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Results: 8
Myc Cooperates with Ras by Programming Inflammation and Immune Suppression.
Roderik M Kortlever, Nicole M Sodir, Catherine H Wilson, Deborah L Burkhart, Luca Pellegrinet, Lamorna Brown Swigart, Trevor D Littlewood, Gerard I Evan
Jan 31, 2018
The two oncogenes KRas and Myc cooperate to drive tumorigenesis, but the mechanism underlying this remains unclear. In a mouse lung model of KRasG12D-driven adenomas, we find that co-activation of Myc drives the immediate...
CCL9 IL-23 Myc NK cells Ras immune suppression Inflammation Lung cancer oncogene cooperation Tumor Microenvironment Adenocarcinoma Adenoma Animals Carcinogenesis Chemokines CC Disease Models Animal Female Inflammation Interleukin-23 Lung Neoplasms Macrophage Inflammatory Proteins MACROPHAGES Male Mice Proto-Oncogene Proteins c-myc Proto-Oncogene Proteins p21(ras) Tumor Microenvironment
Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling.
Peter Kreuzaler, Matthew A Clarke, Elizabeth J Brown, Catherine H Wilson, Roderik M Kortlever, Nir Piterman, Trevor Littlewood, Gerard I Evan, Jasmin Fisher
Oct 14, 2019
Cells with higher levels of Myc proliferate more rapidly and supercompetitively eliminate neighboring cells. Nonetheless, tumor cells in aggressive breast cancers typically exhibit significant and stable heterogeneity in their...
Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution
Nicole Sodir, Luca Pellegrinet, Roderik Kortlever, Tania Campos, Yong-won Kwon, Shinseog Kim, Daniel Garcia, Alessandra Perfetto, Panayiotis Anastasiou, Lamorna Brown Swigart, Mark Arends, Trevor Littlewood, Gerard Evan
Dec 10, 2022
Germ-line hypomorphism of the pleiotropic transcription factor Myc in mice, either through Myc gene haploinsufficiency or deletion of Myc enhancers, delays onset of various cancers while mice remain viable and exhibit only...
Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution
Abstract Germ-line hypomorphism of the pleiotropic transcription factor Myc in mice, either through Myc gene haploinsufficiency or deletion of...
Nicole M Sodir, Luca Pellegrinet, Roderik M Kortlever, Tania Campos, Yong-won Kwon, Shinseog Kim, Daniel Garcia, Alessandra Perfetto, Panayiotis Anastasiou, Lamorna Brown Swigart, Mark J Arends, Trevor D Littlewood, Gerard I Evan
Nov 14, 2022
Discovery of Protoclusters at z∼3.7 and 4.9
Jun Toshikawa, Matthew A. Malkan, Nobunari Kashikawa, Roderik Overzier, Hisakazu Uchiyama, Kazuaki Ota, Shogo Ishikawa, Kei Ito
Jan 13, 2020
We have carried out follow-up spectroscopy on three overdense regions of g- and r-dropout galaxies in the Canada–France–Hawaii Telescope Legacy Survey Deep Fields, finding two new protoclusters at z = 4.898 and 3.721 and a...
Discovery of Protoclusters at z∼3.7 and 4.9
Jun Toshikawa, Matthew A. Malkan, Nobunari Kashikawa, Roderik Overzier, Hisakazu Uchiyama, Kazuaki Ota, Shogo Ishikawa, Kei Ito
Jan 13, 2020
We have carried out follow-up spectroscopy on three overdense regions of g- and r-dropout galaxies in the Canada–France–Hawaii Telescope Legacy Survey Deep Fields, finding two new protoclusters at z = 4.898 and 3.721 and a...
Faint Quasars Live in the Same Number Density Environments as Lyman Break Galaxies at z∼4
Hisakazu Uchiyama, Masayuki Akiyama, Jun Toshikawa, Nobunari Kashikawa, Roderik Overzier, Tohru Nagao, Kohei Ichikawa, Murilo Marinello, Masatoshi Imanishi, Masayuki Tanaka, Yoshiki Matsuoka, Yutaka Komiyama, Shogo Ishikawa, Masafusa Onoue, Mariko Kubo, Yuichi Harikane, Kei Ito, Shigeru Namiki, Yongming Liang
Dec 21, 2020
Characterizing high-z quasar environments is key to understanding the coevolution of quasars and the surrounding galaxies. To restrict their global picture, we statistically examine the g-dropout galaxy overdensity distribution...
Faint Quasars Live in the Same Number Density Environments as Lyman Break Galaxies at z∼4
Hisakazu Uchiyama, Masayuki Akiyama, Jun Toshikawa, Nobunari Kashikawa, Roderik Overzier, Tohru Nagao, Kohei Ichikawa, Murilo Marinello, Masatoshi Imanishi, Masayuki Tanaka, Yoshiki Matsuoka, Yutaka Komiyama, Shogo Ishikawa, Masafusa Onoue, Mariko Kubo, Yuichi Harikane, Kei Ito, Shigeru Namiki, Yongming Liang
Dec 21, 2020
Characterizing high-z quasar environments is key to understanding the coevolution of quasars and the surrounding galaxies. To restrict their global picture, we statistically examine the g-dropout galaxy overdensity distribution...