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Results: 509
Cost effectiveness of population based BRCA1 founder mutation testing in Sephardi Jewish women.
Shreeya Patel, Rosa Legood, D Gareth Evans, Clare Turnbull, Antonis C Antoniou, Usha Menon, Ian Jacobs, Ranjit Manchanda
Mar 09, 2018
BACKGROUND: Population-based BRCA1/BRCA2 founder-mutation testing has been demonstrated as cost effective compared with family history based testing in Ashkenazi Jewish women. However, only 1 of the 3 Ashkenazi Jewish...
BRCA Sephardi Jewish cost effectiveness population testing Adult Cost-Benefit Analysis Female Genes BRCA1 Genetic Testing Hereditary Breast and Ovarian Cancer Syndrome Heterozygote Hormone Replacement Therapy Humans Jews Life Expectancy Magnetic Resonance Imaging Mammography Markov Chains Middle Aged Mutation Ovariectomy Prophylactic Mastectomy Prophylactic Surgical Procedures Quality-Adjusted Life Years United Kingdom United States
Psychosocial Factors Associated With Withdrawal From the United Kingdom Collaborative Trial of Ovarian Cancer Screening After 1 Episode of Repeat Screening.
The 14q32 maternally imprinted locus is a major source of longitudinally stable circulating microRNAs as measured by small RNA sequencing.
Gabriel N Valbuena, Sophia Apostolidou, Rhiannon Roberts, Julie Barnes, Wendy Alderton, Lauren Harper, Ian Jacobs, Usha Menon, Hector C Keun
Oct 31, 2020
Understanding the normal temporal variation of serum molecules is a critical factor for identifying useful candidate biomarkers for the diagnosis and prognosis of chronic disease. Using small RNA sequencing in a longitudinal...
Current detection rates and time-to-detection of all identifiable BRCA carriers in the Greater London population.
Ranjit Manchanda, Oleg Blyuss, Faiza Gaba, Vladimir Sergeevich Gordeev, Chris Jacobs, Matthew Burnell, Carmen Gan, Rohan Taylor, Clare Turnbull, Rosa Legood, Alexey Zaikin, Antonis C Antoniou, Usha Menon, Ian Jacobs
Jun 18, 2018
BACKGROUND: BRCA carrier identification offers opportunities for early diagnoses, targeted treatment and cancer prevention. We evaluate BRCA- carrier detection rates in general and Ashkenazi Jewish (AJ) populations across...
Speech rhythm and language acquisition
Usha Goswami
May 23, 2019
Language lies at the heart of our experience as humans and disorders of language acquisition carry severe developmental costs. Rhythmic processing lies at the heart of language acquisition. Here, I review our understanding of...
A Practitioner's Perspective of Marketing Theory Evolution
The study seeks to explore the history of marketing as a practice and the development of marketing as an academic discipline. The research is set out to decide whether or not marketing theory empowers young marketing...
Published by: IGI Global Scientific Publishing
Language acquisition and speech rhythm patterns
Usha Goswami
Sep 02, 2022
All human infants acquire language, but their brains do not know which language/s to prepare for. This observation suggests that there are fundamental components of the speech signal that contribute to building a language...
Published by: Royal Society open science
Unselected Population Genetic Testing for Personalised Ovarian Cancer Risk Prediction
Faiza Gaba, Samuel Oxley, Xinting Liu, Xin Yang, Dhivya Chandrasekaran, Jatinderpal Kalsi, Antonis Antoniou, Lucy Side, Saskia Sanderson, Jo Waller, Munaza Ahmed, Andrew Wallace, Yvonne Wallis, Usha Menon, Ian Jacobs, Rosa Legood, Dalya Marks, Ranjit Manchanda
Apr 21, 2022
Unselected population-based personalised ovarian cancer (OC) risk assessments combining genetic, epidemiological and hormonal data have not previously been undertaken. We aimed to understand the attitudes, experiences and impact...
Unselected Population Genetic Testing for Personalised Ovarian Cancer Risk Prediction
Faiza Gaba, Samuel Oxley, Xinting Liu, Xin Yang, Dhivya Chandrasekaran, Jatinderpal Kalsi, Antonis Antoniou, Lucy Side, Saskia Sanderson, Jo Waller, Munaza Ahmed, Andrew Wallace, Yvonne Wallis, Usha Menon, Ian Jacobs, Rosa Legood, Dalya Marks, Ranjit Manchanda
Jun 29, 2022
Unselected population-based personalised ovarian cancer (OC) risk assessments combining genetic, epidemiological and hormonal data have not previously been undertaken. We aimed to understand the attitudes, experiences and impact...
Evaluation of polygenic risk scores for ovarian cancer risk prediction in a prospective cohort study.
Xin Yang, Goska Leslie, Aleksandra Gentry-Maharaj, Andy Ryan, Maria Intermaggio, Andrew Lee, Jatinderpal K Kalsi, Jonathan Tyrer, Faiza Gaba, Ranjit Manchanda, Paul DP Pharoah, Simon A Gayther, Susan J Ramus, Ian Jacobs, Usha Menon, Antonis C Antoniou
Jul 23, 2018
BACKGROUND: Genome-wide association studies have identified >30 common SNPs associated with epithelial ovarian cancer (EOC). We evaluated the combined effects of EOC susceptibility SNPs on predicting EOC risk in an independent...
evaluation ovarian cancer polygenic risk scores Prospective cohort study Risk prediction Adult Aged Aged 80 and over Biomarkers Tumor Case-Control Studies Female Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Middle Aged Multifactorial Inheritance Odds Ratio Ovarian Neoplasms Polymorphism Single Nucleotide Risk Assessment Risk Factors
Cost-effectiveness of Population-Based BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2 Mutation Testing in Unselected General Population Women.
Ranjit Manchanda, Shreeya Patel, Vladimir S Gordeev, Antonis C Antoniou, Shantel Smith, Andrew Lee, John L Hopper, Robert J Macinnis, Clare Turnbull, Susan J Ramus, Simon A Gayther, Paul DP Pharoah, Usha Menon, Ian Jacobs, Rosa Legood
Jan 12, 2018
BACKGROUND: The cost-effectiveness of population-based panel testing for high- and moderate-penetrance ovarian cancer (OC)/breast cancer (BC) gene mutations is unknown. We evaluate the cost-effectiveness of population-based...
Adult Aged Aged 80 and over BRCA1 Protein BRCA2 Protein Breast Neoplasms Cost-Benefit Analysis DNA Mutational Analysis Decision Support Techniques Fanconi Anemia Complementation Group N Protein Fanconi Anemia Complementation Group Proteins Female Genetic Testing Humans Incidence Mammography Middle Aged Mutation Ovarian Neoplasms RNA Helicases United Kingdom United States
The role of phase synchronisation between low frequency amplitude modulations in child phonology and morphology speech tasks.
Recent models of the neural encoding of speech suggest a core role for amplitude modulation (AM) structure, particularly regarding AM phase alignment. Accordingly, speech tasks that measure linguistic development in children may...
Population Study of Ovarian Cancer Risk Prediction for Targeted Screening and Prevention
Faiza Gaba, Oleg Blyuss, Xinting Liu, Shivam Goyal, Nishant Lahoti, Dhivya Chandrasekaran, Margarida Kurzer, Jatinderpal Kalsi, Saskia Sanderson, Anne Lanceley, Munaza Ahmed, Lucy Side, Aleksandra Gentry-Maharaj, Yvonne Wallis, Andrew Wallace, Jo Waller, Craig Luccarini, Xin Yang, Joe Dennis, Alison Dunning, Andrew Lee, Antonis C. Antoniou, Rosa Legood, Usha Menon, Ian Jacobs, Ranjit Manchanda
May 16, 2020
Unselected population-based personalised ovarian cancer (OC) risk assessment combining genetic/epidemiology/hormonal data has not previously been undertaken. We aimed to perform a feasibility study of OC risk stratification of...
Population Study of Ovarian Cancer Risk Prediction for Targeted Screening and Prevention.
Faiza Gaba, Oleg Blyuss, Xinting Liu, Shivam Goyal, Nishant Lahoti, Dhivya Chandrasekaran, Margarida Kurzer, Jatinderpal Kalsi, Saskia Sanderson, Anne Lanceley, Munaza Ahmed, Lucy Side, Aleksandra Gentry-Maharaj, Yvonne Wallis, Andrew Wallace, Jo Waller, Craig Luccarini, Xin Yang, Joe Dennis, Alison Dunning, Andrew Lee, Antonis C Antoniou, Rosa Legood, Usha Menon, Ian Jacobs, Ranjit Manchanda
May 12, 2020
UNLABELLED: Unselected population-based personalised ovarian cancer (OC) risk assessment combining genetic/epidemiology/hormonal data has not previously been undertaken. We aimed to perform a feasibility study of OC risk...
Novel word learning deficits in infants at family risk for dyslexia.
Children of reading age diagnosed with dyslexia show deficits in reading and spelling skills, but early markers of later dyslexia are already present in infancy in auditory processing and phonological domains. Deficits in...
Impaired Recognition of Metrical and Syntactic Boundaries in Children with Developmental Language Disorders.
In oral language, syntactic structure is cued in part by phrasal metrical hierarchies of acoustic stress patterns. For example, many children's texts use prosodic phrasing comprising tightly integrated hierarchies of metre and...
The Use of Effective Risk Management in Cloud Computing Projects
Usha Kiran Marichetty
Jan 01, 0001
Project management is one of the most important procedures that promote delivery of services. Examples of such projects include cloud computing projects. Despite the potential benefits associated with cloud computing projects...
Project Management cloud computing and risk management Management Information Systems Management Sciences and Quantitative Methods
Published by: Harrisburg University of Science and Technology
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