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Computational Analysis of Vertebral Body for Compression Fracture Using Texture and Shape Features
The primary goal in this paper is to automate radiological measurements of Vertebral Body (VB) in Magnetic Resonance Imaging (MRI) spinal scans. It starts by preprocessing the images, then detect and localize the VB regions...
Published by: IGI Global Scientific Publishing
Material property calibration is more important than element size and number of different materials on the finite element modelling of vertebral bodies
Finite element (FE) modelling of a vertebral body (VB) is considered challenging due to the many parameters involved such as element size and type, and material properties. Previous studies have reported how these parameters...
Material property calibration is more important than element size and number of different materials on the finite element modelling of vertebral bodies
Finite element (FE) modelling of a vertebral body (VB) is considered challenging due to the many parameters involved such as element size and type, and material properties. Previous studies have reported how these parameters...
Longitudinal associations between prepubertal childhood total energy and macronutrient intakes and subsequent puberty timing in UK boys and girls.
Tuck Seng Cheng, Stephen J Sharp, Soren Brage, Pauline M Emmett, Nita Forouhi, Kenneth Ong
Jul 12, 2021
PURPOSE: Early puberty is associated with adverse health outcomes. To identify potential modifiable factors for puberty timing, we examined the associations of prepubertal childhood macronutrient intakes with puberty timing in...
The crystal structure of AjiA1 reveals a novel structural motion mechanism in the adenylate-forming enzyme family.
Fernanda CR de Paiva, Karen Chan, Markiyan Samborskyy, Ariel M Silber, Peter F Leadlay, Marcio VB Dias
Dec 07, 2020
Adenylate-forming enzymes (AFEs) are a mechanistic superfamily of proteins that are involved in many cellular roles. In the biosynthesis of benzoxazole antibiotics, an AFE has been reported to play a key role in the condensation...
Single-site glycine-specific labeling of proteins.
Landa Purushottam, Srinivasa Rao Adusumalli, Usha Singh, VB Unnikrishnan, Dattatraya Gautam Rawale, Mansi Gujrati, Ram Kumar Mishra, Vishal Rai
Jan 25, 2021
Labeling of native proteins invites interest from diverse segments of science. However, there remains the significant unmet challenge in precise labeling at a single site of a protein. Here, we report the site-specific labeling...
Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK.
Marcio VB Dias, Fanglu Huang, Dimitri Y Chirgadze, Manuela Tosin, Dieter Spiteller, Emily FV Dry, Peter F Leadlay, Jonathan B Spencer, Tom L Blundell
Mar 12, 2021
The thioesterase FlK from the fluoroacetate-producing Streptomyces cattleya catalyzes the hydrolysis of fluoroacetyl-coenzyme A. This provides an effective self-defense mechanism, preventing any fluoroacetyl-coenzyme A formed...
Acetyl Coenzyme A Biocatalysis Catalytic Domain Crystallography X-Ray Hydrophobic and Hydrophilic Interactions Models Molecular Mutagenesis Site-Directed Mutant Proteins Mutation Protein Structure Quaternary Protein Structure Secondary Streptomyces Substrate Specificity Thiolester Hydrolases Threonine
Reproducibility of compartmental modelling of 18 F-FDG PET/CT to evaluate lung inflammation
Laurence D. Vass, Sarah Lee, Frederick J. Wilson, Marie Fisk, Joseph Cheriyan, Ian Wilkinson
Dec 22, 2020
Abstract: Introduction: Compartmental modelling is an established method of quantifying 18F-FDG uptake; however, only recently has it been applied to evaluate pulmonary inflammation. Implementation of compartmental models...
Reproducibility of compartmental modelling of 18F-FDG PET/CT to evaluate lung inflammation.
Laurence D Vass, Sarah Lee, Frederick J Wilson, Marie Fisk, Joseph Cheriyan, Ian Wilkinson
Jan 27, 2020
INTRODUCTION:Compartmental modelling is an established method of quantifying 18F-FDG uptake; however, only recently has it been applied to evaluate pulmonary inflammation. Implementation of compartmental models remains...
Fast Nonparametric Clustering of Structured Time-Series.
In this publication, we combine two Bayesian nonparametric models: the Gaussian Process (GP) and the Dirichlet Process (DP). Our innovation in the GP model is to introduce a variation on the GP prior which enables us to model...
Genomes of coral dinoflagellate symbionts highlight evolutionary adaptations conducive to a symbiotic lifestyle.
M Aranda, Y Li, YJ Liew, S Baumgarten, O Simakov, MC Wilson, J Piel, H Ashoor, S Bougouffa, VB Bajic, T Ryu, T Ravasi, T Bayer, G Micklem, H Kim, J Bhak, TC LaJeunesse, CR Voolstra
Aug 01, 2018
Despite half a century of research, the biology of dinoflagellates remains enigmatic: they defy many functional and genetic traits attributed to typical eukaryotic cells. Genomic approaches to study dinoflagellates are often...
Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility-mass spectrometry.
Daniel Shiu-Hin Chan, Jeannine Hess, Elen Shaw, Christina Spry, Robert Starley, Claudio Dagostin, Marcio VB Dias, Ramesh Kale, Vitor Mendes, Tom L Blundell, Anthony G Coyne, Chris Abell
Sep 13, 2019
CoaBC, part of the vital coenzyme A biosynthetic pathway in bacteria, has recently been validated as a promising antimicrobial target. In this work, we employed native ion mobility-mass spectrometry to gain structural insights...
Platinum-Triggered Bond-Cleavage of Pentynoyl Amide and N-Propargyl Handles for Drug-Activation.
Properties of PMMA end cap holders affect FE stiffness predictions of vertebral specimens
Bone cement is often used, in experimental biomechanics, as a potting agent for vertebral bodies (VB). As a consequence, it is usually included in finite element (FE) models to improve accuracy in boundary condition settings....
Neural correlates of the severity of cocaine, heroin, alcohol, MDMA and cannabis use in polysubstance abusers
Laura Moreno-López, Emmanuel A Stamatakis, Maria José Fernández-Serrano, Manuel Gómez-Río, Antonio Rodríguez-Fernández, Miguel Pérez-García, Antonio Verdejo-García
Aug 08, 2017
INTRODUCTION: Functional imaging studies of addiction following protracted abstinence have not been systematically conducted to look at the associations between severity of use of different drugs and brain dysfunction. Findings...
Properties of PMMA end cap holders affect FE stiffness predictions of vertebral specimens
Bone cement is often used, in experimental biomechanics, as a potting agent for vertebral bodies (VB). As a consequence, it is usually included in finite element (FE) models to improve accuracy in boundary condition settings....
Altered regulation of BRCA1 exon 11 splicing is associated with breast cancer risk in carriers of BRCA1 pathogenic variants.
Gorka Ruiz de Garibay, Ignacio Fernandez-Garcia, Sylvie Mazoyer, Flavia Leme de Calais, Pietro Ameri, Sangeeta Haydeliz Martinez-Ruiz, Francesca Damiola, Laure Barjhoux, Mads Thomassen, Lars VB Andersen, Carmen Herranz, Francesca Mateo, Luis Palomero, Roderic Espin, Antonio Gómez, Nadia García, Daniel Jimenez, Núria Bonifaci, Ana I Extremera, Julio Castaño, Angel Raya, Eduardo Eyras, Xose S Puente, Joan Brunet, Conxi Lázaro, Gemo, CIMBA, Paolo Radice, Daniel R Barnes, Antonis C Antoniou, Amanda B Spurdle, Miguel de la Hoya, Diana Baralle, Mary Helen Barcellos-Hoff, Miquel A Pujana
Sep 01, 2021
Germline pathogenic variants in BRCA1 confer a high risk of developing breast and ovarian cancer. The BRCA1 exon 11 (formally exon 10) is one of the largest exons and codes for the nuclear localization signals of the...
Observation of Gravitational Waves from Two Neutron Star-Black Hole Coalescences
R Abbott, TD Abbott, S Abraham, F Acernese, K Ackley, A Adams, C Adams, RX Adhikari, VB Adya, C Affeldt, D Agarwal, M Agathos, K Agatsuma, N Aggarwal, OD Aguiar, L Aiello, A Ain, P Ajith, T Akutsu, KM Aleman, G Allen, A Allocca, PA Altin, A Amato, S Anand, A Ananyeva, SB Anderson, WG Anderson, M Ando, SV Angelova, S Ansoldi, JM Antelis, S Antier, S Appert, K Arai, K Arai, Y Arai, S Araki, A Araya, MC Araya, JS Areeda, M Arène, N Aritomi, N Arnaud, SM Aronson, KG Arun, H Asada, Y Asali, G Ashton, Y Aso, SM Aston, P Astone, F Aubin, P Aufmuth, K AultONeal, C Austin, S Babak, F Badaracco, MKM Bader, S Bae, Y Bae, AM Baer, S Bagnasco, Y Bai, L Baiotti, J Baird, R Bajpai, M Ball, G Ballardin, SW Ballmer, M Bals, A Balsamo, G Baltus, S Banagiri, D Bankar, RS Bankar, JC Barayoga, C Barbieri, BC Barish, D Barker, P Barneo, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, J Bartlett, MA Barton, I Bartos, R Bassiri, A Basti, M Bawaj, JC Bayley, AC Baylor, M Bazzan, B Bécsy, VM Bedakihale, M Bejger, I Belahcene, V Benedetto
Jul 07, 2021
We report the observation of gravitational waves from two compact binary
coalescences in LIGO's and Virgo's third observing run with properties
consistent with neutron star-black hole (NSBH) binaries. The two events are
named...
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