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Detection of human and rodent 5-HT3B receptor subunits by anti-peptide polyclonal antibodies
Background: The 5-HT3 receptor is a member of a neurotransmitter-gated ion channel family which includes nicotinic acetylcholine, GABA(A), and glycine receptors. While antibodies specific for the 5-HT3A receptor subunit are...
How Does Knowledge Management Matter for Supply Chain Resilience?
Disruption events highlight the importance of supply chain resilience (SCR) and leave managers wondering what characteristics can help firms survive and recover. This study employs the knowledge-based theory to investigate...
Published by: IGI Global Scientific Publishing
Investigation of the impact of the configuration of exhaust after-treatment system for diesel engines
Chung Ting Lao, Jethro Akroyd, Nickolas Eaves, Alastair Smith, Neal Morgan, Daniel Nurkowski, Amit Bhave, Markus Kraft
Apr 09, 2020
Exhaust After-Treatment (EAT) systems are necessary for automotive powertrains to meet stringent emission standards. Computational modelling has been applied to aid designing EAT systems. Models with global kinetic mechanisms...
Mutations of the nACh Receptor M4 Helix Reveal Different Phenotypes in Different Expression Systems
The role of the outermost helix (M4) in the pentameric ligand-gated ion channel (pLGIC) family is currently not fully understood. It is known that M4 is important for receptor assembly, possibly via interactions with neighboring...
A Single Mutation in the Outer Lipid-Facing Helix of a Pentameric Ligand-Gated Ion Channel Affects Channel Function Through a Radially-Propagating Mechanism.
Pentameric ligand-gated ion channels (pLGICs) mediate fast synaptic transmission and are crucial drug targets. Their gating mechanism is triggered by ligand binding in the extracellular domain that culminates in the opening of a...
Multiple regions in the extracellular domain of the glycine receptor determine receptor activity.
Glycine receptors (GlyRs) are Cys-loop receptors that mediate fast synaptic inhibition in the brain stem and spinal cord. They are involved in the generation of motor rhythm, reflex circuit coordination, and sensory signal...
Cys-loop aromatic amino acid Electrophysiology glycine receptor Ion channel Ligand-gated membrane biophysics Mutagenesis mutant pentameric ligand-gated ion channel two-voltage electrode clamp Amino Acid Substitution Animals Humans Loss of Function Mutation Phenylalanine Protein Binding Protein Domains Protein Engineering Receptors Glycine Taurine
Characterization of Residues in the 5-HT3 Receptor M4 Region That Contribute to Function.
5-HT3 receptors are members of the family of pentameric ligand gated ion channels (pLGICs). Each subunit has four transmembrane α-helices (M1-M4), with M4 being most distant from the central pore. Residues in this α-helix...
Ammonia mobility in chabazite
Alexander J. O'Malley, Iain Hitchcock, Misbah Sarwar, Ian P. Silverwood, Sheena Hindocha, C. Richard A. Catlow, Andrew P. E. York, P. J. Collier
Jul 14, 2016
The diffusion of ammonia in commercial NH3-SCR catalyst Cu-CHA was measured and compared with H-CHA using quasielastic neutron scattering (QENS) and molecular dynamics (MD) simulations to assess the effect of...
Ammonia mobility in chabazite
Alexander J. O'Malley, Iain Hitchcock, Misbah Sarwar, Ian P. Silverwood, Sheena Hindocha, C. Richard A. Catlow, Andrew P. E. York, P. J. Collier
Jul 14, 2016
The diffusion of ammonia in commercial NH3-SCR catalyst Cu-CHA was measured and compared with H-CHA using quasielastic neutron scattering (QENS) and molecular dynamics (MD) simulations to assess the effect of...
Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBP.
Cys-loop receptor Ligand-gated ion channel serotonin receptor Amino Acid Sequence Animals Binding Sites Carrier Proteins Crystallography X-Ray HEK293 Cells Humans Hydrogen Bonding Mice Models Molecular Mutation Oocytes Patch-Clamp Techniques Protein Structure Secondary Receptors Serotonin 5-HT3 Serotonin Serotonin Agents Varenicline water Xenopus
Palonosetron-5-HT3Receptor Interactions As Shown by a Binding Protein Cocrystal Structure.
Cys-loop receptor Ligand-gated ion channel serotonin receptor Animals Aplysia Binding Sites Carrier Proteins Crystallography X-Ray Dose-Response Relationship Drug HEK293 Cells Humans Hydrogen Bonding Hydrophobic and Hydrophilic Interactions Isoquinolines Membrane Potentials Models Molecular Molecular Structure Mutation Protein Engineering Quinuclidines Receptors Serotonin 5-HT3 Serotonin 5-HT3 Receptor Antagonists
Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-gated Ion Channel (GLIC) Supports Conserved Gating Motions among Cys-loop Receptors.
Matthew Rienzo, Angela R Rocchi, Stephanie D Threatt, Dennis A Dougherty, Sarah CR Lummis
Jan 26, 2016
Cys-loop receptor Gloeobacter violaceus Electrophysiology Mutagenesis non-canonical amino acid non-standard mutagenesis nonsense suppression proline analogs Protein Conformation structure-function Amino Acid Motifs Amino Acid Sequence Amino Acid Substitution Bacterial Proteins Cyanobacteria Hydrogen Bonding Ion Channel Gating Ligand-Gated Ion Channels Models Molecular Molecular Sequence Data Proline Protein Structure Secondary
Phenylalanine in the pore of the Erwinia ligand-gated ion channel modulates picrotoxinin potency but not receptor function.
Amino Acid Sequence Animals Bacterial Proteins Binding Sites Binding Competitive Cysteine Loop Ligand-Gated Ion Channel Receptors Erwinia Female GABA-A Receptor Antagonists Ion Channel Gating Membrane Potentials Models Molecular Molecular Sequence Data Mutation Missense Oocytes Phenylalanine Picrotoxin Protein Structure Secondary Protein Structure Tertiary Sequence Homology Amino Acid Sesterterpenes Xenopus laevis gamma-Aminobutyric Acid
Physiological Responses to Social and Nonsocial Stimuli in Neurotypical Adults With High and Low Levels of Autistic Traits
Researchers have suggested that the two primary cognitive features of autism spectrum disorder (ASD), a drive toward nonsocial processing and a reduced drive toward social processing, may be unrelated to each other in the...
The binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT3A and 5-HT3AB receptors.
Andrew J Thompson, Mark HP Verheij, Joost Verbeek, Albert D Windhorst, Iwan JP de Esch, Sarah CR Lummis
Oct 22, 2014
5-HT(3) Agonist Antagonist Cys-loop Ion channel Radioligand Amino Acid Sequence Binding Competitive HEK293 Cells Humans Molecular Docking Simulation Molecular Sequence Data Mutagenesis Site-Directed Piperidines Quinoxalines Radioligand Assay Radiopharmaceuticals Receptors Serotonin 5-HT3 Sequence Alignment Tritium
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