Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
Rona J Strawbridge,
Josée Dupuis,
Inga Prokopenko,
Adam Barker,
Emma Ahlqvist,
Denis Rybin,
John R Petrie,
Mary E Travers,
Nabila Bouatia-Naji,
Antigone S Dimas,
Alexandra Nica,
Eleanor Wheeler,
Han Chen,
Benjamin F Voight,
Jalal Taneera,
Stavroula Kanoni,
John F Peden,
Fabiola Turrini,
Stefan Gustafsson,
Carina Zabena,
Peter Almgren,
David JP Barker,
Daniel Barnes,
Elaine M Dennison,
Johan G Eriksson,
Per Eriksson,
Elodie Eury,
Lasse Folkersen,
Caroline S Fox,
Timothy M Frayling,
Anuj Goel,
Harvest F Gu,
Momoko Horikoshi,
Bo Isomaa,
Anne U Jackson,
Karen A Jameson,
Eero Kajantie,
Julie Kerr-Conte,
Teemu Kuulasmaa,
Johanna Kuusisto,
Ruth JF Loos,
Jian'an Luan,
Konstantinos Makrilakis,
Alisa K Manning,
María Teresa Martínez-Larrad,
Narisu Narisu,
Maria Nastase Mannila,
John Ohrvik,
Clive Osmond,
Laura Pascoe,
Felicity Payne,
Avan A Sayer,
Bengt Sennblad,
Angela Silveira,
Alena Stancáková,
Kathy Stirrups,
Amy J Swift,
Ann-Christine Syvänen,
Tiinamaija Tuomi,
Ferdinand M van 't Hooft,
Mark Walker,
Michael N Weedon,
Weijia Xie,
Björn Zethelius,
DIAGRAM Consortium,
GIANT Consortium,
MuTHER Consortium,
CARDIoGRAM consortium,
C4D Consortium,
Halit Ongen,
Anders Mälarstig,
Jemma C Hopewell,
Danish Saleheen,
John Chambers,
Sarah Parish,
John Danesh,
Jaspal Kooner,
Claes-Göran Ostenson,
Lars Lind,
Cyrus C Cooper,
Manuel Serrano-Ríos,
Ele Ferrannini,
Tom J Forsen,
Robert Clarke,
Maria Grazia Franzosi,
Udo Seedorf,
Hugh Watkins,
Philippe Froguel,
Paul Johnson,
Panos Deloukas,
Francis S Collins,
Markku Laakso,
Emmanouil T Dermitzakis,
Michael Boehnke,
Mark I McCarthy,
Nicholas J Wareham,
Leif Groop,
François Pattou,
Anna L Gloyn,
George V Dedoussis,
Valeriya Lyssenko,
James B Meigs,
Inês Barroso,
Richard M Watanabe,
Erik Ingelsson,
Claudia Langenberg,
Anders Hamsten,
Jose C Florez
May 09, 2018
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D)....