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Conformation control of the histidine kinase BceS of <i>Bacillus subtilis</i> by its cognate ABC-transporter facilitates need-based activation of antibiotic resistance
Bacteria closely control gene expression to ensure optimal physiological responses to their environment. Such careful gene expression can minimize the fitness cost associated with antibiotic resistance. We previously described a...
Morphology of powerful suction organs from blepharicerid larvae living in raging torrents
Abstract: Background: Suction organs provide powerful yet dynamic attachments for many aquatic animals, including octopus, squid, remora, and clingfish. While the functional morphology of suction organs from some cephalopods and...
Contact angle as a powerful tool in anisotropic colloid synthesis
Nucleation and growth is a technique widely used to prepare colloids, in which droplets are adsorbed onto substrate particles. Changing the contact angle of the substrates can greatly alter the morphology of the product...
Evolution of protein complexes by duplication of homomeric interactions.
BACKGROUND: Cellular functions are accomplished by the concerted actions of functional modules. The mechanisms driving the emergence and evolution of these modules are still unclear. Here we investigate the evolutionary origins...
CT-guided vs. fluoroscopically guided transforaminal epidural steroid injections for lumbar radiculopathy
Jozef PM Kamp, Jonathan Bartlett, Amr Fahmy, Kendrick To, Rumana Hossain, Maheswara Akula
Apr 17, 2023
INTRODUCTION: There are no formal guidelines for whether CT-guided or fluoroscopy-guided TFESI should be undertaken for patients with symptoms of lumbar nerve root irritation and corresponding nerve impingement. Here, we sought...
Conformation control of the histidine kinase BceS of <i>Bacillus subtilis</i> by its cognate ABC-transporter facilitates need-based activation of antibiotic resistance
Bacteria closely control gene expression to ensure optimal physiological responses to their environment. Such careful gene expression can minimize the fitness cost associated with antibiotic resistance. We previously described a...
On the temperature dependence of enzyme-catalyzed rates
Vickery L. Arcus, Erica J. Prentice, Joanne K. Hobbs, Adrian J. Mulholland, Marc W. van der Kamp, Christopher Roland Pudney, Emily J. Parker, Louis A. Schipper
Mar 29, 2016
One of the critical variables that determine the rate of any reaction is temperature. For biological systems, the effects of temperature are convoluted with myriad (and often opposing) contributions from enzyme catalysis...
Uncovering the relationship between the change in heat capacity for enzyme catalysis and vibrational frequency through isotope effect studies
Hannah B. L. Jones, Rory M. Crean, Christopher Matthews, Anna B. Troya, Michael J. Danson, Steven D. Bull, Vickery L. Arcus, Marc W. van der Kamp, Christopher R. Pudney
Jun 01, 2018
Understanding how enzyme catalysis varies with temperature is key to understanding catalysis itself and, ultimately, how to tune temperature optima. Temperature dependence studies inform on the change in heat capacity during...
Flickering nanometre-scale disorder in a crystal lattice tracked by plasmonic flare light emission
Cloudy Carnegie, Mattin Urbieta, Rohit Chikkaraddy, Bart de Nijs, Jack Griffiths, William M. Deacon, Marlous Kamp, Nerea Zabala, Javier Aizpurua, Jeremy J. Baumberg
Feb 02, 2021
Abstract: The dynamic restructuring of metal nanoparticle surfaces is known to greatly influence their catalytic, electronic transport, and chemical binding functionalities. Here we show for the first time that non-equilibrium...
Tracking interfacial single-molecule pH and binding dynamics via vibrational spectroscopy.
Junyang Huang, David-Benjamin Grys, Jack Griffiths, Bart de Nijs, Marlous Kamp, Qianqi Lin, Jeremy J Baumberg
Jul 28, 2021
Understanding single-molecule chemical dynamics of surface ligands is of critical importance to reveal their individual pathways and, hence, roles in catalysis, which ensemble measurements cannot see. Here, we use a cascaded...
Published by: Science advances
Boosting Optical Nanocavity Coupling by Retardation Matching to Dark Modes.
Rohit Chikkaraddy, Junyang Huang, Dean Kos, Eoin Elliott, Marlous Kamp, Chenyang Guo, Jeremy J Baumberg, Bart de Nijs
Mar 26, 2023
Plasmonic nanoantennas can focus light at nanometer length scales providing intense field enhancements. For the tightest optical confinements (0.5-5 nm) achieved in plasmonic gaps, the gap spacing, refractive index, and facet...
Published by: ACS photonics
On the temperature dependence of enzyme-catalyzed rates
Vickery L. Arcus, Erica J. Prentice, Joanne K. Hobbs, Adrian J. Mulholland, Marc W. van der Kamp, Christopher Roland Pudney, Emily J. Parker, Louis A. Schipper
Mar 29, 2016
One of the critical variables that determine the rate of any reaction is temperature. For biological systems, the effects of temperature are convoluted with myriad (and often opposing) contributions from enzyme catalysis...
A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity.
Katharina Koch, Rudolf Hartmann, Julia Tsiampali, Constanze Uhlmann, Ann-Christin Nickel, Xiaoling He, Marcel A Kamp, Michael Sabel, Roger A Barker, Hans-Jakob Steiger, Daniel Hänggi, Dieter Willbold, Jaroslaw Maciaczyk, Ulf D Kahlert
Apr 20, 2020
Cancer cells upregulate anabolic processes to maintain high rates of cellular turnover. Limiting the supply of macromolecular precursors by targeting enzymes involved in biosynthesis is a promising strategy in cancer therapy....
Rapalink-1 Targets Glioblastoma Stem Cells and Acts Synergistically with Tumor Treating Fields to Reduce Resistance against Temozolomide.
Andres Vargas-Toscano, Ann-Christin Nickel, Guanzhang Li, Marcel Alexander Kamp, Sajjad Muhammad, Gabriel Leprivier, Ellen Fritsche, Roger A Barker, Michael Sabel, Hans-Jakob Steiger, Wei Zhang, Daniel Hänggi, Ulf Dietrich Kahlert
Jan 18, 2021
Glioblastoma (GBM) is a lethal disease with limited clinical treatment options available. Recently, a new inhibitor targeting the prominent cancer signaling pathway mTOR was discovered (Rapalink-1), but its therapeutic potential...
Exposing the Interplay Between Enzyme Turnover, Protein Dynamics and the Membrane Environment in Monoamine Oxidase B
Hannah B L Jones, Rory M Crean, Anna Mullen, Emanuele Kendrick, Steven D Bull, Stephen A Wells, David Ross Carbery, Fraser MacMillan, Marc W van der Kamp, Christopher Roland Pudney
May 07, 2019
There is an increasing realization that structure-based drug design may show improved success by understanding the ensemble of conformations accessible to an enzyme and how the environment affects this ensemble. Human...
Light-Induced Coalescence of Plasmonic Dimers and Clusters.
Andrew R Salmon, Marie-Elena Kleemann, Junyang Huang, William M Deacon, Cloudy Carnegie, Marlous Kamp, Bart de Nijs, Angela Demetriadou, Jeremy J Baumberg
Mar 27, 2020
The properties of nanoplasmonic structures depend strongly on their geometry, creating the need for high-precision control and characterization. Here, by exploiting the low activation energy of gold atoms on nanoparticle...
Boosting Optical Nanocavity Coupling by Retardation Matching to Dark Modes.
Rohit Chikkaraddy, Junyang Huang, Dean Kos, Eoin Elliott, Marlous Kamp, Chenyang Guo, Jeremy J Baumberg, Bart de Nijs
Feb 17, 2023
Plasmonic nanoantennas can focus light at nanometer length scales providing intense field enhancements. For the tightest optical confinements (0.5-5 nm) achieved in plasmonic gaps, the gap spacing, refractive index, and facet...
Protein-mediated gelation and nano-scale assembly of unfunctionalized hyaluronic acid and chondroitin sulfate.
Anthony Tabet, June Y Park, Jarrod Shilts, Kamil Sokolowski, Vijay K Rana, Marlous Kamp, Nina Warner, Dominique Hoogland, Oren A Scherman
Jul 23, 2019
Background: Hyaluronic acid (HA) is a major component of the extracellular matrix (ECM) in the central nervous system and the only purely supramolecular glycosaminoglycan. Much focus has been given to using this high molecular...
Uncovering the relationship between the change in heat capacity for enzyme catalysis and vibrational frequency through isotope effect studies
Hannah B. L. Jones, Rory M. Crean, Christopher Matthews, Anna B. Troya, Michael J. Danson, Steven D. Bull, Vickery L. Arcus, Marc W. van der Kamp, Christopher R. Pudney
Jun 01, 2018
Understanding how enzyme catalysis varies with temperature is key to understanding catalysis itself and, ultimately, how to tune temperature optima. Temperature dependence studies inform on the change in heat capacity during...
Flickering nanometre-scale disorder in a crystal lattice tracked by plasmonic flare light emission.
Cloudy Carnegie, Mattin Urbieta, Rohit Chikkaraddy, Bart de Nijs, Jack Griffiths, William M Deacon, Marlous Kamp, Nerea Zabala, Javier Aizpurua, Jeremy J Baumberg
Dec 12, 2019
The dynamic restructuring of metal nanoparticle surfaces is known to greatly influence their catalytic, electronic transport, and chemical binding functionalities. Here we show for the first time that non-equilibrium...
Multivalent Patchy Colloids for Quantitative 3D Self-Assembly Studies.
Marlous Kamp, Bart de Nijs, Marjolein N van der Linden, Isja de Feijter, Merel J Lefferts, Antonio Aloi, Jack Griffiths, Jeremy J Baumberg, Ilja K Voets, Alfons van Blaaderen
Mar 27, 2020
We report methods to synthesize sub-micron- and micron-sized patchy silica particles with fluorescently labeled hemispherical titania protrusions, as well as routes to efficiently characterize these particles and self-assemble...
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