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Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine
Bram Peter Prins, Liis Leitsalu, Katri Pärna, Krista Fischer, Andres Metspalu, Toomas Haller, Harold Snieder
Apr 30, 2021
The current paradigm of personalized medicine envisages the use of genomic data to provide predictive information on the health course of an individual with the aim of prevention and individualized care. However, substantial...
Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine
Bram Peter Prins, Liis Leitsalu, Katri Pärna, Krista Fischer, Andres Metspalu, Toomas Haller, Harold Snieder
Jun 04, 2021
The current paradigm of personalized medicine envisages the use of genomic data to provide predictive information on the health course of an individual with the aim of prevention and individualized care. However, substantial...
The Ursinus Weekly, March 17, 1947
Authority to speak on Russian affairs on Wednesday nite Weekend of March 28 to offer full schedule of entertainment Sororities accept 21 bids during rushing week J. Ulmer cast as Mr. Whiteside in spring dramatic production ...
Ursinus College Collegeville Pennsylvania newspaper Michael Karpovitch sororities John Ulmer Curtain Club Model United Nations operetta Edwin M. Fogel pre-medical society A. Maxwell Sharpe French Club Ruby legal society debating club German Club Red Cross May Day pageant Basketball track team baseball Women's Athletic Association Religion in Life Week cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The Ursinus Weekly, June 3, 1946
Jane Rathgeb, Virginia Haller, Dwight Morss, Carol Schoeppe, Nancy Twining, Jane E. Brusch, Joan Wilmot
Jan 01, 0001
Gathering to hear Dr. E. F. Campbell at religious meeting Fogel prize offered for winning essay on Pennsylvania Germans President announces lease of building for housing 100 veterans Temple president to deliver address at...
Ursinus College Collegeville Pennsylvania newspaper student government commencement Robert Johnson Brith Sholom Franklin I. Sheeder Edwin M. Fogel E. Fay Campbell YMCA YWCA Dorothy Derr Marjorie Coy Jacqueline Landis Rosicrucians Ruby student housing Women's Athletic Association Norman Bramall tennis baseball Intramural Sports George Kennedy May Day pageant cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Evaluating genotype imputation pipeline for ultra-low coverage ancient genomes.
Although ancient DNA data have become increasingly more important in studies about past populations, it is often not feasible or practical to obtain high coverage genomes from poorly preserved samples. While methods of accurate...
Computation Provides Chemical Insight into the Diverse Hydride NMR Chemical Shifts of [Ru(NHC)<sub>4</sub>(L)H]<sup>0/+</sup> Species (NHC = N-heterocyclic carbene; L = vacant, H<sub>2</sub>, N<sub>2</sub>, CO, MeCN, O<sub>2</sub>, P<sub>4</sub>, SO<sub>2</sub>, H<sup>-</sup>, F<sup>-</sup> and Cl<sup>-</sup>) and their [Ru(R<sub>2</sub>PCH<sub>2</sub>CH<sub>2</sub>PR<sub>2</sub>)<sub>2</sub>(L)H]<sup>+</sup> Congeners
L J L Haller, Elena Mas-Marza, Mateusz K Cybulski, Rajashekharayya A Sanguramath, Stuart A Macgregor, Mary F Mahon, Christophe Raynaud, Christopher A Russell, Michael K Whittlesey
Mar 07, 2017
Relativistic density functional theory calculations, both with and without the effects of spin–orbit coupling, have been employed to model hydride NMR chemical shifts for a series of [Ru(NHC)4(L)H]0/+ species (NHC =...
Computation Provides Chemical Insight into the Diverse Hydride NMR Chemical Shifts of [Ru(NHC)<sub>4</sub>(L)H]<sup>0/+</sup> Species (NHC = N-heterocyclic carbene; L = vacant, H<sub>2</sub>, N<sub>2</sub>, CO, MeCN, O<sub>2</sub>, P<sub>4</sub>, SO<sub>2</sub>, H<sup>-</sup>, F<sup>-</sup> and Cl<sup>-</sup>) and their [Ru(R<sub>2</sub>PCH<sub>2</sub>CH<sub>2</sub>PR<sub>2</sub>)<sub>2</sub>(L)H]<sup>+</sup> Congeners
L J L Haller, Elena Mas-Marza, Mateusz K Cybulski, Rajashekharayya A Sanguramath, Stuart A Macgregor, Mary F Mahon, Christophe Raynaud, Christopher A Russell, Michael K Whittlesey
Mar 07, 2017
Relativistic density functional theory calculations, both with and without the effects of spin–orbit coupling, have been employed to model hydride NMR chemical shifts for a series of [Ru(NHC)4(L)H]0/+ species (NHC =...
The Genetic Origin of Daunians and the Pan-Mediterranean Southern Italian Iron Age Context.
Serena Aneli, Tina Saupe, Francesco Montinaro, Anu Solnik, Ludovica Molinaro, Cinzia Scaggion, Nicola Carrara, Alessandro Raveane, Toomas Kivisild, Mait Metspalu, Christiana L Scheib, Luca Pagani
Feb 17, 2022
The geographical location and shape of Apulia, a narrow land stretching out in the sea at the South of Italy, made this region a Mediterranean crossroads connecting Western Europe and the Balkans. Such movements culminated at...
An invasive Haemophilus influenzae serotype b infection in an Anglo-Saxon plague victim.
Meriam Guellil, Marcel Keller, Jenna M Dittmar, Sarah A Inskip, Craig Cessford, Anu Solnik, Toomas Kivisild, Mait Metspalu, John E Robb, Christiana L Scheib
Feb 03, 2022
BACKGROUND: The human pathogen Haemophilus influenzae was the main cause of bacterial meningitis in children and a major cause of worldwide infant mortality before the introduction of a vaccine in the 1980s. Although the...
An invasive Haemophilus influenzae serotype b infection in an Anglo-Saxon plague victim.
Meriam Guellil, Marcel Keller, Jenna M Dittmar, Sarah A Inskip, Craig Cessford, Anu Solnik, Toomas Kivisild, Mait Metspalu, John E Robb, Christiana L Scheib
Mar 06, 2022
BACKGROUND: The human pathogen Haemophilus influenzae was the main cause of bacterial meningitis in children and a major cause of worldwide infant mortality before the introduction of a vaccine in the 1980s. Although the...
Rare variant analyses across multiethnic cohorts identify novel genes for refractive error.
Anthony M Musolf, Annechien EG Haarman, Robert N Luben, Jue-Sheng Ong, Karina Patasova, Rolando Hernandez Trapero, Joseph Marsh, Ishika Jain, Riya Jain, Paul Zhiping Wang, Deyana D Lewis, Milly S Tedja, Adriana I Iglesias, Hengtong Li, Cameron S Cowan, Consortium for Refractive Error and Myopia (CREAM), Ginevra Biino, Alison P Klein, Priya Duggal, David A Mackey, Caroline Hayward, Toomas Haller, Andres Metspalu, Juho Wedenoja, Olavi Pärssinen, Ching-Yu Cheng, Seang-Mei Saw, Dwight Stambolian, Pirro G Hysi, Anthony P Khawaja, Veronique Vitart, Christopher J Hammond, Cornelia M van Duijn, Virginie JM Verhoeven, Caroline CW Klaver, Joan E Bailey-Wilson
Feb 09, 2023
Refractive error, measured here as mean spherical equivalent (SER), is a complex eye condition caused by both genetic and environmental factors. Individuals with strong positive or negative values of SER require spectacles or...
The blood metabolome of incident kidney cancer
Florence Guida, Vanessa Y Tan, Laura J Corbin, Karl Smith-Byrne, Karine Alcala, Claudia Langenberg, Isobel D Stewart, Adam S Butterworth, Praveen Surendran, David Achaintre, Jerzy Adamski, Pilar Amiano Exezarreta, Manuela M Bergmann, Caroline J Bull, Christina C Dahm, Audrey Gicquiau, Graham G Giles, Marc J Gunter, Toomas Haller, Arnulf Langhammer, Tricia L Larose, Börje Ljungberg, Andres Metspalu, Roger L Milne, David C Muller, Therese H Nøst, Elin Pettersen Sørgjerd, Cornelia Prehn, Elio Riboli, Sabina Rinaldi, Joseph A Rothwell, Augustin Scalbert, Julie A Schmidt, Gianluca Severi, Sabina Sieri, Roel Vermeulen, Emma E Vincent, Melanie Waldenberger, Nicholas J Timpson, Mattias Johansson
Oct 18, 2021
BACKGROUND: Excess bodyweight and related metabolic perturbations have been implicated in kidney cancer aetiology, but the specific molecular mechanisms underlying these relationships are poorly understood. In this study, we...
Divorcing the Late Upper Palaeolithic demographic histories of mtDNA haplogroups M1 and U6 in Africa.
Erwan Pennarun, Toomas Kivisild, Ene Metspalu, Mait Metspalu, Tuuli Reisberg, Jean-Paul Moisan, Doron M Behar, Sacha C Jones, Richard Villems
Jun 17, 2021
BACKGROUND: A Southwest Asian origin and dispersal to North Africa in the Early Upper Palaeolithic era has been inferred in previous studies for mtDNA haplogroups M1 and U6. Both haplogroups have been proposed to show similar...
The blood metabolome of incident kidney cancer
Florence Guida, Vanessa Y Tan, Laura J Corbin, Karl Smith-Byrne, Karine Alcala, Claudia Langenberg, Isobel D Stewart, Adam S Butterworth, Praveen Surendran, David Achaintre, Jerzy Adamski, Pilar Amiano, Manuela M Bergmann, Caroline J Bull, Christina C Dahm, Audrey Gicquiau, Graham G Giles, Marc J Gunter, Toomas Haller, Arnulf Langhammer, Tricia L Larose, Börje Ljungberg, Andres Metspalu, Roger L Milne, David C Muller, Therese H Nøst, Elin Pettersen Sørgjerd, Cornelia Prehn, Elio Riboli, Sabina Rinaldi, Joseph A Rothwell, Augustin Scalbert, Julie A Schmidt, Gianluca Severi, Sabina Sieri, Roel Vermeulen, Emma E Vincent, Melanie Waldenberger, Nicholas J Timpson, Mattias Johansson
Oct 21, 2021
Background
Excess bodyweight and related metabolic perturbations have been implicated in kidney cancer aetiology, but the specific molecular mechanisms underlying these relationships are poorly understood. In this study...
Published by: PLoS Medicine
The blood metabolome of incident kidney cancer
Florence Guida, Vanessa Y. Tan, Laura J. Corbin, Karl Smith-Byrne, Karine Alcala, Claudia Langenberg, Isobel D. Stewart, Adam S. Butterworth, Praveen Surendran, David Achaintre, Jerzy Adamski, Pilar Amiano, Manuela M. Bergmann, Caroline J. Bull, Christina C. Dahm, Audrey Gicquiau, Graham G. Giles, Marc J. Gunter, Toomas Haller, Arnulf Langhammer, Tricia L. Larose, Börje Ljungberg, Andres Metspalu, Roger L. Milne, David C. Muller, Therese H. Nøst, Elin Pettersen Sørgjerd, Cornelia Prehn, Elio Riboli, Sabina Rinaldi, Joseph A. Rothwell, Augustin Scalbert, Julie A. Schmidt, Gianluca Severi, Sabina Sieri, Roel Vermeulen, Emma E. Vincent, Melanie Waldenberger, Nicholas J. Timpson, Mattias Johansson
Oct 07, 2021
Background: Excess bodyweight and related metabolic perturbations have been implicated in kidney cancer aetiology, but the specific molecular mechanisms underlying these relationships are poorly understood. In this study, we...
Rare variant analyses across multiethnic cohorts identify novel genes for refractive error.
Anthony M Musolf, Annechien EG Haarman, Robert N Luben, Jue-Sheng Ong, Karina Patasova, Rolando Hernandez Trapero, Joseph Marsh, Ishika Jain, Riya Jain, Paul Zhiping Wang, Deyana D Lewis, Milly S Tedja, Adriana I Iglesias, Hengtong Li, Cameron S Cowan, Consortium for Refractive Error and Myopia (CREAM), Ginevra Biino, Alison P Klein, Priya Duggal, David A Mackey, Caroline Hayward, Toomas Haller, Andres Metspalu, Juho Wedenoja, Olavi Pärssinen, Ching-Yu Cheng, Seang-Mei Saw, Dwight Stambolian, Pirro G Hysi, Anthony P Khawaja, Veronique Vitart, Christopher J Hammond, Cornelia M van Duijn, Virginie JM Verhoeven, Caroline CW Klaver, Joan E Bailey-Wilson
Jan 04, 2023
The light skin allele of SLC24A5 in South Asians and Europeans shares identity by descent.
Chandana Basu Mallick, Florin Mircea Iliescu, Märt Möls, Sarah Hill, Rakesh Tamang, Gyaneshwer Chaubey, Rie Goto, Simon YW Ho, Irene Gallego Romero, Federica Crivellaro, Georgi Hudjashov, Niraj Rai, Mait Metspalu, CG Nicholas Mascie-Taylor, Ramasamy Pitchappan, Lalji Singh, Marta Mirazon-Lahr, Kumarasamy Thangaraj, Richard Villems, Toomas Kivisild
Sep 08, 2018
Skin pigmentation is one of the most variable phenotypic traits in humans. A non-synonymous substitution (rs1426654) in the third exon of SLC24A5 accounts for lighter skin in Europeans but not in East Asians. A previous...
Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations.
Christina A Eichstaedt, Luca Pagani, Tiago Antao, Charlotte E Inchley, Alexia Cardona, Alexander Mörseburg, Florian J Clemente, Timothy J Sluckin, Ene Metspalu, Mario Mitt, Reedik Mägi, Georgi Hudjashov, Mait Metspalu, Maru Mormina, Guy S Jacobs, Toomas Kivisild
Mar 21, 2018
The aim of this study is to identify genetic variants that harbour signatures of recent positive selection and may facilitate physiological adaptations to hypobaric hypoxia. To achieve this, we conducted whole genome sequencing...
Phylogeography of mtDNA haplogroup R7 in the Indian peninsula.
Gyaneshwer Chaubey, Monika Karmin, Ene Metspalu, Mait Metspalu, Deepa Selvi-Rani, Vijay Kumar Singh, Jüri Parik, Anu Solnik, B Prathap Naidu, Ajay Kumar, Niharika Adarsh, Chandana Basu Mallick, Bhargav Trivedi, Swami Prakash, Ramesh Reddy, Parul Shukla, Sanjana Bhagat, Swati Verma, Samiksha Vasnik, Imran Khan, Anshu Barwa, Dipti Sahoo, Archana Sharma, Mamoon Rashid, Vishal Chandra, Alla G Reddy, Antonio Torroni, Robert A Foley, Kumarasamy Thangaraj, Lalji Singh, Toomas Kivisild, Richard Villems
Jun 14, 2011
"Like sugar in milk"
Gyaneshwer Chaubey, Qasim Ayub, Niraj Rai, Satya Prakash, Veena Mushrif-Tripathy, Massimo Mezzavilla, Ajai Kumar Pathak, Rakesh Tamang, Sadaf Firasat, Maere Reidla, Monika Karmin, Deepa Selvi Rani, Alla G Reddy, Jüri Parik, Ene Metspalu, Siiri Rootsi, Kurush Dalal, Shagufta Khaliq, Syed Qasim Mehdi, Lalji Singh, Mait Metspalu, Toomas Kivisild, Chris Tyler-Smith, Richard Villems, Kumarasamy Thangaraj
Nov 21, 2018
BACKGROUND: The Parsis are one of the smallest religious communities in the world. To understand the population structure and demographic history of this group in detail, we analyzed Indian and Pakistani Parsi populations using...
A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations.
Florian J Clemente, Alexia Cardona, Charlotte E Inchley, Benjamin M Peter, Guy Jacobs, Luca Pagani, Daniel J Lawson, Tiago Antão, Mário Vicente, Mario Mitt, Michael DeGiorgio, Zuzana Faltyskova, Yali Xue, Qasim Ayub, Michal Szpak, Reedik Mägi, Anders Eriksson, Andrea Manica, Maanasa Raghavan, Morten Rasmussen, Simon Rasmussen, Eske Willerslev, Antonio Vidal-Puig, Chris Tyler-Smith, Richard Villems, Rasmus Nielsen, Mait Metspalu, Boris Malyarchuk, Miroslava Derenko, Toomas Kivisild
Nov 12, 2014
The Arrival of Siberian Ancestry Connecting the Eastern Baltic to Uralic Speakers further East.
Lehti Saag, Margot Laneman, Liivi Varul, Martin Malve, Heiki Valk, Maria A Razzak, Ivan G Shirobokov, Valeri I Khartanovich, Elena R Mikhaylova, Alena Kushniarevich, Christiana Lyn Scheib, Anu Solnik, Tuuli Reisberg, Jüri Parik, Lauri Saag, Ene Metspalu, Siiri Rootsi, Francesco Montinaro, Maido Remm, Reedik Mägi, Eugenia D'Atanasio, Enrico Ryunosuke Crema, David Díez-Del-Molino, Mark G Thomas, Aivar Kriiska, Toomas Kivisild, Richard Villems, Valter Lang, Mait Metspalu, Kristiina Tambets
May 03, 2019
In this study, we compare the genetic ancestry of individuals from two as yet genetically unstudied cultural traditions in Estonia in the context of available modern and ancient datasets: 15 from the Late Bronze Age stone-cist...
Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila.
Juan D Matute, Jinzhi Duan, Magdalena B Flak, Paul Griebel, Jose A Tascon-Arcila, Shauni Doms, Thomas Hanley, Agne Antanaviciute, Jennifer Gundrum, Jessica L Mark Welch, Brandon Sit, Shabnam Abtahi, Gwenny M Fuhler, Joep Grootjans, Florian Tran, Stephanie T Stengel, James R White, Niklas Krupka, Dirk Haller, Simon Clare, Trevor D Lawley, Arthur Kaser, Alison Simmons, Jonathan N Glickman, Lynn Bry, Philip Rosenstiel, Gary Borisy, Matthew K Waldor, John F Baines, Jerrold R Turner, Richard S Blumberg
Dec 23, 2022
Published by: J Exp Med
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