Search
Results: 32
Jinsuk Kang, Matthias Lienhard, William A Pastor, Ashu Chawla, Mark Novotny, Ageliki Tsagaratou, Roger S Lasken, Elizabeth C Thompson, M Azim Surani, Sergei B Koralov, Sundeep Kalantry, Lukas Chavez, Anjana Rao
Sep 15, 2015
5-hydroxymethylcytosine 5hmC DNA Methylation TET methylcytosine oxidases cholesterol biosynthesis 5-Methylcytosine Animals Biomarkers Blastocyst Blastomeres Cell Lineage Cholesterol DNA DNA-Binding Proteins Dioxygenases Down-Regulation Embryo Loss Embryo Mammalian Embryonic Development Gene Deletion Gene Expression Regulation Developmental Genomic Imprinting Hedgehog Proteins Mice Inbred C57BL Mice Knockout Proto-Oncogene Proteins Repetitive Sequences Nucleic Acid Sequence Analysis RNA Signal Transduction Transcriptome
Structure-Guided Computational Approaches to Unravel Druggable Proteomic Landscape of Mycobacterium leprae
Sundeep Chaitanya Vedithi, Sony Malhotra, Marta Acebrón-García-de-Eulate, Modestas Matusevicius, Pedro Henrique Monteiro Torres, Tom L. Blundell
May 21, 2021
Leprosy, caused by Mycobacterium leprae (M. leprae), is treated with a multidrug regimen comprising Dapsone, Rifampicin, and Clofazimine. These drugs exhibit bacteriostatic, bactericidal and anti-inflammatory properties...
Mapping structure heterogeneities and visualizing moisture degradation of perovskite films with nano-focus WAXS.
Nian Li, Shambhavi Pratap, Volker Körstgens, Sundeep Vema, Lin Song, Suzhe Liang, Anton Davydok, Christina Krywka, Peter Müller-Buschbaum
Nov 06, 2022
Extensive attention has focused on the structure optimization of perovskites, whereas rare research has mapped the structure heterogeneity within mixed hybrid perovskite films. Overlooked aspects include material and structure...
Sequence homology and expression profile of genes associated with DNA repair pathways in Mycobacterium leprae.
BACKGROUND: Survival of Mycobacterium leprae, the causative bacteria for leprosy, in the human host is dependent to an extent on the ways in which its genome integrity is retained. DNA repair mechanisms protect bacterial DNA...
Genomics, Computational Biology and Drug Discovery for Mycobacterial Infections
Tuberculosis (TB) and leprosy are mycobacterial infections caused by Mycobacterium tuberculosis and Mycobacterium leprae respectively. These diseases continue to be endemic in developing countries where the cost of new medicines...
Computer-aided synthesis of dapsone-phytochemical conjugates against dapsone-resistant Mycobacterium leprae.
Shasank S Swain, Sudhir K Paidesetty, Budheswar Dehury, Madhusmita Das, Sundeep C Vedithi, Rabindra N Padhy
Aug 05, 2020
Leprosy continues to be the belligerent public health hazard for the causation of high disability and eventual morbidity cases with stable prevalence rates, even with treatment by the on-going multidrug therapy (MDT). Today...
Computer-aided synthesis of dapsone-phytochemical conjugates against dapsone-resistant Mycobacterium leprae
Shasank S. Swain, Sudhir K. Paidesetty, Budheswar Dehury, Madhusmita Das, Sundeep C. Vedithi, Rabindra N. Padhy
Apr 22, 2021
Abstract: Leprosy continues to be the belligerent public health hazard for the causation of high disability and eventual morbidity cases with stable prevalence rates, even with treatment by the on-going multidrug therapy (MDT)....
Mapping structure heterogeneities and visualizing moisture degradation of perovskite films with nano-focus WAXS.
Nian Li, Shambhavi Pratap, Volker Körstgens, Sundeep Vema, Lin Song, Suzhe Liang, Anton Davydok, Christina Krywka, Peter Müller-Buschbaum
Dec 08, 2022
Extensive attention has focused on the structure optimization of perovskites, whereas rare research has mapped the structure heterogeneity within mixed hybrid perovskite films. Overlooked aspects include material and structure...
Published by: Nature Communications
Structure-Guided Computational Approaches to Unravel Druggable Proteomic Landscape of Mycobacterium leprae.
Sundeep Chaitanya Vedithi, Sony Malhotra, Marta Acebrón-García-de-Eulate, Modestas Matusevicius, Pedro Henrique Monteiro Torres, Tom L Blundell
Jul 09, 2021
Leprosy, caused by Mycobacterium leprae (M. leprae), is treated with a multidrug regimen comprising Dapsone, Rifampicin, and Clofazimine. These drugs exhibit bacteriostatic, bactericidal and anti-inflammatory properties...
Exploring the structural basis of conformational heterogeneity and autoinhibition of human cGMP-specific protein kinase Iα through computational modelling and molecular dynamics simulations.
Arooma Maryam, Rana Rehan Khalid, Sundeep Chaitanya Vedithi, Abdulilah Ece, Suleyman Selim Çınaroğlu, Abdul Rauf Siddiqi, Tom L Blundell
Aug 04, 2020
Protein kinase Iα (PKGIα) is a pivotal cyclic guanosine monophosphate (cGMP) signalling protein. Major steps related to the structural plasticity of PKGIα have been inferred but the structural aspects of the auto-inhibition and...
Mycobacterial genomics and structural bioinformatics
Vaishali P Waman, Sundeep Chaitanya Vedithi, Sherine E Thomas, Bridget P Bannerman, Asma Munir, Marcin J Skwark, Sony Malhotra, Tom L Blundell
Feb 18, 2019
Of the more than 190 distinct species of Mycobacterium genus, many are economically and clinically important pathogens of humans or animals. Among those mycobacteria that infect humans, three species namely Mycobacterium...
Mycobacterium comparative genomics Drug Resistance Mutation structure-guided drug discovery Animals Bacterial Proteins Computational Biology Drug Discovery Drug Resistance Bacterial Genome Bacterial Humans Molecular Sequence Annotation Mycobacterium Mycobacterium abscessus Mycobacterium leprae Mycobacterium tuberculosis Protein Conformation Proteomics Sequence Analysis DNA
Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae.
Global Development on LCA Research
G. Dangayach, Gaurav Gaurav, Alok Singh, Chandni Khandelwal, Sumit Gupta, Sundeep Kumar, M. Meena
Jan 01, 2023
Research on life cycle assessment (LCA) has been conducted over three decades. According to ISO 14040, LCA is an international standard that provides a methodology for assessing the environmental impact of products and...
Published by: IGI Global Scientific Publishing
Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae
Sundeep Chaitanya Vedithi, Carlos Hm Rodrigues, Stephanie Portelli, Marcin J Skwark, Madhusmita Das, David B Ascher, Tom L Blundell, Sony Malhotra
Mar 13, 2020
ABSTRACT In contrast to the situation with tuberculosis, rifampin resistance in leprosy may remain undetected due to the lack of rapid and effective diagnostic methods. A quick and reliable method is essential to determine the...
COSMIC Cancer Gene Census 3D database
Ali F Alsulami, Pedro HM Torres, Ismail Moghul, Sheikh Mohammed Arif, Amanda K Chaplin, Sundeep Chaitanya Vedithi, Tom L Blundell
Jul 16, 2021
Cancer Gene Census 3D hallmark mutations modelling cancer genes census mutational analyses of cancer drug targets Biomarkers Tumor Computational Biology Data analysis Databases Genetic Humans Models Molecular Mutation Neoplasms Oncogenes Software Structure-Activity Relationship User-Computer Interface Workflow
Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae.
Sundeep Chaitanya Vedithi, Sony Malhotra, Madhusmita Das, Sheela Daniel, Nanda Kishore, Anuja George, Shantha Arumugam, Lakshmi Rajan, Mannam Ebenezer, David B Ascher, Eddy Arnold, Tom L Blundell
Sep 27, 2018
The rpoB gene encodes the β subunit of RNA polymerase holoenzyme in Mycobacterium leprae (M. leprae). Missense mutations in the rpoB gene were identified as etiological factors for rifampin resistance in leprosy. In the present...
Adolescent Adult Bacterial Proteins DNA Bacterial DNA-Directed RNA Polymerases Drug Resistance Bacterial Female Humans india Leprostatic Agents Leprosy Male Microbial Sensitivity Tests Middle Aged Mutation Mycobacterium leprae Protein Binding Protein Stability Recurrence Rifampin Sequence Analysis DNA Structure-Activity Relationship Treatment Outcome Young Adult
Effect of Lithiation upon the Shear Strength of NMC811 Single Crystals
Abstract
An experimental protocol is developed to measure the shear strength of NMC811 single crystals within the cathode of a lithium-ion cell. The cathode is placed upon a set of...
Joe C Stallard, Sundeep Vema, David Hall, Anthony R Dennis, Megan Penrod, Clare Grey, Vikram S Deshpande, Norman Fleck
Apr 09, 2022
|
|< |
< |
1 |