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Results: 272
Virulence Regulation and Innate Host Response in the Pathogenicity of Vibrio cholerae.
Thandavarayan Ramamurthy, Ranjan K Nandy, Asish K Mukhopadhyay, Shanta Dutta, Ankur Mutreja, Keinosuke Okamoto, Shin-Ichi Miyoshi, G Balakrish Nair, Amit Ghosh
Oct 14, 2020
The human pathogen Vibrio cholerae is the causative agent of severe diarrheal disease known as cholera. Of the more than 200 "O" serogroups of this pathogen, O1 and O139 cause cholera outbreaks and epidemics. The rest of the...
Oxygen concentration affects de novo DNA methylation and transcription in in vitro cultured oocytes.
Florence Naillat, Heba Saadeh, Joanna Nowacka-Woszuk, Lenka Gahurova, Fatima Santos, Shin-Ichi Tomizawa, Gavin Kelsey
Sep 05, 2021
BACKGROUND: Reproductive biology methods rely on in vitro follicle cultures from mature follicles obtained by hormonal stimulation for generating metaphase II oocytes to be fertilised and developed into a healthy embryo. Such...
Transcription and chromatin determinants of de novo DNA methylation timing in oocytes.
Lenka Gahurova, Shin-Ichi Tomizawa, Sébastien A Smallwood, Kathleen R Stewart-Morgan, Heba Saadeh, Jeesun Kim, Simon R Andrews, Taiping Chen, Gavin Kelsey
Jun 24, 2019
BACKGROUND: Gametogenesis in mammals entails profound re-patterning of the epigenome. In the female germline, DNA methylation is acquired late in oogenesis from an essentially unmethylated baseline and is established largely as...
Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer.
Kanto Shozu, Syuzo Kaneko, Norio Shinkai, Ai Dozen, Hirofumi Kosuge, Makoto Nakakido, Hidenori Machino, Ken Takasawa, Ken Asada, Masaaki Komatsu, Kouhei Tsumoto, Shin-Ichi Ohnuma, Ryuji Hamamoto
Dec 13, 2022
BACKGROUND: Proline/arginine-rich end leucine-rich repeat protein (PRELP) is a member of the small leucine-rich proteoglycan family of extracellular matrix proteins, which is markedly suppressed in the majority of early-stage...
Deep sequencing and de novo assembly of the mouse oocyte transcriptome define the contribution of transcription to the DNA methylation landscape.
Lenka Veselovska, Sebastien A Smallwood, Heba Saadeh, Kathleen R Stewart, Felix Krueger, Stéphanie Maupetit-Méhouas, Philippe Arnaud, Shin-Ichi Tomizawa, Simon Andrews, Gavin Kelsey
Jun 24, 2019
BACKGROUND: Previously, a role was demonstrated for transcription in the acquisition of DNA methylation at imprinted control regions in oocytes. Definition of the oocyte DNA methylome by whole genome approaches revealed that the...
Animals Cell Cycle Proteins Chromatin Assembly and Disassembly CpG Islands DNA Methylation DNA Transposable Elements Female Gene Expression Profiling Genes Tumor Suppressor Genomic Imprinting High-Throughput Nucleotide Sequencing Mice Mice Transgenic Oocytes Sequence Analysis RNA Transcription Factors Transcription Initiation Site Transcriptome
Dynamic changes in histone modifications precede de novo DNA methylation in oocytes.
Kathleen R Stewart, Lenka Veselovska, Jeesun Kim, Jiahao Huang, Heba Saadeh, Shin-Ichi Tomizawa, Sébastien A Smallwood, Taiping Chen, Gavin Kelsey
Jun 24, 2019
Erasure and subsequent reinstatement of DNA methylation in the germline, especially at imprinted CpG islands (CGIs), is crucial to embryogenesis in mammals. The mechanisms underlying DNA methylation establishment remain poorly...
Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer.
Kanto Shozu, Syuzo Kaneko, Norio Shinkai, Ai Dozen, Hirofumi Kosuge, Makoto Nakakido, Hidenori Machino, Ken Takasawa, Ken Asada, Masaaki Komatsu, Kouhei Tsumoto, Shin-Ichi Ohnuma, Ryuji Hamamoto
Nov 15, 2022
BACKGROUND: Proline/arginine-rich end leucine-rich repeat protein (PRELP) is a member of the small leucine-rich proteoglycan family of extracellular matrix proteins, which is markedly suppressed in the majority of early-stage...
Local asymptotic power of the Im-Pesaran-Shin panel unit root test and the impact of initial observations
In this note we derive the local asymptotic power function of the standardized averaged Dickey–Fuller panel unit root statistic of Im, Pesaran, and Shin (2003, Journal of Econometrics, 115, 53–74), allowing for heterogeneous...
2D coherent charge transport in highly ordered conducting polymers doped by solid state diffusion.
Whole-Genome Sequencing of Retinoblastoma Reveals the Diversity of Rearrangements Disrupting RB1 and Uncovers a Treatment-Related Mutational Signature.
Helen R Davies, Kevin D Broad, Zerrin Onadim, Elizabeth A Price, Xueqing Zou, Ibrahim Sheriff, Esin Kotiloğlu Karaa, Irene Scheimberg, M Ashwin Reddy, Mandeep S Sagoo, Shin-Ichi Ohnuma, Serena Nik-Zainal
Feb 17, 2021
The development of retinoblastoma is thought to require pathological genetic changes in both alleles of the RB1 gene. However, cases exist where RB1 mutations are undetectable, suggesting alternative pathways to malignancy. We...
Local asymptotic power of the Im-Pesaran-Shin panel unit root test and the impact of initial observations
In this note we derive the local asymptotic power function of the standardized averaged Dickey–Fuller panel unit root statistic of Im, Pesaran, and Shin (2003, Journal of Econometrics, 115, 53–74), allowing for heterogeneous...
Whole-Genome Sequencing of Retinoblastoma Reveals the Diversity of Rearrangements Disrupting RB1 and Uncovers a Treatment-Related Mutational Signature
Helen R. Davies, Kevin D. Broad, Zerrin Onadim, Elizabeth A. Price, Xueqing Zou, Ibrahim Sheriff, Esin Kotiloğlu Karaa, Irene Scheimberg, M. Ashwin Reddy, Mandeep S. Sagoo, Shin-Ichi Ohnuma, Serena Nik-Zainal
Feb 12, 2021
The development of retinoblastoma is thought to require pathological genetic changes in both alleles of the RB1 gene. However, cases exist where RB1 mutations are undetectable, suggesting alternative pathways to malignancy. We...
Two Secreted Proteoglycans, Activators of Urothelial Cell–Cell Adhesion, Negatively Contribute to Bladder Cancer Initiation and Progression
Vasiliki Papadaki, Ken Asada, Julie K. Watson, Toshiya Tamura, Alex Leung, Jack Hopkins, Margaret Dellett, Noriaki Sasai, Hongorzul Davaapil, Serena Nik-Zainal, Rebecca Longbottom, Makoto Nakakido, Ryo Torii, Abhi Veerakumarasivam, Syuzo Kaneko, Mandeep S. Sagoo, Gillian Murphy, Akihisa Mitani, Kohei Tsumoto, John D. Kelly, Ryuji Hamamoto, Shin-Ichi Ohnuma
Nov 14, 2020
Osteomodulin (OMD) and proline/arginine-rich end leucine repeat protein (PRELP) are secreted extracellular matrix proteins belonging to the small leucine-rich proteoglycans family. We found that OMD and PRELP were specifically...
Heterogeneous nuclear ribonucleoprotein A1 post-transcriptionally regulates Drp1 expression in neuroblastoma cells.
So Jung Park, Heejin Lee, Doo Shin Jo, Yoon Kyung Jo, Ji Hyun Shin, Han Byeol Kim, Hae Mi Seo, David C Rubinsztein, Jae-Young Koh, Eun Kyung Lee, Dong-Hyung Cho
Oct 27, 2015
Drp1 Mitochondria dynamics RNA binding protein hnRNP A1 3' Untranslated Regions Cell Line Tumor Cell Nucleus Cytoplasm Dynamins GTP Phosphohydrolases Gene Expression Regulation Neoplastic Heterogeneous Nuclear Ribonucleoprotein A1 Heterogeneous-Nuclear Ribonucleoprotein Group A-B Humans Microtubule-Associated Proteins Mitochondrial Dynamics Mitochondrial Proteins Neoplasm Proteins Neuroblastoma Protein Binding Protein Transport RNA processing Post-Transcriptional RNA Messenger RNA Neoplasm
Decoding the regulatory network of early blood development from single-cell gene expression measurements.
Two Secreted Proteoglycans, Activators of Urothelial Cell-Cell Adhesion, Negatively Contribute to Bladder Cancer Initiation and Progression.
Vasiliki Papadaki, Ken Asada, Julie K Watson, Toshiya Tamura, Alex Leung, Jack Hopkins, Margaret Dellett, Noriaki Sasai, Hongorzul Davaapil, Serena Nik-Zainal, Rebecca Longbottom, Makoto Nakakido, Ryo Torii, Abhi Veerakumarasivam, Syuzo Kaneko, Mandeep S Sagoo, Gillian Murphy, Akihisa Mitani, Kohei Tsumoto, John D Kelly, Ryuji Hamamoto, Shin-Ichi Ohnuma
Dec 17, 2020
Osteomodulin (OMD) and proline/arginine-rich end leucine repeat protein (PRELP) are secreted extracellular matrix proteins belonging to the small leucine-rich proteoglycans family. We found that OMD and PRELP were specifically...
An Agent-Based Assessment of Health Vulnerability to Long-Term Particulate Exposure in Seoul Districts
This study presents a proof-of-concept agent-based model (ABM) of health vulnerability to long-term exposure to airborne particulate pollution, specifically to particles less than 10 micrometres in size (PM10), in Seoul, Korea....
Mass Balance Simulation for Wetlands and Estuaries Management
The closed bay formed by a tidal power plant on the west coast of Korea has caused water quality to change due to nutrient increase and salinity alternation. The nutrients of the inner bay are often kept a balance with the aid...
Nanocluster-Based Ultralow-Temperature Driven Oxide Gate Dielectrics for High-Performance Organic Electronic Devices.
Jeong-Wan Jo, Jingu Kang, Kyung-Tae Kim, Seung-Han Kang, Jae-Cheol Shin, Seung Beom Shin, Yong-Hoon Kim, Sung Kyu Park
Feb 22, 2021
The development of novel dielectric materials with reliable dielectric properties and low-temperature processibility is crucial to manufacturing flexible and high-performance organic thin-film transistors (OTFTs) for...
Explicating Consumer Adoption of Wearable Technologies
This research aims to determine the key antecedent factors in consumers’ adoption of and their intention to recommend smartwatch wearable technology. The proposed research model combines the current technology acceptance and...
Published by: IGI Global Scientific Publishing
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