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Lithium and potassium aminoalkoxides
The structures of the Group 1 metal aminoalkoxides Li[OCH(CH CNMe)] (1) and K[OCH(CHCNMe )]·H OCH(CHCNMe) (2) have been determined. 1 is a hexameric drum in which two Li O rings are joined co-facially, whereas 2 is tetrameric...
N-acyl 1,5-diazabicyclo[4.3.0]non-5-ene (DBN) tetraphenylborate salts as O-acylating agents
Air-stable and crystalline N-acyl DBN tetraphenylborate salts have been shown to be effective O-acylating agents, reacting with both primary and secondary alcohols to give the corresponding esters in good yields. In the case of...
Associations between hedonic hunger and BMI during a two-year behavioural weight loss trial.
Bethan R Mead, Emma J Boyland, Paul Christiansen, Jason C G Halford, Susan A Jebb, Amy L Ahern
Jul 28, 2021
Objective
Prospective studies on relationships between hedonic hunger and BMI (Body Mass Index) during weight management are lacking. This study examined if hedonic hunger reduced during a behavioural weight management...
Published by: PLOS ONE
Lithium and potassium aminoalkoxides
The structures of the Group 1 metal aminoalkoxides Li[OCH(CH CNMe)] (1) and K[OCH(CHCNMe )]·H OCH(CHCNMe) (2) have been determined. 1 is a hexameric drum in which two Li O rings are joined co-facially, whereas 2 is tetrameric...
N-acyl 1,5-diazabicyclo[4.3.0]non-5-ene (DBN) tetraphenylborate salts as O-acylating agents
Air-stable and crystalline N-acyl DBN tetraphenylborate salts have been shown to be effective O-acylating agents, reacting with both primary and secondary alcohols to give the corresponding esters in good yields. In the case of...
Reevaluation of SNP heritability in complex human traits
SNP heritability, the proportion of phenotypic variance explained by SNPs, has been reported for many hundreds of traits. Its estimation requires strong prior assumptions about the distribution of heritability across the genome...
Alleles Case-Control Studies Chromosome Fragile Sites Cohort Studies Computer Simulation Deoxyribonuclease I Gene Frequency Genetic Association Studies Genome-Wide Association Study Humans Inheritance Patterns Models Genetic Multifactorial Inheritance Polymorphism Single Nucleotide Quantitative Trait Heritable
Polygenic basis and biomedical consequences of telomere length variation.
Veryan Codd, Qingning Wang, Elias Allara, Crispin Musicha, Stephen Kaptoge, Svetlana Stoma, Tao Jiang, Stephen E Hamby, Peter S Braund, Vasiliki Bountziouka, Charley A Budgeon, Matthew Denniff, Chloe Swinfield, Manolo Papakonstantinou, Shilpi Sheth, Dominika E Nanus, Sophie C Warner, Minxian Wang, Amit V Khera, James Eales, Willem H Ouwehand, John R Thompson, Emanuele Di Angelantonio, Angela M Wood, Adam S Butterworth, John N Danesh, Christopher P Nelson, Nilesh J Samani
Nov 05, 2021
Telomeres, the end fragments of chromosomes, play key roles in cellular proliferation and senescence. Here we characterize the genetic architecture of naturally occurring variation in leukocyte telomere length (LTL) and identify...
Global analysis of the evolution and mechanism of echinocandin resistance in <em>Candida glabrata</em>
S.D. Singh-Babak, T. Babak, S. Diezmann, J. A. Hill, J. L. Xie, Y.-L. Chen, S. M. Poutanen, R. P. Rennie, J. Heitman, L. E. Cowen
May 01, 2012
The evolution of drug resistance has a profound impact on human health. Candida glabrata is a leading human fungal pathogen that can rapidly evolve resistance to echinocandins, which target cell wall biosynthesis and are...
Association between breakfast frequency and physical activity and sedentary time
Julia K. Zakrzewski-Fruer, Fiona B. Gillison, Peter T. Katzmarzyk, Emily F. Mire, Stephanie T. Broyles, Catherine M. Champagne, Jean-Philippe Chaput, Kara D. Denstel, Mikael Fogelholm, Gang Hu, Estelle V. Lambert, Carol Maher, José Maia, Tim Olds, Vincent Onywera, Olga L. Sarmiento, Mark S. Tremblay, Catrine Tudor-Locke, Martyn Standage
Feb 21, 2019
Background: Existing research has documented inconsistent findings for the associations among breakfast frequency, physical activity (PA), and sedentary time in children. The primary aim of this study was to examine the...
Global analysis of the evolution and mechanism of echinocandin resistance in <em>Candida glabrata</em>
S.D. Singh-Babak, T. Babak, S. Diezmann, J. A. Hill, J. L. Xie, Y.-L. Chen, S. M. Poutanen, R. P. Rennie, J. Heitman, L. E. Cowen
May 01, 2012
The evolution of drug resistance has a profound impact on human health. Candida glabrata is a leading human fungal pathogen that can rapidly evolve resistance to echinocandins, which target cell wall biosynthesis and are...
Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study.
Aurélie Moskal, Heinz Freisling, Graham Byrnes, Nada Assi, Michael T Fahey, Mazda Jenab, Pietro Ferrari, Anne Tjønneland, Kristina En Petersen, Christina C Dahm, Camilla Plambeck Hansen, Aurélie Affret, Marie-Christine Boutron-Ruault, Claire Cadeau, Tilman Kühn, Verena Katzke, Khalid Iqbal, Heiner Boeing, Antonia Trichopoulou, Christina Bamia, Androniki Naska, Giovanna Masala, Maria Santucci de Magistris, Sabina Sieri, Rosario Tumino, Carlotta Sacerdote, Petra H Peeters, Bas H Bueno-de-Mesquita, Dagrun Engeset, Idlir Licaj, Guri Skeie, Eva Ardanaz, Genevieve Buckland, José M Huerta Castaño, José R Quirós, Pilar Amiano, Elena Molina-Portillo, Anna Winkvist, Robin Myte, Ulrika Ericson, Emily Sonestedt, Aurora Perez-Cornago, Nick Wareham, Kay-Tee Khaw, Inge Huybrechts, Konstantinos K Tsilidis, Heather Ward, Marc J Gunter, Nadia Slimani
Jan 26, 2018
BACKGROUND: Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major...
Association between breakfast frequency and physical activity and sedentary time
Julia K. Zakrzewski-Fruer, Fiona B. Gillison, Peter T. Katzmarzyk, Emily F. Mire, Stephanie T. Broyles, Catherine M. Champagne, Jean-Philippe Chaput, Kara D. Denstel, Mikael Fogelholm, Gang Hu, Estelle V. Lambert, Carol Maher, José Maia, Tim Olds, Vincent Onywera, Olga L. Sarmiento, Mark S. Tremblay, Catrine Tudor-Locke, Martyn Standage
Feb 21, 2019
Background: Existing research has documented inconsistent findings for the associations among breakfast frequency, physical activity (PA), and sedentary time in children. The primary aim of this study was to examine the...
The frequency and outcome of lupus nephritis
John G Hanly, Aidan G O'Keeffe, Li Su, Murray B Urowitz, Juanita Romero-Diaz, Caroline Gordon, Sang-Cheol Bae, Sasha Bernatsky, Ann E Clarke, Daniel J Wallace, Joan T Merrill, David A Isenberg, Anisur Rahman, Ellen M Ginzler, Paul Fortin, Dafna D Gladman, Jorge Sanchez-Guerrero, Michelle Petri, Ian N Bruce, Mary Anne Dooley, Rosalind Ramsey-Goldman, Cynthia Aranow, Graciela S Alarcón, Barri J Fessler, Kristjan Steinsson, Ola Nived, Gunnar K Sturfelt, Susan Manzi, Munther A Khamashta, Ronald F van Vollenhoven, Asad A Zoma, Manuel Ramos-Casals, Guillermo Ruiz-Irastorza, S Sam Lim, Thomas Stoll, Murat Inanc, Kenneth C Kalunian, Diane L Kamen, Peter Maddison, Christine A Peschken, Soren Jacobsen, Anca Askanase, Chris Theriault, Kara Thompson, Vernon Farewell
Jun 12, 2018
OBJECTIVE: To determine nephritis outcomes in a prospective multi-ethnic/racial SLE inception cohort. METHODS: Patients in the Systemic Lupus International Collaborating Clinics inception cohort (≤15 months of SLE diagnosis)...
inception cohort lupus nephritis outcomes research Systemic Lupus Erythematosus Adult Disease Progression Ethnicity Female Follow-Up Studies Global Health Humans Incidence Lupus Nephritis Male Outcome Assessment Health Care Prospective Studies Quality of life Risk Factors Surveys and Questionnaires Survival Rate
New constraints on the physical conditions in H2-bearing GRB-host damped Lyman-alpha absorbers
K.E Heintz, Jan Bolmer, Cedric Ledoux, P. Noterdaeme, J.K Krogager, J.P.U. Fynbo, P. Jakobsson, S. Covino, V. D'Elia, M. De Pasquale, D.H. Hartmann, L. Izzo, J. Jupelj, D.A. Kann, L. Kaper, P. Petitjean, A. Rossi, R. Salvaterra, Patricia Schady, J. Selsing, R. Starling, N.R. Tanvir, C.C. Thoene, A. de Ugarte Postigo, S.D. Vergani, D. Watson, K. Wiersema, T. Zafar
Sep 30, 2019
New constraints on the physical conditions in H2-bearing GRB-host damped Lyman-alpha absorbers
K.E Heintz, Jan Bolmer, Cedric Ledoux, P. Noterdaeme, J.K Krogager, J.P.U. Fynbo, P. Jakobsson, S. Covino, V. D'Elia, M. De Pasquale, D.H. Hartmann, L. Izzo, J. Jupelj, D.A. Kann, L. Kaper, P. Petitjean, A. Rossi, R. Salvaterra, Patricia Schady, J. Selsing, R. Starling, N.R. Tanvir, C.C. Thoene, A. de Ugarte Postigo, S.D. Vergani, D. Watson, K. Wiersema, T. Zafar
Sep 30, 2019
Polyunsaturated fatty acids and prostate cancer risk
Nikhil K Khankari, Harvey J Murff, Chenjie Zeng, Wanqing Wen, Rosalind A Eeles, Douglas F Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, Jenny L Donovan, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen N Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Wei Zheng, PRACTICAL Consortium
Dec 01, 2017
BACKGROUND: Prostate cancer is a common cancer worldwide with no established modifiable lifestyle factors to guide prevention. The associations between polyunsaturated fatty acids (PUFAs) and prostate cancer risk have been...
Physical activity, sedentary time and gain in overall and central body fat
R Golubic, K Wijndaele, SJ Sharp, RK Simmons, SJ Griffin, NJ Wareham, U Ekelund, S Brage, ProActive Study Group
Jun 13, 2018
OBJECTIVE: The objective of this study is to examine the independent associations of time spent in moderate-to-vigorous physical activity (MVPA) and sedentary (SED-time), with total and abdominal body fat (BF), and the...
Accelerometry Adiposity Adult Cardiovascular Diseases Cohort Studies Diabetes mellitus Type 2 Evidence-Based Medicine Exercise Female Follow-Up Studies Health Knowledge Attitudes practice Health Promotion Humans Male obesity Risk Factors Sedentary Behavior Time Factors Waist Circumference Weight Gain
ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19.
Maik Pietzner, Robert Lorenz Chua, Eleanor Wheeler, Katharina Jechow, Julian DS Willett, Helena Radbruch, Saskia Trump, Bettina Heidecker, Hugo Zeberg, Frank L Heppner, Roland Eils, Marcus A Mall, J Brent Richards, Leif-Erik Sander, Irina Lehmann, Sören Lukassen, Nicholas J Wareham, Christian Conrad, Claudia Langenberg
Aug 15, 2022
Despite two years of intense global research activity, host genetic factors that predispose to a poorer prognosis of COVID-19 infection remain poorly understood. Here, we prioritise eight robust (e.g., ELF5) or suggestive but...
Magnetization transfer imaging of ovarian cancer
Surrin S Deen, Mary A McLean, Andrew B Gill, Robin AF Crawford, John Latimer, Peter Baldwin, Helena M Earl, Christine A Parkinson, Sarah Smith, Charlotte Hodgkin, Mercedes Jimenez-Linan, Cara R Brodie, Ilse Patterson, Helen C Addley, Susan J Freeman, Penelope M Moyle, Martin J Graves, Evis Sala, James D Brenton, Ferdia A Gallagher
Oct 15, 2022
OBJECTIVES: To investigate the relationship between magnetization transfer (MT) imaging and tissue macromolecules in high-grade serous ovarian cancer (HGSOC) and whether MT ratio (MTR) changes following neoadjuvant chemotherapy...
Isolating the direct effects of adverse developmental conditions on in vivo cardiovascular function at adulthood
It is now well accepted that exposure to adverse environmental conditions in utero can predispose a fetus to disease later in life. Using an avian model to study the programming of disease has a unique advantage as it allows...
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.
Sirui Zhou, Guillaume Butler-Laporte, Tomoko Nakanishi, David R Morrison, Jonathan Afilalo, Marc Afilalo, Laetitia Laurent, Maik Pietzner, Nicola Kerrison, Kaiqiong Zhao, Elsa Brunet-Ratnasingham, Danielle Henry, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Meriem Bouab, Louis Petitjean, Charlotte Guzman, Xiaoqing Xue, Chris Tselios, Branka Vulesevic, Olumide Adeleye, Tala Abdullah, Noor Almamlouk, Yiheng Chen, Michaël Chassé, Madeleine Durand, Clare Paterson, Johan Normark, Robert Frithiof, Miklós Lipcsey, Michael Hultström, Celia MT Greenwood, Hugo Zeberg, Claudia Langenberg, Elin Thysell, Michael Pollak, Vincent Mooser, Vincenzo Forgetta, Daniel E Kaufmann, J Brent Richards
Apr 26, 2021
To identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility and severity, we undertook a two-sample Mendelian randomization (MR) study, rapidly scanning hundreds of circulating proteins while...
2' 5'-Oligoadenylate Synthetase Aged Aged 80 and over Animals covid-19 Case-Control Studies Female Genetic Predisposition to Disease Humans Interleukin-10 Receptor beta Subunit Male Mendelian Randomization Analysis Middle Aged Neanderthals Protein Isoforms Quantitative Trait Loci SARS-CoV-2 Severity of Illness Index White People
Long-term mortality of hospitalized pneumonia in the EPIC-Norfolk cohort.
Little is known about cause-specific long-term mortality beyond 30 days in pneumonia. We aimed to compare the mortality of patients with hospitalized pneumonia compared to age- and sex-matched controls beyond 30 days....
All-cause mortality cardiovascular mortality long-term mortality Pneumonia respiratory mortality Adult Aged Cardiovascular Diseases Case-Control Studies Cause of Death England Female Hospitalization Humans Incidence Male Middle Aged Pneumonia Proportional Hazards Models Prospective Studies Respiratory Tract Diseases Time Factors
Common health conditions in childhood and adolescence, school absence, and educational attainment
Amanda Hughes, Kaitlin H. Wade, Matt Dickson, Frances Rice, Alisha R Davies, Neil M Davies, Laura D Howe
Jan 04, 2021
Good health is positively related to children’s educational outcomes, but relationships may not be causal. Demonstrating a causal influence would strongly support childhood and adolescent health as important for education...
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