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Microclustering-Based Multi-Class Classification on Imbalanced Multi-Relational Datasets
In a relational database, classification algorithms are used to look for patterns across several interconnected relations. Most of the methods for multi-relational classification algorithms implicitly assume that the classes in...
Published by: IGI Global Scientific Publishing
Impact of Price-Sensitive Demand and Premium Payment Scheme on Bullwhip Effect
Bullwhip effect reduces the efficiency, responsiveness, and value of the supply chain. There are some indirect causes like lead time, the number of echelons, and some direct causes of bullwhip effect such as rationing or price...
Published by: IGI Global Scientific Publishing
Integrating Keyword Segmentation and Budget Allocation Decisions in Sponsored Search Advertising
Budget constrained sponsored search advertisers must decide how to allocate their advertisement budget across ad campaigns and individual keywords. In this paper, a simulation model that integrates the complex issues involved in...
Published by: IGI Global Scientific Publishing
SACRED
Collaborative research is an opportunity to bring creative minds together and blend multiple disciplines to churn out innovative solutions. In this era of massive social media and information overload, a streamlined process...
Published by: IGI Global Scientific Publishing
Pathogen genomic surveillance of typhoidal Salmonella infection in adults and children reveals no association between clinical outcomes and infecting genotypes
Adaptive-Sunflower-Based Grey Wolf Algorithm for Multipath Routing in IoT Networks
This paper devises a routing method for providing multipath routing in an IoT network. Here the fractional artificial bee colony(FABC) algorithm is devised for initiating the clustering process. Moreover, the multipath routing...
Published by: IGI Global Scientific Publishing
Improving the Quality of Care in Care Homes Using the Quality Improvement Collaborative Approach
Reena Devi, Graham Martin, Jay Banerjee, Louise Butler, Tim Pattison, Lesley Cruickshank, Caroline Maries-Tillott, Tracie Wilson, Sarah Damery, Julienne Meyer, Antonius Poot, Peter Chamberlain, Debbie Harvey, Clarissa Giebel, Kathryn Hinsliff-Smith, Neil Chadborn, Adam Lee Gordon
Oct 20, 2020
The Breakthrough Series Quality Improvement Collaborative (QIC) initiative is a well-developed and widely used approach, but most of what we know about it has come from healthcare settings. In this article, those leading QICs to...
Pathogen genomic surveillance of typhoidal Salmonella infection in adults and children reveals no association between clinical outcomes and infecting genotypes
Pathogen genomic surveillance of typhoidal Salmonella infection in adults and children reveals no association between clinical outcomes and infecting genotypes.
Carl D Britto, Sitarah Mathias, Ashish Bosco, Zoe A Dyson, Gordon Dougan, Savitha Raveendran, VL Abin, Sanju Jose, Savitha Nagaraj, Kathryn E Holt, Andrew J Pollard
Sep 21, 2020
BACKGROUND: India is endemic for enteric fever, and it is not known whether the variations in clinical manifestations between patients are due to host, environmental or pathogen factors.Blood culture surveillance was conducted...
Transcriptomal Insights of Heart Failure from Normality to Recovery.
Mohammed Quttainah, Vineesh Vimala Raveendran, Soad Saleh, Ranjit Parhar, Mansour Aljoufan, Narain Moorjani, Zohair Y Al-Halees, Maie AlShahid, Kate S Collison, Stephen Westaby, Futwan Al-Mohanna
May 24, 2022
Current management of heart failure (HF) is centred on modulating the progression of symptoms and severity of left ventricular dysfunction. However, specific understandings of genetic and molecular targets are needed for more...
Preparing for pandemics
Ishmeala Rigby, Melina Michelen, Vincent Cheng, Andrew Dagens, Dania Dahmash, Samuel Lipworth, Eli Harriss, Erhui Cai, Valeria Balan, Alexandra Oti, Reena Joseph, Helen Groves, Peter Hart, Shevin Jacob, Lucille Blumberg, Peter W Horby, Louise Sigfrid
Dec 09, 2022
BACKGROUND: The COVID-19 pandemic has highlighted the importance of evidence-based clinical decision-making. Clinical management guidelines (CMGs) may help reduce morbidity and mortality by improving the quality of clinical...
Preparing for pandemics
Ishmeala Rigby, Melina Michelen, Vincent Cheng, Andrew Dagens, Dania Dahmash, Samuel Lipworth, Eli Harriss, Erhui Cai, Valeria Balan, Alexandra Oti, Reena Joseph, Helen Groves, Peter Hart, Shevin Jacob, Lucille Blumberg, Peter W Horby, Louise Sigfrid
Nov 08, 2022
BACKGROUND: The COVID-19 pandemic has highlighted the importance of evidence-based clinical decision-making. Clinical management guidelines (CMGs) may help reduce morbidity and mortality by improving the quality of clinical...
Transcriptomal Insights of Heart Failure from Normality to Recovery.
Mohammed Quttainah, Vineesh Vimala Raveendran, Soad Saleh, Ranjit Parhar, Mansour Aljoufan, Narain Moorjani, Zohair Y Al-Halees, Maie AlShahid, Kate S Collison, Stephen Westaby, Futwan Al-Mohanna
Jun 29, 2022
Current management of heart failure (HF) is centred on modulating the progression of symptoms and severity of left ventricular dysfunction. However, specific understandings of genetic and molecular targets are needed for more...
Transmission of B.1.617.2 Delta variant between vaccinated healthcare workers
Abstract Breakthrough infections with SARS-CoV-2 Delta variant have been reported in doubly-vaccinated recipients and as re-infections. Studies of viral spread within hospital settings have...
Steven A Kemp, Mark TK Cheng, William L Hamilton, Kimia Kamelian, Himanshu Chauhan, Tanzin Dikid, Hema Gogia, Hemlata Lall, Kalaiarasan Ponnusamy, Kaptan Verma, Mahesh Shanker Dhar, Manoj K Singh, Meena Datta, Namita Soni, Namonarayan Meena, Preeti Madan, Priyanka Singh, Ramesh Sharma, Rajeev Sharma, Sandhya Kabra, Sattender Kumar, Swati Kumari, Uma Sharma, Urmila Chaudhary, Sridhar Sivasubbu, Vinod Scaria, Chand Wattal, JK Oberoi, Reena Raveendran, S Datta, Saumitra Das, Arindam Maitra, Sreedhar Chinnaswamy, Nidhan Kumar Biswas, Ajay Parida, Sunil K Raghav, Punit Prasad, Apurva Sarin, Satyajit Mayor, Uma Ramakrishnan, Dasaradhi Palakodeti, Aswin Sai Narain Seshasayee, K Thangaraj, Murali Dharan Bashyam, Ashwin Dalal, Manoj Bhat, Yogesh Shouche, Ajay Pillai, Priya Abraham, Varsha Atul Potdar, Sarah S Cherian, Anita Sudhir Desai, Chitra Pattabiraman, MV Manjunatha, Reeta S Mani, Gautam Arunachal Udupi, Vinay Nandicoori, Karthik Bharadwaj Tallapaka, Divya Tej Sowpati, Sujit Singh, Partha Rakshit, Anurag Agrawal, Christopher JR Illingworth, Ravindra K Gupta
Jul 22, 2022
Fuzzy Modelling of Clinical and Epidemiological Factors for COVID-19
During this pandemic outbreak of COVID-19, the whole world is getting severely affected in respect of population health and economy. This novel virus has brought the whole world including the most developed countries to a...
Published by: IGI Global Scientific Publishing
In-depth phenotyping for clinical stratification of Gaucher disease.
Simona D'Amore, Kathleen Page, Aimée Donald, Khadijeh Taiyari, Brian Tom, Patrick Deegan, Chong Y Tan, Kenneth Poole, Simon A Jones, Atul Mehta, Derralynn Hughes, Reena Sharma, Robin H Lachmann, Anupam Chakrapani, Tarekegn Geberhiwot, Saikat Santra, Siddarth Banka, Timothy M Cox, MRC GAUCHERITE Consortium
Sep 23, 2021
Comparison of Optimised MDI versus Pumps with or without Sensors in Severe Hypoglycaemia (the Hypo COMPaSS trial).
Stuart Little, Thomas Chadwick, Pratik Choudhary, Cath Brennand, Julia Stickland, Shalleen Barendse, Tolulope Olateju, Lalantha Leelarathna, Emma Walkinshaw, Horng K Tan, Sally M Marshall, Reena M Thomas, Simon Heller, Mark Evans, David Kerr, Daniel Flanagan, Jane Speight, James Am Shaw
Jan 25, 2013
In-depth phenotyping for clinical stratification of Gaucher disease.
Simona D'Amore, Kathleen Page, Aimée Donald, Khadijeh Taiyari, Brian Tom, Patrick Deegan, Chong Y Tan, Kenneth Poole, Simon A Jones, Atul Mehta, Derralynn Hughes, Reena Sharma, Robin H Lachmann, Anupam Chakrapani, Tarekegn Geberhiwot, Saikat Santra, Siddarth Banka, Timothy M Cox
Nov 22, 2021
Background
The Gaucher Investigative Therapy Evaluation is a national clinical cohort of 250 patients aged 5-87 years with Gaucher disease in the United Kingdom-an ultra-rare genetic disorder. To inform clinical...
cohort Gaucher Disease Enzyme Replacement Therapy substrate reduction therapy Disease-modifying Therapies Gaucherite
Published by: Orphanet journal of rare diseases
Natural history of epilepsy in argininosuccinic aciduria provides new insights into pathophysiology
Nour Elkhateeb, Giorgia Olivieri, Barbara Siri, Stewart Boyd, Karolina M Stepien, Reena Sharma, Andrew AM Morris, Thomas Hartley, Laura Crowther, Stephanie Grunewald, Maureen Cleary, Helen Mundy, Anupam Chakrapani, Robin Lachmann, Elaine Murphy, Saikat Santra, Mari-Liis Uudelepp, Mildrid Yeo, Isaac Bernhardt, Sniya Sudakhar, Alicia Chan, Philippa Mills, Debora Ridout, Paul Gissen, Carlo Dionisi-Vici, Julien Baruteau
Apr 10, 2023
Localising occult prostate cancer metastasis with advanced imaging techniques (LOCATE trial)
Sola Adeleke, Arash Latifoltojar, Harbir Sidhu, Myria Galazi, Taimur T Shah, Joey Clemente, Reena Davda, Heather Ann Payne, Manil D Chouhan, Maria Lioumi, Sue Chua, Alex Freeman, Manuel Rodriguez-Justo, Anthony Coolen, Sachin Vadgama, Steve Morris, Gary J Cook, Jamshed Bomanji, Manit Arya, Simon Chowdhury, Simon Wan, Athar Haroon, Tony Ng, Hashim Uddin Ahmed, Shonit Punwani
Feb 24, 2020
BACKGROUND: Accurate whole-body staging following biochemical relapse in prostate cancer is vital in determining the optimum disease management. Current imaging guidelines recommend various imaging platforms such as computed...
Brachytherapy Cost comparison cost-effectiveness economic evaluation Magnetic Resonance Imaging positron emission tomography prostate cancer Radiotherapy Recurrence Cost-Benefit Analysis ErbB Receptors Exosomes Humans Magnetic Resonance Imaging Male Neoplasm Metastasis Neoplasm Recurrence Local Prospective Studies Prostatic Neoplasms Sensitivity and Specificity Whole Body Imaging
In-depth phenotyping for clinical stratification of Gaucher disease
Simona D’Amore, Kathleen Page, Aimée Donald, Khadijeh Taiyari, Brian Tom, Patrick Deegan, Chong Y. Tan, Kenneth Poole, Simon A. Jones, Atul Mehta, Derralynn Hughes, Reena Sharma, Robin H. Lachmann, Anupam Chakrapani, Tarekegn Geberhiwot, Saikat Santra, Siddarth Banka, Timothy M. Cox, T. M. Cox, F. M. Platt, S. Banka, A. Chakrapani, P. B. Deegan, T. Geberhiwot, D. A. Hughes, S. Jones, R. H. Lachmann, S. Santra, R. Sharma, A. Vellodi
Oct 18, 2021
Abstract: Background: The Gaucher Investigative Therapy Evaluation is a national clinical cohort of 250 patients aged 5–87 years with Gaucher disease in the United Kingdom—an ultra-rare genetic disorder. To inform clinical...
Common genetic variation drives molecular heterogeneity in human iPSCs.
Helena Kilpinen, Angela Goncalves, Andreas Leha, Vackar Afzal, Kaur Alasoo, Sofie Ashford, Sendu Bala, Dalila Bensaddek, Francesco Paolo Casale, Oliver J Culley, Petr Danecek, Adam Faulconbridge, Peter W Harrison, Annie Kathuria, Davis McCarthy, Shane A McCarthy, Ruta Meleckyte, Yasin Memari, Nathalie Moens, Filipa Soares, Alice Mann, Ian Streeter, Chukwuma A Agu, Alex Alderton, Rachel Nelson, Sarah Harper, Minal Patel, Alistair White, Sharad R Patel, Laura Clarke, Reena Halai, Christopher M Kirton, Anja Kolb-Kokocinski, Philip Beales, Ewan Birney, Davide Danovi, Angus I Lamond, Willem H Ouwehand, Ludovic Vallier, Fiona M Watt, Richard Durbin, Oliver Stegle, Daniel J Gaffney
Nov 20, 2018
Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous potential to provide improved cellular models of human disease. However, variable genetic and phenotypic characterization of many existing iPS...
A randomized trial of normothermic preservation in liver transplantation.
David Nasralla, Constantin C Coussios, Hynek Mergental, M Zeeshan Akhtar, Andrew J Butler, Carlo DL Ceresa, Virginia Chiocchia, Susan J Dutton, Juan Carlos García-Valdecasas, Nigel Heaton, Charles Imber, Wayel Jassem, Ina Jochmans, John Karani, Simon R Knight, Peri Kocabayoglu, Massimo Malagò, Darius Mirza, Peter J Morris, Arvind Pallan, Andreas Paul, Mihai Pavel, M Thamara PR Perera, Jacques Pirenne, Reena Ravikumar, Leslie Russell, Sara Upponi, Chris JE Watson, Annemarie Weissenbacher, Rutger J Ploeg, Peter J Friend, Consortium for Organ Preservation in Europe
Jun 12, 2018
Liver transplantation is a highly successful treatment, but is severely limited by the shortage in donor organs. However, many potential donor organs cannot be used; this is because sub-optimal livers do not tolerate...
Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
Anna S. E. Cuomo, Daniel D. Seaton, Davis J. McCarthy, Iker Martinez, Marc Jan Bonder, Jose Garcia-Bernardo, Shradha Amatya, Pedro Madrigal, Abigail Isaacson, Florian Buettner, Andrew Knights, Kedar Nath Natarajan, Ludovic Vallier, John C. Marioni, Mariya Chhatriwala, Oliver Stegle, Chukwuma A. Agu, Alex Alderton, Petr Danecek, Rachel Denton, Richard Durbin, Daniel J. Gaffney, Angela Goncalves, Reena Halai, Sarah Harper, Christopher M. Kirton, Anja Kolb-Kokocinski, Andreas Leha, Shane A. McCarthy, Yasin Memari, Minal Patel, Ewan Birney, Francesco Paolo Casale, Laura Clarke, Peter W. Harrison, Helena Kilpinen, Ian Streeter, Davide Denovi, Ruta Meleckyte, Natalie Moens, Fiona M. Watt, Willem H. Ouwehand, Angus I. Lamond, Dalila Bensaddek, Philip Beales
Feb 09, 2021
Abstract: Recent developments in stem cell biology have enabled the study of cell fate decisions in early human development that are impossible to study in vivo. However, understanding how development varies across individuals...
The tale of TILs in breast cancer
Khalid El Bairi, Harry R Haynes, Elizabeth Blackley, Susan Fineberg, Jeffrey Shear, Sophia Turner, Juliana Ribeiro de Freitas, Daniel Sur, Luis Claudio Amendola, Masoumeh Gharib, Amine Kallala, Indu Arun, Farid Azmoudeh-Ardalan, Luciana Fujimoto, Luz F Sua, Shi-Wei Liu, Huang-Chun Lien, Pawan Kirtani, Marcelo Balancin, Hicham El Attar, Prerna Guleria, Wenxian Yang, Emad Shash, I-Chun Chen, Veronica Bautista, Jose Fernando Do Prado Moura, Bernardo L Rapoport, Carlos Castaneda, Eunice Spengler, Gabriela Acosta-Haab, Isabel Frahm, Joselyn Sanchez, Miluska Castillo, Najat Bouchmaa, Reena R Md Zin, Ruohong Shui, Timothy Onyuma, Wentao Yang, Zaheed Husain, Karen Willard-Gallo, An Coosemans, Edith A Perez, Elena Provenzano, Paula Gonzalez Ericsson, Eduardo Richardet, Ravi Mehrotra, Sandra Sarancone, Anna Ehinger, David L Rimm, John MS Bartlett, Giuseppe Viale, Carsten Denkert, Akira I Hida, Christos Sotiriou, Sibylle Loibl, Stephen M Hewitt, Sunil Badve, William Fraser Symmans, Rim S Kim, Giancarlo Pruneri, Shom Goel, Prudence A Francis, Gloria Inurrigarro, Rin Yamaguchi, Hernan Garcia-Rivello, Hugo Horlings, Said Afqir, Roberto Salgado, Sylvia Adams, Marleen Kok, Maria Vittoria Dieci, Stefan Michiels, Sandra Demaria, Sherene Loi, International Immuno-Oncology Biomarker Working Group
Dec 15, 2021
The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with...
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