Search
Results: 78
Regulation of regulatory T cells in cancer.
The inflammatory response to transformed cells forms the cornerstone of natural or therapeutically induced protective immunity to cancer. Regulatory T (Treg) cells are known for their critical role in suppressing inflammation...
Group 2 innate lymphocytes at the interface between innate and adaptive immunity.
Group 2 innate lymphoid cells (ILC2) are innate immune cells that respond rapidly to their environment through soluble inflammatory mediators and cell-to-cell interactions. As tissue-resident sentinels, ILC2 help orchestrate...
ILC2 T helper cells TH2 innate lymphoid cells type 2 response Adaptive Immunity Animals Cell Differentiation Cytokines Hormones Humans Immunity Innate Interleukins Lipids Lymphocyte Activation Lymphocyte Subsets Mice Models Immunological Neuroimmunomodulation Organ Specificity Receptors Immunologic Thymic Stromal Lymphopoietin
Context Dependent Role of Type 2 Innate Lymphoid Cells in Allergic Skin Inflammation.
David A Rafei-Shamsabadi, Christoph SN Klose, Timotheus YF Halim, Yakup Tanriver, Thilo Jakob
Jan 09, 2020
The discovery of innate lymphoid cells (ILC) has profoundly influenced the understanding of innate and adaptive immune crosstalk in health and disease. ILC and T cells share developmental and functional characteristics such as...
Lack of Type 2 Innate Lymphoid Cells Promotes a Type I-Driven Enhanced Immune Response in Contact Hypersensitivity.
David A Rafei-Shamsabadi, Saskia van de Poel, Britta Dorn, Stefanie Kunz, Stefan F Martin, Christoph SN Klose, Sebastian J Arnold, Yakup Tanriver, Karolina Ebert, Andreas Diefenbach, Timotheus YF Halim, Andrew NJ McKenzie, Thilo Jakob
Sep 05, 2018
Allergic contact dermatitis and its animal model, contact hypersensitivity, are T-cell-mediated inflammatory skin diseases that require activation of the innate immune system. Here we investigate the role of innate lymphoid...
Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance.
Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells.
Early Neutrophilia Marked by Aerobic Glycolysis Sustains Host Metabolism and Delays Cancer Cachexia.
Michele Petruzzelli, Miriam Ferrer, Martijn J Schuijs, Sam O Kleeman, Nicholas Mourikis, Zoe Hall, David Perera, Shwethaa Raghunathan, Michele Vacca, Edoardo Gaude, Michael J Lukey, Duncan I Jodrell, Christian Frezza, Erwin F Wagner, Ashok R Venkitaraman, Timotheus YF Halim, Tobias Janowitz
Feb 17, 2022
An elevated neutrophil-lymphocyte ratio negatively predicts the outcome of patients with cancer and is associated with cachexia, the terminal wasting syndrome. Here, using murine model systems of colorectal and pancreatic cancer...
Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors.
Karsten Bach, Sara Pensa, Marija Zarocsinceva, Katarzyna Kania, Julie Stockis, Silvain Pinaud, Kyren A Lazarus, Mona Shehata, Bruno M Simões, Alice R Greenhalgh, Sacha J Howell, Robert B Clarke, Carlos Caldas, Timotheus YF Halim, John C Marioni, Walid T Khaled
Feb 12, 2021
It is unclear how genetic aberrations impact the state of nascent tumour cells and their microenvironment. BRCA1 driven triple negative breast cancer (TNBC) has been shown to arise from luminal progenitors yet little is known...
Context Dependent Role of Type 2 Innate Lymphoid Cells in Allergic Skin Inflammation.
David A Rafei-Shamsabadi, Christoph S N Klose, Timotheus Y F Halim, Yakup Tanriver, Thilo Jakob
Jan 03, 2020
The discovery of innate lymphoid cells (ILC) has profoundly influenced the understanding of innate and adaptive immune crosstalk in health and disease. ILC and T cells share developmental and functional characteristics such as...
Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors
Karsten Bach, Sara Pensa, Marija Zarocsinceva, Katarzyna Kania, Julie Stockis, Silvain Pinaud, Kyren A. Lazarus, Mona Shehata, Bruno M. Simões, Alice R. Greenhalgh, Sacha J. Howell, Robert B. Clarke, Carlos Caldas, Timotheus Y. F. Halim, John C. Marioni, Walid T. Khaled
Mar 09, 2021
Abstract: It is unclear how genetic aberrations impact the state of nascent tumour cells and their microenvironment. BRCA1 driven triple negative breast cancer (TNBC) has been shown to arise from luminal progenitors yet little...
G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program.
Frann Antignano, Mitchell Braam, Michael R Hughes, Alistair L Chenery, Kyle Burrows, Matthew J Gold, Menno J Oudhoff, David Rattray, Timotheus Y Halim, Alissa Cait, Fumio Takei, Fabio M Rossi, Kelly M McNagny, Colby Zaph
Mar 27, 2018
Innate lymphoid cells (ILCs) are emerging as important regulators of homeostatic and disease-associated immune processes. Despite recent advances in defining the molecular pathways that control development and function of ILCs...
Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits.
Carly E Whyte, Kailash Singh, Oliver T Burton, Meryem Aloulou, Lubna Kouser, Rafael Valente Veiga, Amy Dashwood, Hanneke Okkenhaug, Samira Benadda, Alena Moudra, Orian Bricard, Stephanie Lienart, Pascal Bielefeld, Carlos P Roca, Francisco José Naranjo-Galindo, Félix Lombard-Vadnais, Steffie Junius, David Bending, Masahiro Ono, Tino Hochepied, Timotheus YF Halim, Susan Schlenner, Sylvie Lesage, James Dooley, Adrian Liston
Jul 15, 2022
Free energy pathways of a multistable liquid crystal device
The planar bistable device [Tsakonas et al., Appl. Phys. Lett., 2007, 90, 111913] is known to have two distinct classes of stable equilibria: the diagonal and rotated solutions. We model this device within the two-dimensional...
Free energy pathways of a multistable liquid crystal device
The planar bistable device [Tsakonas et al., Appl. Phys. Lett., 2007, 90, 111913] is known to have two distinct classes of stable equilibria: the diagonal and rotated solutions. We model this device within the two-dimensional...
Governance of Autonomous Agents on the Web
Timotheus Kampik, Adnane Mansour, Olivier Boissier, Sabrina Kirrane, Julian Padget, Terry Payne, Muninder Singh, Valentina Tamma, Antoine Zimmerman
Nov 30, 2022
The study of autonomous agents has a long tradition in the Multiagent System and the Semantic Web communities, with applications ranging from automating business processes to personal assistants. More recently, the Web of Things...
Arabic Authorship Attribution Using Synthetic Minority Over-Sampling Technique and Principal Components Analysis for Imbalanced Documents
Nowadays, dealing with imbalanced data represents a great challenge in data mining as well as in machine learning task. In this investigation, we are interested in the problem of class imbalance in Authorship Attribution (AA)...
Published by: IGI Global Scientific Publishing
Governance of Autonomous Agents on the Web
Timotheus Kampik, Adnane Mansour, Olivier Boissier, Sabrina Kirrane, Julian Padget, Terry Payne, Muninder Singh, Valentina Tamma, Antoine Zimmerman
Nov 30, 2022
The study of autonomous agents has a long tradition in the Multiagent System and the Semantic Web communities, with applications ranging from automating business processes to personal assistants. More recently, the Web of Things...
The Utilization of Social Media by Small and Medium Food Vendors in Brunei Darussalam
Meryeme Bouargan, Rabi'atul Halim, Nuruljannah Husaini, Nor Jusniah, Nur Ahmad, Mohammad Almunawar
Jan 01, 2020
This research examines the factors that contribute to the utilization of social media by the small and medium-sized enterprises (SMEs) operating in the food industry in Brunei Darussalam. It also investigates how social media...
Published by: IGI Global Scientific Publishing
Mixed-linker approach in designing porous zirconium-based metal-organic frameworks with high hydrogen storage capacity
Ayesha Naeem, Valeska P Ting, Ulrich Hintermair, Mi Tian, Richard Telford, Saaiba Halim, Harriott Nowell, Małgorzata Hołyńska, Simon J Teat, Ian J Scowen, Sanjit Nayak
Jun 25, 2016
Three highly porous Zr(iv)-based metal-organic frameworks, UBMOF-8, UBMOF-9, and UBMOF-31, were synthesized by using 2,2'-diamino-4,4'-stilbenedicarboxylic acid, 4,4'-stilbenedicarboxylic acid, and combination of both...
Mixed-linker approach in designing porous zirconium-based metal-organic frameworks with high hydrogen storage capacity
Ayesha Naeem, Valeska P Ting, Ulrich Hintermair, Mi Tian, Richard Telford, Saaiba Halim, Harriott Nowell, Małgorzata Hołyńska, Simon J Teat, Ian J Scowen, Sanjit Nayak
Jun 25, 2016
Three highly porous Zr(iv)-based metal-organic frameworks, UBMOF-8, UBMOF-9, and UBMOF-31, were synthesized by using 2,2'-diamino-4,4'-stilbenedicarboxylic acid, 4,4'-stilbenedicarboxylic acid, and combination of both...
Greater variability in lipid measurements associated with cardiovascular disease and mortality
Eric YF Wan, Esther YT Yu, Weng Y Chin, Jessica K Barrett, Anna HY Mok, Christie ST Lau, Yuan Wang, Ian CK Wong, Esther WY Chan, Cindy LK Lam
Jun 05, 2020
AIM: To examine the associations between variability in lipids and the risk of cardiovascular disease (CVD) and mortality in patients with type 2 diabetes based on low-density lipoprotein-cholesterol (LDL-C), the total...
Novel Insights Into Rheumatoid Arthritis Through Characterization of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients With Differing Numbers of Swollen Joints.
Andrew YF Li Yim, Enrico Ferrero, Klio Maratou, Huw D Lewis, George Royal, David F Tough, Chris Larminie, Marcel MAM Mannens, Peter Henneman, Wouter J de Jonge, Marleen GH van de Sande, Danielle M Gerlag, Rab K Prinjha, Paul P Tak
May 06, 2021
In this study, we sought to characterize synovial tissue obtained from individuals with arthralgia and disease-specific auto-antibodies and patients with established rheumatoid arthritis (RA), by applying an integrative...
DNA Methylation Arthralgia multi-omics analyses rheumatoid arthritis synovial biopsies target identification transcriptomics Adult Aged Aged 80 and over Arthralgia Arthritis Rheumatoid Arthroscopy Biopsy DNA Methylation Epigenesis Genetic Female Humans Male Middle Aged RNA-seq Severity of Illness Index Synovial Membrane whole genome sequencing Young Adult
Integration of copy number and transcriptomics provides risk stratification in prostate cancer
H Ross-Adams, AD Lamb, MJ Dunning, S Halim, J Lindberg, CM Massie, LA Egevad, R Russell, A Ramos-Montoya, SL Vowler, NL Sharma, J Kay, H Whitaker, J Clark, R Hurst, VJ Gnanapragasam, NC Shah, AY Warren, CS Cooper, AG Lynch, R Stark, IG Mills, H Grönberg, DE Neal, CamCaP Study Group
Jul 21, 2015
Biochemical relapse Gene signature Genomics Personalised medicine Prognosis prostate cancer Risk stratification Adult Aged Aged 80 and over Cluster Analysis Cohort Studies Gene Dosage Gene Expression Profiling Gene Expression Regulation Neoplastic Genome Human Humans Male Middle Aged Prognosis Prostatic Neoplasms RNA Messenger Recurrence Reproducibility of Results Risk Factors Transcriptome
|
|< |
< |
1 |