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Results: 78
Collagen fibre implant for tendon and ligament biological augmentation. In vivo study in an ovine model.
Davide Enea, Jessica Gwynne, Simon Kew, Meera Arumugam, Jennifer Shepherd, Roger Brooks, Siddhartha Ghose, Serena Best, Ruth Cameron, Neil Rushton
Apr 19, 2013
PURPOSE: Although most in vitro studies indicate that collagen is a suitable biomaterial for tendon and ligament tissue engineering, in vivo studies of implanted collagen for regeneration of these tissues are still lacking. The...
Developing an Explainable Machine Learning-Based Thyroid Disease Prediction Model
Healthcare and medicine are key areas where machine learning algorithms are widely used. The medical decision support systems thus created are accurate enough, however, they suffer from the lack of transparency in decision...
Published by: IGI Global Scientific Publishing
Sentiment Analysis of Multilingual Tweets Based on Natural Language Processing (NLP)
Multilingual Sentiment analysis plays an important role in a country like India with many languages as the style of expression varies in different languages. The Indian people speak in total 22 different languages and with the...
Published by: IGI Global Scientific Publishing
Coffee consumption and cancer risk
Paul Carter, Shuai Yuan, Siddhartha Kar, Mathew Vithayathil, Amy M Mason, Stephen Burgess, Susanna C Larsson
Oct 07, 2022
BACKGROUND: Coffee contains many bioactive chemicals and associations with cancer have been reported in observational studies. In this Mendelian randomisation (MR) study we investigated the causal associations of coffee...
Sleep duration and risk of overall and 22 site-specific cancers
Olga E Titova, Karl Michaëlsson, Mathew Vithayathil, Amy M Mason, Siddhartha Kar, Stephen Burgess, Susanna C Larsson
Aug 21, 2020
Studies of sleep duration in relation to the risk of site-specific cancers other than breast cancer are scarce. Furthermore, the available results are inconclusive and the causality remains unclear. We aimed to investigate the...
Mendelian randomization Cancer SINGLE-NUCLEOTIDE POLYMORPHISMS Sleep Adult Aged Biological Specimen Banks Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Male Mendelian Randomization Analysis Middle Aged Neoplasms Odds Ratio Polymorphism Single Nucleotide Risk Factors Sleep Time Factors United Kingdom
Assessing the role of cortisol in cancer
BACKGROUND: Cortisol's immunosuppressive, obesogenic, and hyperglycaemic effects suggest that it may play a role in cancer development. However, whether cortisol increases cancer risk is not known. We investigated the potential...
Predicting the effect of statins on cancer risk using genetic variants from a Mendelian randomization study in the UK Biobank.
Paul Carter, Mathew Vithayathil, Siddhartha Kar, Rahul Potluri, Amy M Mason, Susanna C Larsson, Stephen Burgess
Sep 25, 2020
Laboratory studies have suggested oncogenic roles of lipids, as well as anticarcinogenic effects of statins. Here we assess the potential effect of statin therapy on cancer risk using evidence from human genetics. We obtained...
Mendelian randomization causal inference Cell Biology Cholesterol Chromosomes Gene Expression Genetic epidemiology human Lipids Statins Biological Specimen Banks genetic variation Hydroxymethylglutaryl CoA Reductases Hydroxymethylglutaryl-CoA Reductase Inhibitors Mendelian Randomization Analysis Neoplasms prevalence Risk Factors United Kingdom
Causal associations of thyroid function and dysfunction with overall, breast and thyroid cancer
Shuai Yuan, Siddhartha Kar, Mathew Vithayathil, Paul Carter, Amy M Mason, Stephen Burgess, Susanna C Larsson
Mar 13, 2020
Whether thyroid dysfunction plays a causal role in the development of cancer remains inconclusive. We conducted a two-sample Mendelian randomization study to investigate the associations between genetic predisposition to thyroid...
Mendelian randomization Cancer hyperthyroidism Hypothyroidism thyroid-stimulating hormone Thyroxine Biological Specimen Banks Breast Neoplasms Female Humans hyperthyroidism Hypothyroidism Male Mendelian Randomization Analysis Polymorphism Single Nucleotide Thyroid Function Tests Thyroid Gland Thyroid Neoplasms Thyrotropin
Genetically predicted circulating B vitamins in relation to digestive system cancers.
Shuai Yuan, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Amy M Mason, Stephen Burgess, Susanna C Larsson
Mar 30, 2021
BACKGROUND: Folate, vitamin B6 and vitamin B12 have been associated with digestive system cancers. We conducted a two-sample Mendelian randomisation study to assess the causality of these associations. METHODS: Two, one and 14...
Adult Anemia Pernicious Case-Control Studies Digestive System Neoplasms Female Folic Acid Genetic Association Studies Genetic Predisposition to Disease Genetic Testing Humans Male Mendelian Randomization Analysis Polymorphism Single Nucleotide Risk Factors Sweden United Kingdom Vitamin B 12 Vitamin B 6 Vitamin B Complex Vitamin B Deficiency
chromMAGMA
Robbin Nameki, Anamay Shetty, Eileen Dareng, Jonathan Tyrer, Xianzhi Lin, Ovarian Cancer Association Consortium, Paul Pharoah, Rosario I Corona, Siddhartha Kar, Kate Lawrenson
Aug 01, 2022
Candidate causal risk variants from genome-wide association studies reside almost exclusively in noncoding regions of the genome and innovative approaches are necessary to understand their biological function. Multi-marker...
Iron Status and Cancer Risk in UK Biobank
Shuai Yuan, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Edward Giovannucci, Amy M. Mason, Stephen Burgess, Susanna C. Larsson
Feb 20, 2020
We conducted a two-sample Mendelian randomization study to explore the associations of iron status with overall cancer and 22 site-specific cancers. Single-nucleotide polymorphisms for iron status were obtained from a...
Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia
Mathew Vithayathil, Paul Carter, Siddhartha Kar, Amy M. Mason, Stephen Burgess, Susanna C. Larsson
Jul 29, 2021
Background: Evidence for the impact of body size and composition on cancer risk is limited. This mendelian randomisation (MR) study investigates evidence supporting causal relationships of body mass index (BMI), fat mass index...
Iron Status and Cancer Risk in UK Biobank
Shuai Yuan, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Edward Giovannucci, Amy M Mason, Stephen Burgess, Susanna C Larsson
Mar 27, 2020
We conducted a two-sample Mendelian randomization study to explore the associations of iron status with overall cancer and 22 site-specific cancers. Single-nucleotide polymorphisms for iron status were obtained from a...
Published by: Nutrients
Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia
Mathew Vithayathil, Paul Carter, Siddhartha Kar, Amy M Mason, Stephen Burgess, Susanna C Larsson
Aug 29, 2021
Background
Evidence for the impact of body size and composition on cancer risk is limited. This mendelian randomisation (MR) study investigates evidence supporting causal relationships of body mass index (BMI), fat mass...
Published by: PLoS Medicine
Is Type 2 Diabetes Causally Associated With Cancer Risk? Evidence From a Two-Sample Mendelian Randomization Study.
Shuai Yuan, Siddhartha Kar, Paul Carter, Mathew Vithayathil, Amy M Mason, Stephen Burgess, Susanna C Larsson
Apr 29, 2020
We conducted a two-sample Mendelian randomization study to investigate the causal associations of type 2 diabetes mellitus (T2DM) with risk of overall cancer and 22 site-specific cancers. Summary-level data for cancer were...
Iron Status and Cancer Risk in UK Biobank
Shuai Yuan, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Edward Giovannucci, Amy M Mason, Stephen Burgess, Susanna C Larsson
Feb 27, 2020
We conducted a two-sample Mendelian randomization study to explore the associations of iron status with overall cancer and 22 site-specific cancers. Single-nucleotide polymorphisms for iron status were obtained from a...
Mendelian randomization Cancer ferritin Iron Serum transferrin Transferrin Saturation Adult Aged Biological Specimen Banks Brain Neoplasms Female Ferritins Genetic Predisposition to Disease Genome-Wide Association Study Humans Iron Liver Neoplasms Male Mendelian Randomization Analysis Middle Aged Neoplasms Nutritional Status Odds Ratio Polymorphism Single Nucleotide Risk Factors Transferrin United Kingdom White People
Smoking, alcohol consumption, and cancer
Susanna C Larsson, Paul Carter, Siddhartha Kar, Mathew Vithayathil, Amy M Mason, Karl Michaëlsson, Stephen Burgess
Aug 25, 2020
BACKGROUND: Smoking is a well-established cause of lung cancer and there is strong evidence that smoking also increases the risk of several other cancers. Alcohol consumption has been inconsistently associated with cancer risk...
Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia
Mathew Vithayathil, Paul Carter, Siddhartha Kar, Amy M Mason, Stephen Burgess, Susanna C Larsson
Sep 13, 2021
BACKGROUND: Evidence for the impact of body size and composition on cancer risk is limited. This mendelian randomisation (MR) study investigates evidence supporting causal relationships of body mass index (BMI), fat mass index...
Circulating vitamin C and digestive system cancers
Susanna C Larsson, Amy M Mason, Mathew Vithayathil, Paul Carter, Siddhartha Kar, Ju-Sheng Zheng, Stephen Burgess
Sep 20, 2022
BACKGROUND & AIMS: Vitamin C is an antioxidant with a potential role in the prevention of digestive system cancers, but there is yet no consensus whether vitamin C has a causal role in these cancers. The aim of this study was to...
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