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Valproic acid disables the Nrf2 anti-oxidant response in acute myeloid leukaemia cells enhancing reactive oxygen species-mediated killing.
Yao Jiang, Andrew D Southam, Sandro Trova, Flavio Beke, Bader Alhazmi, Thomas Francis, Anshul Radotra, Alessandro di Maio, Mark T Drayson, Chris M Bunce, Farhat L Khanim
Jan 28, 2022
BACKGROUND: We previously demonstrated the in vitro killing of AML cells by the combination of the lipid-lowering agent bezafibrate (BEZ) and the contraceptive hormone medroxyprogesterone acetate (MPA). A phase II trial...
Structural neuroimaging correlates of allelic variation of the BDNF val66met polymorphism.
Natalie J Forde, Lisa Ronan, John Suckling, Cathy Scanlon, Simon Neary, Laurena Holleran, Alexander Leemans, Roger Tait, Catarina Rua, Paul C Fletcher, Ben Jeurissen, Chris M Dodds, Sam R Miller, Edward T Bullmore, Colm McDonald, Pradeep J Nathan, Dara M Cannon
Jun 21, 2018
BACKGROUND: The brain-derived neurotrophic factor (BDNF) val66met polymorphism is associated with altered activity dependent secretion of BDNF and a variable influence on brain morphology and cognition. Although a met-dose...
University-based Teacher Residencies in Texas
Teacher education residencies are an innovative but underutilized clinical teaching practice. Perhaps the reason that university-based teacher preparation programs (TPPs) do not employ residencies more broadly may be due to the...
Published by: Digital Commons @ Texas A&M University-San Antonio
University-based Teacher Residencies in Texas
Teacher education residencies are an innovative but underutilized clinical teaching practice. Perhaps the reason that university-based teacher preparation programs (TPPs) do not employ residencies more broadly may be due to the...
Published by: Digital Commons @ Texas A&M University-San Antonio
University-based Teacher Residencies in Texas
Teacher education residencies are an innovative but underutilized clinical teaching practice. Perhaps the reason that university-based teacher preparation programs (TPPs) do not employ residencies more broadly may be due to the...
Published by: Digital Commons @ Texas A&M University-San Antonio
Exaggeration of PFS by blinded, independent, central review (BICR)
Background Recent published studies have shown meaningful discrepancies between local investigator and blinded, independent, central review (BICR) assessed median progression-free survival (PFS). When the local review but not...
Exaggeration of PFS by blinded, independent, central review (BICR)
Background Recent published studies have shown meaningful discrepancies between local investigator and blinded, independent, central review (BICR) assessed median progression-free survival (PFS). When the local review but not...
Global optimisation approach for designing high-efficiency piezoelectric beam-based energy harvesting devices
Daniil Yurchenko, Lucas Queiroz Machado, Junlei Wang, Chris Bowen, Suleiman Sharkh, Mohamed Moshrefi-Torbati, Dimitri V. Val
Mar 31, 2022
The paper proposes a novel methodology for developing high-power energy harvesting gravity-based devices using an array of piezoelectric beams for wind energy applications. The methodology incorporates a global...
Electrostatic Tuning of the Ligand Binding Mechanism by Glu27 in Nitrophorin 7.
Stefania Abbruzzetti, Alessandro Allegri, Axel Bidon-Chanal, Hideaki Ogata, Giancarlo Soavi, Giulio Cerullo, Stefano Bruno, Chiara Montali, F Javier Luque, Cristiano Viappiani
Nov 21, 2018
Nitrophorins (NP) 1-7 are NO-carrying heme proteins found in the saliva of the blood-sucking insect Rhodnius prolixus. The isoform NP7 displays peculiar properties, such as an abnormally high isoelectric point, the ability to...
The Grizzly, September 17, 1982
Gina Daviso, Theresa Menzel, Tracey Clark, Mark Lewis, Richard P. Richter, Duncan C. Atkins, Martin Atreides, Georgeann Fusco, Peggy Laughran, David Borgstrom, Jean Morrison, Paul Graeff, Leslie Fenton, Adrianne Tuccillo, Scott Sheffler
Jan 01, 0001
New Ursinus Students Welcomed Lantern Needs Associate Editor Vandalism at Myrin Administration Alterations Committee Needs Chairmen Folk Festival Summer Fun Forum Preview Lewis on Wall Street Fencing Anyone? Sendai...
Ursinus College Collegeville Pennsylvania newspaper Myrin Library vandalism Lantern Nicholas Berry Egon Borgman Bernard Lentz Kutztown Folk Festival Cafe International William S. Allerton Investment Club fencing club The Who Lou Reed Tohoku Gakuin University Wismer dining hall student government field hockey cross country Volleyball Football Soccer cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Variation in passing standards for graduation-level knowledge items at UK medical schools.
OBJECTIVES: Given the absence of a common passing standard for students at UK medical schools, this paper compares independently set standards for common 'one from five' single-best-answer (multiple-choice) items used in...
Global optimisation approach for designing high-efficiency piezoelectric beam-based energy harvesting devices
Daniil Yurchenko, Lucas Queiroz Machado, Junlei Wang, Chris Bowen, Suleiman Sharkh, Mohamed Moshrefi-Torbati, Dimitri V. Val
Mar 31, 2022
The paper proposes a novel methodology for developing high-power energy harvesting gravity-based devices using an array of piezoelectric beams for wind energy applications. The methodology incorporates a global...
Neoadjuvant Chemoradiotherapy and Surgery for Esophageal Squamous Cell Carcinoma Versus Definitive Chemoradiotherapy With Salvage Surgery as Needed
Magnus Nilsson, Halla Olafsdottir, Gabriella Alexandersson von Döbeln, Fernanda Villegas, Giovanna Gagliardi, Mats Hellström, Qiao-Li Wang, Hemming Johansson, Val Gebski, Jakob Hedberg, Fredrik Klevebro, Sheraz Markar, Elizabeth Smyth, Pernilla Lagergren, Ghazwan Al-Haidari, Lars Cato Rekstad, Eirik Kjus Aahlin, Bengt Wallner, David Edholm, Jan Johansson, Eva Szabo, John V Reynolds, CS Pramesh, Naveen Mummudi, Amit Joshi, Lorenzo Ferri, Rebecca Ks Wong, Chris O'Callaghan, Jelena Lukovic, Kelvin Kw Chan, Trevor Leong, Andrew Barbour, Mark Smithers, Yin Li, Xiaozheng Kang, Feng-Ming Kong, Yin-Kai Chao, Tom Crosby, Christiane Bruns, Hanneke van Laarhoven, Mark van Berge Henegouwen, Richard van Hillegersberg, Riccardo Rosati, Guillaume Piessen, Giovanni de Manzoni, Florian Lordick
Jul 27, 2022
BACKGROUND: The globally dominant treatment with curative intent for locally advanced esophageal squamous cell carcinoma (ESCC) is neoadjuvant chemoradiotherapy (nCRT) with subsequent esophagectomy. This multimodal treatment...
The Grizzly, September 14, 1999
Erny Hoke, Stephanie Restine, NiPun Suri, Megan Restine, Karen Srebro, Dan Reimold, Stephanie Garwin, Aaron Ranck, Chris Cocca, Paige Miller, Andy Maynard, Aaron Hampton, Susan Patton, Jeff Church, Dave Walker, Cory Braiterman, Fran Shaughnessy
Jan 01, 0001
Tragic Loss for Ursinus College A Computer Makeover Summer Research Experience Freshman Orientation: Breaking in the Baby Bears Car Owners Beware: "Vehicle Cloning" Criminals Multiplying to Collegeville Area Ursinus Chapter...
Ursinus College Collegeville Pennsylvania newspaper field hockey Football laundry system career planning Theft summer fellows Computing Services email Shirley Eaton cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Effect of high-flow nasal therapy on patient-centred outcomes in patients at high risk of postoperative pulmonary complications after cardiac surgery
Melissa Earwaker, Sofia Villar, Julia Fox-Rushby, Melissa Duckworth, Sarah Dawson, Jo Steele, Yi-da Chiu, Edward Litton, Gudrun Kunst, Gavin Murphy, Guillermo Martinez, Vasileios Zochios, Val Brown, Geoff Brown, Andrew Klein
Mar 31, 2022
BACKGROUND: High-flow nasal therapy is a non-invasive form of respiratory support that delivers low-level, flow dependent positive airway pressure. The device can be better tolerated by patients than alternatives such as...
Effect of high-flow nasal therapy on patient-centred outcomes in patients at high risk of postoperative pulmonary complications after cardiac surgery
Melissa Earwaker, Sofia Villar, Julia Fox-Rushby, Melissa Duckworth, Sarah Dawson, Jo Steele, Yi-da Chiu, Edward Litton, Gudrun Kunst, Gavin Murphy, Guillermo Martinez, Vasileios Zochios, Val Brown, Geoff Brown, Andrew Klein
Apr 29, 2022
BACKGROUND: High-flow nasal therapy is a non-invasive form of respiratory support that delivers low-level, flow dependent positive airway pressure. The device can be better tolerated by patients than alternatives such as...
Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases.
Leen Kalash, Cristina Val, Jhonny Azuaje, María I Loza, Fredrik Svensson, AZEDINE Zoufir, Lewis Mervin, Graham Ladds, José Brea, Robert Glen, Eddy Sotelo, Andreas Bender
Mar 07, 2018
Compounds designed to display polypharmacology may have utility in treating complex diseases, where activity at multiple targets is required to produce a clinical effect. In particular, suitable compounds may be useful in...
Clinical Impact of the Predict Prostate Risk Communication Tool in Men Newly Diagnosed with Nonmetastatic Prostate Cancer
The Grizzly, March 27, 1987
Jean M. Kiss, Kristen Rinnander, Angela M. Salas, Richard P. Richter, Lora L. Hart, Dean Lent, Jill Griffiths, Jeanne Radwanski, Vince Leskusky, Andy Standeven, Melissa French, Steve Gall, Kathy Krohnert, Karen Singhofen, Craig DiLouie
Jan 01, 0001
Vandals Violate Student Property Greek Week Comprehensive Conflicts Letter: Brothers Give Thanks Future Changes for Ursinus English Comprehensive Anxieties Table Talk Students Should Become Aware of Career Aid...
Ursinus College Collegeville Pennsylvania newspaper John Pilgrim CAPHE College Choir Flamin' Caucasians Campus Activities Board bears Collette Hall WVOU radio Cub & Key society Perkiomen Valley tennis baseball softball Gwen O'Donohue wrestling Rich Dunlap track team lacrosse golf Dean Lent John Wood career planning Wismer dining hall comprehensive exams Student Union Alpha Chi Sigma Inter-Fraternity Council vandalism cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Germline and Somatic Genetic Variants in the p53 Pathway Interact to Affect Cancer Risk, Progression, and Drug Response.
Ping Zhang, Isaac Kitchen-Smith, Lingyun Xiong, Giovanni Stracquadanio, Katherine Brown, Philipp H Richter, Marsha D Wallace, Elisabeth Bond, Natasha Sahgal, Samantha Moore, Svanhild Nornes, Sarah De Val, Mirvat Surakhy, David Sims, Xuting Wang, Douglas A Bell, Jorge Zeron-Medina, Yanyan Jiang, Anderson J Ryan, Joanna L Selfe, Janet Shipley, Siddhartha Kar, Paul D Pharoah, Chey Loveday, Rick Jansen, Lukasz F Grochola, Claire Palles, Andrew Protheroe, Val Millar, Daniel V Ebner, Meghana Pagadala, Sarah P Blagden, Timothy S Maughan, Enric Domingo, Ian Tomlinson, Clare Turnbull, Hannah Carter, Gareth L Bond
Jan 26, 2021
Animals Antineoplastic Agents Biomarkers Pharmacological Carcinogenesis Case-Control Studies Cell Line Tumor Disease Progression Drug Resistance Neoplasm Female Genetic Predisposition to Disease Genome-Wide Association Study Germ-Line Mutation Humans Male Mice Mice Inbred BALB C Mice Nude Mutation Missense Neoplasms Polymorphism Single Nucleotide Prognosis Risk Factors Signal Transduction Treatment Outcome Tumor Suppressor Protein p53
Nanoparticle vesicle encoding for imaging and tracking cell populations.
Paul Rees, John W Wills, M Rowan Brown, James Tonkin, Mark D Holton, Nicole Hondow, Andrew P Brown, Rik Brydson, Val Millar, Anne E Carpenter, Huw D Summers
Aug 13, 2019
For phenotypic behavior to be understood in the context of cell lineage and local environment, properties of individual cells must be measured relative to population-wide traits. However, the inability to accurately identify...
SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development.
Ivy Kim-Ni Chiang, Martin Fritzsche, Cathy Pichol-Thievend, Alice Neal, Kelly Holmes, Anne Lagendijk, Jeroen Overman, Donatella D'Angelo, Alice Omini, Dorien Hermkens, Emmanuelle Lesieur, Ke Liu, Indrika Ratnayaka, Monica Corada, George Bou-Gharios, Jason Carroll, Elisabetta Dejana, Stefan Schulte-Merker, Benjamin Hogan, Monica Beltrame, Sarah De Val, Mathias Francois
Apr 17, 2019
Arterial enhancer artery Endothelial Cell human MOUSE Notch1 SoxF Transcriptional regulation Zebrafish Amino Acid Sequence Animals Animals Genetically Modified arteries Arteriovenous Malformations Enhancer Elements Genetic Female Gene Expression Regulation Developmental Human Umbilical Vein Endothelial Cells Humans Male Mice Mice Inbred C57BL Mice Knockout Mice Transgenic Pregnancy Receptor Notch1 SOXF Transcription Factors Sequence Homology Amino Acid Signal Transduction Zebrafish Zebrafish Proteins
The Ursinus Weekly, March 1, 1937
Abe E. Lipkin
Jan 01, 0001
Alex Bartha's steel pier orchestra will syncopate at April junior prom Ditter attacks court reform in Sunday's forum Four schools to wrestle here Sat. Directors meet, give Sheeder religion chair "Ozzie" Werley's thirteen...
Ursinus College Collegeville Pennsylvania newspaper J. William Ditter wrestling Franklin I. Sheeder Max McConn Student teachers Chess Club International Relations Club H. Frank Hare Calvin D. Yost debate team Basketball wrestling YMCA YWCA May Day pageant cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The Ursinus Weekly, March 8, 1937
Abe E. Lipkin
Jan 01, 0001
Max McConn uses higher learning as forum topic Lafayette, Gettysburg, Haverford meet here for Middle Atlantics, finish in that order Fenton is selected to reign at May Day Curtain Club brings Hedgerow here twice Alspach goes...
Ursinus College Collegeville Pennsylvania newspaper Mark Alspach wrestling Virginia Fenton Shigeo Kimura Nora McAlister Marion D. Green Warren K. Hess Franklin I. Sheeder Hall Chemical Society Meistersingers debate team Omega Chi Basketball Intramural Sports cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
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