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Transcriptional characterization of human megakaryocyte polyploidization and lineage commitment
Fizzah A. Choudry, Frederik O. Bagger, Iain C. Macaulay, Samantha Farrow, Frances Burden, Carly Kempster, Harriet McKinney, Lars R. Olsen, Ni Huang, Kate Downes, Thierry Voet, Rakesh Uppal, John F. Martin, Anthony Mathur, Willem H. Ouwehand, Elisa Laurenti, Sarah A. Teichmann, Mattia Frontini
Apr 20, 2021
Original Article Thrombosis Megakaryocytes Hematopoietic Stem Cells platelets single cell RNA‐seq Thrombosis
Published by: Journal of Thrombosis and Haemostasis
Transcriptional characterization of human megakaryocyte polyploidization and lineage commitment.
Fizzah A Choudry, Frederik O Bagger, Iain C Macaulay, Samantha Farrow, Frances Burden, Carly Kempster, Harriet McKinney, Lars R Olsen, Ni Huang, Kate Downes, Thierry Voet, Rakesh Uppal, John F Martin, Anthony Mathur, Willem H Ouwehand, Elisa Laurenti, Sarah A Teichmann, Mattia Frontini
Mar 15, 2021
BACKGROUND: Megakaryocytes (MKs) originate from cells immuno-phenotypically indistinguishable from hematopoietic stem cells (HSCs), bypassing intermediate progenitors. They mature within the adult bone marrow and release...
Psychological Disturbances in Lung Cancer Patients
Introduction: Lung cancer may be conceptualized as a stressor with psychological, behavioral and biological components that can severely impact upon quality of life (QOL). Lung cancer patients generally experience decreased QOL...
Published by: IJHS Medical Association
Deterministic Decision Support System for the Assessment of Cities Based on Air Quality Indicators
A deterministic decision support system is developed for the assessment of various Indian cities based on the air quality parameters in this research. The present study shapes the assessment of cities as a multi-criteria...
Published by: IGI Global Scientific Publishing
Fuzzy Distance-Based Approach for the Assessment and Selection of Programming Languages
The desire to develop software with more and more functionalities to make human work easier pushes the industry towards developing various programming languages. The existence of the various programming languages in today's...
Published by: IGI Global Scientific Publishing
Psychological Disturbances in Lung Cancer Patients
Introduction: Lung cancer may be conceptualized as a stressor with psychological, behavioral and biological components that can severely impact upon quality of life (QOL). Lung cancer patients generally experience decreased QOL...
Published by: IJHS Medical Association
Theory of strong coupling between molecules and surface plasmons on a grating.
The strong coupling of molecules with surface plasmons results in hybrid states which are part molecule, part surface-bound light. Since molecular resonances may acquire the spatial coherence of plasmons, which have mm-scale...
Hospital admission with non-alcoholic fatty liver disease is associated with increased all-cause mortality independent of cardiovascular risk factors
Jake P. Mann, Paul Carter, Matthew J. Armstrong, Hesham K. Abdelaziz, Hardeep Uppal, Billal Patel, Suresh Chandran, Ranjit More, Philip N. Newsome, Rahul Potluri
Oct 27, 2020
Non-alcoholic fatty liver disease (NAFLD) is common and strongly associated with the metabolic syndrome. Though NAFLD may progress to end-stage liver disease, the top cause of mortality in NAFLD is cardiovascular disease (CVD)....
Advanced Object Detection in Bio-Medical X-Ray Images for Anomaly Detection and Recognition
The human vision system is mimicked in the format of videos and images in the area of computer vision. As humans can process their memories, likewise video and images can be processed and perceptive with the help of computer...
Published by: IGI Global Scientific Publishing
Policy Gaps and Opportunities
Dylan Cooper, Disha Uppal, Kirsten Railey, Amy Blank Wilson, Katie Maras, Emily Zimmerman, Juan Bornman, Lindsay Shea
Jul 31, 2022
Autism spectrum disorder prevalence is rising, and as this population enters adulthood, preliminary research has identified high rates of contact with the criminal justice system. Policy and programmatic reform are crucial given...
Policy Gaps and Opportunities
Dylan Cooper, Disha Uppal, Kirsten Railey, Amy Blank Wilson, Katie Maras, Emily Zimmerman, Juan Bornman, Lindsay Shea
Jul 31, 2022
Autism spectrum disorder prevalence is rising, and as this population enters adulthood, preliminary research has identified high rates of contact with the criminal justice system. Policy and programmatic reform are crucial given...
A Novel Machine Learning-Based Approach for Outlier Detection in Smart Healthcare Sensor Clouds
A smart healthcare sensor cloud is an amalgamation of the body sensor networks and the cloud that facilitates the early diagnosis of diseases and the real-time monitoring of patients. Sensitive data of the patients which are...
Published by: IGI Global Scientific Publishing
Comprehensive Analysis of State-of-the-Art CAD Tools and Techniques for Chronic Kidney Disease (CKD)
It has been seen that in the last one decade, AI/ML/DL has been considered a core research area in healthcare as we know that kidney is one among the important internal body organs helps in regulation of the fluid within the...
Published by: IGI Global Scientific Publishing
Towards Detecting Dementia via Deep Learning
Dementia is a brain disorder that causes loss of memory leading to disruption in the normal course of life of an individual. It is emerging as a global health problem in adults with age 65 years or above. Early diagnosis of...
Published by: IGI Global Scientific Publishing
Rabies Elimination
Rabies is a vaccine-preventable fatal viral disease that is zoonotic in nature. In this article, we provide a justification why the agreement of the World Health Organization (WHO), the Food and Agriculture Organization (FAO)...
Hospital Based Study on Etiological and Clinical Profile of Patients with Atrial Fibrillation in Kosi Region of Bihar
Atrial fibrillation (AF) can cause significant symptoms and diminished quality of life, but, more importantly, is associated with increased risks of stroke, congestive heart failure, and mortality. This hospital based study was...
Published by: IJHS Medical Association
Hospital admission with non-alcoholic fatty liver disease is associated with increased all-cause mortality independent of cardiovascular risk factors.
Advanced Object Detection in Bio-Medical X-Ray Images for Anomaly Detection and Recognition
The human vision system is mimicked in the format of videos and images in the area of computer vision. As humans can process their memories, likewise video and images can be processed and perceptive with the help of computer...
Medicine and Healthcare Medical Diagnosis and Practice Medical Imaging Computer Science and Information Technology Media and Communications
Published by: IGI Global Scientific Publishing
Improving Performance During Camera Surveillance by Integration of Edge Detection in IoT System
This paper is proposing an IoT-based camera surveillance system. The objective of research is to detect suspicious activities by camera automatically and take decision by comparing current frame to previous frame. Major...
Published by: IGI Global Scientific Publishing
A Study of Anterior Ethmoidal Foramen Exsutural in North Indian Crania
Anterior ethmoidal foramen normally lies on the suture between medial edge of orbital plates of frontal andethmoidal bones in the medial wall of orbit. It occasionally emerges above the suture. Studies of nonmetric...
Published by: IJHS Medical Association
Delivering screening programmes in primary care
Rakesh Narendra Modi, Sarah Kelly, Sarah Hoare, Alison Powell, Isla Kuhn, Juliet Usher-Smith, Jonathan Mant, Jenni Burt
Apr 07, 2021
INTRODUCTION: Screening programmes represent a considerable amount of healthcare activity. As complex interventions, they require careful delivery to generate net benefit. Much screening work occurs in primary care. Despite...
Essential but sparse collagen hydroxylysyl post-translational modifications detected by DNP NMR.
Wing Ying Chow, Rui Li, Ieva Goldberga, David G Reid, Rakesh Rajan, Jonathan Clark, Hartmut Oschkinat, Melinda J Duer, Robert Hayward, Catherine M Shanahan
Nov 21, 2018
The sparse but functionally essential post-translational collagen modification 5-hydroxylysine can undergo further transformations, including crosslinking, O-glycosylation, and glycation. Dynamic nuclear polarization (DNP) and...
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