Nicholas J Wareham, Kay-Tee Khaw, Phyo Kyaw Myint
Feb 28, 2022
Using a large population sample from the UK, we found that self-reported physical functional health may be used to predict future bone mineral density especially in women. It may be a useful and inexpensive way to identify...
Closed-loop insulin delivery system enhances type 1 diabetes glycemic control.
Brown SA, Kovatchev BP, Raghinaru D, Lum JW, Buckingham BA, Kudva YC, et al. Six-Month Randomized, Multicenter Trial of Closed-Loop Control in Type 1 Diabetes. N Engl J Med 2019;381:1707-17.
Question
Among patients with type 1...
Postnatal catch-up growth programs central and peripheral insulin resistance in male mice
Aims: Intra-uterine growth restriction (IUGR) followed by accelerated postnatal growth is associated with an increased risk of obesity and type 2 diabetes. We aimed to determine central and peripheral insulin sensitivity in mice...
Combating small-molecule aggregation with machine learning
Drug discovery is fuelled by small-molecules, either as tools to interrogate biology or as leads for investigational therapeutics.1-3 The successful development of such entities entails a transformative power on disease...
Density functional theory studies of hydrogen bonding vibrations in sI gas hydrates
Abstract
To analyze the vibrational modes of water and methane in structure I gas hydrates, we constructed a 178-atom supercell with two small cages of type...
The interplay of customer experience and commitment
Purpose
This research aims to better understand customer experience, as it relates to customer commitment and provides a framework for future...
T Keiningham, J Ball, S Benoit (née Moeller), HL Bruce, A Buoye, J Dzenkovska, L Nasr, YC Ou, M Zaki
Mar 03, 2017
Hydrodynamic and Contact Contributions to Continuous Shear Thickening in Colloidal Suspensions.
Neil YC Lin, Ben M Guy, Michiel Hermes, Chris Ness, Jin Sun, Wilson CK Poon, Itai Cohen
Sep 09, 2019
Shear thickening is a widespread phenomenon in suspension flow that, despite sustained study, is still the subject of much debate. The longstanding view that shear thickening is due to hydrodynamic clusters has been challenged...
Structural basis for the coiled-coil architecture of human CtIP.
CR Morton, NJ Rzechorzek, JD Maman, M Kuramochi, H Sekiguchi, R Rambo, YC Sasaki, OR Davies, L Pellegrini
Dec 08, 2022
DNA Repair coiled-coil structure human CtIP Amino Acid Sequence Endodeoxyribonucleases Humans Models Molecular Mutation Protein Conformation Protein Interaction Domains and Motifs Protein Multimerization Protein Structure Secondary Recombinant Proteins Spectrum Analysis Structure-Activity Relationship X-Ray Diffraction
Structural basis for the coiled-coil architecture of human CtIP.
CR Morton, NJ Rzechorzek, JD Maman, M Kuramochi, H Sekiguchi, R Rambo, YC Sasaki, OR Davies, L Pellegrini
Jul 28, 2021
The DNA repair factor CtIP has a critical function in double-strand break (DSB) repair by homologous recombination, promoting the assembly of the repair apparatus at DNA ends and participating in DNA-end resection. However, the...
Phonon-assisted electronic states modulation of few-layer PdSe<inf>2</inf> at terahertz frequencies
Abstract Information technology demands high-speed optoelectronic devices, but going beyond the one terahertz (THz) barrier is challenging due to the difficulties associated with generating...
Comparison of Sunyaev-Zel'dovich measurements from Planck and from the Arcminute Microkelvin Imager for 99 galaxy clusters
YC Perrott, M Olamaie, C Rumsey, ML Brown, F Feroz, KJB Grainge, MP Hobson, AN Lasenby, CJ MacTavish, GG Pooley, RDE Saunders, MP Schammel, PF Scott, TW Shimwell, DJ Titterington, EM Waldram, N Aghanim, M Arnaud, M Ashdown, H Aussel, R Barrena, I Bikmaev, H Böhringer, R Burenin, P Carvalho, G Chon, B Comis, H Dahle, J Democles, M Douspis, D Harrison, A Hempel, G Hurier, I Khamitov, R Kneissl, JF MacÍas-Pérez, JB Melin, E Pointecouteau, GW Pratt, JA Rubiño-Martín, V Stolyarov, D Sutton
Jun 25, 2015
Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice.
Rachel A Gioscia-Ryan, Micah L Battson, Lauren M Cuevas, Jason S Eng, Michael P Murphy, Douglas R Seals
Jun 18, 2018
Aortic stiffening is a major independent risk factor for cardiovascular diseases, cognitive dysfunction, and other chronic disorders of aging. Mitochondria-derived reactive oxygen species are a key source of arterial oxidative...
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