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Results: 49
Genetic Variation in Sodium‐glucose Cotransporter 2 and Heart Failure
Julius L. Katzmann, Amy M. Mason, Winfried März, Marcus E. Kleber, Alexander Niessner, Matthias Blüher, Thimoteus Speer, Ulrich Laufs
Jun 21, 2021
Inhibition of sodium‐glucose cotransporter 2 (SGLT2) represents an emerging pharmaceutical approach for the treatment of heart failure. The mechanisms by which SGLT2 inhibitors reduce the risk of heart failure are not well...
Published by: Clinical Pharmacology & Therapeutics
Cannabis-based medicines and medical cannabis for adults with cancer pain
Background: Pain is a common symptom in people with cancer; 30% to 50% of people with cancer will experience moderate‐to‐severe pain. This can have a major negative impact on their quality of life. Opioid (morphine‐like)...
Pharmacological therapies for fibromyalgia (fibromyalgia syndrome) in adults – an overview of Cochrane Reviews (Protocol).
Andrew Moore, Emma Fisher, Winfried Häuser, Rae F Bell, Serge Perrot, J Bidonde, S Makri, Sebastian Straube
Aug 17, 2021
This is a protocol for a Cochrane Review (overview). The objectives are as follows:
To provide an overview of the therapeutic efficacy of pharmacological therapies for fibromyalgia (fibromyalgia syndrome) in adults, and...
To provide an overview of the therapeutic efficacy of pharmacological therapies for fibromyalgia (fibromyalgia syndrome) in adults, and...
APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans.
Dimitrios Tsiantoulas, Mahya Eslami, Georg Obermayer, Marc Clement, Diede Smeets, Florian J Mayer, Máté G Kiss, Lennart Enders, Juliane Weißer, Laura Göderle, Jordi Lambert, Florian Frommlet, André Mueller, Tim Hendrikx, Maria Ozsvar-Kozma, Florentina Porsch, Laure Willen, Taras Afonyushkin, Jane E Murphy, Per Fogelstrand, Olivier Donzé, Gerard Pasterkamp, Matthias Hoke, Stefan Kubicek, Helle F Jørgensen, Nicolas Danchin, Tabassome Simon, Hubert Scharnagl, Winfried März, Jan Borén, Henry Hess, Ziad Mallat, Pascal Schneider, Christoph J Binder
Aug 20, 2021
Efficient Magnus-type integrators for solar energy conversion in Hubbard models
Winfried Auzinger, Juliette Dubois, Karsten Held, Harald Hofstätter, Tobias Jawecki, Anna Kauch, Othmar Koch, Karolina Kropielnicka, Pranav Singh, Clemens Watzenböck
Jan 31, 2022
Strongly interacting electrons in solids are generically described by Hubbardtype models, and the impact of solar light can be modeled by an additional time-dependence. This yields a finite dimensional system of ordinary...
Cannabis-based medicines and medical cannabis for adults with cancer pain
Background: Pain is a common symptom in people with cancer; 30% to 50% of people with cancer will experience moderate‐to‐severe pain. This can have a major negative impact on their quality of life. Opioid (morphine‐like)...
Efficient Magnus-type integrators for solar energy conversion in Hubbard models
Winfried Auzinger, Juliette Dubois, Karsten Held, Harald Hofstätter, Tobias Jawecki, Anna Kauch, Othmar Koch, Karolina Kropielnicka, Pranav Singh, Clemens Watzenböck
Jan 31, 2022
Strongly interacting electrons in solids are generically described by Hubbardtype models, and the impact of solar light can be modeled by an additional time-dependence. This yields a finite dimensional system of ordinary...
Pharmacological therapies for fibromyalgia (fibromyalgia syndrome) in adults – an overview of Cochrane Reviews (Protocol).
Andrew Moore, Emma Fisher, Winfried Häuser, Rae F Bell, Serge Perrot, J Bidonde, S Makri, Sebastian Straube
Aug 17, 2021
This is a protocol for a Cochrane Review (overview). The objectives are as follows:
To provide an overview of the therapeutic efficacy of pharmacological therapies for fibromyalgia (fibromyalgia syndrome) in adults, and...
To provide an overview of the therapeutic efficacy of pharmacological therapies for fibromyalgia (fibromyalgia syndrome) in adults, and...
Preliminary paleohistological observations of the StW 573 ('Little Foot') skull.
Amélie Beaudet, Robert C Atwood, Winfried Kockelmann, Vincent Fernandez, Thomas Connolley, Nghia Trong Vo, Ronald Clarke, Dominic Stratford
Apr 19, 2021
Numerous aspects of early hominin biology remain debated or simply unknown. However, recent developments in high-resolution imaging techniques have opened new avenues in the field of paleoanthropology. More specifically, X-ray...
T cell stimulator cells, an efficient and versatile cellular system to assess the role of costimulatory ligands in the activation of human T cells.
Judith Leitner, Werner Kuschei, Katharina Grabmeier-Pfistershammer, Ramona Woitek, Ernst Kriehuber, Otto Majdic, Gerhard Zlabinger, Winfried F Pickl, Peter Steinberger
Jan 02, 2019
It is well established that full activation of T cells requires the interaction of the TCR complex with the peptide-MHC complex (Signal 1) and additional signals (Signal 2). These second signals are generated by the interaction...
Animals Antibodies Antigens CD Biological Assay Cell Line Tumor Humans Immunologic Factors Lymphocyte Activation Major Histocompatibility Complex Mice Peptides Receptor-CD3 Complex Antigen T-Cell Receptors Cell Surface Signaling Lymphocytic Activation Molecule Family Member 1 T-Lymphocytes Tumor Necrosis Factor Ligand Superfamily Member 15
Mesoporous tertiary oxides via a novel amphiphilic approach
Natasha Bennett, Annela M. Seddon, James E. Hallett, Winfried Kockelmann, Valeska P. Ting, Sajanikumari Sadasivan, Robert P. Tooze, Simon R. Hall
Jan 01, 2016
We report a facile biomimetic sol-gel synthesis using the sponge phase formed by the lipid monoolein as a structure-directing template, resulting in high phase purity, mesoporous dysprosium- and gadolinium titanates. The...
Mesoporous tertiary oxides via a novel amphiphilic approach
Natasha Bennett, Annela M. Seddon, James E. Hallett, Winfried Kockelmann, Valeska P. Ting, Sajanikumari Sadasivan, Robert P. Tooze, Simon R. Hall
Jan 01, 2016
We report a facile biomimetic sol-gel synthesis using the sponge phase formed by the lipid monoolein as a structure-directing template, resulting in high phase purity, mesoporous dysprosium- and gadolinium titanates. The...
Structural insights into the redox-switch mechanism of the MarR/DUF24-type regulator HypR.
Gottfried J Palm, Bui Khanh Chi, Paul Waack, Katrin Gronau, Dörte Becher, Dirk Albrecht, Winfried Hinrichs, Randy J Read, Haike Antelmann
May 11, 2020
Bacillus subtilis encodes redox-sensing MarR-type regulators of the OhrR and DUF24-families that sense organic hydroperoxides, diamide, quinones or aldehydes via thiol-based redox-switches. In this article, we characterize the...
Bacillus subtilis Bacterial Proteins Base Sequence Cysteine DNA-Binding Proteins Diamide Gene Expression Regulation Bacterial Models Molecular Molecular Sequence Data Nitroreductases Operator Regions Genetic Oxidation-Reduction Oxidoreductases Sodium Hypochlorite Stress Physiological Trans-Activators Transcriptional Activation
Stepwise Conformational Stabilization of a HIV-1 Clade C Consensus Envelope Trimer Immunogen Impacts the Profile of Vaccine-Induced Antibody Responses
Alexandra Hauser, George Carnell, Kathrin Held, Guidenn Sulbaran, Nadine Tischbierek, Lisa Rogers, Georgios Pollakis, Paul Tonks, Michael Hoelscher, Song Ding, Rogier W. Sanders, Christof Geldmacher, Quentin Sattentau, Winfried Weissenhorn, Jonathan L. Heeney, David Peterhoff, Ralf Wagner
Jul 28, 2021
Stabilization of the HIV-1 Envelope glycoprotein trimer (Env) in its native pre-fusion closed conformation is regarded as one of several requirements for the induction of neutralizing antibody (nAb) responses, which, in turn...
Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men.
Anna L Eriksson, John RB Perry, Andrea D Coviello, Graciela E Delgado, Luigi Ferrucci, Andrew R Hoffman, Ilpo T Huhtaniemi, M Arfan Ikram, Magnus K Karlsson, Marcus E Kleber, Gail A Laughlin, Yongmei Liu, Mattias Lorentzon, Kathryn L Lunetta, Dan Mellström, Joanne M Murabito, Anna Murray, Maria Nethander, Carrie M Nielson, Inga Prokopenko, Stephen R Pye, Leslie J Raffel, Fernando Rivadeneira, Priya Srikanth, Lisette Stolk, Alexander Teumer, Thomas G Travison, André G Uitterlinden, Dhananjay Vaidya, Dirk Vanderschueren, Joseph M Zmuda, Winfried März, Eric S Orwoll, Pamela Ouyang, Liesbeth Vandenput, Frederick CW Wu, Frank H de Jong, Shalender Bhasin, Douglas P Kiel, Claes Ohlsson
Jun 26, 2018
CONTEXT: Serum estradiol (E2) and estrone (E1) levels exhibit substantial heritability. OBJECTIVE: To investigate the genetic regulation of serum E2 and E1 in men. DESIGN, SETTING, AND PARTICIPANTS: Genome-wide association study...
Stepwise Conformational Stabilization of a HIV-1 Clade C Consensus Envelope Trimer Immunogen Impacts the Profile of Vaccine-Induced Antibody Responses.
Alexandra Hauser, George Carnell, Kathrin Held, Guidenn Sulbaran, Nadine Tischbierek, Lisa Rogers, Georgios Pollakis, Paul Tonks, Michael Hoelscher, Song Ding, Rogier W Sanders, Christof Geldmacher, Quentin Sattentau, Winfried Weissenhorn, Jonathan L Heeney, David Peterhoff, Ralf Wagner
Sep 27, 2021
Stabilization of the HIV-1 Envelope glycoprotein trimer (Env) in its native pre-fusion closed conformation is regarded as one of several requirements for the induction of neutralizing antibody (nAb) responses, which, in turn...
A fusion intermediate gp41 immunogen elicits neutralizing antibodies to HIV-1.
Rachel PJ Lai, Miriam Hock, Jens Radzimanowski, Paul Tonks, David Lutje Hulsik, Gregory Effantin, David J Seilly, Hanna Dreja, Alexander Kliche, Ralf Wagner, Susan W Barnett, Nancy Tumba, Lynn Morris, Celia C LaBranche, David C Montefiori, Michael S Seaman, Jonathan L Heeney, Winfried Weissenhorn
Mar 11, 2016
AIDS HIV-1 HIV-1 gp41 Membrane Fusion Protein Conformation Vaccine Development X-ray Scattering Amino Acid Sequence Animals Antibodies Neutralizing Antibody Affinity Female Guinea Pigs HIV Antibodies HIV Envelope Protein gp41 Humans Immune Sera Immunization Immunoglobulin G Molecular Sequence Data neutron diffraction Protein Structure Tertiary Proteolipids SCATTERING Small Angle
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.
Konrad Aden, Florian Tran, Go Ito, Raheleh Sheibani-Tezerji, Simone Lipinski, Jan W Kuiper, Markus Tschurtschenthaler, Svetlana Saveljeva, Joya Bhattacharyya, Robert Häsler, Kareen Bartsch, Anne Luzius, Marlene Jentzsch, Maren Falk-Paulsen, Stephanie T Stengel, Lina Welz, Robin Schwarzer, Björn Rabe, Winfried Barchet, Stefan Krautwald, Gunther Hartmann, Manolis Pasparakis, Richard S Blumberg, Stefan Schreiber, Arthur Kaser, Philip Rosenstiel
Sep 08, 2018
A coding variant of the inflammatory bowel disease (IBD) risk gene ATG16L1 has been associated with defective autophagy and deregulation of endoplasmic reticulum (ER) function. IL-22 is a barrier protective cytokine by inducing...
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
Xia Jiang, Paul F O'Reilly, Hugues Aschard, Yi-Hsiang Hsu, J Brent Richards, Josée Dupuis, Erik Ingelsson, David Karasik, Stefan Pilz, Diane Berry, Bryan Kestenbaum, Jusheng Zheng, Jianan Luan, Eleni Sofianopoulou, Elizabeth A Streeten, Demetrius Albanes, Pamela L Lutsey, Lu Yao, Weihong Tang, Michael J Econs, Henri Wallaschofski, Henry Völzke, Ang Zhou, Chris Power, Mark I McCarthy, Erin D Michos, Eric Boerwinkle, Stephanie J Weinstein, Neal D Freedman, Wen-Yi Huang, Natasja M van Schoor, Nathalie van der Velde, Lisette CPGM de Groot, Anke Enneman, L Adrienne Cupples, Sarah L Booth, Ramachandran S Vasan, Ching-Ti Liu, Yanhua Zhou, Samuli Ripatti, Claes Ohlsson, Liesbeth Vandenput, Mattias Lorentzon, Johan G Eriksson, M Kyla Shea, Denise K Houston, Stephen B Kritchevsky, Yongmei Liu, Kurt K Lohman, Luigi Ferrucci, Munro Peacock, Christian Gieger, Marian Beekman, Eline Slagboom, Joris Deelen, Diana van Heemst, Marcus E Kleber, Winfried März, Ian H de Boer, Alexis C Wood, Jerome I Rotter, Stephen S Rich, Cassianne Robinson-Cohen, Martin den Heijer, Marjo-Riitta Jarvelin, Alana Cavadino, Peter K Joshi, James F Wilson, Caroline Hayward, Lars Lind, Karl Michaëlsson, Stella Trompet, M Carola Zillikens, Andre G Uitterlinden, Fernando Rivadeneira, Linda Broer, Lina Zgaga, Harry Campbell, Evropi Theodoratou, Susan M Farrington, Maria Timofeeva, Malcolm G Dunlop, Ana M Valdes, Emmi Tikkanen, Terho Lehtimäki, Leo-Pekka Lyytikäinen, Mika Kähönen, Olli T Raitakari, Vera Mikkilä, M Arfan Ikram, Naveed Sattar, J Wouter Jukema, Nicholas J Wareham, Claudia Langenberg, Nita G Forouhi, Thomas E Gundersen, Kay-Tee Khaw, Adam S Butterworth, John Danesh, Timothy Spector, Thomas J Wang, Elina Hyppönen, Peter Kraft, Douglas P Kiel
Mar 02, 2018
Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC...
Genetically determined height and coronary artery disease.
Christopher P Nelson, Stephen E Hamby, Danish Saleheen, Jenna C Hopewell, Lingyao Zeng, Themistocles L Assimes, Stavroula Kanoni, Christina Willenborg, Stephen Burgess, Phillipe Amouyel, Sonia Anand, Stefan Blankenberg, Bernhard O Boehm, Robert J Clarke, Rory Collins, George Dedoussis, Martin Farrall, Paul W Franks, Leif Groop, Alistair S Hall, Anders Hamsten, Christian Hengstenberg, G Kees Hovingh, Erik Ingelsson, Sekar Kathiresan, Frank Kee, Inke R König, Jaspal Kooner, Terho Lehtimäki, Winifred März, Ruth McPherson, Andres Metspalu, Markku S Nieminen, Christopher J O'Donnell, Colin NA Palmer, Annette Peters, Markus Perola, Muredach P Reilly, Samuli Ripatti, Robert Roberts, Veikko Salomaa, Svati H Shah, Stefan Schreiber, Agneta Siegbahn, Unnur Thorsteinsdottir, Giovani Veronesi, Nicholas Wareham, Cristen J Willer, Pierre A Zalloua, Jeanette Erdmann, Panos Deloukas, Hugh Watkins, Heribert Schunkert, John Danesh, John R Thompson, Nilesh J Samani, CARDIoGRAM+C4D Consortium
Jun 03, 2015
Association analyses based on false discovery rate implicate new loci for coronary artery disease
CP Nelson, A Goel, AS Butterworth, S Kanoni, TR Webb, E Marouli, L Zeng, I Ntalla, FY Lai, JC Hopewell, O Giannakopoulou, T Jiang, SE Hamby, E Di Angelantonio, TL Assimes, EP Bottinger, JC Chambers, R Clarke, CNA Palmer, RM Cubbon, P Ellinor, R Ermel, E Evangelou, PW Franks, C Grace, D Gu, AD Hingorani, JMM Howson, E Ingelsson, A Kastrati, T Kessler, T Kyriakou, T Lehtimäki, X Lu, Y Lu, W März, R McPherson, A Metspalu, M Pujades-Rodriguez, A Ruusalepp, EE Schadt, AF Schmidt, MJ Sweeting, PA Zalloua, K AlGhalayini, BD Keavney, JS Kooner, RJF Loos, RS Patel, MK Rutter, M Tomaszewski, I Tzoulaki, E Zeggini, J Erdmann, G Dedoussis, JLM Björkegren, EPIC-CVD Consortium, CARDIoGRAMplusC4D, UK Biobank CardioMetabolic Consortium CHD working group, H Schunkert, M Farrall, J Danesh, NJ Samani, H Watkins, P Deloukas
Aug 21, 2017
Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities.
Sindhu R Johnson, Ralph Brinks, Karen H Costenbader, David Daikh, Marta Mosca, Rosalind Ramsey-Goldman, Josef S Smolen, David Wofsy, Dimitrios T Boumpas, Diane L Kamen, David Jayne, R Cervera, Nathalie Costedoat-Chalumeau, Betty Diamond, Dafna D Gladman, Bevra Hahn, Falk Hiepe, Søren Jacobsen, Dinesh Khanna, Kirsten Lerstrøm, Elena Massarotti, Joseph McCune, Guillermo Ruiz-Irastorza, Jorge Sanchez-Guerrero, Matthias Schneider, Murray Urowitz, George Bertsias, Bimba F Hoyer, Nicolai Leuchten, Chiara Tani, Sara K Tedeschi, Zahi Touma, Gabriela Schmajuk, Branimir Anic, Florence Assan, Tak Mao Chan, Ann Elaine Clarke, Mary K Crow, László Czirják, Andrea Doria, Winfried B Graninger, Bernadett Halda-Kiss, Sarfaraz Hasni, Peter M Izmirly, Michelle Jung, Gábor Kumánovics, Xavier Mariette, Ivan Padjen, José M Pego-Reigosa, Juanita Romero-Diaz, Íñigo Rúa-Figueroa, Raphaèle Seror, Georg H Stummvoll, Yoshiya Tanaka, Maria G Tektonidou, Carlos Vasconcelos, Edward M Vital, DJ Wallace, Sule Yavuz, Pier Luigi Meroni, Marvin J Fritzler, Ray Naden, Thomas Dörner, Martin Aringer
Aug 17, 2020
Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function
Philipp S Wild, Janine F Felix, Arne Schillert, Alexander Teumer, Ming-Huei Chen, Maarten JG Leening, Uwe Völker, Vera Großmann, Jennifer A Brody, Marguerite R Irvin, Sanjiv J Shah, Setia Pramana, Wolfgang Lieb, Reinhold Schmidt, Alice V Stanton, Dörthe Malzahn, Albert Vernon Smith, Johan Sundström, Cosetta Minelli, Daniela Ruggiero, Leo-Pekka Lyytikäinen, Daniel Tiller, J Gustav Smith, Claire Monnereau, Marco R Di Tullio, Solomon K Musani, Alanna C Morrison, Tune H Pers, Michael Morley, Marcus E Kleber, Jayashri Aragam, Emelia J Benjamin, Joshua C Bis, Egbert Bisping, Ulrich Broeckel, Susan Cheng, Jaap W Deckers, Fabiola del Greco M, Frank Edelmann, Myriam Fornage, Lude Franke, Nele Friedrich, Tamara B Harris, Edith Hofer, Albert Hofman, Jie Huang, Alun D Hughes, Mika Kähönen, Knhi Investigators, Jochen Kruppa, Karl J Lackner, Lars Lannfelt, Rafael Laskowski, Lenore J Launer, Margrét Leosdottir, Honghuang Lin, Cecilia M Lindgren, Christina Loley, Calum A MacRae, Deborah Mascalzoni, Jamil Mayet, Daniel Medenwald, Andrew P Morris, Christian Müller, Martina Müller-Nurasyid, Stefania Nappo, Peter M Nilsson, Sebastian Nuding, Teresa Nutile, Annette Peters, Arne Pfeufer, Diana Pietzner, Peter P Pramstaller, Olli T Raitakari, Kenneth M Rice, Fernando Rivadeneira, Jerome I Rotter, Saku T Ruohonen, Ralph L Sacco, Tandaw E Samdarshi, Helena Schmidt, Andrew SP Sharp, Denis C Shields, Rossella Sorice, Nona Sotoodehnia, Bruno H Stricker, Praveen Surendran, Simon Thom, Anna M Töglhofer, André G Uitterlinden, Rolf Wachter, Henry Völzke, Andreas Ziegler, Thomas Münzel, Winfried März, Thomas P Cappola, Joel N Hirschhorn, Gary F Mitchell, Nicholas L Smith, Ervin R Fox, Nicole D Dueker, Vincent WV Jaddoe, Olle Melander, Martin Russ, Terho Lehtimäki, Marina Ciullo, Andrew A Hicks, Lars Lind, Vilmundur Gudnason, Burkert Pieske, Anthony J Barron, Robert Zweiker, Heribert Schunkert, Erik Ingelsson, Kiang Liu, Donna K Arnett, Bruce M Psaty, Stefan Blankenberg, Martin G Larson, Stephan B Felix, Oscar H Franco, Tanja Zeller, Ramachandran S Vasan, Marcus Dörr
Nov 27, 2017
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