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Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion.
Valentin Gorboulev, Annette Schürmann, Volker Vallon, Helmut Kipp, Alexander Jaschke, Dirk Klessen, Alexandra Friedrich, Stephan Scherneck, Timo Rieg, Robyn Cunard, Maike Veyhl-Wichmann, Aruna Srinivasan, Daniela Balen, Davorka Breljak, Rexhep Rexhepaj, Helen E Parker, Fiona M Gribble, Frank Reimann, Florian Lang, Stefan Wiese, Ivan Sabolic, Michael Sendtner, Hermann Koepsell
Jan 31, 2020
To clarify the physiological role of Na(+)-D-glucose cotransporter SGLT1 in small intestine and kidney, Sglt1(-/-) mice were generated and characterized phenotypically. After gavage of d-glucose, small intestinal glucose...