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Mitochondrial DNA transcription and translation
Diagnosing primary mitochondrial diseases is challenging in clinical practice. Although, defective oxidative phosphorylation (OXPHOS) is the common final pathway, it is unknown why different mtDNA or nuclear mutations result in...
mitochondrial tRNA modifications mitochondrial tRNA processing mitochondrial tRNA synthetases mitochondrial translation DNA Mitochondrial Electron Transport Humans Mitochondrial Diseases Mitochondrial Proteins Mutation Oxidative Phosphorylation Phenotype Protein Biosynthesis RNA Precursors RNA processing Post-Transcriptional RNA Messenger RNA Transfer Syndrome Transcription Genetic
Amyloid-β in mitochondrial disease
There is increasing evidence that common molecular pathways in neurons are closely linked with mitochondrial function and that mitochondrial dysfunction is connected to various forms of neurodegenerative diseases. For instance...
Vaccinia Virus Infection Inhibits Skin Dendritic Cell Migration to Draining Lymph Node
There is a paucity of information on dendritic cell (DC) responses to vaccinia virus (VACV), including the traffic of DCs to draining lymph node (dLN). Herein we studied skin DC migration in response to VACV and compared it to...
Survivors of Hell
UNLABELLED: Approximately half of the world's displaced population are children and a significant proportion of these are unaccompanied asylum-seeking children (UASC). UASC are the most vulnerable of all refugee populations. Up...
The role of tRNA synthetases in neurological and neuromuscular disorders.
Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed enzymes responsible for charging tRNAs with their cognate amino acids, therefore essential for the first step in protein synthesis. Although the majority of protein...
Diffusion tensor imaging of the normal-appearing deep gray matter in primary and secondary progressive multiple sclerosis.
Background Despite strongly overlapping patterns of clinical and histopathologic findings in primary and secondary progressive multiple sclerosis, differences concerning motor symptoms...
Ramona Woitek, Fritz Leutmezer, Assunta Dal-Bianco, Julia Furtner, Gregor Kasprian, Daniela Prayer, Veronika Schöpf
Sep 10, 2019
Investigating the cross-lingual translatability of VerbNet-style classification.
Olga Majewska, Ivan Vulić, Diana McCarthy, Yan Huang, Akira Murakami, Veronika Laippala, Anna Korhonen
May 23, 2018
VerbNet-the most extensive online verb lexicon currently available for English-has proved useful in supporting a variety of NLP tasks. However, its exploitation in multilingual NLP has been limited by the fact that such...
Evolution of large males is associated with female-skewed adult sex ratios in amniotes
András Liker, Veronika Bókony, Ivett Pipoly, Jean Francois Lemaître, Jean Michel Gaillard, Tamás Székely, Robert P. Freckleton
Jul 19, 2021
Body size often differs between the sexes (leading to sexual size dimorphism, SSD), as a consequence of differential responses by males and females to selection pressures. Adult sex ratio (ASR, the proportion of males in the...
Evolution of large males is associated with female-skewed adult sex ratios in amniotes
András Liker, Veronika Bókony, Ivett Pipoly, Jean Francois Lemaître, Jean Michel Gaillard, Tamás Székely, Robert P. Freckleton
Jul 19, 2021
Body size often differs between the sexes (leading to sexual size dimorphism, SSD), as a consequence of differential responses by males and females to selection pressures. Adult sex ratio (ASR, the proportion of males in the...
The genetic sex-determination system predicts adult sex ratios in tetrapods
Ivett Pipoly, Veronika Bókony, Mark Kirkpatrick, Paul F. Donald, Tamás Székely, András Liker
Nov 05, 2015
The adult sex ratio (ASR) has critical effects on behaviour, ecology and population dynamics, but the causes of variation in ASRs are unclear. Here we assess whether the type of genetic sex determination influences the ASR...
The genetic sex-determination system predicts adult sex ratios in tetrapods
Ivett Pipoly, Veronika Bókony, Mark Kirkpatrick, Paul F. Donald, Tamás Székely, András Liker
Nov 05, 2015
The adult sex ratio (ASR) has critical effects on behaviour, ecology and population dynamics, but the causes of variation in ASRs are unclear. Here we assess whether the type of genetic sex determination influences the ASR...
The relationship between eye movement and vision develops before birth.
Veronika Schöpf, Thomas Schlegl, Andras Jakab, Gregor Kasprian, Ramona Woitek, Daniela Prayer, Georg Langs
Jan 02, 2019
While the visuomotor system is known to develop rapidly after birth, studies have observed spontaneous activity in vertebrates in visually excitable cortical areas already before extrinsic stimuli are present. Resting state...
Financial Stress Interacts With CLOCK Gene to Affect Migraine.
Daniel Baksa, Xenia Gonda, Nora Eszlari, Peter Petschner, Veronika Acs, Lajos Kalmar, JF William Deakin, Gyorgy Bagdy, Gabriella Juhasz
Feb 17, 2020
Previous studies suggested that both maladaptive stress response and circadian dysregulation might have a role in the background of migraine. However, effects of circadian genes on migraine have not been tested yet. In the...
Sexually Dimorphic Neurosteroid Synthesis Regulates Neuronal Activity in the Murine Brain.
Philipp Wartenberg, Imre Farkas, Veronika Csillag, William H Colledge, Erik Hrabovszky, Ulrich Boehm
Oct 13, 2021
Sex steroid hormones act on hypothalamic kisspeptin neurons to regulate reproductive neural circuits in the brain. Kisspeptin neurons start to express estrogen receptors in utero, suggesting steroid hormone action on these cells...
Altered 2-thiouridylation impairs mitochondrial translation in reversible infantile respiratory chain deficiency.
Veronika Boczonadi, Paul M Smith, Angela Pyle, Aurora Gomez-Duran, Ulrike Schara, Mar Tulinius, Patrick F Chinnery, Rita Horvath
Mar 07, 2019
Childhood-onset mitochondrial encephalomyopathies are severe, relentlessly progressive conditions. However, reversible infantile respiratory chain deficiency (RIRCD), due to a homoplasmic mt-tRNA(Glu) mutation, and reversible...
New Model of Ventral Spinal Cord Lesion Induced by Balloon Compression in Rats.
Petr Krupa, Katerina Stepankova, Jessica CF Kwok, James W Fawcett, Veronika Cimermanova, Pavla Jendelova, Lucia Machova Urdzikova
May 18, 2021
Despite the variety of experimental models of spinal cord injury (SCI) currently used, the model of the ventral compression cord injury, which is commonly seen in humans, is very limited. Ventral balloon compression injury...
New Model of Ventral Spinal Cord Lesion Induced by Balloon Compression in Rats
Petr Krupa, Katerina Stepankova, Jessica CF. Kwok, James W. Fawcett, Veronika Cimermanova, Pavla Jendelova, Lucia Machova Urdzikova
Nov 09, 2020
Despite the variety of experimental models of spinal cord injury (SCI) currently used, the model of the ventral compression cord injury, which is commonly seen in humans, is very limited. Ventral balloon compression injury...
Behr's Syndrome is Typically Associated with Disturbed Mitochondrial Translation and Mutations in the C12orf65 Gene.
Angela Pyle, Venkateswaran Ramesh, Marina Bartsakoulia, Veronika Boczonadi, Aurora Gomez-Duran, Agnes Herczegfalvi, Emma L Blakely, Tania Smertenko, Jennifer Duff, Gail Eglon, David Moore, Patrick Yu-Wai-Man, Konstantinos Douroudis, Mauro Santibanez-Koref, Helen Griffin, Hanns Lochmüller, Veronika Karcagi, Robert W Taylor, Patrick F Chinnery, Rita Horvath
Mar 07, 2019
BACKGROUND: Behr's syndrome is a classical phenotypic description of childhood-onset optic atrophy combined with various neurological symptoms, including ophthalmoparesis, nystagmus, spastic paraparesis, ataxia, peripheral...
SLAM-ITseq
Wayo Matsushima, Veronika A Herzog, Tobias Neumann, Katharina Gapp, Johannes Zuber, Stefan L Ameres, Eric A Miska
Oct 10, 2018
Cell type-specific transcriptome analysis is an essential tool for understanding biological processes in which diverse types of cells are involved. Although cell isolation methods such as fluorescence-activated cell sorting...
Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.
Michele Giunta, Shimon Edvardson, Yaobo Xu, Markus Schuelke, Aurora Gomez-Duran, Veronika Boczonadi, Orly Elpeleg, Juliane S Müller, Rita Horvath
Mar 07, 2019
The exosome complex is the most important RNA processing machinery within the cell. Mutations in its subunits EXOSC8 and EXOSC3 cause pontocerebellar hypoplasia, spinal muscular atrophy (SMA) and central nervous system...
Intrathyroidal parathyroid adenomas
Shravan V Gowrishankar, Rohan Bidaye, Tilak Das, Veronika Majcher, Brian Fish, Ruth Casey, Liam Masterson
Dec 23, 2022
Intrathyroidal parathyroid adenomas (IPAs) are a rare cause of primary hyperparathyroidism. They are often difficult to localize preoperatively and intraoperatively, making diagnosis and treatment challenging. Current data on...
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