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The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.
Han Seok Koh, Chi Young Chang, Sae-Bom Jeon, Hee Jung Yoon, Ye-Hyeon Ahn, Hyung-Seok Kim, In-Hoo Kim, Sung Ho Jeon, Randall S Johnson, Eun Jung Park
Mar 13, 2020
Inflammation is closely related to the extent of damage following cerebral ischaemia, and the targeting of this inflammation has emerged as a promising therapeutic strategy. Here, we present that hypoxia-induced glial T-cell...
Animals Astrocytes Brain Carotid Artery Common Cell Movement Cells Cultured Hepatitis A Virus Cellular Receptor 2 Hypoxia-Inducible Factor 1 alpha Subunit Hypoxia-Ischemia Brain Immunohistochemistry In Vitro Techniques Inflammation Ligation Magnetic Resonance Imaging Mesencephalon Mice Microglia Neuroglia Neutrophils RNA Messenger Receptors Virus Reverse Transcriptase Polymerase Chain Reaction
IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients
R Tallerico, CM Cristiani, E Staaf, C Garofalo, R Sottile, M Capone, Y Pico de Coaña, G Madonna, E Palella, M Wolodarski, V Carannante, D Mallardo, E Simeone, AM Grimaldi, S Johansson, P Frumento, E Gulletta, A Anichini, F Colucci, G Ciliberto, R Kiessling, K Kärre, PA Ascierto, E Carbone
Jul 20, 2017
Despite the success of immune checkpoint blockade in melanoma, the majority of patients do not respond. We hypothesized that the T and NK cell subset frequencies and expression levels of their receptors may predict responses and...
Governor Appoints Don Long and Tim Hopkins to Winthrop Board of Trustees
Winthrop University
Jan 01, 0001
Don Long of Lake Wylie will fill the appointee slot held by Tommy Pope, who was elected to the S.C. House of Representatives in November and had to resign. Tim Hopkins, an executive director of elementary education in the...
Published by: Winthrop University
Complete Assembly of Escherichia coli Sequence Type 131 Genomes Using Long Reads Demonstrates Antibiotic Resistance Gene Variation within Diverse Plasmid and Chromosomal Contexts.
Arun Gonzales Decano, Catherine Ludden, Theresa Feltwell, Kim Judge, Julian Parkhill, Tim Downing
Jul 25, 2019
The incidence of infections caused by extraintestinal Escherichia coli (ExPEC) is rising globally, which is a major public health concern. ExPEC strains that are resistant to antimicrobials have been associated with excess...
Psychology Professor Tim Daugherty Elected as New Chair of Faculty Conference
Winthrop University
Jan 01, 0001
Tim Daugherty, an associate professor of psychology in the College of Arts and Sciences, will replace Marilyn Smith, a professor of business administration who has served since 2002. He will become the faculty chair in July...
Published by: Winthrop University
Genomic surveillance of Escherichia coli ST131 identifies local expansion and serial replacement of subclones.
Catherine Ludden, Arun Gonzales Decano, Dorota Jamrozy, Derek Pickard, Dearbhaile Morris, Julian Parkhill, Sharon J Peacock, Martin Cormican, Tim Downing
Mar 10, 2020
Escherichia coli sequence type 131 (ST131) is a pandemic clone that is evolving rapidly with increasing levels of antimicrobial resistance. Here, we investigated an outbreak of E. coli ST131 producing extended spectrum...
Translating student evaluation of teaching
Student evaluation of teaching (SET) has not yet been studied historically and comparatively. Based on our interviews with professors and administrators at 18 universities in three countries, we discuss how SET diffused in all...
Translating student evaluation of teaching
Student evaluation of teaching (SET) has not yet been studied historically and comparatively. Based on our interviews with professors and administrators at 18 universities in three countries, we discuss how SET diffused in all...
Searching for doppelgängers
© The Institution of Engineering and Technology 2016. The authors generated 316,250 entire distributions of IrisCode impostor scores, each distribution obtained by comparing one iris against hundreds of thousands of others in a...
Estimating the prevalence of problem drug use from drug-related mortality data.
Hayley E Jones, Ross J Harris, Beatrice C Downing, Matthias Pierce, Tim Millar, AE Ades, Nicky J Welton, Anne M Presanis, Daniela De Angelis, Matthew Hickman
Aug 26, 2020
BACKGROUND AND AIMS: Indirect estimation methods are required for estimating the size of populations where only a proportion of individuals are observed directly, such as problem drug users (PDUs). Capture-recapture and...
Optimising seismic imaging design parameters via bilevel learning
Full waveform inversion (FWI) is a standard algorithm in seismic imaging. It solves the inverse problem of computing a model of the physical properties of the earth’s subsurface by minimising the misfit between actual...
Optimising seismic imaging design parameters via bilevel learning
Full waveform inversion (FWI) is a standard algorithm in seismic imaging. It solves the inverse problem of computing a model of the physical properties of the earth’s subsurface by minimising the misfit between actual...
Investigating the Impact of Crohn's Disease on the Bioaccessibility of a Lipid-Based Formulation with an in Vitro Dynamic Gastrointestinal Model
Angela Effinger, Mark McAllister, Irena Tomaszewska, Caitriona M. O'Driscoll, Mark Taylor, Steve Gomersall, James Heaton, Kieran L. Smith, Inese Sarcevica, Sam L. Young, Nikoletta Fotaki
Apr 05, 2021
The aim of the study was to investigate the impact of Crohn's disease (CD) on the performance of a lipid-based formulation of ciprofloxacin in a complex gastrointestinal simulator (TIM-1, TNO) and to compare the luminal...
Investigating the Impact of Crohn's Disease on the Bioaccessibility of a Lipid-Based Formulation with an in Vitro Dynamic Gastrointestinal Model
Angela Effinger, Mark McAllister, Irena Tomaszewska, Caitriona M. O'Driscoll, Mark Taylor, Steve Gomersall, James Heaton, Kieran L. Smith, Inese Sarcevica, Sam L. Young, Nikoletta Fotaki
Apr 05, 2021
The aim of the study was to investigate the impact of Crohn's disease (CD) on the performance of a lipid-based formulation of ciprofloxacin in a complex gastrointestinal simulator (TIM-1, TNO) and to compare the luminal...
Factors Influencing Intention to Use Online Consumer Reviews
Online consumer reviews have been shown to play an important role that can influence consumers' attitudes, behaviors, and purchasing decisions. This study seeks to understand factors that affect user intention to use online...
Published by: IGI Global Scientific Publishing
Greenville Event Planned for Alumni Association's New President
Winthrop University
Jan 01, 0001
Magee, a Greenville, S.C., resident, replaces Tim Hopkins who was recently appointed to the Winthrop Board of Trustees as a designee for S.C. Governor Nikki Haley. The Alumni Association will host a reception welcoming Magee in...
Published by: Winthrop University
AUTHOR BOOK TALK
The Rockefeller University
Jan 01, 0001
Tim M. Berra: Wallace's Acceptance of Darwin's Priority in His Own Words
Published by: The Rockefeller University
Prism adaptation does not alter configural processing of faces
Patients with hemispatial neglect ('neglect') following a brain lesion show difficulty responding or orienting to objects and events on the left side of space. Substantial evidence supports the use of a sensorimotor training...
Interventions to increase physical activity in children 0-5 years old
OBJECTIVE: The objective of the study is to evaluate the effectiveness of interventions to increase physical activity (PA) in 0-5 year olds and to determine what works, for whom, in what circumstances. DESIGN: Systematic review...
Two New Board Members Added to Winthrop Board of Trustees
Winthrop University
Jan 01, 0001
Tommy Pope and Tim Sease will join the Winthrop Board of Trustees in July. Pope has law enforcement and courtroom experience, while Sease oversees an investment company.
Published by: Winthrop University
American Party Event on Sept. 30 Features Co-Founder and U.S. Senate Candidate
Winthrop University
Jan 01, 0001
Jill Bossi of Tega Cay, South Carolina, is running for the U.S. Senate seat held by Tim Scott. Jim Rex, one of the American Party founders and a former S.C. education superintendent, will talk about creation of the party and...
Published by: Winthrop University
Prism adaptation does not alter configural processing of faces
Patients with hemispatial neglect ('neglect') following a brain lesion show difficulty responding or orienting to objects and events on the left side of space. Substantial evidence supports the use of a sensorimotor training...
A Comparative Study of Trust in Mobile Banking
With the rapid growth of mobile phone usage, mobile services have influenced many industries including banking. Mobile banking has become a popular service as it offers a convenient channel for customers to perform banking...
Published by: IGI Global Scientific Publishing
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