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Parasite-derived microRNAs in host serum as novel biomarkers of helminth infection.
Anna M Hoy, Rachel J Lundie, Alasdair Ivens, Juan F Quintana, Norman Nausch, Thorsten Forster, Frances Jones, Narcis B Kabatereine, David W Dunne, Francisca Mutapi, Andrew S MacDonald, Amy H Buck
May 20, 2021
BACKGROUND: MicroRNAs (miRNAs) are a class of short non-coding RNA that play important roles in disease processes in animals and are present in a highly stable cell-free form in body fluids. Here, we examine the capacity of host...
INTERFEROME
INTERFEROME is an open access database of types I, II and III Interferon regulated genes (http://www.interferome.org) collected from analysing expression data sets of cells treated with IFNs. This database of interferon...
High concentrations of morphine sensitize and activate mouse dorsal root ganglia via TRPV1 and TRPA1 receptors.
BACKGROUND: Morphine and its derivatives are key drugs in pain control. Despite its well-known analgesic properties morphine at high concentrations may be proalgesic. Particularly, short-lasting painful sensations have been...
Acrolein Animals Bradykinin Calcitonin Gene-Related Peptide Calcium Signaling Capsaicin Dose-Response Relationship Drug Extremities Ganglia Spinal Hot Temperature Humans Ion Channel Gating Mice Morphine Naloxone Neurons Skin TRPA1 Cation Channel TRPV Cation Channels Transient Receptor Potential Channels
Innovation in low carbon construction technologies
Purpose – The purpose of this paper is to evaluate the risks of building defects associated with rapid advancement of “green” construction technologies. It identifies the methods adopted by the sector for the determination of...
Diagnosing cancer in patients with 'non-alarm' symptoms
Efforts to improve cancer outcomes have led to the introduction of policies to enable ‘fast-track’ referrals from primary to secondary care for patients with possible cancer. Although these schemes, also known as ‘two-week-wait’...
An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway.
Kevin A Robertson, Wei Yuan Hsieh, Thorsten Forster, Mathieu Blanc, Hongjin Lu, Peter J Crick, Eylan Yutuc, Steven Watterson, Kimberly Martin, Samantha J Griffiths, Anton J Enright, Mami Yamamoto, Madapura M Pradeepa, Kimberly A Lennox, Mark A Behlke, Simon Talbot, Jürgen Haas, Lars Dölken, William J Griffiths, Yuqin Wang, Ana Angulo, Peter Ghazal
Nov 17, 2017
In invertebrates, small interfering RNAs are at the vanguard of cell-autonomous antiviral immunity. In contrast, antiviral mechanisms initiated by interferon (IFN) signaling predominate in mammals. Whilst mammalian IFN-induced...
Stage IV Colorectal Cancer Patients with High Risk Mutation Profiles Survived 16 Months Longer with Individualized Therapies.
Alexander Hendricks, Anu Amallraja, Tobias Meißner, Peter Forster, Philip Rosenstiel, Greta Burmeister, Clemens Schafmayer, Andre Franke, Sebastian Hinz, Michael Forster, Casey B Williams
Feb 09, 2020
Personalized treatment vs. standard of care is much debated, especially in clinical practice. Here we investigated whether overall survival differences in metastatic colorectal cancer patients are explained by tumor mutation...
Development of a virtual sensor for the comparison of heat partitions in milling under cryogenic cooling lubrication and high-pressure cutting fluid supply
Thorsten Augspurger, Matthias Koch, Thomas Lakner, Andrea De Bartolomeis, Alborz Shokrani, Thomas Bergs
Nov 30, 2021
Manufacturing high precision and high performance parts in aerospace, automotive and medical industries often requires machining of difficult-to-cut materials such as titanium, nickel and hardened alloyed steel alloys. Low...
The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification.
The precise relationship of embryonic stem cells (ESCs) to cells in the mouse embryo remains controversial. We present transcriptional and functional data to identify the embryonic counterpart of ESCs. Marker profiling shows...
Animals Biomarkers Blastocyst Inner Cell Mass Cell Differentiation Cell Line Cell Lineage Cell Proliferation Clone Cells Embryo Culture Techniques Embryo Implantation Embryonic Stem Cells Extracellular Signal-Regulated MAP Kinases Gene Expression Profiling Gene Expression Regulation Developmental Germ Layers Gestational Age Laminin Mice Mice 129 Strain Mice Inbred C57BL Mice Inbred CBA Phenotype Pluripotent Stem Cells Transcription Factors
Innovation in low carbon construction technologies
Purpose – The purpose of this paper is to evaluate the risks of building defects associated with rapid advancement of “green” construction technologies. It identifies the methods adopted by the sector for the determination of...
Evaluating novelty
Building on a unique, multi-source, and multi-method study of R&D projects in a leading professional service firm, we develop the argument that organizations are more likely to fund projects with intermediate levels of...
Defence against antimicrobial peptides
The Firmicutes constitute a phylum of bacteria that can be found in a wide variety of habitats, from soil to the gastrointestinal tract of animals, where they have to thrive in complex communities. Competition in these...
Tritium O-Methylation of N-Alkoxy Maleimide Derivatives as Labeling Reagents for Biomolecules
An efficient procedure to access tritium-labeled maleimide derivatives in a high specific activity has been developed. N-Substituted maleimides containing the hydroxy functionality are O-methylated in a three-step synthesis...
Tritium O-Methylation of N-Alkoxy Maleimide Derivatives as Labeling Reagents for Biomolecules
An efficient procedure to access tritium-labeled maleimide derivatives in a high specific activity has been developed. N-Substituted maleimides containing the hydroxy functionality are O-methylated in a three-step synthesis...
Origin and function of the yolk sac in primate embryogenesis.
Human embryogenesis is hallmarked by two phases of yolk sac development. The primate hypoblast gives rise to a transient primary yolk sac, which is rapidly superseded by a secondary yolk sac during gastrulation. Moreover...
Supramolecular polymer dot ensemble for ratiometric detection of lectins and targeted delivery of imaging agents
Chang Zheng Wang, Jia Li Chen, Ying Tang, Yi Zang, Guo Rong Chen, Tony D. James, Jia Li, Changfeng Wu, Xiao Peng He
Feb 01, 2017
A supramolecular, polymer-dot-based ensemble has been developed for the ratiometric detection of lectins and targeted delivery of glycoprobes. Self-assembly between a blueemitting polymer dot and a red-emitting glycoprobe...
Determination of complex subclonal structures of hematological malignancies by multiplexed genotyping of blood progenitor colonies.
Alleles Clone Cells Cluster Analysis DNA Mutational Analysis DNA Neoplasm Erythroid Precursor Cells Genotyping Techniques Granulocytes Hematologic Neoplasms High-Throughput Nucleotide Sequencing Humans Janus Kinase 2 Mutation Mutation Missense Polycythemia Vera Polymorphism Single Nucleotide Sequence Analysis DNA
Substitution of the native <i>srfA</i> promoter by constitutive P<i>veg</i> in two <i>B. subtilis </i>strains and evaluation of the effect on surfactin production
Judit Willenbacher, Teresa Mohr, Marius Henkel, Susanne Gebhard, Thorsten Mascher, Christoph Syldatk, Rudolf Hausmann
Apr 01, 2016
The genetic enhancement of Surfactin production increasingly gained attention in the last years, since relatively low product yields limit the industrial application of this biosurfactant. The natural quorum sensing regulation...
Experiences of 'traditional' and 'one-stop' MRI-based prostate cancer diagnostic pathways in England
Samuel William David Merriel, Stephanie Archer, Alice S Forster, David Eldred-Evans, John McGrath, Hashim Uddin Ahmed, Willie Hamilton, Fiona M Walter
Aug 10, 2022
OBJECTIVES: This study aimed to understand and explore patient and general practitioner (GP) experiences of 'traditional' and 'one-stop' prostate cancer diagnostic pathways in England. DESIGN: Qualitative study using...
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