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Vinylidene Homologation of Boronic Esters and its Application to the Synthesis of the Proposed Structure of Machillene
Alkenyl boronic esters are important reagents in organic synthesis. Herein, we report that these valuable products can be accessed by the homologation of boronic esters with lithiated epoxysilanes. Aliphatic and electron-rich...
Vinylidene Homologation of Boronic Esters and its Application to the Synthesis of the Proposed Structure of Machillene
Alkenyl boronic esters are important reagents in organic synthesis. Herein, we report that these valuable products can be accessed by the homologation of boronic esters with lithiated epoxysilanes. Aliphatic and electron-rich...
Enantioselective Total Synthesis of (‐)‐Finerenone using Asymmetric Transfer Hydrogenation
Varinder Kumar Aggarwal, Andreas Lerchen, Narasimhulu Gandhamsetty, Elliot Farrar, Nils Winter, Johannes Platzek, Matthew Grayson
Dec 14, 2020
(−)‐Finerenone is a nonsteroidal mineralocorticoid receptor antagonist currently in phase III clinical trials for the treatment of chronic kidney disease in type 2 diabetes. It contains an unusual dihydronaphthyridine core. We...
Enantioselective Total Synthesis of (‐)‐Finerenone using Asymmetric Transfer Hydrogenation
Varinder Kumar Aggarwal, Andreas Lerchen, Narasimhulu Gandhamsetty, Elliot Farrar, Nils Winter, Johannes Platzek, Matthew Grayson
Dec 14, 2020
(−)‐Finerenone is a nonsteroidal mineralocorticoid receptor antagonist currently in phase III clinical trials for the treatment of chronic kidney disease in type 2 diabetes. It contains an unusual dihydronaphthyridine core. We...
Anti-thrombotic efficacy of S007-867
Ankita Misra, Prem Prakash, Hobby Aggarwal, Priyanka Dhankani, Sachin Kumar, Chandra Prakash Pandey, Nicholas Pugh, Dominique Bihan, Manoj Kumar Barthwal, Richard W Farndale, Dinesh Kumar Dikshit, Madhu Dikshit
Mar 15, 2018
Pharmacological inhibition of platelet collagen interaction is a promising therapeutic strategy to treat intra-vascular thrombosis. S007-867 is a novel synthetic inhibitor of collagen-induced platelet aggregation. It has shown...
Blood Flow Velocity Collagen Hemostasis Platelet Activation Thrombosis Animals Aspirin Blood Coagulation Chlorides Clopidogrel Dose-Response Relationship Drug Ferric Compounds Fibrinolytic Agents Male Mice Piperidines Platelet Adhesiveness Platelet Aggregation Pyrrolidines Rats Rats Sprague-Dawley Thrombosis
Prediction of Piezoelectric Tile Performance in Flat and Mountainous Terrains Through Deep Neural Network
Jitendra Adhikari, Kamalpreet Singh, Anjani Kumar Sagar, Vikki Kumar Sharma, Rajeev Kumar, Satish Chandra Jain
Sep 13, 2023
Piezoelectric tiles harvest mechanical vibrations and convert them into electrical energy, making them an attractive energy-harvesting technology. However, their performance is heavily influenced by the terrain where they are...
PSK Method for Solving Mixed and Type-4 Intuitionistic Fuzzy Solid Transportation Problems
P. Kumar
Apr 01, 2019
In this article, the author categorises the solid transportation problem (STP) under uncertain environments. He formulates the mixed and fully intuitionistic fuzzy solid transportation problems (FIFSTPs) and utilizes the...
Published by: IGI Global Scientific Publishing
Prediction of Piezoelectric Tile Performance in Flat and Mountainous Terrains Through Deep Neural Network
Jitendra Adhikari, Kamalpreet Singh, Anjani Kumar Sagar, Vikki Kumar Sharma, Rajeev Kumar, Satish Chandra Jain
Sep 13, 2023
Piezoelectric tiles harvest mechanical vibrations and convert them into electrical energy, making them an attractive energy-harvesting technology. However, their performance is heavily influenced by the terrain where they are...
Analysis of mutations in pncA reveals non-overlapping patterns among various lineages of Mycobacterium tuberculosis
Abstract Pyrazinamide (PZA) is an important first-line anti-tuberculosis drug, resistance to which occurs primarily due to mutations in pncA ...
Ramani Baddam, Narender Kumar, Lothar H Wieler, Aditya Kumar Lankapalli, Niyaz Ahmed, Sharon J Peacock, Torsten Semmler
May 30, 2018
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes.
Analysis of mutations in pncA reveals non-overlapping patterns among various lineages of Mycobacterium tuberculosis.
Ramani Baddam, Narender Kumar, Lothar H Wieler, Aditya Kumar Lankapalli, Niyaz Ahmed, Sharon J Peacock, Torsten Semmler
Sep 26, 2018
Pyrazinamide (PZA) is an important first-line anti-tuberculosis drug, resistance to which occurs primarily due to mutations in pncA (Rv2043c) that encodes the pyrazinamidase enzyme responsible for conversion of pro-drug PZA into...
Efficient One-Pot Solvothermal Synthesis and Characterization of Zirconia Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposites
Nalinee Kanth Kadiyala, Badal Kumar Mandal, L Vinod Kumar Reddy, Crispin HW Barnes, Luis De Los Santos Valladares, Dwaipayan Sen
Feb 23, 2023
This study mainly deals with an effective one-pot solvothermal synthetic pathway for the preparation of uniformly dispersed zirconium oxide nanoparticles on the flattened rough surface of reduced graphene oxide (ZrO2/rGO NCs)...
Nanobubbles in water and wastewater treatment systems
Mingyi Jia, Muhammad Usman Farid, Jehad A. Kharraz, Nallapaneni Manoj Kumar, Shauhrat S. Chopra, Am Jang, John Chew, Samir Kumar Khanal, Guanghao Chen, Alicia An
Oct 15, 2023
Since the discovery of nanobubbles (NBs) in 1994, NBs have been attracting growing attention for their fascinating properties and have been studied for application in various environmental fields, including water and wastewater...
Investigating the growth of AlGaN/AlN heterostructure by modulating the substrate temperature of AlN buffer layer
Neha Aggarwal, Shibin Krishna, Lalit Goswami, Shubhendra Kumar Jain, Akhilesh Pandey, Abhiram Gundimeda, Pargam Vashishtha, Jasveer Singh, Sandeep Singh, Govind Gupta
Feb 08, 2021
Abstract: We have investigated the impact of AlN buffer layer growth parameters for developing highly single crystalline AlGaN films. The low mobility of Al adatoms and high temperature for compound formation are amongst the...
Biogenic Photo-Catalyst TiO2 Nanoparticles for Remediation of Environment Pollutants.
Boya Palajonnala Narasaiah, Pravallika Banoth, Angel Guillermo Bustamante Dominguez, Badal Kumar Mandal, Challa Kiran Kumar, Crispin HW Barnes, Luis De Los Santos Valladares, Pratap Kollu
Sep 07, 2022
This article reports a benign environmentally friendly fabrication method of titanium dioxide (TDO) nanoparticles (named TDO NPs3, TDO NPs5, and TDO NPs8) using aqueous extract of durva herb waste. This synthesis process avoids...
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes.
Taniya Bhardwaj, Kundlik Gadhave, Shivani K Kapuganti, Prateek Kumar, Zacharias Faidon Brotzakis, Kumar Udit Saumya, Namyashree Nayak, Ankur Kumar, Richa Joshi, Bodhidipra Mukherjee, Aparna Bhardwaj, Krishan Gopal Thakur, Neha Garg, Michele Vendruscolo, Rajanish Giri
Mar 24, 2023
The phenomenon of protein aggregation is associated with a wide range of human diseases. Our knowledge of the aggregation behaviour of viral proteins, however, is still rather limited. Here, we investigated this behaviour in the...
Animals Mammals Humans Proteome Amyloidogenic Proteins covid-19 SARS-CoV-2 Severe acute respiratory syndrome-related coronavirus
Published by: Nature Communications
Efficient One-Pot Solvothermal Synthesis and Characterization of Zirconia Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposites
Nalinee Kanth Kadiyala, Badal Kumar Mandal, L Vinod Kumar Reddy, Crispin HW Barnes, Luis De Los Santos Valladares, Dwaipayan Sen
Jan 18, 2023
This study mainly deals with an effective one-pot solvothermal synthetic pathway for the preparation of uniformly dispersed zirconium oxide nanoparticles on the flattened rough surface of reduced graphene oxide (ZrO2/rGO NCs)...
Nanobubbles in water and wastewater treatment systems
Mingyi Jia, Muhammad Usman Farid, Jehad A. Kharraz, Nallapaneni Manoj Kumar, Shauhrat S. Chopra, Am Jang, John Chew, Samir Kumar Khanal, Guanghao Chen, Alicia An
Oct 15, 2023
Since the discovery of nanobubbles (NBs) in 1994, NBs have been attracting growing attention for their fascinating properties and have been studied for application in various environmental fields, including water and wastewater...
Functional balance between Tcf21-Slug defines cellular plasticity and migratory modalities in high grade serous ovarian cancer cell lines.
Sagar S Varankar, Madhuri More, Ancy Abraham, Kshama Pansare, Brijesh Kumar, Nivedhitha J Narayanan, Mohit Kumar Jolly, Avinash M Mali, Sharmila A Bapat
Dec 19, 2019
Cellular plasticity and transitional phenotypes add to complexities of cancer metastasis that can be initiated by single cell epithelial to mesenchymal transition (EMT) or cooperative cell migration (CCM). Our study identifies...
Insights on Imparting Medical Education in Medieval India
Mumtaz Alam
Dec 20, 2019
The imparting of medical education in India since ancient to medieval times has been a theme of research among several historians like Mark Harrison, Deepak Kumar, Anil Kumar, Syed Ali Nadeem Rezavi, Irfan Habib and others, who...
Published by: Department of History, University of Karachi
Pressure-Induced Enhancement of Thermoelectric Figure of Merit and Structural Phase Transition in TiNiSn.
Jason L Baker, Changyong Park, Curtis Kenney-Benson, Vineet Kumar Sharma, V Kanchana, G Vaitheeswaran, Chris J Pickard, Andrew Cornelius, Nenad Velisavljevic, Ravhi S Kumar
Jan 13, 2021
Half-Heusler thermoelectric materials are potential candidates for high thermoelectric efficiency. We report high-pressure thermoelectric and structural property measurements, density functional theory calculations on the...
Identification and Characterization of Genetic Determinants of Isoniazid and Rifampicin Resistance in Mycobacterium tuberculosis in Southern India
Asma Munir, Narender Kumar, Suresh Babu Ramalingam, Sembulingam Tamilzhalagan, Siva Kumar Shanmugam, Alangudi Natarajan Palaniappan, Dina Nair, Padma Priyadarshini, Mohan Natarajan, Srikanth Tripathy, Uma Devi Ranganathan, Sharon J. Peacock, Julian Parkhill, Tom L. Blundell, Sony Malhotra
Jul 15, 2020
Abstract: Drug-resistant tuberculosis (TB), one of the leading causes of death worldwide, arises mainly from spontaneous mutations in the genome of Mycobacterium tuberculosis. There is an urgent need to understand the mechanisms...
Divergent evolution of Corynebacterium diphtheriae in India
Naveen Kumar Devanga Ragupathi, Dhiviya Prabaa Muthuirulandi Sethuvel, Dhivya Murugan, Ranjini Ranjan, Vikas Gautam, Prashanth Gupta, Jaichand Johnson, Naresh Chand Sharma, Ankur Mutreja, Pradeep Haldar, Arun Kumar, Pankaj Bhatnagar, Lucky Sangal, Balaji Veeraraghavan
Jan 05, 2022
Diphtheria is caused by a toxigenic bacterium Corynebacterium diphtheria which is being an emerging pathogen in India. Since diphtheria morbidity and mortality continues to be high in the country, the present study aimed to...
Divergent evolution of Corynebacterium diphtheriae in India
Naveen Kumar Devanga Ragupathi, Dhiviya Prabaa Muthuirulandi Sethuvel, Dhivya Murugan, Ranjini Ranjan, Vikas Gautam, Prashanth Gupta, Jaichand Johnson, Naresh Chand Sharma, Ankur Mutreja, Pradeep Haldar, Arun Kumar, Pankaj Bhatnagar, Lucky Sangal, Balaji Veeraraghavan
Jan 28, 2022
Diphtheria is caused by a toxigenic bacterium Corynebacterium diphtheria which is being an emerging pathogen in India. Since diphtheria morbidity and mortality continues to be high in the country, the present study aimed to...
A comprehensive framework from real‐time prognostics to maintenance decisions
Amit Kumar Jain, Maharshi Dhada, Marco Perez Hernandez, Manuel Herrera, Ajith Kumar Parlikad
Jun 09, 2021
Abstract: Studying the influence of imperfect prognostics information on maintenance decisions is an underexplored area. To bridge this gap, a new comprehensive maintenance support system is proposed. First, a survival...
Published by: IET Collaborative Intelligent Manufacturing
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