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The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.
Han Seok Koh, Chi Young Chang, Sae-Bom Jeon, Hee Jung Yoon, Ye-Hyeon Ahn, Hyung-Seok Kim, In-Hoo Kim, Sung Ho Jeon, Randall S Johnson, Eun Jung Park
Mar 13, 2020
Inflammation is closely related to the extent of damage following cerebral ischaemia, and the targeting of this inflammation has emerged as a promising therapeutic strategy. Here, we present that hypoxia-induced glial T-cell...
Animals Astrocytes Brain Carotid Artery Common Cell Movement Cells Cultured Hepatitis A Virus Cellular Receptor 2 Hypoxia-Inducible Factor 1 alpha Subunit Hypoxia-Ischemia Brain Immunohistochemistry In Vitro Techniques Inflammation Ligation Magnetic Resonance Imaging Mesencephalon Mice Microglia Neuroglia Neutrophils RNA Messenger Receptors Virus Reverse Transcriptase Polymerase Chain Reaction
IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients
R Tallerico, CM Cristiani, E Staaf, C Garofalo, R Sottile, M Capone, Y Pico de Coaña, G Madonna, E Palella, M Wolodarski, V Carannante, D Mallardo, E Simeone, AM Grimaldi, S Johansson, P Frumento, E Gulletta, A Anichini, F Colucci, G Ciliberto, R Kiessling, K Kärre, PA Ascierto, E Carbone
Jul 20, 2017
Despite the success of immune checkpoint blockade in melanoma, the majority of patients do not respond. We hypothesized that the T and NK cell subset frequencies and expression levels of their receptors may predict responses and...
Governor Appoints Don Long and Tim Hopkins to Winthrop Board of Trustees
Winthrop University
Jan 01, 0001
Don Long of Lake Wylie will fill the appointee slot held by Tommy Pope, who was elected to the S.C. House of Representatives in November and had to resign. Tim Hopkins, an executive director of elementary education in the...
Published by: Winthrop University
Dr. Loades and Prof. Reynolds Reply
It is heartening to see that our rapid systematic review1 is stimulating others to highlight the needs of particular subsets of vulnerable children and adolescents. We found evidence that loneliness in children and...
Dr. Loades and Prof. Reynolds Reply
It is heartening to see that our rapid systematic review1 is stimulating others to highlight the needs of particular subsets of vulnerable children and adolescents. We found evidence that loneliness in children and...
Psychology Professor Tim Daugherty Elected as New Chair of Faculty Conference
Winthrop University
Jan 01, 0001
Tim Daugherty, an associate professor of psychology in the College of Arts and Sciences, will replace Marilyn Smith, a professor of business administration who has served since 2002. He will become the faculty chair in July...
Published by: Winthrop University
Numerical investigation of laboratory tested cross-flow tidal turbines and Reynolds number scaling
The cross-flow, or vertical axis tidal turbine, is a prominent configuration of marine renewable energy device aimed at converting tidal currents into electrical energy. This paper highlights the hydrodynamic limitations of...
Numerical investigation of laboratory tested cross-flow tidal turbines and Reynolds number scaling
The cross-flow, or vertical axis tidal turbine, is a prominent configuration of marine renewable energy device aimed at converting tidal currents into electrical energy. This paper highlights the hydrodynamic limitations of...
How Do Magnetic Field Models Affect Astrophysical Limits on Light Axion-like Particles? An X-Ray Case Study with NGC 1275
Axion-like particles (ALPs) are a well-motivated extension to the standard
model of particle physics, and X-ray observations of cluster-hosted AGN
currently place the most stringent constraints on the ALP coupling...
How Do Magnetic Field Models Affect Astrophysical Limits on Light Axion-like Particles? An X-Ray Case Study with NGC 1275
James H. Matthews, Christopher S. Reynolds, M. C. David Marsh, Júlia Sisk-Reynés, Payton E. Rodman
May 09, 2022
Abstract: Axion-like particles (ALPs) are a well-motivated extension to the standard model of particle physics, and X-ray observations of cluster-hosted AGN currently place the most stringent constraints on the ALP coupling to...
Infant Mortality and Working-Class Child Care, 1850-1899. By Melanie Reynolds
A Reid
Mar 07, 2017
This book sets out to prove that nineteenth-century working class women were not always bad mothers. For the volume, Reynolds scoured an enormous volume of contemporary reports, newspaper and journal articles, and other sources...
Translating student evaluation of teaching
Student evaluation of teaching (SET) has not yet been studied historically and comparatively. Based on our interviews with professors and administrators at 18 universities in three countries, we discuss how SET diffused in all...
Aerodynamics of biplane and tandem wings at low Reynolds numbers
Experiments were performed to investigate the aerodynamic characteristics of two-wing configurations at a low Reynolds number of 100,000. The wing models were rectangular flat plates with a semi-aspect ratio of two. The stagger...
Aerodynamics of biplane and tandem wings at low Reynolds numbers
Experiments were performed to investigate the aerodynamic characteristics of two-wing configurations at a low Reynolds number of 100,000. The wing models were rectangular flat plates with a semi-aspect ratio of two. The stagger...
Translating student evaluation of teaching
Student evaluation of teaching (SET) has not yet been studied historically and comparatively. Based on our interviews with professors and administrators at 18 universities in three countries, we discuss how SET diffused in all...
Numerical modelling of unsteady turbulent flow in tubes, including the effects of roughness and large changes in Reynolds number
David Nigel Johnston
Aug 01, 2011
A method has been developed for predicting unsteady turbulent friction in smooth, transitional and rough pipe flow. For transitional and rough pipe flow the effective viscosity at the wall is varied depending on Reynolds number...
Lift enhancement by means of small-amplitude airfoil oscillations at low Reynolds numbers
Force and particle image velocimetry measurements were conducted on a NACA 0012 airfoil undergoing small-amplitude sinusoidal plunge oscillations at a poststall angle of attack and Reynolds number of 10,000. With increasing...
Investigating the Impact of Crohn's Disease on the Bioaccessibility of a Lipid-Based Formulation with an in Vitro Dynamic Gastrointestinal Model
Angela Effinger, Mark McAllister, Irena Tomaszewska, Caitriona M. O'Driscoll, Mark Taylor, Steve Gomersall, James Heaton, Kieran L. Smith, Inese Sarcevica, Sam L. Young, Nikoletta Fotaki
Apr 05, 2021
The aim of the study was to investigate the impact of Crohn's disease (CD) on the performance of a lipid-based formulation of ciprofloxacin in a complex gastrointestinal simulator (TIM-1, TNO) and to compare the luminal...
Investigating the Impact of Crohn's Disease on the Bioaccessibility of a Lipid-Based Formulation with an in Vitro Dynamic Gastrointestinal Model
Angela Effinger, Mark McAllister, Irena Tomaszewska, Caitriona M. O'Driscoll, Mark Taylor, Steve Gomersall, James Heaton, Kieran L. Smith, Inese Sarcevica, Sam L. Young, Nikoletta Fotaki
Apr 05, 2021
The aim of the study was to investigate the impact of Crohn's disease (CD) on the performance of a lipid-based formulation of ciprofloxacin in a complex gastrointestinal simulator (TIM-1, TNO) and to compare the luminal...
Factors Influencing Intention to Use Online Consumer Reviews
Online consumer reviews have been shown to play an important role that can influence consumers' attitudes, behaviors, and purchasing decisions. This study seeks to understand factors that affect user intention to use online...
Published by: IGI Global Scientific Publishing
Lift enhancement by means of small-amplitude airfoil oscillations at low Reynolds numbers
Force and particle image velocimetry measurements were conducted on a NACA 0012 airfoil undergoing small-amplitude sinusoidal plunge oscillations at a poststall angle of attack and Reynolds number of 10,000. With increasing...
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