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Soo-Ul-Qiniya (Iron Deficiency Anemia)
Soo-ul-Qiniya is a combination of two words “Soo and Qiniya” both are Arabic words Soo means defect whereas Qiniya means treasure or assets. By continuing both words it become Soo-ul-Qiniya means defect in the asset of the body....
Published by: IJHS Medical Association
Soo-Ul-Qiniya (Iron Deficiency Anemia)
Soo-ul-Qiniya is a combination of two words “Soo and Qiniya” both are Arabic words Soo means defect whereas Qiniya means treasure or assets. By continuing both words it become Soo-ul-Qiniya means defect in the asset of the body....
Published by: IJHS Medical Association
Characterisation of PALB2 tumours through whole-exome and whole-transcriptomic analyses.
Pei Sze Ng, Jia Wern Pan, Muhammad Mamduh Ahmad Zabidi, Pathmanathan Rajadurai, Cheng Har Yip, Oscar M Reuda, Alison M Dunning, Antonis C Antoniou, Douglas F Easton, Carlos Caldas, Suet-Feung Chin, Soo Hwang Teo
May 13, 2021
Rare protein-truncating variants (PTVs) in PALB2 confer increased risk to breast cancer, but relatively few studies have reported the characteristics of tumours with PALB2 PTVs. In this study, we describe molecular...
The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences
Jia-Wern Pan, Muhammad Mamduh Ahmad Zabidi, Pei-Sze Ng, Mei-Yee Meng, Siti Norhidayu Hasan, Bethan Sandey, Stephen-John Sammut, Cheng-Har Yip, Pathmanathan Rajadurai, Oscar M. Rueda, Carlos Caldas, Suet-Feung Chin, Soo-Hwang Teo
Dec 22, 2020
Abstract: Molecular profiling of breast cancer has enabled the development of more robust molecular prognostic signatures and therapeutic options for breast cancer patients. However, non-Caucasian populations remain...
Characterisation of PALB2 tumours through whole-exome and whole-transcriptomic analyses
The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences.
Prevalence of BRCA1 and BRCA2 pathogenic variants in a large, unselected breast cancer cohort.
Jingmei Li, Wei Xiong Wen, Martin Eklund, Anders Kvist, Mikael Eriksson, Helene Nordahl Christensen, Astrid Torstensson, Svetlana Bajalica-Lagercrantz, Alison M Dunning, Brennan Decker, Jamie Allen, Craig Luccarini, Karen Pooley, Jacques Simard, Leila Dorling, Douglas F Easton, Soo-Hwang Teo, Per Hall, Åke Borg, Henrik Grönberg, Kamila Czene
Oct 03, 2018
Breast cancer patients with BRCA1/2-driven tumors may benefit from targeted therapy. It is not clear whether current BRCA screening guidelines are effective at identifying these patients. The purpose of our study was to evaluate...
Epidemiological and ES cell-based functional evaluation of BRCA2 variants identified in families with breast cancer.
Teresa Sullivan, Eswary Thirthagiri, Chan-Eng Chong, Stacey Stauffer, Susan Reid, Eileen Southon, Tiara Hassan, Aravind Ravichandran, Eldarina Wijaya, Joanna Lim, Nur Aishah Mohd Taib, Farhana Fadzli, Cheng Har Yip, Mikael Hartman, Jingmei Li, Rob M van Dam, Susan L North, Ranabir Das, Douglas F Easton, Kajal Biswas, Soo-Hwang Teo, Shyam K Sharan, SGBCC Investigators, MYBRCA Investigators
Dec 23, 2020
The discovery of high-risk breast cancer susceptibility genes, such as Breast cancer associated gene 1 (BRCA1) and Breast cancer associated gene 2 (BRCA2) has led to accurate identification of individuals for risk management and...
Use of Bayesian statistics to calculate transient heat fluxes on compressor disks
Future gas turbine engines require improved understanding of the heat transfer between compressor disks and air in compressor cavities under transient operating conditions. Calculation of transient heat fluxes from...
Use of Bayesian statistics to calculate transient heat fluxes on compressor disks
Future gas turbine engines require improved understanding of the heat transfer between compressor disks and air in compressor cavities under transient operating conditions. Calculation of transient heat fluxes from...
Influential Indicators and Measurements of Mediating and Moderating Roles on SME Performance
Seok-Soo Kim
Jan 01, 2022
Overcoming the failure of SMEs has been an important research topic. The critical research finding is that it has verified the essential elements of performance improvement. We presented a solution to the research question, "Is...
Published by: IGI Global Scientific Publishing
Germline breast cancer susceptibility genes, tumor characteristics, and survival
Peh Joo Ho, Alexis J. Khng, Hui Wen Loh, Weang-Kee Ho, Cheng Har Yip, Nur Aishah Mohd-Taib, Veronique Kiak Mien Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Ern Yu Tan, Swee Ho Lim, Suniza Jamaris, Yirong Sim, Fuh Yong Wong, Joanne Ngeow, Elaine Hsuen Lim, Mei Chee Tai, Eldarina Azfar Wijaya, Soo Chin Lee, Ching Wan Chan, Shaik Ahmad Buhari, Patrick M. Y. Chan, Juliana J. C. Chen, Jaime Chin Mui Seah, Wai Peng Lee, Chi Wei Mok, Geok Hoon Lim, Evan Woo, Sung-Won Kim, Jong Won Lee, Min Hyuk Lee, Sue K. Park, Alison M. Dunning, Douglas F. Easton, Marjanka K. Schmidt, Soo-Hwang Teo, Jingmei Li, Mikael Hartman
Dec 15, 2021
Abstract: Background: Mutations in certain genes are known to increase breast cancer risk. We study the relevance of rare protein-truncating variants (PTVs) that may result in loss-of-function in breast cancer susceptibility...
Germline breast cancer susceptibility genes, tumor characteristics, and survival.
Peh Joo Ho, Alexis J Khng, Hui Wen Loh, Weang-Kee Ho, Cheng Har Yip, Nur Aishah Mohd-Taib, Veronique Kiak Mien Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Ern Yu Tan, Swee Ho Lim, Suniza Jamaris, Yirong Sim, Fuh Yong Wong, Joanne Ngeow, Elaine Hsuen Lim, Mei Chee Tai, Eldarina Azfar Wijaya, Soo Chin Lee, Ching Wan Chan, Shaik Ahmad Buhari, Patrick MY Chan, Juliana JC Chen, Jaime Chin Mui Seah, Wai Peng Lee, Chi Wei Mok, Geok Hoon Lim, Evan Woo, Sung-Won Kim, Jong Won Lee, Min Hyuk Lee, Sue K Park, Alison M Dunning, Douglas F Easton, Marjanka K Schmidt, Soo-Hwang Teo, Jingmei Li, Mikael Hartman
Jan 10, 2022
BACKGROUND: Mutations in certain genes are known to increase breast cancer risk. We study the relevance of rare protein-truncating variants (PTVs) that may result in loss-of-function in breast cancer susceptibility genes on...
Biodegradable, flexible silicon nanomembrane-based NO x gas sensor system with record-high performance for transient environmental monitors and medical implants
Gwan-Jin Ko, Soo Deok Han, Jeong-Ki Kim, Jia Zhu, Won Bae Han, Jinmook Chung, Seung Min Yang, Huanyu Cheng, Dong-Hwee Kim, Chong-Yun Kang, Suk-Won Hwang
Nov 09, 2020
Abstract: A novel transient electronics technology that is capable of completely dissolving or decomposing in certain conditions after a period of operation offers unprecedented opportunities for medical implants, environmental...
Homologous recombination DNA repair defects in PALB2-associated breast cancers.
Anqi Li, Felipe C Geyer, Pedro Blecua, Ju Youn Lee, Pier Selenica, David N Brown, Fresia Pareja, Simon SK Lee, Rahul Kumar, Barbara Rivera, Rui Bi, Salvatore Piscuoglio, Hannah Y Wen, John R Lozada, Rodrigo Gularte-Mérida, Luca Cavallone, kConFab Investigators, Zoulikha Rezoug, Tu Nguyen-Dumont, Paolo Peterlongo, Carlo Tondini, Thorkild Terkelsen, Karina Rønlund, Susanne E Boonen, Arto Mannerma, Robert Winqvist, Marketa Janatova, Pathmanathan Rajadurai, Bing Xia, Larry Norton, Mark E Robson, Pei-Sze Ng, Lai-Meng Looi, Melissa C Southey, Britta Weigelt, Teo Soo-Hwang, Marc Tischkowitz, William D Foulkes, Jorge S Reis-Filho
Jun 11, 2019
Characterisation of protein-truncating and missense variants in PALB2 in 15 768 women from Malaysia and Singapore.
Pei Sze Ng, Rick ACM Boonen, Eldarina Wijaya, Chan Eng Chong, Milan Sharma, Sabine Knaup, Shivaani Mariapun, Weang Kee Ho, Joanna Lim, Sook-Yee Yoon, Nur Aishah Mohd Taib, Mee Hoong See, Jingmei Li, Swee Ho Lim, Ern Yu Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Veronique Kiat-Mien Tan, Rob Martinus van Dam, Kartini Rahmat, Cheng Har Yip, Sara Carvalho, Craig Luccarini, Caroline Baynes, Alison M Dunning, Antonis Antoniou, Haico Van Attikum, Douglas F Easton, Mikael Hartman, Soo Hwang Teo
May 13, 2021
BACKGROUND: Rare protein-truncating variants (PTVs) in partner and localiser of BRCA2 (PALB2) confer increased risk to breast cancer, but relatively few studies have reported the prevalence in South-East Asian populations. Here...
Whole genome sequencing of an ethnic Pathan (Pakhtun) from the north-west of Pakistan.
Muhammad Ilyas, Jong-Soo Kim, Jesse Cooper, Young-Ah Shin, Hak-Min Kim, Yun Sung Cho, Seungwoo Hwang, Hyunho Kim, Jaewoo Moon, Oksung Chung, JeHoon Jun, Achal Rastogi, Sanghoon Song, Junsu Ko, Andrea Manica, Ziaur Rahman, Tayyab Husnain, Jong Bhak
Sep 29, 2016
BACKGROUND: Pakistan covers a key geographic area in human history, being both part of the Indus River region that acted as one of the cradles of civilization and as a link between Western Eurasia and Eastern Asia. This region...
Inherited mutations in BRCA1 and BRCA2 in an unselected multiethnic cohort of Asian patients with breast cancer and healthy controls from Malaysia.
Wei Xiong Wen, Jamie Allen, Kah Nyin Lai, Shivaani Mariapun, Siti Norhidayu Hasan, Pei Sze Ng, Daphne Shin-Chi Lee, Sheau Yee Lee, Sook-Yee Yoon, Joanna Lim, Shao Yan Lau, Brennan Decker, Karen Pooley, Leila Dorling, Craig Luccarini, Caroline Baynes, Don M Conroy, Patricia Harrington, Jacques Simard, Cheng Har Yip, Nur Aishah Mohd Taib, Weang Kee Ho, Antonis C Antoniou, Alison M Dunning, Douglas F Easton, Soo Hwang Teo
Jan 19, 2018
BACKGROUND: Genetic testing for BRCA1 and BRCA2 is offered typically to selected women based on age of onset and family history of cancer. However, current internationally accepted genetic testing referral guidelines are built...
Pathogenic viruses as a global commons
In light of the Covid-19 pandemic, the international community’s approach towards pathogenic viruses needs to be re-evaluated. This commentary notes that attempts to justify viral sovereignty, either under treaties or...
Tessa Sze-Myn Teo
Jun 18, 2021
Netrin Guides Spinal Commissural Axons to the Midline at Long Range Through the Receptors DCC and Neogenin
Sze Sing Shaun Teo
Jan 01, 0001
During neurodevelopment, commissural axons are guided to the ventral midline in a remarkably precise and stereotyped way. Netrin, a secreted laminin-related protein, provides the major attractive cue for midline guidance. It is...
Published by: Rockefeller University
An Evaluation Study of User Authentication in the Malaysian FinTech Industry With uAuth Security Analytics Framework
The increased cyberattack frequency and ferocity have alerted the fintech industry in detecting existential security threats and risks. Various authentication mechanisms have been deployed to countermeasure cyberattacks; whether...
Published by: IGI Global Scientific Publishing
A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma.
Li Ren Kong, Nur Afiqah Binte Mohamed Salleh, Richard Weijie Ong, Tuan Zea Tan, Nicholas L Syn, Robby Miguel Goh, Chee Wai Fhu, Daniel SW Tan, N Gopalakrishna Iyer, Srinivasaraghavan Kannan, Chandra S Verma, Yaw Chyn Lim, Ross Soo, Jingshan Ho, Yiqing Huang, Joline SJ Lim, Benedict Junrong Yan, Min En Nga, Seng Gee Lim, H Phillip Koeffler, Soo Chin Lee, Dennis Kappei, Huynh The Hung, Boon Cher Goh
Mar 25, 2021
c-MET receptors are activated in cancers through genomic events like tyrosine kinase domain mutations, juxtamembrane splicing mutation and amplified copy numbers, which can be inhibited by c-MET small molecule inhibitors. Here...
Animals Antineoplastic Agents Carcinoma Squamous Cell Cell Line Tumor Head and Neck Neoplasms Humans Lung Neoplasms Mice Mutation Phenotype Phosphorylation Polymorphism Genetic Prognosis Protein Binding Protein Interaction Domains and Motifs Protein Kinase Inhibitors Proto-Oncogene Proteins c-met Receptor ErbB-2 Signal Transduction Xenograft Model Antitumor Assays
Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models
Peh Joo Ho, Weang Kee Ho, Alexis J Khng, Yen Shing Yeoh, Benita Kiat-Tee Tan, Ern Yu Tan, Geok Hoon Lim, Su-Ming Tan, Veronique Kiak Mien Tan, Cheng-Har Yip, Nur-Aishah Mohd-Taib, Fuh Yong Wong, Elaine Hsuen Lim, Joanne Ngeow, Wen Yee Chay, Lester Chee Hao Leong, Wei Sean Yong, Chin Mui Seah, Siau Wei Tang, Celene Wei Qi Ng, Zhiyan Yan, Jung Ah Lee, Kartini Rahmat, Tania Islam, Tiara Hassan, Mei-Chee Tai, Chiea Chuen Khor, Jian-Min Yuan, Woon-Puay Koh, Xueling Sim, Alison M Dunning, Manjeet K Bolla, Antonis Antoniou, Soo-Hwang Teo, Jingmei Li, Mikael Hartman
Apr 26, 2022
BACKGROUND: Family history, and genetic and non-genetic risk factors can stratify women according to their individual risk of developing breast cancer. The extent of overlap between these risk predictors is not clear. METHODS...
Characterisation of protein-truncating and missense variants in PALB2 in 15 768 women from Malaysia and Singapore
Pei Sze Ng, Rick ACM Boonen, Eldarina Wijaya, Chan Eng Chong, Milan Sharma, Sabine Knaup, Shivaani Mariapun, Weang Kee Ho, Joanna Lim, Sook-Yee Yoon, Nur Aishah Mohd Taib, Mee Hoong See, Jingmei Li, Swee Ho Lim, Ern Yu Tan, Benita Kiat-Tee Tan, Su-Ming Tan, Veronique Kiat-Mien Tan, Rob Martinus van Dam, Kartini Rahmat, Cheng Har Yip, Sara Carvalho, Craig Luccarini, Caroline Baynes, Alison M Dunning, Antonis Antoniou, Haico Van Attikum, Douglas F Easton, Mikael Hartman, Soo Hwang Teo
Apr 07, 2021
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