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Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
A Saini, AR Norman, D Cunningham, I Chau, M Hill, D Tait, T Hickish, T Iveson, F Lofts, D Jodrell, PJ Ross, J Oates
Sep 02, 2020
We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of 5-fluorouracil (5-FU) delivered by protracted intravenous infusion (PVI 5-FU) against the standard bolus regimen of 5-FU and folinic...
Mechanical Properties of MJ-Class Toroidal Magnet Wound by Composite HTS Conductor
An MJ-class superconducting magnetic energy storage (SMES) system has a wide range of potential applications in electric power systems. The composite high-temperature superconducting HTS conductor, which has the advantages of...
Mechanical Properties of MJ-Class Toroidal Magnet Wound by Composite HTS Conductor
An MJ-class superconducting magnetic energy storage (SMES) system has a wide range of potential applications in electric power systems. The composite high-temperature superconducting HTS conductor, which has the advantages of...
Numerical Study on AC Loss Properties of HTS Cable Consisting of YBCO Coated Conductor for HTS Power Devices
Shanshan Fu, Ming Qiu, Jiahui Zhu, Huiming Zhang, Jun Gong, Xin ZHAO, Weijia Yuan, Jianbo Guo
Jun 01, 2018
High-current high temperature superconducting (HTS) cables have been developed for use in HTS power devices. This paper presented the structures of HTS cables, including Conductor on Round Core (CORC) cable, Twisted...
Numerical Study on AC Loss Properties of HTS Cable Consisting of YBCO Coated Conductor for HTS Power Devices
Shanshan Fu, Ming Qiu, Jiahui Zhu, Huiming Zhang, Jun Gong, Xin ZHAO, Weijia Yuan, Jianbo Guo
Jun 01, 2018
High-current high temperature superconducting (HTS) cables have been developed for use in HTS power devices. This paper presented the structures of HTS cables, including Conductor on Round Core (CORC) cable, Twisted...
Outdoor PM2.5 concentration and rate of change in COVID-19 infection in provincial capital cities in China.
Yang Han, Jacqueline CK Lam, Victor OK Li, Jon Crowcroft, Jinqi Fu, Jocelyn Downey, Illana Gozes, Qi Zhang, Shanshan Wang, Zafar Gilani
Dec 15, 2021
This study investigates thoroughly whether acute exposure to outdoor PM2.5 concentration, P, modifies the rate of change in the daily number of COVID-19 infections (R) across 18 high infection provincial capitals in China...
Big Data for Healthcare in China
Shanshan Zhang
Apr 26, 2016
Secondary Metabolites of Osmanthus fragrans
Chen-Chen Fu, Fa-Ying Xu, Yu-Chen Qian, Hoi-Lun Koo, Yi-Fan Duan, Geng-Min Weng, Tai-Ping Fan, Mo-Xian Chen, Fu-Yuan Zhu
Aug 01, 2022
Osmanthus fragrans (scientific name: Osmanthus fragrans (Thunb.) Lour.) is a species of the Osmanthus genus in the family Oleaceae, and it has a long history of cultivation in China. O. fragrans is edible and is well known for...
On a new proposed mechanism of 5-fluorouracil-mediated cytotoxicity
Shobbir Hussain
May 01, 2020
The major molecular mode of action of the cytotoxic drug 5-fluorouracil (5-FU) is generally considered to result from thymidylate synthase inhibition. Recent findings relating to the function of the human uracil-5...
Intensive Imaging-based Follow-up of Surgically Treated Localised Renal Cell Carcinoma Does Not Improve Post-recurrence Survival
Saeed Dabestani, Christian Beisland, Grant D Stewart, Karim Bensalah, Eirikur Gudmundsson, Thomas B Lam, William Gietzmann, Paimaun Zakikhani, Lorenzo Marconi, Sergio Fernandéz-Pello, Serenella Monagas, Samuel Paul Williams, Christian Torbrand, Thomas Powles, Erik Van Werkhoven, Richard Meijer, Alessandro Volpe, Michael Staehler, Börje Ljungberg, Axel Bex
Dec 03, 2018
The optimal follow-up (FU) strategy for patients treated for localised renal cell carcinoma (RCC) remains unclear. Using the RECUR database, we studied imaging intensity utilised in contemporary FU to evaluate its association...
Accuracy and bias of experts' adjusted forecasts
This study investigates whether experts' group-based judgmental adjustments to econometric forecasts of tourism demand improve the accuracy of the forecasts and whether the adjusted forecasts are unbiased. The Delphi method was...
Topical treatment of actinic keratoses in organ transplant recipients
Zeeshaan-Ul Hasan, Ikhlaaq Ahmed, Rubeta N Matin, Victoria Homer, John T Lear, Ferina Ismail, Tristan Whitmarsh, Adele C Green, Jason Thomson, Alan Milligan, Sarah Hogan, Vanessa Van-de-Velde, Liza Mitchell-Worsford, Jonathan Kentley, Claire Gaunt, Yolande Jefferson-Hulme, Sarah J Bowden, Piers Gaunt, Keith Wheatley, Charlotte M Proby, Catherine A Harwood
Jun 14, 2022
BACKGROUND: The risk of cutaneous squamous cell carcinoma (cSCC) is significantly increased in organ transplant recipients (OTRs). Clearance of actinic keratoses (AKs) is generally regarded as a surrogate biomarker for cSCC...
Design of a College English Smart Teaching Platform Based on Big Multimedia Data Technology
College English teaching should give full play to the important role of network resources, implement the student-centered network autonomous learning model, and give full play to learners' autonomous learning potential. At...
Published by: IGI Global Scientific Publishing
On a new proposed mechanism of 5-fluorouracil-mediated cytotoxicity
Shobbir Hussain
May 01, 2020
The major molecular mode of action of the cytotoxic drug 5-fluorouracil (5-FU) is generally considered to result from thymidylate synthase inhibition. Recent findings relating to the function of the human uracil-5...
‘I am just a loser of higher education’
This paper proposes a unique framework for comparative analysis of different Adult Higher Education (AHE) systems. The framework combines, a conceptualisation of how students’ outcomes are shaped by the way that they and...
Accuracy and bias of experts' adjusted forecasts
This study investigates whether experts' group-based judgmental adjustments to econometric forecasts of tourism demand improve the accuracy of the forecasts and whether the adjusted forecasts are unbiased. The Delphi method was...
A Corpus-Based Study on the Translation Style of Five English Versions of Fu Sheng Liu Ji, Vol I
Bing Zhang
Oct 31, 2022
Using a corpus approach, this article investigates the translation styles of the first chapter of Fu Sheng Liu Ji at three levels: the statistical parameters, the translation of culture-specific lexis, and readability...
Published by: IGI Global Scientific Publishing
‘I am just a loser of higher education’
This paper proposes a unique framework for comparative analysis of different Adult Higher Education (AHE) systems. The framework combines, a conceptualisation of how students’ outcomes are shaped by the way that they and...
Non-alcoholic fatty liver is associated with increased risk of irritable bowel syndrome
Shanshan Wu, Changzheng Yuan, Zhirong Yang, Si Liu, Qian Zhang, Shutian Zhang, Shengtao Zhu
Aug 22, 2022
BACKGROUND: The relationship between non-alcoholic fatty liver degree as well as non-alcoholic fatty liver disease (NAFLD) and irritable bowel syndrome (IBS) remains poorly understood. We aimed to investigate the prospective...
SC3s
BACKGROUND: Today it is possible to profile the transcriptome of individual cells, and a key step in the analysis of these datasets is unsupervised clustering. For very large datasets, efficient algorithms are required to ensure...
SC3s
BACKGROUND: Today it is possible to profile the transcriptome of individual cells, and a key step in the analysis of these datasets is unsupervised clustering. For very large datasets, efficient algorithms are required to ensure...
Bilateral Habenula deep brain stimulation for treatment-resistant depression
Chencheng Zhang, Yingying Zhang, Huichun Luo, Xinmeng Xu, Ti-Fei Yuan, Dianyou Li, Yi-Yun Cai, Hengfen Gong, Dai-Hui Peng, Yi-Ru Fang, Valerie Voon, Bomin Sun
Mar 07, 2022
Deep brain stimulation (DBS) of structures in the brain's reward system is a promising therapeutic option for patients with treatment-resistant depression (TRD). Recently, DBS of the habenula (HB) in the brain's anti-reward...
“Small, yet Beautiful”
We reconsider whether a grand multi-winner contest elicits more equilibrium effort than a collection of sub-contests. Fu and Lu (2009) employ a sequential winner-selection mechanism and find support for running a grand contest....
Non-alcoholic fatty liver is associated with increased risk of irritable bowel syndrome
Shanshan Wu, Changzheng Yuan, Zhirong Yang, Si Liu, Qian Zhang, Shutian Zhang, Shengtao Zhu
Sep 22, 2022
BACKGROUND: The relationship between non-alcoholic fatty liver degree as well as non-alcoholic fatty liver disease (NAFLD) and irritable bowel syndrome (IBS) remains poorly understood. We aimed to investigate the prospective...
Anti-tumour efficacy of capecitabine in a genetically engineered mouse model of pancreatic cancer.
Aurélie Courtin, Frances M Richards, Tashinga E Bapiro, Jo L Bramhall, Albrecht Neesse, Natalie Cook, Ben-Fillippo Krippendorff, David A Tuveson, Duncan I Jodrell
Feb 12, 2020
Capecitabine (CAP) is a 5-FU pro-drug approved for the treatment of several cancers and it is used in combination with gemcitabine (GEM) in the treatment of patients with pancreatic adenocarcinoma (PDAC). However, limited...
Animals Antineoplastic Combined Chemotherapy Protocols Capecitabine Carcinoma Pancreatic Ductal Cell Line Tumor Cytidine Deaminase Deoxycytidine Disease Models Animal Drug Screening Assays Antitumor Fluorouracil Mice Mice Transgenic Neoplasm Transplantation Pancreatic Neoplasms prodrugs Tissue Distribution Gemcitabine
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