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Results: 578
MiRNA-15b and miRNA-125b are associated with regional Aβ-PET and FDG-PET uptake in cognitively normal individuals with subjective memory complaints.
Andrea Vergallo, Simone Lista, Yuhai Zhao, Pablo Lemercier, Stefan J Teipel, Marie-Claude Potier, Marie-Odile Habert, Bruno Dubois, Walter J Lukiw, Harald Hampel, INSIGHT-preAD study group, Alzheimer Precision Medicine Initiative (APMI)
Jan 27, 2021
There is substantial experimental evidence for dysregulation of several microRNA (miRNA) expression levels in Alzheimer's disease (AD). MiRNAs modulate critical brain intracellular signaling pathways and are associated with AD...
Vegetarian Society President Discusses Making a Lifestyle Change on World Vegetarian Day
Winthrop University
Jan 01, 0001
World Vegetarian Day is Oct. 1. October is also Vegetarian Awareness Month. Simone Mayers decided to make a lifestyle change after taking an ecological psychology course at Winthrop.
Published by: Winthrop University
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease.
Gabriella T Heller, Francesco A Aprile, Thomas CT Michaels, Ryan Limbocker, Michele Perni, Francesco Simone Ruggeri, Benedetta Mannini, Thomas Löhr, Massimiliano Bonomi, Carlo Camilloni, Alfonso De Simone, Isabella C Felli, Roberta Pierattelli, Tuomas PJ Knowles, Christopher M Dobson, Michele Vendruscolo
Dec 14, 2020
Disordered proteins are challenging therapeutic targets, and no drug is currently in clinical use that modifies the properties of their monomeric states. Here, we identify a small molecule (10074-G5) capable of binding and...
Narratives of travel
This article explores a philosophical question concerned with the nature of the desire that moves one to travel, to engage with and know the world in its difference. Drawing upon French feminist theory I take up the...
Simone Fullagar
Dec 31, 2002
This article explores a philosophical question concerned with the nature of the desire that moves one to travel, to engage with and know the world in its difference. Drawing upon French feminist theory I take up the...
Leisure practices as counter-depressants
Simone Fullagar
Jan 01, 2008
This paper draws on post-structural feminist theories of emotion to explore the significance of leisure within women's narratives of recovery from depression. I engage with the stories of 48 women in rural and urban Australia to...
Tuning crystal morphology of succinic acid using a polymer additive
The effect of the triblock copolymer Pluronic P123 (PP123) on the growth of succinic acid crystals from aqueous solutions is reported at two batch process scales: 10 and 350 mL. The presence of small quantities of PP123 is shown...
A high-throughput multi-microfluidic crystal generator (MMicroCryGen) platform for facile screening of polymorphism and crystal morphology for pharmaceutical compounds
In this work, a novel multi-microfluidic crystallization platform called MMicroCryGen is presented, offering a facile methodology for generating individual crystals for fast and easy screening of the polymorphism and crystal...
Ion-triggered selectivity in bacterial sodium channels
Since the availability of the first crystal structure of a bacterial Na+ channel in 2011, understanding selectivity across this family of membrane proteins has been the subject of intense research efforts. Initially, free...
Lifestyle drift and the phenomenon of ‘citizen shift’ in contemporary UK health policy
Despite political change over the past 25 years in Britain there has been an unprecedented national policy focus on the social determinants of health and population-based approaches to prevent chronic disease. Yet, policy...
Habit Formation, Dynastic Altruism, and Population Dynamics
We study the general equilibrium properties of two growth models with overlapping generations, habit formation, and endogenous fertility. In the neoclassical model, habits modify the economy’s growth rate and generate...
Quantifying the cost of decision fatigue
Making decisions over extended periods of time is cognitively taxing and can lead to decision fatigue, which is linked to a preference for the ‘default’ option, namely whatever decision involves relatively little cognitive...
Narratives of travel
This article explores a philosophical question concerned with the nature of the desire that moves one to travel, to engage with and know the world in its difference. Drawing upon French feminist theory I take up the...
Simone Fullagar
Dec 31, 2002
This article explores a philosophical question concerned with the nature of the desire that moves one to travel, to engage with and know the world in its difference. Drawing upon French feminist theory I take up the...
Leisure practices as counter-depressants
Simone Fullagar
Jan 01, 2008
This paper draws on post-structural feminist theories of emotion to explore the significance of leisure within women's narratives of recovery from depression. I engage with the stories of 48 women in rural and urban Australia to...
One question on ritual and religion
Simone Kotva
Apr 08, 2019
Ion-triggered selectivity in bacterial sodium channels
Since the availability of the first crystal structure of a bacterial Na+ channel in 2011, understanding selectivity across this family of membrane proteins has been the subject of intense research efforts. Initially, free...
Becoming roller derby grrrls
This article explores how the global revival of roller derby as an alternative sport for women has been mobilised through online social networks, league promotion and fan sites that create imagined communities of 'roller...
Thinking Together and Governance in Transport Planning
Sustainability issues challenge most conventional approaches to policy design and implementation. One broader concern is how to create the conditions for the desired sustainability options to be realized. In this pursuit, policy...
Published by: IGI Global Scientific Publishing
Digital Gaming for Cross-Cultural Learning
Although game-based learning has gained significant attention in higher education globally, it is difficult to harness its engagement and interactions to improve student success. This paper argues that the use of digital games...
Published by: IGI Global Scientific Publishing
SMGen
Several software tools for the simulation and analysis of biochemical reaction networks have been developed in the last decades; however, assessing and comparing their computational performance in executing the typical...
Simone G Riva, Paolo Cazzaniga, Marco S Nobile, Simone Spolaor, Leonardo Rundo, Daniela Besozzi, Andrea Tangherloni
Jan 28, 2022
Membrane Interactions and Toxicity by Misfolded Protein Oligomers.
The conversion of otherwise soluble proteins into insoluble amyloid aggregates is associated with a range of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases, as well as non-neuropathic conditions such...
Inhibition of the Eukaryotic 80S Ribosome as a Potential Anticancer Therapy
Protein biosynthesis is a vital process for all kingdoms of life. The ribosome is the massive ribonucleoprotein machinery that reads the genetic code, in the form of messenger RNA (mRNA), to produce proteins. The mechanism of...
Disease and Disapproval
Prior research has indicated that disease threat and disgust are associated with harsher moral condemnation. We investigated the role of a specific, highly salient health concern, namely the spread of the coronavirus, and...
Narrating the multiplicity of ‘Derby Grrrl’
Driven by an ethos of self-organization and empowerment women involved in the revived version of roller derby have created an embodied and virtual leisure practice that challenges gender norms and invites different identities....
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